PNAS Table of Contents for 25 July 2017; Vol. 114, No. 30

[PNAS][Proceedings of the National Academy of Sciences] /content/current/content/multimedia/site/authors/index.xhtml/site/aboutpnas/index.xhtml/site/misc/collectedpapers.xhtml/search/content/early/recent [Call for Physical Sciences papers](/cgi/adclick/?ad=51397&adclick=true&url=http%3A%2F%2Fwww.pnascentral.org) [Proceedings of the National Academy of Sciences](?etoc) [25 July 2017; Vol. 114, No. 30]( ) This Week in PNAS [In This Issue]( --------------------------------------------------------------- Letters (Online Only) [Reappraisal of dioxygen binding in NOV1 crystal structures]( Philip D. Kiser [Reply to Kiser: Dioxygen binding in NOV1 crystal structures]( Ryan P. McAndrew, Noppadon Sathitsuksanoh, Michael M. Mbughuni, Richard A. Heins, Jose H. Pereira, Anthe George, Kenneth L. Sale, Brian G. Fox, Blake A. Simmons, and Paul D. Adams [Linking brain networks and behavioral variability to different types of mind-wandering]( Gábor Csifcsák and Matthias Mittner [Reply to Csifcsák and Mittner: Fitting data to neural models of mind-wandering]( Aaron Kucyi, Michael Esterman, and Eve M. Valera --------------------------------------------------------------- News Feature [News Feature: Can animal culture drive evolution?]( [Front Matter Article] Carolyn Beans An in-depth look at trending science issues. --------------------------------------------------------------- Profile [Profile of Stephen C. West]( Paul Gabrielsen --------------------------------------------------------------- Commentaries [Different phosphodiesterases (PDEs) regulate distinct phosphoproteomes during cAMP signaling]( Paul M. Epstein [Uncoupling protein 1 controls reactive oxygen species in brown adipose tissue]( Martin Jastroch [Regular patterns link individual behavior to population persistence]( Frederic Guichard [Big-time insights from a tiny bird fossil]( Daniel J. Field --------------------------------------------------------------- PNAS Plus Significance Statements [PNAS Plus Significance Statements]( Brief statements written by the authors about the significance of their papers. --------------------------------------------------------------- Perspective [Why eyewitnesses fail]( Thomas D. Albright --------------------------------------------------------------- Sackler Colloquium on Extension of Biology Through Culture (Free Online) Introduction [The extension of biology through culture]( Andrew Whiten, Francisco J. Ayala, Marcus W. Feldman, and Kevin N. Laland Colloquium Papers [Cultural evolutionary theory: How culture evolves and why it matters]( Nicole Creanza, Oren Kolodny, and Marcus W. Feldman [Culture extends the scope of evolutionary biology in the great apes]( Andrew Whiten [Synchronized practice helps bearded capuchin monkeys learn to extend attention while learning a tradition]( Dorothy M. Fragaszy, Yonat Eshchar, Elisabetta Visalberghi, Briseida Resende, Kellie Laity, and Patrícia Izar [Older, sociable capuchins (Cebus capucinus) invent more social behaviors, but younger monkeys innovate more in other contexts]( Susan E. Perry, Brendan J. Barrett, and Irene Godoy [Gene–culture coevolution in whales and dolphins]( Hal Whitehead [Song hybridization events during revolutionary song change provide insights into cultural transmission in humpback whales]( Ellen C. Garland, Luke Rendell, Luca Lamoni, M. Michael Poole, and Michael J. Noad [Conformity does not perpetuate suboptimal traditions in a wild population of songbirds]( Lucy M. Aplin, Ben C. Sheldon, and Richard McElreath [A social insect perspective on the