Woof! Dog Longevity Start-Up Secures $45 million

New Personalized Longevity Supplementation From Saints One  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ March 22nd, 2024 | [Read Online]( Saints One is your longevity 360°. Personalized daily supplementation, DNA Age Testing, 24/7 AI via the Saints One app, and your own longevity concierge – all in one plan. Good Morning , The recent developments in the longevity and healthcare sectors, underscored by notable investments, technological advancements, and strategic organizational shifts, present a rich tapestry of opportunities and challenges. Among these, three pivotal narratives stand out, each representing a unique facet of the ongoing transformation in healthcare: the successful funding round of Loyal, a biotech startup focused on extending the lifespan of dogs; the strategic insights gleaned from the J.P. Morgan Healthcare Conference, highlighting key trends for payers, providers, and health tech companies; and the pioneering efforts of Kayla Barnes in democratizing access to longevity training, particularly for women. Loyal’s significant achievement in securing $45 million in Series B funding not only marks a milestone for the company but also serves as a beacon for the broader sector focused on longevity and health technologies. This case underscores the increasing investor confidence in innovative approaches to health and wellness, reflecting a broader trend of capital flowing towards ventures that promise to extend not just the lifespan but also the health span of individuals and their animal companions. The J.P. Morgan Healthcare Conference, an annual event that garners the attention of the global healthcare industry, provides critical insights into the evolving landscape of healthcare. The 2024 conference spotlighted several transformative trends, including the growing embrace of payvider structures by nonprofit systems, the strategic expansion of outpatient services, and the accelerating integration of AI and digital health technologies. The emergence of Kayla Barnes as a leading figure in the longevity training space represents another significant trend in healthcare: the democratization and personalization of health and wellness strategies. By leveraging digital platforms to share insights and practical advice, Barnes is not just challenging the traditional, often exclusive domains of biohacking and longevity science but is also fostering a more inclusive and accessible approach to health optimization. Her focus on gender-specific research and wellness advice addresses a critical gap in the longevity discourse, underscoring the need for more nuanced and equitable approaches in health and wellness research and practice. Let’s dive in … FRIDAY SPOTLIGHT Healthspan vs. Lifespan Dog Longevity Start-Up Secures $45m Loyal, a San Francisco-based start-up, has recently announced a successful $45 million Series B funding round, led by Bain Capital Ventures, with significant contributions from new backers like Valor Equity Partners and continued support from existing investors including Khosla Ventures and First Round Capital. This financial milestone is earmarked for the development and market introduction of Loyal's pioneering longevity drug for dogs, marking a significant step in veterinary and possibly human healthcare. Loyal's innovative approach focuses on extending the healthy lifespan of dogs through a drug that targets hormonal imbalances, specifically the reduction of circulating levels of GH/IGF-1. This hormone is known to drive rapid growth in larger dog breeds during puberty, potentially reducing their overall lifespan. This successful funding round signals strong market confidence in Loyal and the broader longevity sector. With a valuation that has seen a marked increase since its previous funding round in 2022, Loyal is setting new standards in the health technology space. Moreover, the involvement of a diverse array of investors highlights the cross-sector appeal of Loyal's work, bridging traditional biotech investment with broader health and wellness interests. The decision by the Food and Drug Administration’s Center for Veterinary Medicine to deem Loyal’s LOY-001 drug program as having a “reasonable expectation of effectiveness” further bolsters investor confidence. This regulatory nod is a crucial step in validating ‘longevity’ as a clinical endpoint, providing a clear pathway for those operating on the human side of things. The parallels between human and veterinary medicine in the context of longevity are striking, with potential applications of Loyal's research extending beyond canine health. The company’s ability to navigate regulatory pathways and demonstrate the efficacy of its treatments will be closely watched by industry observers and potential investors alike. [WSJ Venture Capital]( The most striking discovery was in the elderly, where taurine levels were a staggering 80% lower than in their younger counterparts. This nutrient's potential seems promising, especially when considering its ability to add an estimated seven to eight years to human life. JP Morgan - HealthTech Trends in 2024 Epidemiological observations have long hinted at a curious phenomenon: populations residing at high altitudes often live longer and seem less susceptible to certain diseases. This study sought to replicate these findings in a controlled animal setting, shedding light on the potential benefits of high-altitude living. A significant shift towards payvider structures among nonprofit healthcare systems was a prominent theme at the conference. This model, which combines payer and provider roles within a single organization, has gained traction as a strategic response