Breakthrough: herb makes 80yo brain 20 years old

It’s the very first nootropic, and legend says it can help men live very long lives… can't see this image? Click on "load images" or "always allow images for this sender" -----Important Message for Men Who Want to Live to 120----- Best-selling book tells you how — get your free copy I don’t know about you, but I plan on living to at least 120. And doing it naturally, without pills or procedures. And you can too with the help of my best-selling book, Healthy to 120. This book is my life’s work, where you can find every single one of my discoveries in plain, easy to understand language. And these breakthrough discoveries will allow you to live to 120 and beyond — healthier, happier, and having more sex than ever before. Here’s just a peek of what you’ll find inside Healthy to 120: - I’ve discovered something that lowers testosterone in men, causes heart attacks, and increases the risk of stroke and other deadly diseases… it’s the #1 killer that no one talks about…and no, it’s NOT sugar or bread. Most of the people I’ve met who live the longest eat bread and chocolate, and still live a long, healthy life…(page 48) - Despite their time in the spotlight, Keto and high-fat diets are actually BAD for men… these type of diets make men insulin resistant and increase harmful blood fat in the bloodstream… I discovered that losing weight this way may be the WORST thing men can do and that strenuous exercise makes blood fat worse…but then I found a better, safer way for men to lose weight and reduce harmful blood fat, and you don’t even have to get up off the couch to do it…(page 290) - Another one of my discoveries comes from the longest living men on Earth… they eat these 2 secret foods to live to age 100 and beyond… and some of these men still smoke cigarettes, drink alcohol, and eat sweets — so what’s their secret? I’m revealing it now, and it will allow you to reclaim your youth and vigor…(page 280) - Believe it or not, I’ve found that a certain type of intercourse can add decades to your life… I know it sounds strange, but this certain way of approaching sexual intercourse produces the most pleasure… and I’ve discovered that if you do it this specific way, you can have terrific erections that last for hours and feel extreme sexual pleasure all over your body…(page 347) - Did you know the secret to better erections is better blood flow? I developed a “roto rooter” for your arteries that removes built-up plaque. This restores the arteries’ flexibility, and creates better blood flow all over the body, especially to the penis… resulting in thicker, more engorged erections and better sexual performance…(page 139) - And so much more… I know you’re going to love this book, and if you hurry, you can still [get one of the last copies for free — click here](. ------------- Breakthrough: herb makes 80yo brain 20 years old No list of herbal nootropics is complete without Bacopa monnieri, a perennial creeping herb with white flowers. Although Bacopa monnieri grows worldwide, it was first appreciated by subcontinental Asians (in India). This plant appears in many ancient Ayurvedic texts… The root is indicated for enhancing cognition. That makes it one of the first official “nootropics” – about 2,000 years before the term existed. “This successful Rasayana alleviates old age and diseases, promotes memory and intellect, enhances life span – and provides nourishment, excellence, clarity of voice, complexion, and ojas.” (from the Charaka Samhita, c. 100 BC) (ojas = vital essence of the tissues) Bacopa monnieri is also mentioned in another great Ayurvedic classic (nearly as old), called the Sushruta Samhita. In this particular Ayurvedic text, and in nearly all others, it is referred to as “Bráhmi.” This is a more detailed text and states that Bacopa “improves the memory, leads to the expansion of the intellectual faculties, and imparts a celestial glow to the complexion.” But that text also claims this plant enables the user “to live for five hundred years”… So I am a bit skeptical. There is no reliable record of anyone living for even a fraction of that length of time… And that simple fact casts a shadow of doubt on the entire book chapter. If living to 500 years were even possible (and I plan to live to 120), I cannot imagine that any particular plant could make it happen… Even if that plant was blessed “a thousand times with the proper Mantras,” as is directed. “He should take the expressed juice of the Bráhmi in an adequate dose after consecrating the juice a thousand times with the proper Mantras.” (from the Sushruta Samhita, c. 100 AD) Notwithstanding the quaint aspects of ayurvedic medicine, something could probably be said about one particular herb being extolled above all others for so long. Moreover, the value of Bacopa monnieri has recently been confirmed by science… This is now a veritable nootropic herb. Yet its mechanism of action has remained elusive ever since being studied biochemically. Researchers have proposed multiple explanations… and then abandoned them… These range from GABAA activation to acetylcholinesterase inhibition. Yet none of these mechanisms are particularly straightforward or even realistic… Bacopa extracts only start inhibiting acetylcholinesterase at massive unphysiological concentrations. The small acetylcholinesterase effect from concentrated extracts can easily be accounted for by the nicotine it contains –Chopra, 1956. While certainly cognitive enhancing, nicotine alone cannot account for the diverse array of effects observed from Bacopa monnieri – specifically the time delay. Although very convincing and consistent, the clinical effects of Bacopa monnieri in humans begin to occur after weeks or months… Whereas nicotine works immediately and then stops working as soon as it’s metabolized – which is the reverse effect. “No known clinical studies have yet evidenced an acute effect of Bacopa monnieri