evolution of social learning mechanisms]( Ellouise Leadbeater and Erika H. Dawson [Cultural macroevolution matters]( Russell D. Gray and Joseph Watts [Pursuing Darwin’s curious parallel: Prospects for a science of cultural evolution]( Alex Mesoudi [Evolutionary neuroscience of cumulative culture]( Dietrich Stout and Erin E. Hecht [Identifying early modern human ecological niche expansions and associated cultural dynamics in the South African Middle Stone Age]( Francesco d’Errico, William E. Banks, Dan L. Warren, Giovanni Sgubin, Karen van Niekerk, Christopher Henshilwood, Anne-Laure Daniau, and María Fernanda Sánchez Goñi [Cumulative cultural learning: Development and diversity]( Cristine H. Legare [Young children communicate their ignorance and ask questions]( Paul L. Harris, Deborah T. Bartz, and Meredith L. Rowe [Changes in cognitive flexibility and hypothesis search across human life history from childhood to adolescence to adulthood]( Alison Gopnik, Shaun O’Grady, Christopher G. Lucas, Thomas L. Griffiths, Adrienne Wente, Sophie Bridgers, Rosie Aboody, Hoki Fung, and Ronald E. Dahl [How language shapes the cultural inheritance of categories]( Susan A. Gelman and Steven O. Roberts [Coevolution of cultural intelligence, extended life history, sociality, and brain size in primates]( Sally E. Street, Ana F. Navarrete, Simon M. Reader, and Kevin N. Laland [The evolution of cognitive mechanisms in response to cultural innovations]( Arnon Lotem, Joseph Y. Halpern, Shimon Edelman, and Oren Kolodny --------------------------------------------------------------- Physical Sciences Biophysics and Computational Biology [Continuous immunotypes describe human immune variation and predict diverse responses]( [Open Access Article] Kevin J. Kaczorowski, Karthik Shekhar, Dieudonné Nkulikiyimfura, Cornelia L. Dekker, Holden Maecker, Mark M. Davis, Arup K. Chakraborty, and Petter Brodin Chemistry [Modeling adsorption properties of structurally deformed metal–organic frameworks using structure–property map]( WooSeok Jeong, Dae-Woon Lim, Sungjune Kim, Aadesh Harale, Minyoung Yoon, Myunghyun Paik Suh, and Jihan Kim Earth, Atmospheric, and Planetary Sciences [Mercury evidence for pulsed volcanism during the end-Triassic mass extinction]( [From the Cover] Lawrence M. E. Percival, Micha Ruhl, Stephen P. Hesselbo, Hugh C. Jenkyns, Tamsin A. Mather, and Jessica H. Whiteside [Early Paleocene landbird supports rapid phylogenetic and morphological diversification of crown birds after the K–Pg mass extinction]( Daniel T. Ksepka, Thomas A. Stidham, and Thomas E. Williamson Engineering [On the debris-level origins of adhesive wear]( Ramin Aghababaei, Derek H. Warner, and Jean-François Molinari Physics [Enhanced coupling of light into a turbid medium through microscopic interface engineering]( Jonathan V. Thompson, Brett H. Hokr, Wihan Kim, Charles W. Ballmann, Brian E. Applegate, Javier Jo, Alexey Yamilov, Hui Cao, Marlan O. Scully, and Vladislav V. Yakovlev [Entanglement and thermodynamics after a quantum quench in integrable systems]( Vincenzo Alba and Pasquale Calabrese [Probing large viscosities in glass-formers with nonequilibrium simulations]( Vikram Jadhao and Mark O. Robbins --------------------------------------------------------------- Social Sciences Anthropology [Cultural evolutionary theory: How culture evolves and why it matters]( Nicole Creanza, Oren Kolodny, and Marcus W. Feldman [Culture extends the scope of evolutionary biology in the great apes]( Andrew Whiten [Cultural macroevolution matters]( Russell D. Gray and Joseph Watts [Evolutionary neuroscience of