This alcohol can strengthen bones and prevent fractures

Crazy but true -- and great news for men who like to drink! [Can't see this image? Click on 'load images' or 'always allow images for this sender'] ----Important Message for Men Looking to Naturally Boost Size---- Paint this on “down there” and watch it grow Just a few drops is all it takes… put in the right place of course… And then you’re growing right before her very eyes… thicker, fatter, more engorged… Her eyes grow wide and she’s licking her lips in anticipation… And as she drops to her knees, you are filled with the most sure-fire confidence any man has ever felt… [Just paint it on and watch it grow “down there”…]( ---------- This alcohol can strengthen bones and prevent fractures As we humans age, there is a tendency towards a lower bone density and many problems -- for men just as much for women. Bone problems can be reliably measured using radiographic techniques, and has been positively correlated with dietary factors such as calcium, magnesium, folate, and vitamins C & K. While some of these correlations could be biomarkers for the things they're associated with in foods, it is quite logical that others would increase bone density. Vitamin C is indispensable for collagen synthesis because it hydroxylates the amino acid proline, and also because it induces procollagen synthesis. Vitamin K is a cofactor for a group of enzymes which catalyze the formation of γ-carboxyglutamyl side-chains on proteins, thereby creating calcium-chelating domains for the bone matrix. Vitamin K helps to solubilize and disperse calcium, making it intuitive why it's deficiency leads to arterial calcification. And calcium, of course, demands no explanation. There are also hormones that control mineralization in a variety of ways. Although estrogen gets most attention in osteoporosis, melatonin and the vitamins A & D appear more significant. Yet in the process of discovering which dietary factors are correlated most with bone density, scientists had begun to notice an interesting twist in the late '80s. In the pursuit of studying dietary factors vs bone density in postmenopausal females, it had been discovered that alcohol intake was a factor -- yet not in the expected direction: 'Iron was a positive predictor of bone mineral density (BMD) in the femoral neck and alcohol intake a positive predictor of BMD in the trochanteric region of the proximal femur in premenopausal women by multiple regression analysis.' ―Angus This no doubt came as a surprise in the late '80s when nobody thought anything good could come from ingesting alcohol, tobacco, or saturated fats. This result had likely been shrugged off as a coincidence by most, especially when considering the small number of subjects involved (n = 159). And since there was no immediately-apparent biochemical mechanism that could account for this, even scientists not on the anti-drinking bandwagon were helpless to give it theoretical substantiation. Yet just 2 years later came another study reporting the same (Slemenda, 1990), and two more confirmations came in quick succession a year after that (Hansen, 1991; Laitinen, 1991). 'Surprisingly, a moderate alcohol consumption was found to be positively associated with bone mass. Other studies also showed a tendency towards higher bone mass (forearm and lumbar spine) in peri- and postmenopausal women with a moderate alcohol consumption.' ―Hansen [Can't see this image? Click on 'load images' or 'always allow images for this sender'] This effect was getting progressively more undeniable every year, and there eventually had come a time -- 5 years after the first report -- that enough studies had accumulated to demand a more thorough investigation. The study above was conducted in California and included 449 subjects, both male and female. This was the very first to focus explicitly on alcohol and bone density. Having a more rigorous design, this study was positioned to either confirm or deny the earlier findings. Because this one had 2 to 3 times more subjects than each of the 3 previous studies, and a few more than Laitinen's, it trumps all previous studies in statistical power. This was also done on Americans, our demographic, which is important because there could've been something funny about the Australians and Norwegians of the initial reports… Perhaps on account of them drinking more milk-based White Russians or something? Yet this study actually confirmed the previous ones in spades: they found positive correlations between alcohol and bone density in all of the 4 body locations examined. [Can't see this image? Click on 'load images' or 'always allow images for this sender'] This would certainly be perplexing to most people, yet it is consistent and occurs in all countries studied. This effect also occurs regardless of the type of alcohol consumed -- be it whiskey, wine, brandy, bourbon, or beer. 