Candidemia is the number one worse, but undetected infection, yet no one is talking about it. Here’s what you need to know...
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Candidemia -- Are You Infected?
Most people will accept the idea that an infection can cause fatigue.
Mononucleosis and African sleeping sickness are two well-known infections with fatigue as the defining trait, one caused by a virus and the other by a trypanosome (a parasite).
In the case of yeast, the term “overgrowth” is used instead of “infection.”
That’s because Candida albicans normally co-exists in harmony with the other intestinal flora in most people.
The common wording tends to downplay the link, making it seem minor – although a full-fledged “yeast overgrowth” is equivalent to an infection in every practical sense.
Medical people downplay the link even more. Doctors, dietitians, nurses, pharmacologists, salesmen, and Big Pharma executives all minimize the importance of yeast overgrowth because they themselves are to blame for the epidemic – for the most part.
Antibiotics, corticosteroids, and bad dietary advice are the prime causes of yeast overgrowth.
Although C. albicans is the most common and the most dangerous, other species are sometimes involved.
Even Aspergillus and Saccharomyces species have been isolated…
And an infection with common brewer’s yeast has been shown to produce enough ethanol to make a person legally drunk (BACs between .2 and .3 have been reported).
Ironically, the overly broad group of people with “chronic fatigue” people owe their diagnosis to the non-diagnosability of it.
Besides fatigue, it is the inability to “find anything else wrong with them” that creates this disease classification itself.
But with no reliable biochemical, histological, or radiographic parameter to help define it, “chronic fatigue” means about as much as the imaginary “always tired” syndrome.
But there are very few commonalities in serum profiles among cases so the confusion is understandable.
But could this lack of an official biological explanation just be a way of skirting liability for the reckless promotion of antibiotics?
Candidemia is the number one hospital-caused infection and needs to be taken seriously.
Chronically undertreating a condition or treating it under the wrong paradigm helps keep the medical complex making money – and it is almost standard operating procedure outside of the narrow field of emergency medicine.
But there’s actually a significant connection.
Candida albicans and fatigue are often used in the very same sentence in the popular press – testimonials from patients confirm the ability of yeast to cause fatigue.
And studies have found this too.
In a study limited to just the symptomatic aspects: “tiredness,” “decreasing strength,” and “vegetative complaints” were some of the most commonly reported.
Although “tiredness” and the “vegetative state” are not exactly the same word as “fatigue.”
But they are synonyms. Maybe the editors of medical journals have a reason to avoid the word “fatigue” from being explicitly linked to C. albicans?
But seriously, candidiasis is a real phenomenon and should be seen as such – yeast in the body can cause serious effects.
Although there are very few commonalities among the broad group of patients with “chronic fatigue,” the commonalities that do exist all strongly imply a yeast connection.
AND get this: The very same tryptophan metabolite responsible for African sleeping sickness is produced by C. albicans.
This molecule is called tryptophol and it is very potent.
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Tryptophol also explains why tryptophan reliably causes drowsiness even though serotonin itself does not.
And that involves this missing metabolite.
Tryptophol also explains the longstanding contradictory findings in the link between fatigue – chronic or otherwise – and tryptophan.
In fact, there are many parallels between tryptophan and chronic fatigue yet most studies don’t focus on this…
And the ones that do don’t measure tryptophol, only 5-HIAA/serotonin.
Many scientists and medical doctors believe that serotonin and 5-HIAA are the only indoles worth considering.
But tryptophol, which is related, is surprisingly powerful in many aspects.
...not the least of which is the promotion of sleep:
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Scientists have known about this molecule for over a century.
But they didn’t discover how it affects sleep until the 1960s.
They discovered oleamide thirty years later. Until then, tryptophol was thought to be the most powerful endogenous sleep inducer.
(Endogenous means not having an external cause.)
“The present study does suggest that there are certain common metabolic effects of tryptophol and barbiturates…”
In this classic study, biochemists at Texas A&M University elaborated on some of the finer aspects of tryptophol.
They discovered that tryptophol has a peculiar ability to swell red blood cells to the point of explosion.
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Serotonin can’t do this at the concentration used.
They showed that, among tryptophan metabolites, tryptophol is by far the most oil-soluble.
This means that it should be able to cross the blood-brain barrier more readily, and that has been confirmed.
They even replicated the earlier sleep experiments.
But this time they used a full panel of tryptophan congeners for comparison:
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Of the indoles shown above, the only ones that induced sleep were 5-methoxytryptophol and tryptophol.
Serotonin, which normally gets the most of the attention, failed to promote sleep.
And all tryptamine did, to this end, was to cause death in 50% of the animals… something that parents euphemistically tell children is “like going to sleep.”
Nothing is really comparable to tryptophol when it comes to inducing sleep.
But despite the uniqueness of tryptophol in so many ways, and especially its obvious potential to explain chronic fatigue, this metabolite is not routinely measured.
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It’s actually extremely rare even to even see this molecule mentioned in modern studies of any type, except those on trypanosomes – which cause African sleeping sickness.
“These alterations may account for the behavioral changes observed in human trypanosomiasis.”
But, besides protozoa, yeast has been found to assimilate tryptophan from its environment and convert it into tryptophol.
And scientists have known this for over a century.
Since tryptophol powerfully induces sleep, any infection that produces it can be logically supposed to cause fatigue...or tiredness and the “vegetative state.”
Candida albicans is the most common yeast pathogen and was specifically shown to do this in 1968:
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This yeast can make and excrete tryptophol, just like the protozoan parasite that causes African sleeping sickness.
“A comparison of the infrared and mass spectra of compound II with those of an authentic sample of tryptophol showed them to be identical.”
And this has been later confirmed: Candida albicans can excrete tryptophol into its growth medium at concentrations ranging up to 191·μg/mL.
But there’s even more reason to believe that tryptophol causes chronic fatigue.
Sufferers of chronic fatigue have been reported to significantly improve after antifungal treatment:
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Dr. Carter, who did this study, lays down a good case for the association.
The immunological parameters present a good clue.
Chronic fatigue patients often present a characteristic cytokine profile.
That is not particularly unusual in itself. But it is also true of people with chronic candidiasis.
Even more importantly, they respond to antifungal drugs:
“Dr. Carol Jessop reported her findings in 1,100 patients with chronic fatigue syndrome at the Chronic Fatigue Syndrome Conference, April, 1989 (8). 84% of the patients had a favorable response to oral ketoconazole…”
Perhaps out of fear of liability and to ensure future profits, the AMA will probably continue to ignore this link for some time to come.
But it could still become an “open secret” to the public – if it hasn’t already.
Because chronic fatigue is defined so broadly, there are other causes, of course…
For example, there will always be a certain subset of chronic fatigue cases caused by autoimmune antibodies and by other infections.
But candidiasis is quite possibly the most common causative factor.
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