cumulative culture]( Dietrich Stout and Erin E. Hecht [Identifying early modern human ecological niche expansions and associated cultural dynamics in the South African Middle Stone Age]( Francesco d’Errico, William E. Banks, Dan L. Warren, Giovanni Sgubin, Karen van Niekerk, Christopher Henshilwood, Anne-Laure Daniau, and María Fernanda Sánchez Goñi Economic Sciences [Bayesian markets to elicit private information]( [Open Access Article] Aurélien Baillon Psychological and Cognitive Sciences [Attention model of binocular rivalry]( Hsin-Hung Li, James Rankin, John Rinzel, Marisa Carrasco, and David J. Heeger [A social insect perspective on the evolution of social learning mechanisms]( Ellouise Leadbeater and Erika H. Dawson [Pursuing Darwin’s curious parallel: Prospects for a science of cultural evolution]( Alex Mesoudi [Cumulative cultural learning: Development and diversity]( Cristine H. Legare [Young children communicate their ignorance and ask questions]( Paul L. Harris, Deborah T. Bartz, and Meredith L. Rowe [Changes in cognitive flexibility and hypothesis search across human life history from childhood to adolescence to adulthood]( Alison Gopnik, Shaun O’Grady, Christopher G. Lucas, Thomas L. Griffiths, Adrienne Wente, Sophie Bridgers, Rosie Aboody, Hoki Fung, and Ronald E. Dahl [How language shapes the cultural inheritance of categories]( Susan A. Gelman and Steven O. Roberts [The evolution of cognitive mechanisms in response to cultural innovations]( Arnon Lotem, Joseph Y. Halpern, Shimon Edelman, and Oren Kolodny [Harm to self outweighs benefit to others in moral decision making]( Lukas J. Volz, B. Locke Welborn, Matthias S. Gobel, Michael S. Gazzaniga, and Scott T. Grafton [Reduced orbitofrontal cortical volume is associated with interdependent self-construal]( Shinobu Kitayama, Kuniaki Yanagisawa, Ayahito Ito, Ryuhei Ueda, Yukiko Uchida, and Nobuhito Abe --------------------------------------------------------------- Biological Sciences Agricultural Sciences [Light-mediated self-organization of sunflower stands increases oil yield in the field]( Mónica López Pereira, Victor O. Sadras, William Batista, Jorge J. Casal, and Antonio J. Hall Anthropology [Older, sociable capuchins (Cebus capucinus) invent more social behaviors, but younger monkeys innovate more in other contexts]( Susan E. Perry, Brendan J. Barrett, and Irene Godoy [Pursuing Darwin’s curious parallel: Prospects for a science of cultural evolution]( Alex Mesoudi Applied Biological Sciences [Enhanced coupling of light into a turbid medium through microscopic interface engineering]( Jonathan V. Thompson, Brett H. Hokr, Wihan Kim, Charles W. Ballmann, Brian E. Applegate, Javier Jo, Alexey Yamilov, Hui Cao, Marlan O. Scully, and Vladislav V. Yakovlev Biochemistry [Anti-inflammatory ω-3 endocannabinoid epoxides]( Daniel R. McDougle, Josephine E. Watson, Amr A. Abdeen, Reheman Adili, Megan P. Caputo, John E. Krapf, Rodney W. Johnson, Kristopher A. Kilian, Michael Holinstat, and Aditi Das [Structural insights into lipoprotein N-acylation by Escherichia coli apolipoprotein N-acyltransferase]( Cameron L. Noland, Michele D. Kattke, Jingyu Diao, Susan L. Gloor, Homer Pantua, Mike Reichelt, Anand K. Katakam, Donghong Yan, Jing Kang, Inna Zilberleyb, Min Xu, Sharookh B. Kapadia, and Jeremy M. Murray [G9a coordinates with the RPA complex to promote DNA damage repair and cell survival]( [Open Access Article] Qiaoyan Yang, Qian Zhu, Xiaopeng Lu, Yipeng Du, Linlin Cao, Changchun Shen, Tianyun Hou, Meiting Li, Zhiming Li, Chaohua Liu, Di Wu, Xingzhi Xu, Lina Wang, Haiying Wang, Ying Zhao, Yang