on human cognition… To summarize, the clinical research evidence B. monnieri to be effective in decreasing the rate of forgetting, but perhaps only in tandem with chronic use.” The delayed effects of Bacopa are probably best understood through a hormonal mechanism. And that is actually in accordance with the first molecule implicated in its effects. Bacoside-A is the main component of Bacopa monnieri – accounting for 3-5% of its dry mass. This molecule is classified as a saponin, based on its physical properties… Yet it’s core is actually a steroid: can't see this image? Click on "load images" or "always allow images for this sender" Such glycosides have been shown to be hydrolyzed in the stomach by hydrochloric acid – and also by intestinal enzymes should that fail. Moreover, cell membranes have enzymes that are capable of cleaving these glycosidic bonds. So you can rest assured that bacoside-A doesn’t stay that way for long… It transforms into its aglycone steroid (bacogenin-A1). You could think of the glucose molecules as being delivery agents for what’s attached. Glucose makes fat-soluble molecules more water-soluble and increases their dispersal within the plasma. This is important because bacoside is very similar to ginsenoside, the saponin that scientists think is responsible for the effects of Panax ginseng. can't see this image? Click on "load images" or "always allow images for this sender" After hydrolysis, both free steroids would have hydroxy groups on the #20 and #3 carbons, two methyl groups on the #4 carbon, and an identical isoprene “tail.” This means that Bacopa monnieri could very well have a mechanism of action indistinguishable from Panax ginseng… And that herb is actually more highly prized and researched. There are eight times more published articles about ginseng on Google Scholar – so it should be no surprise that its mechanism is more understood. “Ginsenoside Rg1 has notably neurotropic and neuroprotective effects in various models in vivo and in vitro…” Ginsenoside becomes panaxadiol after metabolism. Decades ago, scientists showed that it activates the glucocorticoid. And this theory of the mechanism is believable because of its structure. And because of its similarity to panaxadiol, bacogenin could be suspected of functioning the same way. Both ginsenoside and bacoside have steroidal metabolites (panaxadiol and bacogenin). And those are both novel primary components of their respective plants (requisites that explain why these and not just any herb have the reputation they have). can't see this image? Click on "load images" or "always allow images for this sender" Glucocorticoids, as a class, have acquired a bad reputation because most also activate the mineralocorticoid receptor. “Recent studies demonstrated that ginsenoside metabolites had greater biological effects than ginsenosides.” And despite the fact that dexamethasone binds to the mineralocorticoid receptor with the greatest affinity, it’s still known as a “glucocorticoid” by many. So then all negative effects of corticosteroids that originate from activating the mineralocorticoid receptor are chalked up as “glucocorticoid effects”… And that corrupts the literature with a negative bias. can't see this image? Click on "load images" or "always allow images for this sender" On account of this substantial receptor cross-reactivity, it would be better to simply call them “corticosteroids”… And maybe reserve the terms “mineralocorticoid” or “glucocorticoid” for those having a high specificity for just one receptor type. Panaxadiol is one such steroid… It has a roughly five fold specificity for the glucocorticoid over the mineralocorticoid receptor. can't see this image? Click on "load images" or "always allow images for this sender" Using purified steroid receptors, Australian researchers determined the steroid-binding affinities of Panax ginseng extracts. Receptors for androgens, estrogens, glucocorticoids, mineralocorticoids, and progesterone were all assayed for the ability of Panax ginseng to displace their respective ligands: - Dihydrotestosterone - Estradiol - Dexamethasone - Aldosterone - Promegestone The highest binding affinity was found towards the glucocorticoid receptor, with the mineralocorticoid receptor coming in at a distant second. And many other studies imply that ginsenosides don’t bind and activate the mineralocorticoid receptor, such as studies showing that ginseng increases hair growth. can't see this image? Click on "load images" or "always allow images for this sender" Panax ginseng had no activity on either estrogen or androgen receptors, though Siberian ginseng was able to displace estradiol. But since Siberian ginseng (Eleutherococcus senticosus) belongs to an entirely different genus from Panax ginseng, this fact shouldn’t affect your perception of ginsenosides. Siberian ginseng is not even related to true ginseng, being a berry that contains primarily nonsteroidal terpenes. “When two additional sources of estrogen receptor were examined (human breast tumor, sheep uterus) Panax ginseng similarly showed no ability to compete…” The chance of adulteration is another reason why Bacopa monnieri may be a better choice than Panax ginseng. Besides containing a slightly higher concentration of steroid glycosides (3% vs. 4%), Bacopa monnieri is: (1) easier to grow (2) has a greater geographical prevalence (3) is cheaper (4) is thus not likely sold adulterated with other plants The more consistent saponin concentration of Bacopa monnieri testifies to a higher purity, showing a less variable composition than commercial ginseng. Panax pseudoginseng is also suspected of being used as a cheaper substitute for true ginseng. “Highest affinity binding was to glucocorticoid receptors, with an approximate Ki of 8 μM for Panax ginseng. Such interactions may explain the reported glucocorticoid-like effects of ginseng in vivo.” Subsequent studies show that pure ginsenoside (not dilute extract) has a binding affinity between 1–10 μM (Lee, 1997). This is on par with our endogenous glucocorticoids… It is certainly potent enough to work after routine consumption. So it appears that ginsenoside is a selective glucocorticoid, a rarity. Now let’s see what this can do to cells: can't see this image? Click on "load images" or "always allow images for this sender" After previously confirming ginsenosides can activate the glucocorticoid receptor more than anything, these researchers investigated its actions on stem cells. They found that ginsenoside Rg could induce differentiation of cells into neurons. Neurons are elongated brain cells responsible for cognition. So it’s reasonable to expect anything that promotes the growth of these to increase cognition. can't see this image? Click on "load images" or "always allow images for this sender" This happened at a reasonable concentration of 10 μM, which is certainly within the range achievable from routine ginseng consumption. “After 10 days of treatment, Rg1 significantly increased the population of neuron-like cells with neurites that were three times longer…” They also found that 1 nM of dexamethasone worked initially and then stopped after six days, perhaps on account of mineralocorticoid receptor expression. On the other hand, ginsenoside Rg1 kept working indefinitely. can't see this image? Click on "load images" or "always allow images for this sender" This could be how it works in people… Selective glucocorticoids could enhance both neurogenesis and glucose levels in the brain, all without activating the problematic mineralocorticoid receptor. Cortisol activates both receptors, which is perhaps exactly what you’d want for a stress hormone. By liberating glucose and increasing blood pressure all at once, the body is primed for action in times of threat. This nootropic action could be why ginseng is so highly prized in China and Japan. This plant contains ginsenosides, which are selective plant glucocorticoids without mineralocorticoid action. A meta-analysis published in the British Journal of Pharmacology concluded, after reviewing all the human trials, that Bacopa and ginseng both have real effects. They also concluded that there was more nootropic evidence for Bacopa monnieri working than ginseng… But that might have been only because the ginseng trials were all short-term and the trials using Bacopa lasted for months. “Chronic Bacopa monnieri interventions generally produced the most consistent and largest effect sizes… The highest effect sizes for cognitive outcomes were 0.77 for modafinil, 0.86 for Ginseng, and 0.95 for Bacopa.” So there’s every reason to suppose that Panax ginseng does what it does by acting on the glucocorticoid receptor… With the chemically similar Bacopa monnieri doing likewise by extension. So science eventually confirmed (using double-blind clinical trials and in vitro cell studies) what Ayurvedic medicine had been saying (though exaggerating) for thousands of years. And whichever you choose, if any, it’s important to note that the effects could take a few weeks to manifest. The active metabolite appears to be the aglycone (i.e. the steroid core) – so it could take some time before brain levels increase to the point of efficacy. “In addition, a study of reported side effects in a number of patients led to the description of a syndrome not unlike that of glucocorticoid excess, termed the Ginseng Abuse Syndrome…” -----Important Message for Men Who Want to Live Longer----- A fast metabolism is youthful — here’s how I get a fast metabolism at home with a simple little exercise When I want more potency and vigor, I do this simple little exercise at home and I’m raring to go. It works because it raises my temperatures and literally makes my metabolism the same as when I was a young man of 20. Right now, I’m doing it, and my temperatures at 98.8, and I’m raring to go. And you can do the same in your life. In fact, if you don’t, you will find that you deflate as a man and find everything tougher, slower, lower, and colder. But with this simple little exercise — well now you are always ready, always hot to trot. And it’s wonderful for a man’s overall health and longevity too. [Here’s what you can do at home to restore a youthful metabolism.]( can't see this image? Click on 'load images' or 'always allow images for this sender' ------------- Daily Medical Discoveries is dedicated to uncovering secret, buried or censored studies that can help men live great lives to 120 and beyond. You are subscribed because you joined one of our lists by opting in. We never rent or share your email address. Daily Medical Discoveries is published by Calworth Glenford LLC which also publishes other affiliated companies. By giving us your email address, you consent for Daily Medical Discoveries and its affiliated companies to delivering you a healthy daily portion of email issues and advertisements. To end your email subscription and associated external offers sent from Daily Medical Discoveries, feel free to [click here]( FREE BOOK: As a Daily Medical Discoveries subscriber in good standing, you’re eligible to receive a FREE book containing underground, buried and ignored remedies that help men live a happy, healthy and sexy life to 120 years old, including specific help for men who want more sex, more life and more of everything. [Click here to claim your copy.]( Comments / Questions? You can hit REPLY to this email or email me, Matt, at matt@getrapidhelp.com Missing issues? How to make sure you NEVER miss an issue! The real key is CLICKING and OPENING emails. That shows your email provider (Yahoo, Gmail or whoever) that you WANT our email. If you don’t click or open, you won’t be getting them anymore, sadly. BIG TIP: Hit REPLY and say “Hi Matt” or ask a question, and THAT will assure your email provider that you want our emails! 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