In a first, doctors successfully treated a rare genetic disease before birth

Plus: Geometrical miracle: A massive secret Ancient Egypt tunnel just unearthed Nov 12, 2022 [Blueprint]( For the first time ever, doctors [successfully treated a genetic disorder before birth](. They were able to treat the fetus for a fatal genetic condition called Pompe disease. After treatments for a few weeks prior to birth, the baby was born healthy and is now 16 months old. The doctors treated her using replacement enzyme therapy (ERT), which is usually given after birth. But in her case, she was given the treatment before she was born, and doctors delivered the enzyme through a needle inserted in her mother’s abdomen and into the baby’s umbilical cord. The innovation was having the ability to treat the baby earlier and while still in utero. Before reading this unbelievable story, in another world of firsts, take a look at the [first computer ever made]( or more so, what inspired the creation of the first computer, since the prototype was 23 feet long and 10 feet tall. Good morning. I’m Brittney, an Editor at IE. Welcome to today’s issue of The Blueprint. Let’s get started. Last Saturday, Blueprint subscribers heard an exclusive interview from the chief communications officer at KenGen, a company looking to help countries use geothermal power and renewable energy. This weekend, premium subscribers can read about [new breakthroughs in cancer treatments]( and learn about why more people are beating cancer than ever before. Don't miss out — [subscribe to IE+]( today to receiv e exclusive interviews, features, and much more. [premium] [Play]VIDEO OF THE DAY [A rare discovery: Redditor finds vintage computer systems from 1956 and 1970 in their grandparents' basement.]( ["The only thing I know is that my grandfather used it for some civil engineering calculations in the 60s."]( "The only thing I know is that my grandfather used it for some civil engineering calculations in the 60s." [Must Read]MUST READ [In a first, doctors successfully treated a rare genetic disease before birth.]( [The toddler, now 16 months old, is growing up healthy.]( [The toddler, now 16 months old, is growing up healthy.]( UC San Francisco/YouTube In a medical first, [doctors successfully treated a fetus for a fatal genetic condition]( called Pompe disease. The enzyme needed to treat the condition was delivered through a needle inserted through the mother's abdomen and guided into a vein in the umbilical cord. The baby, Ayla Bashir, is the focus of the case study and is now 16 months old. She is an active, happy girl who has met her developmental milestones, according to her parents. → The condition is typically treated with replacement enzyme therapy (ERT) soon after birth. However, some babies are born with an immune condition that blocks the infused enzymes, so the therapy eventually stops working. The hope is that early treatment before birth will reduce the severity of that immune response. [READ MORE [Arrow]]( [CULTURE]CULTURE [Geometrical miracle: A massive secret Ancient Egypt tunnel just unearthed.]( Archaeologists find a massive "miracle" tunnel under an Ancient Egyptian temple, and [some scholars think that this tunnel may be the passage to the lost-long tomb of Cleopatra](. There are still debates among scholars whether the temple at Taposiris Magna is likely to contain Cleopatra. [READ MORE [Arrow]]( And Other Stories in Culture - Divers find [Space Shuttle]( segment in the Atlantic over 30 years after the Challenger disaster. - Iran claims that it has built a [hypersonic missile](. Here's what we know. - Elon Musk tells [Twitter]( staff about possible bankruptcy, top executives leave. 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