IL-6: A Pleiotropic Inflammatory Cytokine

Created for {EMAIL} | [Web Version]( This is a paid advertisement. Live Science [Sino Biological]( [IL6: A Pleiotropic Inflammatory Cytokine]( [Interleukin 6 (IL-6)]( is a pro-inflammatory cytokine involved in immune responses, hematopoiesis, bone metabolism, and embryonic development. Elevated IL-6 is observed in patients with microbial infections and other inflammatory conditions. Targeting IL-6 has important clinical implications for diagnosing, managing, and preventing infectious diseases. The pro-inflammatory function of IL-6 is regulated by a trans-signaling process involving soluble IL-6R (sIL-6R) and [gp130]( receptor. The production of sIL-6R is activated by [IL-1beta]( and [TNF-alpha](. These two pro-inflammatory cytokines induce the proteolytic cleavage of [IL-6R]( by activating [ADAM10]( and [ADAM17](. Unlike most other soluble receptors (e.g. [IL-1RA]( and [IL-18BP]( sIL-6R is NOT an inhibitor of IL-6. Instead, it activates IL-6 signaling by forming a complex with IL-6 and gp130. [10398-h08h] Human IL-6R (cat#: [10398-H08H]( enhance the IL-6 activity on M1 mouse myeloid leukemia cells. The ED50 is typically 20-80 ng/mL. Sino Biological has developed a panel of high-quality recombinant IL-6 and receptor proteins to support the study of this cytokine. Recombinant IL-6 and Receptors Sino Biological has developed bioactive recombinant IL-6 cytokines from various species, such as human, mouse, rat, rhesus, and pig. • Featured IL-6 Protein Human IL-6 Protein: 10395-HNAE High-purity Low-endotoxin Tag-free HPLC-verified [10700-H03H] > 95 % as determined by SDS-PAGE [10584-HNAE] [10584-HNAE] Cell proliferation assay using TF-1 human erythroleukemic cells Batch-to-batch Consistency • Bioactive Recombinant IL-6 from Multiple Species Species Cat# Activity Validated Human [10395-HNAE]( Bind to Human IL-6R Cell proliferation Mouse [50136-MNAE]( Cell proliferation Rat [80076-RNAE]( Cell proliferation Rhesus [90197-CNAE]( Cell proliferation Sus scrofa (Pig) [62006-WNAE]( Bind to Human IL-6R ([10398-H08H]( • Recombinant Membrane-bound IL-6 Receptor: IL-6R IL-6 demonstrates limited cross-species bioactivity. Human IL-6 can bind to both human and mouse IL-6R, but mouse IL-6 can only bind to mouse [IL-6R](. Human IL-6 Receptor [10398-H08H]( Mouse IL-6 Receptor [50280-M08H]( Rat IL-6 Receptor [81072-R08H]( Canine IL-6 Receptor [70117-D08H]( Rhesus IL-6 Receptor [90324-C08H]( • Recombinant Gp130 [Gp130]( is a common receptor and signal transducer shared by most IL-6 family cytokines. [Recombinant Human gp130]( [Recombinant Mouse gp130]( [Recombinant Rat gp130]( [Recombinant Rhesus gp130]( • More IL-6 Family Cytokines [IL-11]( [LIF]( [OSM]( [CNTF]( [IL-31]( [IL-27]( [NNT-1]( [CT-1]( Antibodies for IL-6 and Receptors Sino Biological has developed a comprehensive panel of antibodies targeting IL-6 cytokines and receptors, which can be used in ELISA, WB, IHC-P, and IP. • Neutralization Antibodies: IL-6 and IL-6R IL-6 Neutralizing Antibody (Cat#: [10395-R508]( IL-6R Neutralizing Antibody (Cat#: [10398-MM08]( [IL-6 Neutralizing Antibody] [IL-6R Neutralizing Antibody] Neutralize IL-6 induced proliferation in the T1165 mouse plasmacytoma cells. The IC50 is typically 80-320ng/mL IL-6-dependent Inhibition of cell proliferation is neutralized by Human IL-6R neutralizing Monoclonal Antibody. The IC50 is typically 0.15-0.6 μg/mL. ELISA Kits and ELISA Detection Pairs for IL-6 and Receptors [IL-6 ELISA Kit]( [IL-6R ELISA Kit]( [gp130 ELISA Kit]( [IL-6 Detection Pairs]( [IL-6R Detection Pairs]( [gp130 Detection Pairs]( [Sino Biological]( U.S.A Sino Biological US Inc. order_us@sinobiologicalus.com Europe Sino Biological Europe GmbH order_eu@sinobiologicaleu.com Global Sino Biological, Inc. order@sinobiological.com About this email: Future will occasionally send emails from our business partners promoting products and services likely to be of interest to our readers. [Unsubscribe]( | [Privacy Policy]( Future US LLC © 1100 13th St. NW, Suite 1000, Washington, DC 20005