Destroy harmful blood fat that blocks up male blood flow ----Important Message---- This washes the penile chambers clean from blood fat Blood fat irritates the linings of the penile chambers in the male member: [Can't see this image? Click on 'load images' or 'always allow images for this sender'] These linings are called endothelium. And there are at least 1,000 studies showing how blood fat causes what scientists call “endothelial dysfunction.” [Can't see this image? Click on 'load images' or 'always allow images for this sender'] The linings of the arteries and the linings in the penile chambers become swollen, inflamed, and angry when they are exposed to blood fat. Then plaque begins to build up in the arteries, the arteries that you need to be nice and clear if you want to get good “rockiness” again… Some of these arteries feeding blood to the male member are barely the width of a human hair. So it doesn’t take much blood fat to clog up the arteries that you need down in the penile chambers. Many men feel they are getting less and less blood flow down there as they get older…and it’s not their imagination! Blood fat is reducing blood flow to the penile chambers and that’s why many men can’t get great rockiness anymore. And it gets even worse… … because the linings of the penile chambers and the linings of the arteries and organs are all made of this endothelium. So it’s not only the male member that doesn’t get good blood flow, it’s also other crucial organs like the liver and the heart. Luckily, you can stop this dangerous blood fat from spreading and make it commit mass suicide! And that will not only clear the penile chambers, but it will also result in loss of flab... [Discover the only way to safely remove this blood fat and get good health and great rockiness again]( ---------- L-Serine: a new nootropic that is safe and increases thinking and memory The idea that individual amino acids can influence the brain is certainly not new. Up to this point in time, however, the influence of amino acids on psychology has focused primarily on aromatic amino acids. Tryptophan as the direct precursor for serotonin, Lâhistidine for histamine, and Lâtyrosine for dopamine. [Can't see this image? Click on 'load images' or 'always allow images for this sender'] But serine hasn't received much attention until only recently. Although Dâserine was known to be a coagonist for the NMDA receptor as far back as 1988 (Kleckner, 1988), it wasn’t until four years later that it was found to be a natural metabolite (Hashimoto, 1992). Since Dâamino acids weren't thought to have a biological role at the time, the activity of Dâserine on the NMDA receptor was seen as unphysiological and something of interest only to chemical treatment designers. 'Binding of the coagonist is an obligatory requirement for NMDA receptor/ channel activity, as the channel does not operate without it.' âWolosker, 2007 Yet it is now known that Dâserine is naturally found in the brain in oneâthird the concentration of Lâserine, and after being shown necessary for NMDA activity in the hippocampus it'd gradually become known as an important neuromodulator. This is very important because NMDA receptors are known to control spatial learning and memory formation. This is the receptor type activated by piracetam, the original 'nootropic treatment’ (Giurgea, 1972). The NMDA receptor shapes hippocampal plasticity by mediating the influx of Ca2+, its second messenger that goes on to quickly disassemble and remodel the actin and microtubule cytoskeletons. [Can't see this image? Click on 'load images' or 'always allow images for this sender'] Microtubules are found inside every nerve surrounded by myelin running lengthwise, and are what mediate nerve impulses throughout the body. Unmyelinated microtubules are also found inside every cell where they also occupy a structural role. 'Ca2+ entry during NMDA receptor stimulation can trigger intracellular second messenger pathways leading to persistent changes of excitatory postsynaptic current [...]' âPanatier, 2006 The structural remodeling mediated by NMDA receptors leads to neurite outgrowth (Pearce, 1987). In this manner, agonists and coâagonists such as piracetam and Dâserine could help form new brain connections. And the theoretical expectations have played out -- enough experimental evidence has accumulated on Dâserine since 1988 to conclude that it DOES have piracetam-like effects on cognition. This is fortunate because its precursor is Lâserine: a humble, nonessential, straightâchain, and safe amino acid available overâtheâcounter. 'These results indicate that endogenous glutamate, possibly released by granule cells themselves, stimulated neurite outgrowth through activation of the NMDA class of glutamate receptors.' âPearce, 1987 And besides being a precursor for the Dâisomer, it is also a significant precursor of acetylcholine via the Bremer Pathway. - Serine is first incorporated into phosphatidylserine…
- Decarboxylated into phosphatidylethanolamine…
- Methylated three times into phosphatidylcholine...
