IL-6: A Pivotal Pleiotropic Inflammatory Cytokine

[NS Logo]( [Sino Biological Logo]( Every now and then, New Scientist helps a carefully selected commercial partner speak to our audience. Their support helps us produce the high quality journalism we bring you every week. We hope you find today's message relevant and useful. [Sino Biological]( [IL6: A Pleiotropic Inflammatory Cytokine]( [Interleukin 6 (IL-6)]( is a pro-inflammatory cytokine involved in immune responses, hematopoiesis, bone metabolism, and embryonic development. Elevated IL-6 is observed in patients with microbial infections and other inflammatory conditions. Targeting IL-6 has important clinical implications for diagnosing, managing, and preventing infectious diseases. The pro-inflammatory function of IL-6 is regulated by a trans-signaling process involving soluble IL-6R (sIL-6R) and [gp130]( receptor. The production of sIL-6R is activated by [IL-1beta]( and [TNF-alpha](. These two pro-inflammatory cytokines induce the proteolytic cleavage of [IL-6R]( by activating [ADAM10]( and [ADAM17](. Unlike most other soluble receptors (e.g. [IL-1RA]( and [IL-18BP]( sIL-6R is NOT an inhibitor of IL-6. Instead, it activates IL-6 signaling by forming a complex with IL-6 and gp130. [10398-h08h] Human IL-6R (cat#: [10398-H08H]( enhance the IL-6 activity on M1 mouse myeloid leukemia cells. The ED50 is typically 20-80 ng/mL. Sino Biological has developed a panel of high-quality recombinant IL-6 and receptor proteins to support the study of this cytokine. Recombinant IL-6 and Receptors Sino Biological has developed bioactive recombinant IL-6 cytokines from various species, such as human, mouse, rat, rhesus, and pig. • Featured IL-6 Protein Human IL-6 Protein: 10395-HNAE High-purity Low-endotoxin Tag-free [10700-H03H] > 95 % as determined by SDS-PAGE [10584-HNAE] [10584-HNAE] Cell proliferation assay using TF-1 human erythroleukemic cells Batch-to-batch Consistency • Bioactive Recombinant IL-6 from Multiple Species Species Cat# Activity Validated Human [10395-HNAE]( Bind to Human IL-6R Cell proliferation Mouse [50136-MNAE]( Cell proliferation Rat [80076-RNAE]( Cell proliferation Rhesus [90197-CNAE]( Cell proliferation Sus scrofa (Pig) [62006-WNAE]( Bind to Human IL-6R ([10398-H08H]( • Recombinant Membrane-bound IL-6 Receptor: IL-6R IL-6 demonstrates limited cross-species bioactivity. Human IL-6 can bind to both human and mouse IL-6R, but mouse IL-6 can only bind to mouse [IL-6R](. Human IL-6 Receptor [10398-H08H]( Mouse IL-6 Receptor [50280-M08H]( Rat IL-6 Receptor [81072-R08H]( Canine IL-6 Receptor [70117-D08H]( Rhesus IL-6 Receptor [90324-C08H]( • Recombinant Gp130 [Gp130]( is a common receptor and signal transducer shared by most IL-6 family cytokines. [Recombinant Human gp130]( [Recombinant Mouse gp130]( [Recombinant Rat gp130]( [Recombinant Rhesus gp130]( • More IL-6 Family Cytokines [IL-11]( [LIF]( [OSM]( [CNTF]( [IL-31]( [IL-27]( [NNT-1]( [CT-1]( Antibodies for IL-6 and Receptors Sino Biological has developed a comprehensive panel of antibodies targeting IL-6 cytokines and receptors, which can be used in ELISA, WB, IHC-P, and IP. • Neutralization Antibodies: IL-6 and IL-6R IL-6 Neutralizing Antibody (Cat#: [10395-R508]( IL-6R Neutralizing Antibody (Cat#: [10398-MM08]( [IL-6 Neutralizing Antibody] [IL-6R Neutralizing Antibody] Neutralize IL-6 induced proliferation in the T1165 mouse plasmacytoma cells. The IC50 is typically 80-320ng/mL IL-6-dependent Inhibition of cell proliferation is neutralized by Human IL-6R neutralizing Monoclonal Antibody. The IC50 is typically 0.15-0.6 μg/mL. ELISA Kits and ELISA Detection Pairs for IL-6 and Receptors [IL-6 ELISA Kit]( [IL-6R ELISA Kit]( [gp130 ELISA Kit]( [IL-6 Detection Pairs]( [IL-6R Detection Pairs]( [gp130 Detection Pairs]( [Sino Biological]( U.S.A Sino Biological US Inc. order_us@sinobiologicalus.com Europe Sino Biological Europe GmbH order_eu@sinobiologicaleu.com Global Sino Biological, Inc. order@sinobiological.com * This email has been sent to {EMAIL} * [Unsubscribe]( from further emails relating to selected third party partners from New Scientist. * Read our [privacy policy]( [Contact Us]( Disclaimer This message is intended only for the use of the person(s) ("Intended Recipient") to whom it is addressed. It may contain information which is privileged and confidential. 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