Reagent Resource for Studying SARS-CoV-2 Variants

Three fast-spreading new variants of SARS-CoV-2 virus have emerged in recent months [Live Science](   Wednesday 27 January 2021 [View this email online](   SPONSORED CONTENT [Reagent Resource for Studying SARS-CoV-2 Variants]( Three fast-spreading new variants of SARS-CoV-2 virus have emerged in recent months: the U.K. variant B.1.1.7, the Brazil variant P.1, and the South Africa variant B.1.351. A subset of the mutations identified in the RBD domain of the spike protein occurs in more than one strain, although the three variants are believed to be independently evolved. These convergent mutations, specifically, the N501Y (shared by all three, [40592-V08H82]( and E484K (shared between B.1.351 and P.1, [40592-V08H84]( are of high interest because they may be the cause of the increased transmissibility. The mutations in these strains also occur in the nucleocapsid protein, which is commonly used as the biomarker in rapid antigen tests. It’s critical to assess whether the current commercial antigen tests can detect the mutated N proteins with the same sensitivity and specificity as their WT counterpart. Sino Biological has developed a panel of recombinant RBD/Spike and nucleocapsid protein variants carrying the aforementioned mutations as below: # Recombinant Mutants from the U.K. Variant Catalogue Order Antigen Mutation 40592-V08H82 [Order]( RBD N501Y 40591-V08H7 [Order]( S1 HV69-70 deletion, N501Y, D614G 40591-V08H12 [Order]( S1 H69del, V70del, Y144del, N501Y, A570D, D614G, P681H 40588-V07E7 [Order]( N D3L, R203K, G204R, S235F 40588-V07E8 [Order]( N D3L, S235F 40589-V08B6 Under Development S-ECD H69del, V70del, Y144del, N501Y, A570D, D614G, P681H, T716I, S982A, D1118H # Recombinant Mutants from the South Africa Variant Catalogue Order Antigen Mutation 40592-V08H82 [Order]( RBD N501Y 40592-V08H84 [Order]( RBD E484K 40592-V08H59 [Order]( RBD K417N 40591-V08H10 [Order]( S1 K417N, E484K, N501Y, D614G # Recombinant Mutants from the Brazil Variant Catalogue Order Antigen Mutation 40592-V08H82 [Order]( RBD N501Y 40592-V08H84 [Order]( RBD E484K [Full List of SARS-CoV-2 Mutations]( Sino Biological has developed a large panel of antibodies against SARS-CoV-2 N protein and the S protein. Extensive testing was performed and we have identified several pairs for each of the two targets. These pairs can be used to assemble detection assays for the corresponding antigen. # Antibody Pairs for N Protein Antibody Pairs Capture Ab Detection Ab Pair I [40143-R004]( [40143-R040]( Pair II [40143-MM05]( [40143-R001]( Pair III [40143-MM08]( [40143-R004]( Antibody Pairs Capture Ab Detection Ab Pair IV [40143-MM05]( [40588-R001]( Pair V [40588-MM123]( [40588-R001]( Pair VI [40588-MM123]( [40588-MM124]( # Antibody Pairs for S Protein Antibody Pairs Capture Ab Detection Ab Pair I [40150-D003]( [40150-D001]( Pair II [40150-D002]( [40150-D004]( Pair III [40150-D006]( [40591-MM43]( # [Sino Biological]( +1-215-583-7898 | [order_us@sinobiological.com]( 1400 Liberty Ridge Drive, Suite 101, Wayne, PA 19087 [Future Logo] © Future US, Inc., 11 W 42nd Street, 15th Floor, New York, NY 10036 This email is intended for {EMAIL} To unsubscribe from LiveScience emails, or update your email preferences please [click here]( We've updated our Privacy Policy. The updates include additional information we have added in response to the California Consumer Privacy Act. The updated policy is effective as of January 2020. We encourage you to read the complete updated Privacy Policy [here](. View our Terms and Conditions [here](