Yang, and Wei-Guo Zhu [UCP1 deficiency causes brown fat respiratory chain depletion and sensitizes mitochondria to calcium overload-induced dysfunction]( [Open Access Article] Lawrence Kazak, Edward T. Chouchani, Irina G. Stavrovskaya, Gina Z. Lu, Mark P. Jedrychowski, Daniel F. Egan, Manju Kumari, Xingxing Kong, Brian K. Erickson, John Szpyt, Evan D. Rosen, Michael P. Murphy, Bruce S. Kristal, Steven P. Gygi, and Bruce M. Spiegelman [Stable membrane orientations of small dual-topology membrane proteins]( Nir Fluman, Victor Tobiasson, and Gunnar von Heijne [MmpL3 is the flippase for mycolic acids in mycobacteria]( Zhujun Xu, Vladimir A. Meshcheryakov, Giovanna Poce, and Shu-Sin Chng [mTORC1 activates SREBP-2 by suppressing cholesterol trafficking to lysosomes in mammalian cells]( Walaa Eid, Kristin Dauner, Kevin C. Courtney, AnneMarie Gagnon, Robin J. Parks, Alexander Sorisky, and Xiaohui Zha Biophysics and Computational Biology [Size and mobility of lipid domains tuned by geometrical constraints]( Ole M. Schütte, Ingo Mey, Jörg Enderlein, Filip Savić, Burkhard Geil, Andreas Janshoff, and Claudia Steinem [Monomeric and fibrillar α-synuclein exert opposite effects on the catalytic cycle that promotes the proliferation of Aβ42 aggregates]( [Open Access Article] Sean Chia, Patrick Flagmeier, Johnny Habchi, Veronica Lattanzi, Sara Linse, Christopher M. Dobson, Tuomas P. J. Knowles, and Michele Vendruscolo [Crystal structure of CO-bound cytochrome c oxidase determined by serial femtosecond X-ray crystallography at room temperature]( Izumi Ishigami, Nadia A. Zatsepin, Masahide Hikita, Chelsie E. Conrad, Garrett Nelson, Jesse D. Coe, Shibom Basu, Thomas D. Grant, Matthew H. Seaberg, Raymond G. Sierra, Mark S. Hunter, Petra Fromme, Raimund Fromme, Syun-Ru Yeh, and Denis L. Rousseau [Antibody-induced uncoating of human rhinovirus B14]( Yangchao Dong, Yue Liu, Wen Jiang, Thomas J. Smith, Zhikai Xu, and Michael G. Rossmann [Otoferlin is a multivalent calcium-sensitive scaffold linking SNAREs and calcium channels]( Nicole Hams, Murugesh Padmanarayana, Weihong Qiu, and Colin P. Johnson Cell Biology [Functional characterization of human pluripotent stem cell-derived arterial endothelial cells]( Jue Zhang, Li-Fang Chu, Zhonggang Hou, Michael P. Schwartz, Timothy Hacker, Vernella Vickerman, Scott Swanson, Ning Leng, Bao Kim Nguyen, Angela Elwell, Jennifer Bolin, Matthew E. Brown, Ron Stewart, William J. Burlingham, William L. Murphy, and James A. Thomson [TRPM7 senses oxidative stress to release Zn2+ from unique intracellular vesicles]( Sunday A. Abiria, Grigory Krapivinsky, Rajan Sah, Ana G. Santa-Cruz, Dipayan Chaudhuri, Jin Zhang, Pichet Adstamongkonkul, Paul G. DeCaen, and David E. Clapham Developmental Biology [Deletion of Gas2l3 in mice leads to specific defects in cardiomyocyte cytokinesis during development]( Sabine Stopp, Marco Gründl, Marc Fackler, Jonas Malkmus, Marina Leone, Ronald Naumann, Stefan Frantz, Elmar Wolf, Björn von Eyss, Felix B. Engel, and Stefan Gaubatz Ecology [Biological annihilation via the ongoing sixth mass extinction signaled by vertebrate population losses and declines]( [Open Access Article] Gerardo Ceballos, Paul R. Ehrlich, and Rodolfo Dirzo [Song hybridization events during revolutionary song change provide insights into cultural transmission in humpback whales]( Ellen C. Garland, Luke Rendell, Luca Lamoni, M. Michael Poole, and Michael J. Noad [Identifying early modern human ecological niche expansions and associated cultural dynamics in the South African Middle Stone Age]( Francesco d’Errico, William E. Banks, Dan L. Warren, Giovanni