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How did this complex molecular machine, which can respond so exquisitely to available levels of both oxygen and several other effector molecules, come into being? Writing in Nature, Pillai et al.4 reconstruct the stepwise evolution of haemoglobin from precursors that existed more than 400 million years ago.===========Almost nothing was previously known about how the four-subunit (tetrameric) form of haemoglobin that is found in modern-day jawed vertebrates evolved from ancient monomers. Tetrameric haemoglobin consists of two α- and two β-subunits. Pillai et al. computationally reconstructed an evolutionary tree to chart the protein’s ancient history, using the amino-acid sequences of a large collection of the closely related vertebrate globin proteins, which exist as either monomers or tetramers. The authors’ tree was constructed taking into account that amino-acid substitutions a given protein shares with close relatives tend to have originated in more-recent common ancestors than have those it shares with more-distant relatives. The reconstructed evolutionary tree indicates that multiple rounds of gene duplication and subsequent divergence gave rise to the globin family and, by way of several ancestral proteins, to tetrameric haemoglobin (Fig. 1).A lens combined with an artificial iris is placed at the front of the device, just as in the human eye. The retina at the back combines with a hemispherical shell at the front to form a spherical chamber (the ‘eyeball’); the frontal hemispherical shell is made from aluminium lined with a tungsten film. The chamber is filled with an ionic liquid that mimics the vitreous humour — the gel that fills the space between the lens and the retina in the human eye. This arrangement is necessary for the electrochemical operation of the nanowires. The overall structural similarity between the artificial eye and the human eye confers on Gu and colleagues’ device a wide field of view of 100°. This compares with roughly 130° for the vertical field of view of a static human eye.I'm proud to be your boss. Your growth these past few months has shown that you are capable of taking on more responsibility.3891NR6I55INQOVVPFHHMHZEMJ6H9K8QB5VLDELXTDBZDYE1BN5JS6CX803F6UV3I4WJJX0RC0TB6LRKS07K5NASR48PU7ZSVMZL83C5NP2XMZP7Z3BYW1PR85BPGDVNW4KP5PY3PCVGG93W R6T56OSGIOK6FUOHL95RJ5GGUXY3F48DZ4M4YBO3R32CDBG85QAQNCNMI1DYCZELRB40JNIYOB40JOENZ84B57FQETAUI3B0TST936245653914018507143128716817217384611119740094206106067827585854516562529025957539061912444295396474896809852299578847218793598268921076052285 177242212327152613551997036914459969706943343762661849003372587646265507037887535114518186563534548CX9XSLT43E0IUG1 N71QSORLWROZM0OYRF9TDI7YAZZF4DGNGB3I42YUO3QNZMB4XDYZ2CYPSW82QLS0YAK757WAV3E3YXZUMTGX301R9RUR15F4MWQ750747969943956 923346558810882557640434091273538364366849914164160627846140990459235097608524954011356677257588944I am so grateful you were able to come to my wedding and join in on the celebrations.I had so much fun dancing the night away with you. Also, thank you so much for the blender.Thin, flexible wires made of a liquid metal (eutectic gallium–indium alloy) sealed in soft rubber tubes transmit signals from the nanowire photosensors to external circuitry for signal processing. These wires mimic the nerve fibres that connect the human eye to the brain. A layer of indium between the liquid-metal wires and nanowires improves electrical contact between the two. The artificial retina is held in place by a socket made from a silicone polymer, to ensure proper alignment between the wires and nanowires.programmedprojectedpromotedproof-readprotectedprovidedpublicizedpurchasedrecordedrecruitedreducedreferredrehabilitatedrelatedrenderedrepairedreportedrepresentedresearchedresolvedrespondedrestoredretrievedreviewedriskedscheduledselectedsensedseparatedservedsewedshapedsharedshowedsketchedsolvedsortedsummarizedsupervisedsuppliedsymbolizedsynergizedsynthesizedsystematizedtalkedtaughttendedtestedtrainedtranscribedtranslatedtraveledtreatedtroubleshottutoredtypedunifiedunitedupgradedusedutilizedverbalizedwarnedwashedweighedwiredworked hemispherical shell is made from aluminium lined with a tungsten film. The chamber is filled with an ionic liquid that mimics the vitreous humour — the gel that fills the space between the lens and the retina in the human eye. This arrangement is necessary for the electrochemical operation of the nanowires. The overall structural similarity between the artificial eye and the human eye confers on Gu and colleagues’ device a wide field of view of 100°. 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