🏥 Innovations at every level of healthcare

An evolution in gut health & urgent care   Hey {NAME}, Here at Republic, we’re always looking for innovation at every level of healthcare, from preventive care to emergency medicine. Today, we’re sharing two companies developing new forms of healing. There is growing consensus that an imbalance in the gut microbiome (Dysbiosis) can contribute to a variety of human diseases with an estimated combined economic burden of $1.5T in the U.S. alone — yet there are no validated tests that provide a standardized diagnosis of dysbiosis. That’s why [32 Biosciences](~/AAQRxQA~/RgRophhWP0THaHR0cHM6Ly9yZXB1YmxpYy5jb20vMzJiaW9zY2llbmNlcz91dG1fc291cmNlPXJlcHVibGljLmNvbSZ1dG1fbWVkaXVtPWVtYWlsJnV0bV9jYW1wYWlnbj1taWxlc3RvbmVfcm91bmR1cCZ1dG1fY29udGVudD00ODRlMjBkMy03NTJmLTRmMWMtODc0Ny0zMzQxNDcyNzlmYmZfYWxsJnV0bV90ZXJtPTMyYmlvc2NpZW5jZXMmbGlkPTY3YW16d3BwazhsNlcDc3BjQgpmu1aTw2a4KVekUht0cmlzdHJhbWJhbGR3aW45MEBnbWFpbC5jb21YBAAAAc4~) is developing their proprietary diagnostic tool. Derived from over 100,000 stool metabolic signals using AI, the test defines gut microbiome health by quantitatively measuring the health of the metabolic “conversation” between the human body and the gut microbiome. Their lead indication is for management of Irritable Bowel Syndrome (IBS), a condition that currently has no FDA approved diagnostic tool despite the fact that it impacts 10% of Americans. Their goal is to unlock the future of personalized medicine by diagnosing and correcting dysbiosis to prevent and treat human disease. Meanwhile, in the emergency room, the most effective and modern tools are needed. It’s surprising that some procedures and instruments used there date back more than 50 years. That need for more effective and modern tools was the inspiration for trauma surgeon and biomedical engineer Dr Chris Salvino to start [SharpMed](~/AAQRxQA~/RgRophhWP0S9aHR0cHM6Ly9yZXB1YmxpYy5jb20vc2hhcnBtZWQ_dXRtX3NvdXJjZT1yZXB1YmxpYy5jb20mdXRtX21lZGl1bT1lbWFpbCZ1dG1fY2FtcGFpZ249bWlsZXN0b25lX3JvdW5kdXAmdXRtX2NvbnRlbnQ9NDg0ZTIwZDMtNzUyZi00ZjFjLTg3NDctMzM0MTQ3Mjc5ZmJmX2FsbCZ1dG1fdGVybT1zaGFycG1lZCZsaWQ9M3Q2bnYxZ3NoODV5VwNzcGNCCma7VpPDZrgpV6RSG3RyaXN0cmFtYmFsZHdpbjkwQGdtYWlsLmNvbVgEAAABzg~~) as an incubator in the $164B medical device market. In development are brand new tools to eliminate hypoxia (absence of oxygen necessary to stay alive) during emergency intubations, an inexpensive dilation measurement tool designed to replace the “two-finger method,” and a suite of chest tube insertion instruments. With six patents issued and 16 more pending, SharpMed focuses on managing every stage of development, from incubation to market—and to eventually modernize emergency rooms everywhere. ~/AAQRxQA~/RgRophhWP0RXaHR0cHM6Ly9hcHBzLmFwcGxlLmNvbS91cy9hcHAvcmVwdWJsaWMtaW52ZXN0LWluLXN0YXJ0dXBzL2lkMTQ3NTIzMDAyMj9saWQ9OWl0bTVhcnEzMG1pVwNzcGNCCma7VpPDZrgpV6RSG3RyaXN0cmFtYmFsZHdpbjkwQGdtYWlsLmNvbVgEAAABzg~~ ~/AAQRxQA~/RgRophhWP0RaaHR0cHM6Ly9wbGF5Lmdvb2dsZS5jb20vc3RvcmUvYXBwcy9kZXRhaWxzP2lkPWNvbS5yZXB1YmxpY21vYmlsZSZobD1lbl9VUyZsaWQ9aDBqbHIyZ3phcnJ5VwNzcGNCCma7VpPDZrgpV6RSG3RyaXN0cmFtYmFsZHdpbjkwQGdtYWlsLmNvbVgEAAABzg~~   Private equity investing could be risky—learn more. Crowdfunding investments can result in total loss, and may be impossible to resell. Read about risks. This brief should not be construed as investment advice. Always consult with trusted professional advisors before making investments. Private investments are inherently illiquid and may result in total loss. 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