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How Mass. won the "NASA for health care"

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Also: This year's COVID vaccine rollout is off to a bumpy start October 3, 2023 Hi CommonHealth

Also: This year's COVID vaccine rollout is off to a bumpy start [Donate ❤️]( [View in Browser](  October 3, 2023 Hi CommonHealth reader, Earlier this year, a group of public officials, scientists, business leaders and community advocates held a secret meeting in Cambridge. Federal officials were in town, and this group was on a mission. They had just a few hours to convince the feds to choose Massachusetts as a hub for the [Advanced Research Projects Agency for Health]( or ARPA-H, a new federal initiative to invest in solving big and complex health problems. The pitch they crafted included the state's track record for medical innovation in everything from anesthesia and surgery to COVID vaccines. It was delivered directly by Gov. Maura Healey, researchers, investors and others. Last week, we learned this aggressive strategy paid off. Massachusetts — and specifically, Cambridge’s Kendall Square — will [become one of three hubs]( for ARPA-H. Kendall Square is already recognized nationally as a hotbed of life sciences research. But Brian Johnson, president of the Massachusetts Medical Device Industry Council, said hosting ARPA-H is a big deal. He likened it to landing "what's essentially NASA for health care." Johnson was among a handful of business leaders and state officials — they called themselves the "tiger team" — who worked to win this designation. First, in April, they wrote up a detailed pitch. Then they learned ARPA-H officials wanted to meet in person, and they had just a few days to plan a site visit, in May, that they hoped would seal the deal. "We said Massachusetts has proven time and time again that we have the ability to take early-stage concepts of innovation and commercialize them into global health care solutions," Johnson told me. "The argument was that there is no better place in the world than Kendall Square to house this, because you basically can't walk down the street without bumping into some place or some person who invented some major health care breakthrough," he said. Johnson and others involved in this effort told me they weren’t allowed to discuss it publicly until now — or Massachusetts risked being disqualified. I asked them: Why put so much time and energy into wooing federal officials? The answer has to do with the lofty ambition of ARPA-H. The agency is hiring program managers to distribute big chunks of federal funding to researchers who take on big challenges, from treating cancer and dementia, to making health care more equitable. Program managers will be based in Cambridge. So they’ll be able to see up close the work going on in local research labs. "This is like thinking about trying to put a man on the moon," Massachusetts Secretary of Economic Development Yvonne Hao told me. "This is a very ambitious, inspirational project, and it's going to be headquartered here – which means that if you're someone who wants to think about these problems and work on these problems, you're going to be in Massachusetts." It's still unclear how many ARPA-H jobs will be based in the state, or how much research funding the agency will distribute locally. But that isn’t tempering the excitement of the group that, for a stretch, worked seven days a week to bring the agency here. As Valerie Fleishman, chief innovation officer at the Massachusetts Health & Hospital Association, said: "This is a once-in-a-lifetime opportunity." P.S.— One of the great things about the CommonHealth newsletter is that it is always available for free. Listeners and readers like you make this possible by giving to support independent journalism. [Please join them](. We need 2,500 new monthly donors by Thursday to reach our goal. Priyanka Dayal McCluskey Senior Health Reporter [Follow]( Editor's note: This newsletter will take a break next week due to Indigenous Peoples Day, but we’ll be back in your inboxes Oct. 17. Support the news  This Week's Must Reads [Nobel Prize goes to scientists who made mRNA COVID vaccines possible]( Hungarian-born biochemist Katalin Karikó and American immunologist Drew Weissman found that a chemical change to genetic code called mRNA eliminated a problematic side effect when used in vaccines. [Read more.]( [Nobel Prize goes to scientists who made mRNA COVID vaccines possible]( Hungarian-born biochemist Katalin Karikó and American immunologist Drew Weissman found that a chemical change to genetic code called mRNA eliminated a problematic side effect when used in vaccines. [Read more.]( [This year's COVID vaccine rollout is off to a bumpy start, despite high demand]( Some people are finding pharmacies still don't have supply of the shots, and others are having insurance coverage troubles. Here's what's going on. [Read more.]( [This year's COVID vaccine rollout is off to a bumpy start, despite high demand]( Some people are finding pharmacies still don't have supply of the shots, and others are having insurance coverage troubles. Here's what's going on. [Read more.]( [Health care has a massive carbon footprint. These doctors are trying to change that]( Around the country, health care workers continue to grapple with their industry's massive carbon footprint. In Pittsburgh, doctors formed Clinicians for Climate Action to address the problem. [Read more.]( [Health care has a massive carbon footprint. These doctors are trying to change that]( Around the country, health care workers continue to grapple with their industry's massive carbon footprint. In Pittsburgh, doctors formed Clinicians for Climate Action to address the problem. [Read more.]( [PrEP prevents HIV infections, but it's not reaching Black women]( A significant number of new HIV infections happen among Black women, and a health education effort in Atlanta wants to make sure Black women can access the HIV-prevention medicines known as PrEP. [Read more.]( [PrEP prevents HIV infections, but it's not reaching Black women]( A significant number of new HIV infections happen among Black women, and a health education effort in Atlanta wants to make sure Black women can access the HIV-prevention medicines known as PrEP. [Read more.]( [Brain cells, interrupted: How some genes may cause autism, epilepsy and schizophrenia]( Researchers have identified 46 genes that can disrupt a process that is critical to early brain development. The finding could help scientists find new treatments for disorders including autism. [Read more.]( [Brain cells, interrupted: How some genes may cause autism, epilepsy and schizophrenia]( Researchers have identified 46 genes that can disrupt a process that is critical to early brain development. The finding could help scientists find new treatments for disorders including autism. [Read more.]( What We're Reading 📚 - There are no words ([The Boston Globe]( - Mosquitoes Are a Growing Public Health Threat, Reversing Years of Progress ([The New York Times]( - The prices hospitals post online can be wildly different than what they tell patients over the phone ([Vox]( "We're at a point where we're throwing away complex robotic surgical instruments." — Jodi Sherman, of Yale School of Medicine, about the [massive carbon footprint of hospitals]( From the Archives [Commentary: How Our Brutal Science System Almost Cost Us A Pioneer Of mRNA Vaccines]( After professor Katalin Karikó was awarded the Nobel Prize in medicine on Monday, we look back at this 2021 piece by Dr. David Scales, a doctor who witnessed first-hand the tribulations of the mRNA vaccine pioneer in a system that puts make-or-break financial pressures on American scientists. [Read more.]( [Commentary: How Our Brutal Science System Almost Cost Us A Pioneer Of mRNA Vaccines]( After professor Katalin Karikó was awarded the Nobel Prize in medicine on Monday, we look back at this 2021 piece by Dr. David Scales, a doctor who witnessed first-hand the tribulations of the mRNA vaccine pioneer in a system that puts make-or-break financial pressures on American scientists. [Read more.]( 🧠💥 Did you know...💥🧠 ...mammals' days on Earth are numbered? British scientists predict we have [another 250 million years to go](. That's how long they say it will be before the planet reaches a tipping point making it uninhabitable for mammalian life. 😎 Forward to a friend. They can sign up [here](. 🔎 Explore [WBUR's Field Guide]( stories, events and more. 📣 Give us your feedback: newsletters@wbur.org 📧 Get more WBUR stories sent to your inbox. [Check out all of our newsletter offerings.]( Support the news     Want to change how you receive these emails? Stop getting this newsletter by [updating your preferences.](  I don't want to hear from WBUR anymore. Unsubscribe from all WBUR editorial newsletters [here.](  Interested in learning more about corporate sponsorship? [Click here.]( Copyright © 2023 WBUR-FM, All rights reserved.

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