IL-18: A Pleiotropic Pro-Inflammatory Cytokine

[NS Logo]( [Sino Biological Logo]( Every now and then, New Scientist helps a carefully selected commercial partner speak to our audience. Their support helps us produce the high quality journalism we bring you every week. We hope you find today's message relevant and useful. [Sino Biological]( [IL-18: A Pleiotropic Pro-Inflammatory Cytokine]( Interleukin-18 ([IL-18]( is a pleiotropic pro-inflammatory cytokine. It belongs to the [IL-1 superfamily]( and participates in innate and acquired immunity. Recent studies have implicated the IL-18 pathway in autoimmune diseases, metabolic disorders, and cancers. IL-18 mediates host immunity by regulating [IFN-γ]( production in synergy with [IL-12](. In the presence of [IL-2]( IL-18 stimulates natural killer (NK) cells, NKT cells, and established Th1 cells to produce [IL-3]( [IL-9]( and [IL-13](. IL-18 similarly activates downstream signal transduction as [IL-1β](. IL18 binds with its receptor [IL-18 receptor α (IL-18Rα)](. [IL-18Rβ / IL-18RAcP]( is subsequently recruited to the complex, and the downstream cellular signal is initiated. IL-18 signaling is negatively regulated by the secreted antagonist receptor [IL-18BP](. IL-18Rα may also bind [IL-37]( in association with [SIGIRR]( to transduce an anti-inflammatory signal. Sino Biological has developed a panel of recombinant IL-18 and IL-18 receptor protein reagents to support the study of the biology of IL-18. Recombinant IL-18 Cytokines and Receptors Sino Biological has produced high-quality [recombinant IL-18]( and receptor proteins from various species, such as human, mouse, cynomolgus, rhesus, rat, and canine. • Featured IL-18 Protein Human IL-18 Protein: 10119-HNCE High-purity Low-endotoxin Tag-free HPLC-verified [10700-H03H] > 95 % as determined by SEC-HPLC [10584-HNAE] [10584-HNAE] Ability to induce IFN-gamma secretion by KG‑1 human acute myelogenous leukemia cells in the presence of TNF-alpha Batch-to-batch Consistency • Featured IL-18 Receptor Proteins [Mouse IL-18Rα Protein (Cat#: 50094-M38H]( [Human IL-18BP Protein (Cat#: 10357-H08H]( [50094-m38h]( [10357-h08h]( Binding Ability in a Functional ELISA, Bind to Mouse IL-18 (Cat: [50073-MNCE]( Ability to Inhibit the IL-18-induced Response of KG-1 Human Acute Myelogenous Leukemia Cells • More Related Proteins Cytokine [IL-18]( Receptor [IL-18Rα]( Receptor Accessory Protein [IL-18Rβ / IL-18RAcP]( Receptor Antagonist & Decoy Receptor [IL-18BP]( Antibodies for IL-18 Cytokines and Receptors Sino Biological has developed a panel of antibodies targeting IL-18 cytokines and receptors that can be used in ELISA, WB, IF, IP, FCM, and ICC. [Anti-IL-18Rβ / IL-18RAcP Antibody (Cat#: 10176-T24]( [Anti-IL-18 Antibody (Cat#: 310203-T44]( [10176-T24]( [310203-T44]( Immunochemical Staining of Human IL-18Rβ in Human Colon Carcinoma Cells Immunochemical Staining of Human IL-18 in Human Lymph Node Cells • More Related Antibodies [Anti-IL-18]( [Anti-IL-18Rα]( [Anti-IL-18Rβ]( [Anti-IL-18BP]( [Sino Biological]( U.S.A Sino Biological US Inc. order_us@sinobiologicalus.com Europe Sino Biological Europe GmbH order_eu@sinobiologicaleu.com Global Sino Biological, Inc. order@sinobiological.com * This email has been sent to {EMAIL} * [Unsubscribe]( from further emails relating to selected third party partners from New Scientist. * Read our [privacy policy]( [Contact Us]( Disclaimer This message is intended only for the use of the person(s) ("Intended Recipient") to whom it is addressed. It may contain information which is privileged and confidential. Accordingly any dissemination, distribution, copying or other use of this message or any of its content by any person other than the Intended Recipient may constitute a breach of civil or criminal law and is strictly prohibited. If you are not the Intended Recipient, please contact the sender as soon as possible. We and our third party service providers may use cookies and other web technologies in conjunction with this email. These technologies are used to understand activity with this email and on certain portions of our website. This enables us to improve our site, your experience on our site, and the offerings that we may provide to you. If you do not want these technologies placed on your device, please opt-out of receiving emails from us. Copyright New Scientist Registered Office: New Scientist, Northcliffe House, 2 Derry Street, Kensington, London, W8 5TT Registered in England under Company No. 10644366 Australian mailing address: PO Box 2315, Strawberry Hills, NSW 2012, Australia Registered in Australia under ABN 22 621 413 170