VEGFs and Receptors: Key Mediators in Vascular and Nervous Systems

Every now and then, New Scientist helps a carefully selected commercial partner speak to our audience. Their support helps us produce the high quality journalism we bring you every week. We hope you find today's message relevant and useful. [VEGFs and Receptors]( Vascular endothelial growth factors (VEGFs) are a family of secreted polypeptides with mitogenic and angiogenic activities. The importance of VEGFs and receptors in angiogenesis, tumorigenesis, and neuroprotection makes them attractive targets for drug development. The VEGF family members [VEGF-A]( [VEGF-B]( [VEGF-C]( [VEGF-D]( VEGF-E, VEGF-F, and [PlGF]( bind in specific patterns to three related receptor protein tyrosine kinases, [VEGFR1/FLT1]( [VEGFR2/KDR]( and [VEGFR3/FLT4]( and two non-tyrosine kinase transmembrane proteins, neuropilin-1 ( [NRP1]( and neuropilin-2 ([NRP2](. The ligand-receptor binding induces the formation of homo- and heteromeric receptor complexes and activates downstream signaling. In addition to VEGF signaling, neuropilins also act as co-receptors to numerous other signaling pathways, including those triggered by Epidermal Growth Factor ( [EGF]( Fibroblast Growth Factor ([FGF]( Hepatocyte Growth Factor ( [HGF]( Insulin-like Growth Factor ( [IGF]( Platelet-Derived Growth Factor ([PDGF]( and Transforming Growth Factor beta ( [TGFβ](. [Register Now]( VEGF Family Ligands and Receptors Sino Biological has over 65 recombinant VEGF & receptor proteins covering all VEGF family members and several isoforms of VEGF. A vast majority of these recombinant proteins were expressed in eukaryotic cells (human cells or insect cells), which ensures proper modification and higher activity of proteins. • High Activity Human / Cynomolgus VEGF165 (Cat#: [11066-HNAH]( Human KDR (Cat#: [10012-H08H]( Cell proliferation assay using human umbilical vein endothelial cells (HUVEC) Inhibit the VEGF-dependent proliferation of human umbilical vein endothelial cells (HUVEC) • Recommended Recombinant VEGF & Receptor Proteins Cat# Molecule Species Activity Tag [10136-H02H]( VEGFR1/FLT-1 Human Active hFc [10136-H08H]( VEGFR1/FLT-1 Human Active His [10136-H08H1]( VEGFR1/FLT-1 Human Active His [10806-H02H]( VEGFR3/FLT4 (ECD) Human Active hFc [50584-M02H]( VEGFR3/FLT-4 Mouse Active hFc [10012-H02H]( VEGFR2/KDR Human Active hFc [10012-H02H1]( VEGFR2/KDR (Domain 1&2&3) Human Active hFc [10012-H02H1-B]( VEGFR2/KDR (Domain 1&2&3) Human hFc [10012-H02H2]( VEGFR2/KDR (Domain 2&3) Human Active hFc [10012-H08H2]( VEGFR2/KDR (Domain 2&3) Human His [10012-H20B1]( VEGFR2/KDR Human Active GST & His [50998-M08H-B]( VEGFR2/KDR Mouse Active His [80113-R02H]( VEGFR2/KDR Rat Active hFc [80113-R08H]( VEGFR2/KDR Rat His [90907-C08H]( VEGFR2/KDR Cynomolgus His [10011-H08H]( NRP1 Human Active His [10695-H02H]( NRP2 Human Active hFc [11066-HNAB-B]( VEGF165 Human, Cynomolgus Native [11066-HNAH]( VEGF165 Human, Cynomolgus Active Native [63004-ZNAB]( VEGF165 Danio rerio (zebrafish) Active Native [70004-DNAH]( VEGF164 Canine Active Native [80006-RNAB]( VEGF164 Rat Active Native [10544-H01H]( VEGFB Human Active hFc [80103-R01H]( VEGFC (aa 108-223) Mouse, Rat Active hFc [80103-R08H]( VEGFC (aa 108-223) Mouse, Rat Active His [50157-M01H]( VEGFD Mouse Active hFc [50157-M08H]( VEGFD Mouse Active His [80104-R01H]( VEGFD Rat Active hFc [10274-H05H]( PIGF Human Active mFc • More Recombinant VEGF & Receptor Proteins [VEGFA]( [VEGFB]( [VEGFC]( [VEGFD]( [PIGF]( [VEGFR1/FLT-1]( [VEGFR2/KDR]( [VEGFR3/FLT-4]( [NRP1]( [NRP2]( VEGF/VEGFR Antibodies Sino Biological has over 100 antibodies against VEGF & receptor proteins with validated activities in various applications, including western blotting, ELISA, immunohistochemistry, immunofluorescence, flow cytometry, and neutralization. ELISA kits and ELISA pair sets are also available. • Antibody List of CSFs and CSFR [Anti-VEGFA]( [Anti-VEGFC]( [Anti-VEGFD]( [Anti-PIGF]( [Anti-VEGFR1/FLT-1]( [Anti-VEGFR2/KDR]( [Anti-VEGFR3/FLT-4]( [Anti-NRP1]( [Anti-NRP2]( [Sino Biological]( Sino Biological US Inc. [Tel:] +1-215-583-7898 [Order:]order_us@sinobiologicalus.com [CRO Service:]cro_us@sinobiologicalus.com [Address] 1400 Liberty Ridge Drive, Suite 101, Wayne, PA 19087 * This email has been sent to {EMAIL} * [Unsubscribe]( from further emails relating to selected third party partners from New Scientist. * Read our [privacy policy]( Disclaimer This message is intended only for the use of the person(s) ("Intended Recipient") to whom it is addressed. It may contain information, which is privileged and confidential. 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