'In men the mean bone mineral density of the femoral neck increased significantly with increasing alcohol intake, and in women bone mineral density in the spine increased significantly with increasing alcohol intake.' ―Holbrook Besides having a good-sized study group, it was published in the British Medical Journal, giving it a wide circulation to disseminate the findings. Around this time, the subscribers were likely scratching their heads in confoundment, perhaps then pouring themselves a Scotch with a puzzled look on their faces. After a few thousand raised eyebrows, it was decided to do another study even more comprehensive than the last. [Can't see this image? Click on 'load images' or 'always allow images for this sender'] This study was an offshoot of the famous Framingham Study and a bit larger than Holbrook's, including nearly as many subjects as the 5 previous ones combined (1,154 vs 1,204). They even used an equation for estimating the ethanol content of each drink, as we all know that 2 beers don't even equal one Dry Martini or Long Island Iced Tea. 'Additional analyses were performed evaluating intake of liquor per week because of reports of an estrogen-like compound from some sources of bourbon.' ―Felson This is important information because there are other things in wine and beer. Beer actually has significant amounts of hydrated silica, or silicic acid (H4SiO4), which is actually known to enhance bone growth. But also: making the point clear that this is an ethanol effect and nothing else would prevent flakier scientists from proposing a role for resveratrol in wine… ...as they'd done towards heart disease when explaining-away the “The French Paradox” I talked about a few weeks back. So the researchers converted the alcohol intake data into ounces of pure ethanol -- e.g. Everclear® -- and subanalyzed that by sex. By using their large Boston-area study group, they found more-or-less exactly the same thing as the others. 'Men who consumed 14 oz of alcohol per week had higher bone mineral density at every site than nondrinkers, with differences ranging from 3.5 percent to 8.8 percent [...]' ―Felson And as professional statisticians, they did a more extensive multivariate analysis than either Holbrook or Laitinen, adjusting for such things as: age, weight, height, smoking, age at menopause, years of estrogen therapy, caffeine intake, vitamin D, and level of physical activity. After making adjustments the trend was still there, and it was even EXAGGERATED in some instances. Two of the previous reports had found caffeine to not be correlated with bone density, so I wonder what exactly they'd been 'adjusting' for? For this reason, and the paradoxical effects of vitamin D on bone (also adjusted for), I'd discount the multivariate analysis and stick to the raw data. 'These latter adjustments did not affect the observed unadjusted relation between alcohol and bone mineral density.' ―Felson So the effect of alcohol on bone density became progressively substantiated between 1988 to 1995, almost yearly, with no conflicting data appearing anywhere in the literature. Yet as there was no clear biochemical explanation, you still had a few doubters, and perhaps even a few researchers hoping to amaze the scientific community with some hidden non-ethanol factor they could discover. So even though the alcohol vs bone density correlation had always been consistent from day one, curiosity and disbelief ensured more research would be done. So not to be outdone and striving for closure, the study below was conducted, and included even more subjects than the last. [Can't see this image? Click on 'load images' or 'always allow images for this sender'] This study had surveyed 5,865 subjects in 4 different U.S. locations, conveniently made possible through affiliation with the Cardiovascular Health Study. And again we see the dose-dependent increase in bone density as more alcohol is consumed, increasing from 1 drink per week, all the way to 14 and over. [Can't see this image? Click on 'load images' or 'always allow images for this sender'] They also compiled data for fracture incidence, after which they derived a U-shaped curve. 'Alcohol intake was associated with bone mineral density of the total hip and femoral neck in a stepwise manner [...]' ―Mukamal Apparently alcohol protects against hip fractures by increasing bone mineral density, yet only to the point where you get tipsy, after which you incur the propensity for falling down. [Can't see this image? Click on 'load images' or 'always allow images for this sender'] In numbers, the 'tipping point' occurs at the 14 and over group. This is of course different for everyone, and it also matters how the drinks are spaced-out. Yet from personal experience, I would guess the fractures occurred in those drinking the undefined quantities above 14 per week. Data on marijuana intake wasn’t reported. So the effect is almost set in stone, completely consistent and dose-dependent. A review article on the topic plotted most of the previous studies on 1 graph with a good fit, including data from 0 to 3 drinks per day. [Can't see this image? Click on 'load images' or 'always allow images for this sender'] Yet because all these studies adjusted data differently based on what they perceived as 'confounding variables,' and had different locations, you wouldn't expect a perfect fit between any 2 variables. They had also validated both the U-shaped curve and the idea that increased fracture rates, those long-observed in alcoholics, are simply the result of falling down. Despite the consistency of this effect, there is still no convincing mechanism to explain it. The best the epidemiologists and doctors could do is parrot the offhand mention from Laitinen's 1991 article, in which he proposed estrogen as being responsible in 1 run-on