SARS-CoV-2 Neutralizing MAbs and S2-Specific MAbs

SARS-CoV-2 Neutralizing Antibodies [Live Science](   Wednesday 17 June 2020 [View this email online](   SPONSORED CONTENT [SARS-CoV-2 Neutralizing Antibodies | S2-Specific Antibodies]( [Antibody Whitepaper]( To support COVID-19 research, Sino Biological has developed a large collection of antibodies against different antigens of SARS-CoV-2. These antibodies can be used to detect and/or neutralize the virus in a variety of assays including ELISA, western blot, immunofluorescent staining, immunohistochemistry, SPR (Biacore and Octet), pseudovirus infection, and potentially in vivo animal studies. [Antibody Guidebook]( [Get Free Antibody Guidebook]( This week, Sino Biological announces the new additions to this product line: The publication of SARS-CoV-2 antibody whitepaper. The publication of SARS-CoV-2 antibody whitepaper. The launch of two mouse mAbs with strong neutralizing activities. These antibodies are SARS-CoV-2 specific, with no cross-reactivity with SARS-CoV, and other common coronaviruses. The launch of a chimeric antibody specifically recognizing the S2 domain of SARS-CoV-2. [Full List of SARS-CoV-2 Antibodies]( Specific and Neutralizing Antibodies against SARS-CoV-2 Spike Cat # [40591-MM43]( [40592-MM57]( Description Anti-Spike S1 Anti-Spike RBD Type Mouse MAb Mouse MAb Ig Type Mouse IgG1 Mouse IgG2b Application Neutralization, ELISA Neutralization, ELISA Neutralization Activity Assay Neutralizing antibodies can effectively inhibit the infection of SARS-CoV-2 Spike pseudovirus on ACE2 overexpression 293T cells. S1 Neutralizing Antibody RBD Neutralizing Antibody Conc. (µg/mL) Inhibition% Conc. (µg/mL) Inhibition% 100 96.39% 100 95.51% 10 94.57% 10 93.32% 1 42.24% 1 75.69% 0.1 -5.53% 0.1 10.11% Competitive-ELISA Assay Neutralizing ability was detected by [SARS-CoV-2 Inhibitor Screening ELISA Kit]( (Catalog# KIT001) using competitive ELISA. S1 Neutralizing Antibody RBD Neutralizing Antibody # # Specificity Assay These two anti-spike antibodies have been tested against all seven coronaviruses, and are shown to be specific to SARS-CoV-2 spike. The reactivity of the antibodies against the known coronaviruses is assessed in ELISA. The reactivity (OD450) is illustrated in the figures below. S1 Neutralizing Antibody RBD Neutralizing Antibody # # Antibody Against SARS-CoV-2 Spike S2 Cat # [40590-D001]( Description SARS-CoV-2 Spike S2 Antibody Type Chimeric MAb Ig Type Mouse V domain & Human IgG1 Cross-reactivity No cross-reactivity in ELISA with [SARS-CoV-2 (2019-nCoV) Spike S1 (Cat# 40591-V08H)]( [SARS-CoV-2 (2019-nCoV) Spike RBD (Cat# 40592-V05H)]( [Sino Biological]( +1-215-583-7898 | [order_us@sinobiological.com]( 1400 Liberty Ridge Drive, Suite 101, Wayne, PA 19087 [Future Logo] © Future US, Inc., 11 W 42nd Street, 15th Floor, New York, NY 10036 This email is intended for {EMAIL} To unsubscribe from LiveScience emails, or update your email preferences please [click here]( We've updated our Privacy Policy. The updates include additional information we have added in response to the California Consumer Privacy Act. The updated policy is effective as of January 2020. We encourage you to read the complete updated Privacy Policy [here](. View our Terms and Conditions [here](