Sgubin, Karen van Niekerk, Christopher Henshilwood, Anne-Laure Daniau, and María Fernanda Sánchez Goñi [Behavioral self-organization underlies the resilience of a coastal ecosystem]( [From the Cover] Hélène de Paoli, Tjisse van der Heide, Aniek van den Berg, Brian R. Silliman, Peter M. J. Herman, and Johan van de Koppel Environmental Sciences [Interannual cycles of Hantaan virus outbreaks at the human–animal interface in Central China are controlled by temperature and rainfall]( [Open Access Article] Huaiyu Tian, Pengbo Yu, Bernard Cazelles, Lei Xu, Hua Tan, Jing Yang, Shanqian Huang, Bo Xu, Jun Cai, Chaofeng Ma, Jing Wei, Shen Li, Jianhui Qu, Marko Laine, Jingjun Wang, Shilu Tong, Nils Chr. Stenseth, and Bing Xu Evolution [Cultural evolutionary theory: How culture evolves and why it matters]( Nicole Creanza, Oren Kolodny, and Marcus W. Feldman [Culture extends the scope of evolutionary biology in the great apes]( Andrew Whiten [Gene–culture coevolution in whales and dolphins]( Hal Whitehead [A social insect perspective on the evolution of social learning mechanisms]( Ellouise Leadbeater and Erika H. Dawson [Cultural macroevolution matters]( Russell D. Gray and Joseph Watts [Coevolution of cultural intelligence, extended life history, sociality, and brain size in primates]( Sally E. Street, Ana F. Navarrete, Simon M. Reader, and Kevin N. Laland [The evolution of cognitive mechanisms in response to cultural innovations]( Arnon Lotem, Joseph Y. Halpern, Shimon Edelman, and Oren Kolodny [Early Paleocene landbird supports rapid phylogenetic and morphological diversification of crown birds after the K–Pg mass extinction]( Daniel T. Ksepka, Thomas A. Stidham, and Thomas E. Williamson [Haploid selection within a single ejaculate increases offspring fitness]( [Open Access Article] Ghazal Alavioon, Cosima Hotzy, Khriezhanuo Nakhro, Sandra Rudolf, Douglas G. Scofield, Susanne Zajitschek, Alexei A. Maklakov, and Simone Immler Genetics [Fast and accurate HLA typing from short-read next-generation sequence data with xHLA]( [Open Access Article] Chao Xie, Zhen Xuan Yeo, Marie Wong, Jason Piper, Tao Long, Ewen F. Kirkness, William H. Biggs, Ken Bloom, Stephen Spellman, Cynthia Vierra-Green, Colleen Brady, Richard H. Scheuermann, Amalio Telenti, Sally Howard, Suzanne Brewerton, Yaron Turpaz, and J. Craig Venter Immunology and Inflammation [Continuous immunotypes describe human immune variation and predict diverse responses]( [Open Access Article] Kevin J. Kaczorowski, Karthik Shekhar, Dieudonné Nkulikiyimfura, Cornelia L. Dekker, Holden Maecker, Mark M. Davis, Arup K. Chakraborty, and Petter Brodin [Influenza infection triggers disease in a genetic model of experimental autoimmune encephalomyelitis]( Stephen Blackmore, Jessica Hernandez, Michal Juda, Emily Ryder, Gregory G. Freund, Rodney W. Johnson, and Andrew J. Steelman [Suboptimal T-cell receptor signaling compromises protein translation, ribosome biogenesis, and proliferation of mouse CD8 T cells]( Thomas C. J. Tan, John Knight, Thomas Sbarrato, Kate Dudek, Anne E. Willis, and Rose Zamoyska Medical Sciences [Loss-of-function mutation in Mirta22/Emc10 rescues specific schizophrenia-related phenotypes in a mouse model of the 22q11.2 deletion]( Anastasia Diamantopoulou, Ziyi Sun, Jun Mukai, Bin Xu, Karine Fenelon, Maria Karayiorgou, and Joseph A. Gogos [Combined epigenetic and differentiation-based treatment inhibits neuroblastoma tumor growth and links HIF2α to tumor suppression]( Isabelle Westerlund, Yao Shi, Konstantinos Toskas, Stuart M. Fell, Shuijie Li, Olga Surova, Erik Södersten, Per Kogner, Ulrika