- Hydrolyzed into free choline…
- And finally acetylated by choline acetyltransferase into acetylcholine. And moreover, serine is the primary source of methyl groups in the brain. The enzyme serine hydroxymethyltransferase transforms Lâserine into glycine, capturing its βâcarbon as a folateâbound methyl group in the process. So serine is one thing you can take, and quite safely, that will potentiate both cholinergic and glutamatergic systems at once. These are both central to cognition. This may sound like a tall order for an “nonessential amino acid,” yet there is direct evidence of this occurring in humans: [Can't see this image? Click on 'load images' or 'always allow images for this sender'] This study had been conducted on healthy normal volunteers free of any current or prior psychological issues. They had been given 2.1 grams of Dâserine or placebo followed by a battery of cognitive tests. The specific tests were chosen on account of being affected by ketamine, the classic NMDA antagonist along with PCP. You'd expect that if Dâserine were to have an effect, it would probably show up on tests known to be affected by NMDA receptor function. And they were affected. The test group demonstrated an improvement in multiple cognitive tests scores over placebo, which also increased some due to repetition. This was a doubleâblind trial using standardized tests so this data should reflect a real change. Moreover, it was a crossover design, so every person eventually participated in both Dâserine and placebo groups. [Can't see this image? Click on 'load images' or 'always allow images for this sender'] Scores increased more than placebo in the Continuous Performance Test and the Rey Auditory Verbal Learning Test. These parameters, improved by Dâserine, are classically associated with NMDA receptor activation and enhanced hippocampal plasticity. Test scores in the Dâserine group also improved in the Category Fluency Test, the Digits Forward Task, and the Benton Visual Retention Test. Since studies using NMDA receptor knockout mice show a general deficit in spatial memory (Tsien, 1996), any test dependent on integrating visual input should be improved by NMDA agents. Although Dâserine is not as readily available as Lâserine, this is okay because the latter will readily become the former. Humans express an enzyme called serine racemase. This is a bidirectional enzyme that converts Lâserine into Dâserine, and vice versa, and is known to be expressed in the brain, liver, kidney, heart and skeletal muscle (Xia, 2004). In the brain it is found highest in the hippocampus and corpus callosum (De Miranda, 2000), coincidentally two areas also dense in NMDA receptors. 'In the four neurons tested, D-serine increased NMDA responses by 230.2% [...]' âPanatier, 2006 The close proximity of this enzyme to NMDA receptors has not been overlooked. This was an important finding leading to Dâserine, but not glycine, being recognized as the primary coagonist of this receptor. Concentrations of Dâserine in the brain closely parallel NMDA receptors while those of glycine are increased in the brainstem (Schell, 1997). Also giving Dâserine priority over glycine is its potency. It has been shown that Dâserine binds the NMDA receptor about 3âfold more strongly than glycine by some researchers (Matsui, 1995), and ~6âfold more strongly by others (Furukawa, 2003). [Can't see this image? Click on 'load images' or 'always allow images for this sender'] Experiments using Dâamino acid oxidase have conclusively shown that Dâserine is the primary endogenous modulator of the NMDA receptor in certain brain regions (Panatier, 2006). This is our natural piracetamâlike neuromodulator. Although glutamate is needed along with Dâserine to activate the NMDA receptor it's nonspecific and also acts on a few others. Glycine also activates more than one receptor (NMDA and GlyR), yet Dâserine is only known to have one target: The NMDA receptor. It is also only known to have only one precursor, its Lâisomer, which could be necessary considering availability. [Can't see this image? Click on 'load images' or 'always allow images for this sender'] Studies before this showed serine racemase converts Lâ to Dâserine in the brain (Dunlop, 1997), but this was one of the first to show this also occurs after systemic administration. After injecting rats with a stiff dose of Lâserine, about one gram per kilogram body weight, they demonstrated a substantial increase in brain Dâserine in all regions analyzed: [Can't see this image? Click on 'load images' or 'always allow images for this sender'] The brain exhibits a variable expression of serine racemase and Dâamino acid oxidase, the enzymes which create and destroy it, so you'd have to expect some variation of Dâserine across regions. Serine racemase also has pyridoxal (B6) for a cofactor, so nutrition could determine Dâserine levels in a few ways. Serine racemase is also powerfully inhibited by nitric oxide (Mustafa, 2006), so with certain treatments an immune activation could decrease it. 'The increase in the levels of Dâ and Lâserine in the cortex and striatum after the Lâserine injection are in good agreement with previous reports.' âHashimoto, 2002 Although these rats had been given a very high dose, you wouldn't need to take so much to get an effect. In vitro evidence shows that only small changes in brain Dâserine affect the NMDA receptor (Panatier, 2006). [Can't see this image? Click on 'load images' or 'always allow images for this sender'] Although it's generally assumed that the brain produces Dâserine entirely from brain Lâserine, some could actually be formed in the plasma and this could cross the blood brain barrier. It has been shown, in rats at least, that Dâserine has a 2- to 3âfold greater brain uptake than Lâserine (Bauer, 2005). You'd expect anything Dâserine formed in the plasma would eventually concentrate the brain, so even a modest dose could have an effect. Although plasma Lâserine outânumbers Dâserine about 10â¶1, which varies greatly personâtoâperson (Nagata, 1992), this ratio is decreased to about 3â¶1 in the brain (Hashimoto, 1993). And since most of the brain choline produced de novo ultimately comes from Lâserine, its nootropic activity is almost certain. And it does pass the acid test for nootropics. Like all good NMDA agents, Dâserine has been shown to enhance longâterm potentiation. Longâterm potentiation is an experimental phenomenon in which certain frequencies of pulses are found to be 'strengthened' over time. In other words, the amplitude of the evoked potential measured at the end of a nerve tract will increase upon repeated stimulation. 