SARS-CoV-2 Neutralizing MAbs and S2-Specific MAbs

[View this email in your browser]( Every now and then, New Scientist helps a carefully selected commercial partner speak to our audience. Their support helps us produce high-quality journalism we bring you every week. We hope you find today's message relevant and useful. SARS-CoV-2 Neutralizing Antibodies [SARS-CoV-2 Neutralizing Antibodies | S2-Specific Antibodies]( [Antibody Whitepaper]( To support COVID-19 research, Sino Biological has developed a large collection of antibodies against different antigens of SARS-CoV-2. These antibodies can be used to detect and/or neutralize the virus in a variety of assays including ELISA, western blot, immunofluorescent staining, immunohistochemistry, SPR (Biacore and Octet), pseudovirus infection, and potentially in vivo animal studies. [Antibody Guidebook]( [Get Free Antibody Guidebook]( This week, Sino Biological announces the new additions to this product line: The publication of SARS-CoV-2 antibody whitepaper. The publication of SARS-CoV-2 antibody whitepaper. The launch of two mouse mAbs with strong neutralizing activities. These antibodies are SARS-CoV-2 specific, with no cross-reactivity with SARS-CoV, and other common coronaviruses. The launch of a chimeric antibody specifically recognizing the S2 domain of SARS-CoV-2. [Full List of SARS-CoV-2 Antibodies]( Specific and Neutralizing Antibodies against SARS-CoV-2 Spike Cat # [40591-MM43]( [40592-MM57]( Description Anti-Spike S1 Anti-Spike RBD Type Mouse MAb Mouse MAb Ig Type Mouse IgG1 Mouse IgG2b Application Neutralization, ELISA Neutralization, ELISA Neutralization Activity Assay Neutralizing antibodies can effectively inhibit the infection of SARS-CoV-2 Spike pseudovirus on ACE2 overexpression 293T cells. S1 Neutralizing Antibody RBD Neutralizing Antibody Conc. (µg/mL) Inhibition% Conc. (µg/mL) Inhibition% 100 96.39% 100 95.51% 10 94.57% 10 93.32% 1 42.24% 1 75.69% 0.1 -5.53% 0.1 10.11% Competitive-ELISA Assay Neutralizing ability was detected by [SARS-CoV-2 Inhibitor Screening ELISA Kit]( (Catalog# KIT001) using competitive ELISA. S1 Neutralizing Antibody RBD Neutralizing Antibody Specificity Assay These two anti-spike antibodies have been tested against all seven coronaviruses, and are shown to be specific to SARS-CoV-2 spike. The reactivity of the antibodies against the known coronaviruses is assessed in ELISA. The reactivity (OD450) is illustrated in the figures below. S1 Neutralizing Antibody RBD Neutralizing Antibody Antibody Against SARS-CoV-2 Spike S2 Cat # [40590-D001]( Description SARS-CoV-2 Spike S2 Antibody Type Chimeric MAb Ig Type Mouse V domain & Human IgG1 Cross-reactivity No cross-reactivity in ELISA with [SARS-CoV-2 (2019-nCoV) Spike S1 (Cat# 40591-V08H)]( [SARS-CoV-2 (2019-nCoV) Spike RBD (Cat# 40592-V05H)]( [Sino Biological]( +1-215-583-7898 | order_us@sinobiological.com 1400 Liberty Ridge Drive, Suite 101, Wayne, PA 19087 This email has been sent to {EMAIL} [UNSUBSCRIBE]( from further emails relating to selected third-party partners from New Scientist. [PRIVACY POLICY]( [CONTACT US]( Copyright New Scientist Registered Office: 25 Bedford Street, London, WC2E 9ES Registered in England under Company No. 10644366 Australian mailing address: PO Box 2315, Strawberry Hills, NSW 2012, Australia Registered in Australia under ABN 22 621 413 170 Disclaimer This message is intended only for the use of the person(s) ("Intended Recipient") to whom it is addressed. It may contain information which is privileged and confidential. Accordingly any dissemination, distribution, copying or other use of this message or any of its content by any person other than the Intended Recipient may constitute a breach of civil or criminal law and is strictly prohibited. If you are not the Intended Recipient, please contact the sender as soon as possible. We and our third party service providers may use cookies and other web technologies in conjunction with this email. These technologies are used to understand activity with this email and on certain portions of our website. This enables us to improve our site, your experience on our site, and the offerings that we may provide to you. If you do not want these technologies placed on your device, please opt-out of receiving emails from us. This email was sent to {EMAIL} [why did I get this?]( [unsubscribe from this list]( [update subscription preferences]( New Scientist · 25 Bedford Street · Covent Garden · London, London WC2E 9ES · United Kingdom