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Therapeutic Targets for Alzheimer’s Disease: APP, Tau, BACE1, and More

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Mon, Oct 23, 2023 07:01 AM

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A message from our partner Alzheimer's disease is a complex neurological disorder that significan

A message from our partner [New Scientist logo] Every now and then, New Scientist helps a carefully selected commercial partner speak to our audience. Their support helps us produce the high quality journalism we bring you every week. We hope you find today's message relevant and useful.   [Follow [LinkedIn]](  [Subscribe [YouTube]]( [Therapeutic Targets for Alzheimer’s Disease: APP, Tau, BACE1, and More]( [Sino Biological]( [Featured Products]( [Featured Cytokines]( [CRO Services]( Alzheimer's disease (AD) is a complex neurological disorder that significantly impacts the aging population. Molecular biomarkers, including [APP](, [Tau](, [BACE1](, [ApoE](, [GLP1R](, [NGF](, [BDNF](, [GSK3B](, [CASP9](, [CLU](, [AGER](, [DPYSL2](, and [PNMT](, play pivotal roles in AD's pathological processes, offering potential targets for therapeutic interventions. The process from research to clinical success is challenging, marked by ongoing trials exploring novel Alzheimer's therapeutics targeting Aβ, tau, neuroinflammation, and synaptic preservation. Notably, FDA-approved anti-Aβ antibodies like aducanumab (Aduhelm®) and lecanemab (Leqembi®) have emerged. The research landscape relies on recombinant proteins such as Aβ, tau, GLP1R, and ApoE to drive drug discovery and mechanistic studies. [Download Poster]( Alzheimer's Disease (AD) Pathogenesis    [Learn More]( [Sino Biological is at the forefront of Alzheimer's research, offering recombinant biomarkers and providing valuable insights to supporting drug discovery and novel therapeutics development.](   Featured Recombinant Proteins for AD Drug Targets  HPLC-verified Validated activity Broad coverage of species and tags Highly cited in reputable journals   Human BACE1 Protein, HPLC-verified Human GLP1R Protein, HPLC-verified Cat#: [10064-H08H]( Cat#: [13944-H49H-B]( High-purity: ≥ 95 % as determined by SDS-PAGE & SEC-HPLC. High-purity: ≥ 95 % as determined by SDS-PAGE & SEC-HPLC.  Human GSK3B Protein, Activity-validated Human NGF Protein, Activity-validated Cat#: [10044-H07B]( 4 Citations Cat#: [11050-HNAC]( 3 Citations Activity-validated: Immobilized His-GSK3B can bind to biotinylated human HG3C-CTNNB1 (Cat#: [11279-H20B](). Activity-validated: Cell proliferation assay using TF-1 human erythroleukemic cells.  [More Recombinant AD Drug Targets]( Featured Antibodies Against AD Targets  Anti-BACE1 Antibody, Rabbit mAb Anti-ApoE Antibody, Rabbit pAb Cat#: [10064-R027]( Applications: FCM, ICC/IF Cat#: [10817-RP02]( Applications: ELISA, IHC-P Immunofluorescence staining of Human BACE1 in Hela cells. Immunochemical staining of human APOE in human liver.  [More Antibodies Against AD Targets]( More Recommended AD Target Products Product Type Cat# Product Name Recombinant Protein [11629-HCCH]( Human RAGE Protein (No Tag) Recombinant Protein [10703-H02H]( Human APP Protein (hFc Tag) Recombinant Protein [11297-H08H]( Human Clusterin Protein (His Tag) Recombinant Protein [10058-H07E]( Human Tau Protein (His Tag) Recombinant Protein [50240-M08H]( Mouse BDNF Protein (His Tag) Antibody [10044-T32]( Anti-GSK3B Antibody, Rabbit pAb Antibody [203068-T38]( Anti-DPYSL2 Antibody, Rabbit pAb Antibody [11297-MM01]( Anti-Clusterin Antibody, Mouse mAb  [Gain Valuable Insights for Developing Novel Alzheimer’s Therapeutics | Download]( [A Comprehensive Guide to Choosing High-quality Cytokines Based on Applications | Click]( [Sino Biological]( Sino Biological, Inc. (China) order@sinobiological.com Sino Biological US Inc. (U.S.A.) order_us@sinobiologicalus.com Sino Biological Europe GmbH (Europe) order_eu@sinobiologicaleu.com æ ªå¼ä¼šç¤¾æ—¥æœ¬ã‚·ãƒŽãƒã‚¤ã‚ªãƒ­ã‚¸ã‚«ãƒ« (Japan) order@sinobiological.co.jp   [Facebook]( [Twitter]( [Instagram]( [LinkedIn]( [TikTok]( [Update preferences]( | [Help]( | [Contact us]( [View in browser]( This email has been sent to {EMAIL}. [Unsubscribe]( from further emails relating to selected third party partners from New Scientist. Do not reply directly to this email. If you have an enquiry, please contact us using the relevant contact details [listed here](. Copyright © New Scientist Ltd Registered Office: Northcliffe House, 2 Derry Street, London, W8 5TT Registered in England. No.10644366 Australian mailing address: PO Box 2315, Strawberry Hills, NSW 2012, Australia Registered in Australia. ABN 22 621 413 170 [Privacy Policy]( | [Terms & Conditions](

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