The ‘soy boy’ conspiracy theory

Why many men believe soybeans are part of a very real “conspiracy against manhood” -----Important Message----- The secret to male confidence, stamina and muscles (even better “Rockiness”) Ray was married three times. The latest wife filed for divorce and Ray was devastated. “I thought she was the one. But I can’t blame her.” Ray realized that his entire life he had suffered from low confidence. “Women are attracted to very confident men,” he says. “I needed a way to become more confident.” Ray then found out through my teaching how testosterone makes men more confident. He got his T checked, and it was very low. [So I showed him how to raise T, from 302 to 907 in his case.]( If you are a man who wants to have a great life, you need to have high T. High Testosterone leads to these benefits: - Makes you super confident - You don’t care anymore about stupid little things (and everything is a stupid little thing) - You have a strong drive - You enjoy great stamina in bed - You build muscles even if you don’t work out - Belly fat is dropping off all the time even though you eat whatever you want [Here’s the secret Ray used to raise testosterone from 302 to 907 in less than 5 weeks]( ----------------- The ‘soy boy’ conspiracy theory Over the years, there's been talk about “plant polyphenols” having estrogenic effects, sometimes with the implication that all of them do. This is not true. Only a few flavonoids have estrogenic effects. And there is at least one that is a powerful anti-estrogen. “In conclusion, we identified baicalein, a naturally occurring flavone, as an anti-estrogen.” Only kaempferol, genistein, and daidzein have significant affinity for the estrogen receptor alpha (ERα). Genistein and daidzein are found in soybeans. Kaempferol is somewhat particular to strawberries. That's basically it... No other flavonoid polyphenols will bind the estrogen receptor at physiological concentrations, much less activate it: [01-18-19-IMG-1] can't see this image? Click on "load images" or "always allow images for this sender" The soy isoflavone genistein is about ten times more potent than its nearest competitors (daidzein and kaempferol)... And that is the best reason for men to avoid soy. Because women have more estradiol available for inhibition, genistein can be inhibitory for them. Because of genistein’s strong binding affinity to estrogen receptors, it can compete with the more active estradiol in female cells that have high amounts. Yet in males, genistein unambiguously has estrogenic activity. Soy should be avoided by all rational men, yet women and trans women may find it useful. All three estrogenic flavonoids have one thing in common: They have a hydroxy group on carbon #4 of the B-ring, flanked by nothing else in every case. They need this configuration to mimic estrogen: [01-18-19-IMG-2] can't see this image? Click on "load images" or "always allow images for this sender" Dozens of flavonoids have a 4-hydroxy group, yet most of them also have adjacent groups that will prevent it from binding to estrogen receptors. Many flavonoids, such as baicalein, don't have a 4-hydroxy group at all. Baicalein has absolutely nothing on its B-ring, and it is a flavone besides – not an iso-flavone like genistein and daidzein: [01-18-19-IMG-3] can't see this image? Click on "load images" or "always allow images for this sender" Its inability to interact directly with estrogen receptor alpha (ERα) makes its action seem perplexing. How exactly does baicalein inhibit ERα transactivation without actually binding to it? And it doesn't inhibit aromatase either. The answer may surprise you… It’s the same reason why baicalein is also the best anti-cancer flavonoid in general. [01-18-19-IMG-4] can't see this image? Click on "load images" or "always allow images for this sender" This study proved the anti-estrogenic activity of baicalein in the most direct way possible. These scientists injected human cells with short DNA strands that encode for luciferase enzymes, which can then produce fluorescence. Since these DNA strands all had ERα response elements (such as GGTCA and TGACC), they could only be transcribed through ERα. Hence, in this study: Estrogen receptor alpha activity is directly proportional to fluorescence. The gene that encodes the prolactin receptor also has an ERα response element… So the curves in the graph below are also proportional to man boob size!. [01-18-19-IMG-5] can't see this image? Click on "load images" or "always allow images for this sender" As expected, soy genistein was estrogenic at low concentrations and anti-estrogenic at higher concentrations. But the higher 100 μM concentration used above cannot realistically be achieved through oral consumption. Yet a concentration of 10 μM is achievable for most flavonoids, and in many organs. And this is true for baicalein… This flavone progressively inhibited ERα activity in concentrations of 10, 50, and 100 μM and it is safe to