to the financial pressures and service delivery challenges highlighted by the COVID-19 pandemic. The discussion reflected a broader industry realization that diversifying revenue sources through closer alignment of care delivery and insurance functions can offer a more resilient and patient-centered healthcare model. The conference also spotlighted the ongoing shift from hospital-based care to outpatient services, a trend accelerated by patient preference for more accessible, cost-effective care options. Systems like Sutter Health and Tampa General Hospital outlined ambitious plans for expanding their outpatient networks, signaling a strategic pivot towards "asset light" models that prioritize community-based care. The expansion of outpatient services is seen as key to meeting evolving patient needs while addressing the cost pressures facing the healthcare system. Perhaps the most forward-looking discussions at the conference centered on the role of AI and digital health technologies. From predictive analytics to patient engagement platforms, the potential of AI to revolutionize healthcare was a recurring theme. Healthcare leaders shared insights into how AI is being integrated into their operations, from improving diagnostic accuracy to optimizing patient flows and enhancing personalized care. The enthusiasm for AI and digital health reflects a broader industry consensus on the need for innovation to address the complex challenges of modern healthcare delivery. The growing adoption of payvider models points to opportunities in integrated healthcare services, while the expansion of outpatient services signals a shift in investment priorities towards community-based care models. Moreover, the embrace of AI and digital health technologies suggests a burgeoning market for innovations that enhance efficiency, patient engagement, and clinical outcomes. The insights from the J.P. Morgan Healthcare Conference provide a valuable guide for these efforts, highlighting the trends that will shape the future of healthcare and the opportunities for those ready to lead the way. [Fierce Healthcare]( Meet Kayla Barnes, the female Bryan Johnson Unlike the traditional, often opaque realm of biohacking and longevity training dominated by affluent individuals like Bryan Johnson, Kayla Barnes is carving a niche by focusing on transparency, inclusivity, and practicality. Her approach, leveraging social media and direct engagement, is breaking down barriers to entry, making longevity training accessible to a wider demographic. Barnes's work is significant not just for its focus on women, who have historically been underrepresented in clinical research, but also for its potential to inspire a more inclusive model of health optimization. Barnes's emphasis on addressing the gender disparity in longevity research is particularly noteworthy. By openly sharing her journey, insights, and data-driven strategies, she is not only educating a broad audience but also advocating for more nuanced, gender-specific research in longevity and health optimization. This aspect of her work is critical, considering the historical bias toward male participants in clinical studies, which has left a gap in our understanding of female-specific health and aging processes. Another key facet of Barnes's impact is her role in democratizing access to longevity strategies. Through her platform, she provides clear, actionable advice on everything from laboratory tests to daily habits that promote longevity. This open-source approach to wellness knowledge represents a shift away from the elitism historically associated with advanced health optimization techniques. By championing gender-specific research, democratizing access to longevity strategies, and leveraging digital platforms to engage and educate, Barnes is not just contributing to the evolution of longevity training but also shaping the future of personal and public health. [The Standard]( Sima, the last surviving rat from the study, stands as a testament to the treatment's potential. She has already surpassed the typical lifespan for her species, drawing parallels to a human living beyond 126 years. The narratives of Loyal's groundbreaking funding achievement, the strategic foresights from the J.P. Morgan Healthcare Conference, and Kayla Barnes's innovative approach to democratizing longevity training collectively highlight a pivotal shift in healthcare. In synthesizing these insights, it is clear that the healthcare and longevity sectors are ripe with opportunities for strategic investment. However, navigating this landscape requires a nuanced understanding of the technological, societal, and regulatory dynamics at play. The confluence of investment, technology, and innovative healthcare models presents a unique opportunity to redefine health and wellness for generations to come. Until next time, The Longr Reads Team "Health is like money, we never have a true idea of its value until we lose it." Josh Billings Longr Reads' of the Week - Generative AI will Transform Healthcare ([Bain & Company]( - Requests for Startups in 2024 ([VC Cafe]( - 5 steps to put healthcare on the AI fast-track ([WEF]( Longr is building access to longevity across: generative AI, therapeutics, wellness products, clinics, research, community, and marketplaces. Transforming visionary concepts into tangible solutions - we are facilitating widespread adoption of longevity-enhancing products and platforms. [Advertise with us](mailto:partnerships@longr.io) // [Book a call with Longr](mailto:ir@longr.io) 107 North Orange Street, Wilmington, Delaware 19801, United States You received this email from Longr Reads. If you would like to unsubscribe, [click here](.