Nyman, Susanne Schlisio, and Johan Holmberg [Multiplexed RNAi therapy against brain tumor-initiating cells via lipopolymeric nanoparticle infusion delays glioblastoma progression]( Dou Yu, Omar F. Khan, Mario L. Suvà, Biqin Dong, Wojciech K. Panek, Ting Xiao, Meijing Wu, Yu Han, Atique U. Ahmed, Irina V. Balyasnikova, Hao F. Zhang, Cheng Sun, Robert Langer, Daniel G. Anderson, and Maciej S. Lesniak [Stem cell-released oncolytic herpes simplex virus has therapeutic efficacy in brain metastatic melanomas]( Wanlu Du, Ivan Seah, Oumaima Bougazzoul, GiHun Choi, Katrina Meeth, Marcus W. Bosenberg, Hiroaki Wakimoto, David Fisher, and Khalid Shah [Intestinal virome changes precede autoimmunity in type I diabetes-susceptible children]( Guoyan Zhao, Tommi Vatanen, Lindsay Droit, Arnold Park, Aleksandar D. Kostic, Tiffany W. Poon, Hera Vlamakis, Heli Siljander, Taina Härkönen, Anu-Maaria Hämäläinen, Aleksandr Peet, Vallo Tillmann, Jorma Ilonen, David Wang, Mikael Knip, Ramnik J. Xavier, and Herbert W. Virgin [BMTP-11 is active in preclinical models of human osteosarcoma and a candidate targeted drug for clinical translation]( [Open Access Article] Valerae O. Lewis, Eswaran Devarajan, Marina Cardó-Vila, Dafydd G. Thomas, Eugenie S. Kleinerman, Serena Marchiò, Richard L. Sidman, Renata Pasqualini, and Wadih Arap [tsRNA signatures in cancer]( Veronica Balatti, Giovanni Nigita, Dario Veneziano, Alessandra Drusco, Gary S. Stein, Terri L. Messier, Nicholas H. Farina, Jane B. Lian, Luisa Tomasello, Chang-gong Liu, Alexey Palamarchuk, Jonathan R. Hart, Catherine Bell, Mariantonia Carosi, Edoardo Pescarmona, Letizia Perracchio, Maria Diodoro, Andrea Russo, Anna Antenucci, Paolo Visca, Antonio Ciardi, Curtis C. Harris, Peter K. Vogt, Yuri Pekarsky, and Carlo M. Croce Microbiology [Two dynamin-like proteins stabilize FtsZ rings during Streptomyces sporulation]( [Open Access Article] Susan Schlimpert, Sebastian Wasserstrom, Govind Chandra, Maureen J. Bibb, Kim C. Findlay, Klas Flärdh, and Mark J. Buttner [Bifunctionality of a biofilm matrix protein controlled by redox state]( [Open Access Article] Sofia Arnaouteli, Ana Sofia Ferreira, Marieke Schor, Ryan J. Morris, Keith M. Bromley, Jeanyoung Jo, Krista L. Cortez, Tetyana Sukhodub, Alan R. Prescott, Lars E. P. Dietrich, Cait E. MacPhee, and Nicola R. Stanley-Wall [Polar delivery of Legionella type IV secretion system substrates is essential for virulence]( Kwangcheol C. Jeong, Debnath Ghosal, Yi-Wei Chang, Grant J. Jensen, and Joseph P. Vogel Neuroscience [Attention model of binocular rivalry]( Hsin-Hung Li, James Rankin, John Rinzel, Marisa Carrasco, and David J. Heeger [Acetylcholine-producing NK cells attenuate CNS inflammation via modulation of infiltrating monocytes/macrophages]( [Open Access Article] Wei Jiang, Daojing Li, Ranran Han, Chao Zhang, Wei-Na Jin, Kristofer Wood, Qiang Liu, Fu-Dong Shi, and Junwei Hao [Synaptic properties of the lemniscal and paralemniscal pathways to the mouse somatosensory thalamus]( Christina Mo, Iraklis Petrof, Angela N. Viaene, and S. Murray Sherman [Corticogeniculate feedback sharpens the temporal precision and spatial resolution of visual signals in the ferret]( J. Michael Hasse and Farran Briggs [Auditory cortex interneuron development requires cadherins operating hair-cell mechanoelectrical transduction]( [Open Access Article] [Inaugural Article] Baptiste Libé-Philippot, Vincent Michel, Jacques Boutet de Monvel, Sébastien Le Gal, Typhaine Dupont, Paul Avan, Christine Métin, Nicolas Michalski, and Christine Petit [Evolutionary neuroscience of cumulative culture]( Dietrich Stout