The dawning of a new era? A dawning of a new era? Dr. Anil Bajnath reveals new research on women's reproductive lifespan. You are receiving this email because you subscribed to Longevity Insider HQ.
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[Longevity Insider HQ logo] Scientific Alert: Genes Linked to Reproductive Lifespan Expansion in Women Anil Bajnath, MD | August 09, 2021 | Baltimore, MD Dear Longevity Insider,Dr. Anil Bajnath here with your Monday roundup.Longevity is just as much about us as it is our loved ones. Not only do we desire a long, healthy, happy life – but we want that for our offspring, our legacy. This is where men and women differ… Due to biological differences, the reproductive lifespan in men is much longer than that of women.Men in their 60s (and some in their 80s) have fathered newborn children. And women? They don’t have a chance at these ages, unless it was some type of miraculous circumstance. You see, women’s reproductive years peak between late teens and late 20s. When women hit 30, their ability to get pregnant starts to decline. Once they hit their mid-30s, this decline becomes more rapid. And when 45 comes knocking, it becomes extremely difficult for women to get pregnant naturally. Has Mother nature spoken? Men and women may be slated to this 30- to 40-year gap in reproductive lifespan...But a recent scientific discovery reveals 300 reasons suggesting otherwise. Scientists just identified nearly 300 gene variations that influence women’s reproductive lifespan. The research is a global collaboration involving academics from over 180 different institutions.Namely, University of Exeter, the MRC Epidemiology Unit at the University of Cambridge, the Institute of Biotechnology and Biomedicine at the Universitat Autònoma de Barcelona, and the DNRF Center for Chromosome Stability at the University of Copenhagen jointly lead this initiative. This research has been achieved by a global collaboration involving academics from more than 180 institutions, and jointly led by the University of Exeter, the MRC Epidemiology Unit at the University of Cambridge, the Institute of Biotechnology and Biomedicine at the Universitat Autònoma de Barcelona, and the DNRF Center for Chromosome Stability at the University of Prior to this recent discovery, scientists only knew of 56 genetic variations linked to women’s reproductive lifespan. But thanks to this collaborative effort, that 56 just jumped to 290. Even more exciting, the team has successfully manipulated several key genes associated with the 300 variants to extend the reproductive lifespan in mice. Co-author Professor Eva Hoffmann, of the University of Copenhagen, said: It is clear that repairing damaged DNA in eggs is very important for establishing the pool of eggs women are born with and also for how quickly they are lost throughout life. Improved understanding of the biological processes involved in reproductive ageing could lead to improvements in fertility treatment options. This is just the tip of the iceberg. There’s still so much I haven’t even shared with you about how scientists have collected this data and what implications it could have for the future. [Get the full story here.]( To your longevity, Anil Bajnath MD
CEO/Founder, Institute for Human Optimization
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