sentence 'Alcohol is an inducer of adrenal production of androstenedione, and, furthermore, it is an inducer of extraadrenal conversion of androstenedione to estrone [39], the main circulating estrogen of a postmenopausal woman.' ―Laitinen Yet perhaps more plausible than sex hormones could be pineal hormones, specifically 5-methoxytryptophol. Drinking alcohol increases 5-hydroxytryptophol, a direct precursor for the pineal hormone 5-methoxytryptophol. This is induced so consistently by alcohol that it is considered the most reliably biomarker for such in forensic medicine, and more reliable than even methanol. Hydroxytryptophol is produced within the body all the time by monoamine oxidase working on serotonin, yet because alcohol dehydrogenase is occupied by ethanol, it readily accumulates during drinking. Hydroxytryptophol is just 1 methyl group away from becoming a full-fledged pineal hormone, 5-methoxytryptophol, and needs only 1 enzyme to do it: Hydroxyindole-O-methyltransferase (HIOMT) is expressed nearly everywhere, and is the enzyme that gives melatonin and 5-methoxytryptophol their methyl groups. [Can't see this image? Click on 'load images' or 'always allow images for this sender'] Melatonin is now officially known to be produced outside of the pineal gland, and since 5-methoxytryptophol production requires the same enzyme (HIOMT) you could bet the farm this is as well. Hormonally speaking, melatonin and 5-methoxytryptophol are approximately equivalent. Although 5-methoxytryptophol has absolutely no effect on the melatonin membrane receptors (MT1, MT2), it has full activity at the 3 melatonin nuclear receptors (RORα, RORβ, RORγ). So whatever melatonin can do on bone, 5-methoxytryptophol can do just as well. In fact, it is even slightly more potent gram for gram, perhaps because it's not bound-up by melatonin membrane receptors and instead heads straight into the nucleus: [Can't see this image? Click on 'load images' or 'always allow images for this sender'] Melatonin transcribes the bone-forming sialoproteins, calcium-binding proteins that have been shown to nucleate crystal growth at low calcium concentrations. Melatonin undoubtedly has a beneficial effect on bone density, and has been detected there in relatively high amounts. Now assuming melatonin–methoxytryptophol equivalency, you would expect alcohol to increase bone density. In fact, I found these studies with that very expectation in mind. 'Men who were heavy drinkers also had higher bone densities than light drinkers,' ―Felson Methoxytryptophol is safe in moderate amounts, and could even be responsible for alcohol's notorious effects on libido. Though not as thoroughly studied as melatonin is, pineal scientists have assigned a role for 5-methoxytryptophol in seasonal reproduction. This pineal hormone isn't just melatonin's less glamorous little sister, as it has a slightly different distribution and exerts similar genomic effects -- all without influencing blood pressure or cortisol. And for non-drinkers out there looking to maintain bone density, ULTRA-low-dose melatonin at night should be fine. Surprisingly, just 2 milligrams of melatonin leads to plasma levels about 20-fold greater than the normal nighttime peak. For this reason I gravitate towards the 300μg dose, which is a common size. Melatonin is surprisingly potent, and also depresses the innate immune system in humans (but not in nocturnal animals, such as owls and a few mouse strains.) So drink to health, and also bone density. The effects of sulfites in beer and wine can be abrogated by taking molybdenum, a cofactor for sulfite oxidase. This enzyme converts sulfite into harmless sulfate, yet can do nothing without molybdenum. 'This study suggests that moderate social drinking is associated with higher bone mineral density in both men and women.' ―Holbrook 'Based on our formulae, this degree of alcohol consumption could be achieved by drinking two drinks of liquor per day, almost three beers per day, or three glasses of wine per day.' ―Felson ----Important Message for Men Who Want Stronger Bones---- This new type of vitamin C increases collagen production for stronger bones [Can't see this image? Click on 'load images' or 'always allow images for this sender'] When men take normal vitamin C, it only stays in the bloodstream for a few minutes. But when men take SUPER vitamin C, it says in the bloodstream for HOURS… And it penetrates the tissues, the organs, the glands, and even the bones! So this new SUPER vitamin C delivers more health benefits than regular vitamin C, like helping to increase collagen production. And more collagen can make the bones stronger and less likely to break, even during a fall. [Try my special Super C for all these benefits and more]( ---------- Daily Medical Discoveries is dedicated to uncovering secret, buried or censored studies that can help men live great lives to 120 and beyond. You are subscribed because you joined one of our lists by opting in. We never rent or share your email address. Daily Medical Discoveries is published by Calworth Glenford LLC which also publishes other affiliated companies. By giving us your email address, you consent for Daily Medical Discoveries and its affiliated companies to delivering you a healthy daily portion of email issues and advertisements. 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