Insert preview text here. [View this email in your browser]( | [Manage newsletter subscriptions](newsletter=wir) [WIRED Special Edition: Letter from the Editor] 09.10.21 We hope you enjoy this free edition of Gideon Lichfieldâs Letter from the Editor. [Subscribe to WIRED]( to receive future editions of this exclusive email. [SUBSCRIBE NOW]( It may have seemed like a logical solution to the opioid crisis: Create an algorithm to identify patients at high risk of overusing opioids, and advise doctors not to prescribe opioid-based painkillers to them. But that strategy may only have made the epidemic worse, as Maia Szalavitz [reports for WIRED](. The algorithm, NarxCare, is a kind of âsecret credit scoreâ for opioid risk. It often flags people it shouldnât, and by denying meds to people in severe pain, itâs driving many to seek out illegal drugs that theyâre more likely to get addicted to. And even as prescribing has fallen sharply over the past decade, overdose deaths have risen to a record high. As weâve been reporting, AI is working its way into ever more spheres of medicine. Itâs being used to [screen for breast cancer](. It could [predict when viruses will mutate](. In the future it may help doctors [remotely track patientsâ vital signs]( to spot dangerous conditions before they become fatal. Thereâs great promise here. So why does it sometimes go spectacularly wrong, as with NarxCare? I think part of the answer is in this story by WIREDâs Tom Simonite about [another risk-assessment algorithm](, one used to alert nurses that a patient might be developing sepsis, a frequent killer in American hospitals. It forces changes in routines and workflows, but doctors donât always believe it, or are more receptive to its diagnoses at some times than at others. The algorithm, as Tom writes, has âa complicated social life.â The phrase made me think of the book The Social Life of DNA, by Alondra Nelson, a Princeton sociologist who is now deputy head of the White Houseâs Office of Science and Technology Policy. WIREDâs Khari Johnson [interviewed her in June](, and one of her key points was that the AI field needs to âmove from technical standards to ⦠socio-technical standards.â That means, among other things, that people developing an AI tool shouldnât just evaluate whether it accurately predicts cancer or sepsis or opioid risk, but also how people will interpret and act on those predictionsâand whether those actions could end up doing more harm than good. Building an AI, these days, can be almost trivial. Figuring out its effects is much harder. These are just a few of the complex, thought-provoking stories we've published recently; some of my other favorites are listed below. Gideon Lichfield | Global Editorial Director, WIRED If you liked this Editor's Note, please consider [subscribing to WIRED]( in order to receive future editions. [SUBSCRIBE NOW]( [[GET WIRED]( [Stare the future right in the eye.]( [Get 1 year of unlimited access to WIRED for less than $1 per month. That includes Steven Levy's exclusive newsletter and a free tote!]( [Subscribe now.](]( [The Delta Variant Is Making Covid a Pandemic of the Young]( [BY GREGORY BARBER | 6-MINUTE READ]( [Now that children are becoming the biggest group of unvaccinated people in Western countries, itâs become clear theyâre not as immune as they seemed.]( [Looks That Quill: The Dark Side of Hedgehog Instagram]( [BY NOELLE MATEER | 11-MINUTE READ]( [How a cute species got sacrificed on the altar of popularity algorithms.]( [Fleeing Disaster Is Hard. 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