ingest: [01-18-19-IMG-6] can't see this image? Click on "load images" or "always allow images for this sender" Who would have guessed the most potent anti-estrogen flavonoid would come from a flower? And a purple one at that? (Scutellaria baicalensis, AKA Baikal skullcap, an herb used in Chinese medicine). It’s also in thyme. These effects are very consistent and fully corroborated by other studies. Baicalein is officially a potent anti-estrogen. The graphs below show it incrementally inhibiting estrogen-induced growth throughout the low micromolar range (1–8 μM): [01-18-19-IMG-7] can't see this image? Click on "load images" or "always allow images for this sender" But still, how does baicalein inhibit ERα activity without directly binding to it, or through inhibiting aromatase? Well, that happens to be through baicalein's classic function. Consistently, studies show that baicalein is the most potent glyoxalase I (GLOI) inhibitor among the entire flavonoid class. “In this study, 16 flavonoids were examined, and only baicalein...is identified as a potent in vitro GLOI inhibitor.” Baicalein is second only to lapachol and beta-lapachone among all plant compounds in glyoxalase inhibition. (Both of those come from the lapacho tree and have anti-cancer and anti-inflammatory properties.) This means that baicalein can increase intracellular concentrations of methylglyoxal... Methylglyoxal inhibits and reverses cancer cells without damaging normal cells. But nobody knew how that actually worked until just recently. Paul Thornalley proved in 2007 that methylglyoxal can modify transcription factors at arginine side-chains thereby affecting gene expression: [01-18-19-IMG-8] can't see this image? Click on "load images" or "always allow images for this sender" Estrogen receptors are technically transcription factors – they also have an arginine side-chain in the binding pocket. In the estrogen receptor alpha: Arginine-394 lies directly across from the 3-hydroxy group of estradiol, analogous to the 4-hydroxy group, the soy isoflavones: [01-18-19-IMG-9] can't see this image? Click on "load images" or "always allow images for this sender" The conversion of arginine-394 to hydroimidazolone, via methylglyoxal, would certainly inhibit estrogen binding. Mutation studies reveal that this arginine is necessary for receptor activity. The positively charged arginine is needed to bind the negatively polarized 3-hydroxy group of estradiol. “In contrast, baicalein significantly decreased the estradiol-induced nuclear translocation of estrogen receptor alpha.” The enzymes glyoxalase I and glyoxalase II and glutathione continuously keep methylglyoxal concentrations in check. But methyl glyoxylate concentrations can be increased by using natural glyoxalase inhibitors such as baicalein, lapachol, and beta-lapachone. Science is beginning to understand the mechanisms underlying the classical effects of methylglyoxal. And they involve the selective modification of arginine side-chains on transcription factors and enzymes. This is a natural process. And it appears to be the primary way the cell quickly responds to changing glucose/fructose metabolism. “...treatment with estradiol resulted in the obvious nuclear localization of estrogen receptor alpha...the nuclear localization of ERα was inhibited in the presence of baicalein.” ----Important Message---- My two step size system You may or may not know that the male unit is made up of three chambers or (columns of tissue). [01-18-19-IMG-10] can't see this image? Click on "load images" or "always allow images for this sender" The blood flow to these three chambers is often blocked. This restricts blood flow. Not good if you want to have great sex. And it affects size: the size of the male unit is dictated by how much blood the two big chambers can hold. To “embiggen” your unit there is one thing that we must achieve - to get these chambers to take more blood. Here’s where it gets weird. [Here’s the two step size system that makes your penile chambers expand more and makes your member bigger, while also fixing blood pressure]( ------------- Daily Medical Discoveries is dedicated to uncovering secret, buried or censored studies that can help men live great lives to 120 and beyond. You are subscribed because you joined one of our lists by opting in. We never rent or share your email address. Daily Medical Discoveries is published by Calworth Glenford LLC which also publishes other affiliated companies. By giving us your email address, you consent for Daily Medical Discoveries and its affiliated companies to delivering you a healthy daily portion of email issues and advertisements. To end your email subscription and associated external offers sent from Daily Medical Discoveries, feel free to [click here]( Comments / Questions? You can hit REPLY to this email or email me, Matt, at matt@getrapidhelp.com Missing issues? How to make sure you NEVER miss an issue! 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