Dementia could be prevented with protein clusters

Plus: The woman who saved the Moon landing (who you’ve probably never heard of). Nov 11, 2022 [Blueprint]( Cures for dementia – there’s a reason we talk a lot about this. We all really, really want one. Now, in great news, it seems the clean-up of toxic protein clumps [could prevent neurodegenerative diseases]( according to a new study. In short, it found that the relationship between two key enzymes could prevent dementia. The proteins in question were the enzyme Fyn and the protein Tau. They studied the area of the brain that causes frontotemporal dementia, a form of brain disorder that forms when parts of the frontal and temporal lobes are damaged, affecting behavior, language and movement. And it proved fruitful, to say the least. But before you check that out, check out this incredible woman, Margaret Hamilton. Never heard of her? Well, you have now. [This video]( shows Margaret Hamilton, the pioneering software engineer who saved the Moon landing. Yep, and yet hardly any of us have heard of her. Madness. Good morning. I’m Alice, an Editor at IE. This is The Blueprint. Let’s dive in. [Dark matter behavior may conflict with our best theory of the universe](. [premium] A new paper, published in the Astronomy and Astrophysics journal, discovered unexpected characteristics for the elusive dark matter that likely goes against our best theory of the universe – the Lambda-Cold Dark Matter model. [Play]VIDEO OF THE DAY [Margaret Hamilton: the pioneering software engineer who saved the Moon landing.]( [Margaret Hamilton: the pioneering software engineer who saved the Moon landing.]( Quite the claim to fame, we think you’ll agree. [Must Read]MUST READ [Dementia could be prevented by restoring and normalizing protein clusters.]( [Dementia could be prevented.]( A new study has found that focusing on the relationship between two key enzymes [could prevent dementia](. The enzyme Fyn and the protein Tau were under particular scrutiny. Researchers studied the area of the brain that causes frontotemporal dementia, a form of brain disorder that forms when parts of the frontal and temporal lobes are damaged, affecting behavior, language and movement. They found that Fyn, which is an enzyme that plays a significant role in learning and memory, became active when it was immobilized within the synapses – a link between two nerve cells – that connected hubs between neurons, where the enzymes normally communicate. The biggest discovery made though, was that enzymes change into an opened structure, like a blossoming flower, when they are activated. They also slow down their movement and group together to form clusters of protein. They then fold back into each other and disperse, before doing the same thing all over again. This matters because it meant they found out how Fyn and Tau cause the progression of different types of dementia. And, more specifically, which molecular mechanisms exactly are behind the interactions of proteins. → As a result, the team behind this research think Tau enzymes could hold the key to reverting this toxic chain reaction with Fyn proteins, which is what they say causes dementia. [READ MORE [Arrow]]( [Facebook]( [Twitter]( [Linkedin]( [SCIENCE]SCIENCE [The next “big one” solar storm could send decimate our electrical infrastructure.]( At its worst, it even has the potential to damage satellites and [can even trigger power outages]( on Earth. While our planet has shields against this most of the time, these waves of particles can prove very dangerous for technology. [READ MORE [Arrow]]( And Other Stories in Science - Scientists use a [quantum state of matter]( to simulate the early universe’s expansion. - Researchers [proposed a new theory]( to grow pure carbon nanotubes. - Soon you’ll be able to take a [portable version of the Earth's magnetic field]( to outer space. [premium] [INNOVATION]INNOVATION [A startup turns e-waste into solar lanterns to solve Nigeria’s frequent power outage problem. [premium]]( Idunnu is a rechargeable solar light with [batteries and frames made from e-waste](. Each lantern weighs roughly 2.5 kg and is made up of 70 percent recycled electronic waste and 30 percent imported parts. [READ MORE [Arrow]]( And Other Stories in Innovation - Indian space tech company successfully test-fires [world's first single-piece 3D-rocket engine](. - DragonFire: UK's laser weapon [can fire beams at 50kW]( and beyond. - [Starlink announces a 1 TB data cap]( for users during peak daytime hours. [MAIL & MUSINGS]MAIL & MUSINGS Dementia could be prevented with protein clusters. Do you think we’ll see a cure for dementia in the next decade? [No, but beyond that hopefully]( [Yes, we’re making huge strides]( [If it gets given enough funding]( [It’s difficult to say either way]( YESTERDAY'S RESULTS Yesterday, we asked you if you would consider playing the new VR game that kills you if you die in the game, and 53 percent of you said no, the stakes are far too high. 53% No, the stakes are too high 39% It won’t come to market anyway 4% I am unsure either way 4% Yes, as I am excellent at games [QUOTE OF THE DAY]QUOTE OF THE DAY “Falsity in intellectual action is intellectual immorality.” Thomas Crowder Chamberlain, American geologist. [9 mini electirc fireplace heaters.]( [THINGS WE LOVE]THINGS WE LOVE [image]( [SHOWME Laser Keyboard]( [image]( [eufy by Anker BoostIQ RoboVac 11S]( [image]( [Kids Playzoom 2 Smartwatch]( [image]( [IGOKOTI Personal Air Purifier]( [AND ANOTHER THING]AND ANOTHER THING - Sexual activity could [trigger asthma flare-ups]( study reveals. - Greenland’s frozen hinterlands are [bleeding worse than we thought](. (Science News) - Weird [magic neurons in the spine]( can make people with paralysis walk again. - Quantum trick sees light [move forwards and back]( in time simultaneously. (New Scientist) - New protein discovery could [aid in lung cancer treatment](. - [Why fandom feels good]( — and may be good for you. (SN Explores) - Watch as this woman removes rings [stuck on her fingers for 15 years](. Prepared by Alice Cooke Enjoy Reading? Forward this email to a friend. Was this email forwarded to you? 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