'Long-term potentiation (LTP) and long-term depression (LTD) induction relies on Ca2+ entry through NMDA receptors.' âPanatier, 2006 Glutamate has been shown to do this (Malgoroli, 1992), NMDA has been shown to do this (Collingridge, 2003), and even calcium -- their second messenger -- has been shown to do this (Turner, 1982). If you were to guess that piracetam can enhance longâterm potentiation, you'd be right (Satoh, 1988). The NMDA receptor is a classic mediator of longâterm potentiation, an electrophysiological effect thought to underlie the very process of learning. [Can't see this image? Click on 'load images' or 'always allow images for this sender'] The study was conducted on the supraoptic nucleus, a brain region in the hypothalamus controlled primarily by glutamate and GABA. Upon both adding and removing Dâserine from the brain slices, through Dâamino acid oxidase, they showed its importance to the region. The electrical transmission of cells was greatly reduced in its absence. The addition of glycine oxidase on the other hand did nothing, proving that Dâserine was the primary NMDA coâagonist in that brain region. 'We provide direct evidence that in this hypothalamic structure the endogenous coagonist of NMDA receptors is D-serine and not glycine.' âPanatier, 2006 And they also showed that Dâserine enhances longâterm potentiation in the supraoptic nucleus, perhaps what you'd expect from an area high in NMDA receptors. Although this effect occurred in all rats, it was most pronounced in the pregnant ones -- perhaps on account of pregnancy hormones, such as oxytocin, actively suppressing it. The supraoptic nucleus controls the pituitary gland, among other things, so it's somewhat intuitive that it's under hormonal control. [Can't see this image? Click on 'load images' or 'always allow images for this sender'] So to get piracetamâlike effects on the NMDA receptor naturally, serine could be a good thing to take. The Dâisomer of serine has been shown to increase cognition in humans through the NMDA receptor, and the Lâisomer is an acetylcholine precursor. Phosphatidylserine has also been shown to increase cognition (Cenacchi, 1993), but seeing as it's invariably soyâderived it would be roughly 60% linolelate by mass. Better would be to simply biosynthesize your own using safer fatty acids, such as palmitate and oleate, which would depend on diet. The cholinergic and glutamatergic neurotransmitter systems are the two most classically associated with cognition, and Lâserine is the only thing that I'm aware of that should upregulate both. 'Changes in calcium homeostasis and alterations of NMDA receptor are predominantly responsible for the age-related deficit of synaptic plasticity.' âMothet, 2006 ----Important Message About Oxytocin---- Oxytocin works 113 times better than testosterone for boosting rockiness [Can't see this image? Click on 'load images' or 'always allow images for this sender'] This is great news for men with low T or men taking testosterone treatments. Because now there’s something else you can use to get better, longer-lasting boners -- and it’s 100% natural. It’s called oxytocin, and it increases the quality of your boners. It increases the length of time you can keep a boner. And it increases the number of times you can come. And you know how sometimes it seems that intercourse just doesn’t feel as good as it used to? Well good news -- because oxytocin in increasing the amount of pleasure you feel at the same time it is giving you a strong rocky one: [Can't see this image? Click on 'load images' or 'always allow images for this sender'] With high oxytocin, you feel pleasure not just in your member, but all over your body. And it is sex like you’ve never experienced before. Sex the way it should be. You may now be thinking, “How can I get ahold of some oxytocin?” [Just use my Pleasure Protocol to naturally increase oxytocin overnight.]( ---------- Daily Medical Discoveries is dedicated to uncovering secret, buried or censored studies that can help men live great lives to 120 and beyond. You are subscribed because you joined one of our lists by opting in. We never rent or share your email address. Daily Medical Discoveries is published by Calworth Glenford LLC which also publishes other affiliated companies. By giving us your email address, you consent for Daily Medical Discoveries and its affiliated companies to delivering you a healthy daily portion of email issues and advertisements. To end your email subscription and associated external offers sent from Daily Medical Discoveries, feel free to [click here]( FREE BOOK: As a Daily Medical Discoveries subscriber in good standing, you're eligible to receive a FREE book containing underground, buried and ignored remedies that help men live a happy, healthy and sexy life to 120 years old, including specific help for men who want more sex, more life and more of everything. [Click here to claim your copy.]( Comments / Questions? You can hit REPLY to this email or email me, Matt, at matt@getrapidhelp.com Missing issues? How to make sure you NEVER miss an issue! The real key is CLICKING and OPENING emails. That shows your email provider (Yahoo, Gmail or whoever) that you WANT our email. If you don't click or open, you won't be getting them anymore, sadly. BIG TIP: Hit REPLY and say "Hi Matt" or ask a question, and THAT will assure your email provider that you want our emails! 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