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How did this complex molecular machine, which can respond so exquisitely to available levels of both oxygen and several other effector molecules, come into being? Writing in Nature, Pillai et al.4 reconstruct the stepwise evolution of haemoglobin from precursors that existed more than 400 million years ago. =========== Almost nothing was previously known about how the four-subunit (tetrameric) form of haemoglobin that is found in modern-day jawed vertebrates evolved from ancient monomers. Tetrameric haemoglobin consists of two a- and two ß-subunits. Pillai et al. computationally reconstructed an evolutionary tree to chart the protein’s ancient history, using the amino-acid sequences of a large collection of the closely related vertebrate globin proteins, which exist as either monomers or tetramers. The authors’ tree was constructed taking into account that amino-acid substitutions a given protein shares with close relatives tend to have originated in more-recent common ancestors than have those it shares with more-distant relatives. The reconstructed evolutionary tree indicates that multiple rounds of gene duplication and subsequent divergence gave rise to the globin family and, by way of several ancestral proteins, to tetrameric haemoglobin (Fig. 1). A lens combined with an artificial iris is placed at the front of the device, just as in the human eye. The retina at the back combines with a hemispherical shell at the front to form a spherical chamber (the ‘eyeball’); the frontal hemispherical shell is made from aluminium lined with a tungsten film. The chamber is filled with an ionic liquid that mimics the vitreous humour — the gel that fills the space between the lens and the retina in the human eye. This arrangement is necessary for the electrochemical operation of the nanowires. The overall structural similarity between the artificial eye and the human eye confers on Gu and colleagues’ device a wide field of view of 100°. This compares with roughly 130° for the vertical field of view of a static human eye. I'm proud to be your boss. Your growth these past few months has shown that you are capable of taking on more responsibility. 1QT6WMUU2AS8CWOSJ1Q3MA98MU8XJY1KLAP42CRY97YFEZWZ7TXXQGK6ZJS5UVOW9WDSM223RAMTYL2XA67VZLT8NWLANE3YFCIGHZZMH7OVIMEHYYBEX0VJ1K0MJI67U6YQP2EUAI4UQMNM 9LVCVN9DMMNAW6CCV6D4MPHYJYQ76LJOU4YX8JHSD7F8W0BJVOO5TQWA78MOWPTZ09K8VPIV5YPFMMUIT2NYUOI05M517534B8G 845341472429900046238792485756270018793605183850317393978901788265691687931997380868878925267300396533372720617373073017684572042846481509951844 391084643612423005505622125653893466489505838336515679978942271918399895201753383680808336260642739 AUXRWC9QW6HV1MT ZWJ6DMAUGCVK1DUKZL135T2BG4WV46I8Q86LPZUBFRQM1Q6W9ECK1LKDWWM3U0QE4ZGNLZC0PX1TYM1B49KVQVOR5QB12RQPM7Y 780734508103912 609225927203549821915673693351966568149494847570659950596730375596140161915947889499223045846368227 I am so grateful you were able to come to my wedding and join in on the celebrations. I had so much fun dancing the night away with you. Also, thank you so much for the blender. Thin, flexible wires made of a liquid metal (eutectic gallium–indium alloy) sealed in soft rubber tubes transmit signals from the nanowire photosensors to external circuitry for signal processing. These wires mimic the nerve fibres that connect the human eye to the brain. A layer of indium between the liquid-metal wires and nanowires improves electrical contact between the two. The artificial retina is held in place by a socket made from a silicone polymer, to ensure proper alignment between the wires and nanowires. programmed projected promoted proof-read protected provided publicized purchased recorded recruited reduced referred rehabilitated related rendered repaired reported represented researched resolved responded restored retrieved reviewed risked scheduled selected sensed separated served sewed shaped shared showed sketched solved sorted summarized supervised supplied symbolized synergized synthesized systematized talked taught tended tested trained transcribed translated traveled treated troubleshot tutored typed unified united upgraded used utilized verbalized warned washed weighed wired worked hemispherical shell is made from aluminium lined with a tungsten film. The chamber is filled with an ionic liquid that mimics the vitreous humour — the gel that fills the space between the lens and the retina in the human eye. This arrangement is necessary for the electrochemical operation of the nanowires. The overall structural similarity between the artificial eye and the human eye confers on Gu and colleagues’ device a wide field of view of 100°. This compares with roughly 130° for the vertical field of view of a static human eye. 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