and Erin E. Hecht [Frequency-specific directed interactions in the human brain network for language]( Jan-Mathijs Schoffelen, Annika Hultén, Nietzsche Lam, André F. Marquand, Julia Uddén, and Peter Hagoort [Acute inflammation regulates neuroregeneration through the NF-κB pathway in olfactory epithelium]( Mengfei Chen, Randall R. Reed, and Andrew P. Lane [Genetic identification of a hindbrain nucleus essential for innate vocalization]( [Open Access Article] Luis Rodrigo Hernandez-Miranda, Pierre-Louis Ruffault, Julien C. Bouvier, Andrew J. Murray, Marie-Pierre Morin-Surun, Niccolò Zampieri, Justyna B. Cholewa-Waclaw, Elodie Ey, Jean-Francois Brunet, Jean Champagnat, Gilles Fortin, and Carmen Birchmeier Pharmacology [Prediction of intracellular exposure bridges the gap between target- and cell-based drug discovery]( [Open Access Article] André Mateus, Laurie J. Gordon, Gareth J. Wayne, Helena Almqvist, Hanna Axelsson, Brinton Seashore-Ludlow, Andrea Treyer, Pär Matsson, Thomas Lundbäck, Andy West, Michael M. Hann, and Per Artursson [Analyses of PDE-regulated phosphoproteomes reveal unique and specific cAMP-signaling modules in T cells]( Michael-Claude G. Beltejar, Ho-Tak Lau, Martin G. Golkowski, Shao-En Ong, and Joseph A. Beavo Physiology [Loss of mouse cardiomyocyte talin-1 and talin-2 leads to β-1 integrin reduction, costameric instability, and dilated cardiomyopathy]( Ana Maria Manso, Hideshi Okada, Francesca M. Sakamoto, Emily Moreno, Susan J. Monkley, Ruixia Li, David R. Critchley, and Robert S. Ross [Caffeine induces gastric acid secretion via bitter taste signaling in gastric parietal cells]( [Open Access Article] Kathrin Ingrid Liszt, Jakob Peter Ley, Barbara Lieder, Maik Behrens, Verena Stöger, Angelika Reiner, Christina Maria Hochkogler, Elke Köck, Alessandro Marchiori, Joachim Hans, Sabine Widder, Gerhard Krammer, Gareth John Sanger, Mark Manuel Somoza, Wolfgang Meyerhof, and Veronika Somoza Plant Biology [Genomic architecture of biomass heterosis in Arabidopsis]( Mei Yang, Xuncheng Wang, Diqiu Ren, Hao Huang, Miqi Xu, Guangming He, and Xing Wang Deng [Structure of the Arabidopsis TOPLESS corepressor provides insight into the evolution of transcriptional repression]( [Open Access Article] Raquel Martin-Arevalillo, Max H. Nanao, Antoine Larrieu, Thomas Vinos-Poyo, David Mast, Carlos Galvan-Ampudia, Géraldine Brunoud, Teva Vernoux, Renaud Dumas, and François Parcy [NLR network mediates immunity to diverse plant pathogens]( Chih-Hang Wu, Ahmed Abd-El-Haliem, Tolga O. Bozkurt, Khaoula Belhaj, Ryohei Terauchi, Jack H. Vossen, and Sophien Kamoun Psychological and Cognitive Sciences [Synchronized practice helps bearded capuchin monkeys learn to extend attention while learning a tradition]( Dorothy M. Fragaszy, Yonat Eshchar, Elisabetta Visalberghi, Briseida Resende, Kellie Laity, and Patrícia Izar [Conformity does not perpetuate suboptimal traditions in a wild population of songbirds]( Lucy M. Aplin, Ben C. Sheldon, and Richard McElreath [Intranasal oxytocin treatment for social deficits and biomarkers of response in children with autism]( [Open Access Article] Karen J. Parker, Ozge Oztan, Robin A. Libove, Raena D. Sumiyoshi, Lisa P. Jackson, Debra S. Karhson, Jacqueline E. Summers, Kyle E. Hinman, Kara S. Motonaga, Jennifer M. Phillips, Dean S. Carson, Joseph P. Garner, and Antonio Y. Hardan --------------------------------------------------------------- Correction (Online Only) [Correction for Li et al., Targeting reactive nitrogen species suppresses hereditary pancreatic cancer]( [Cover] Open Access From the Cover Inaugural Article Classic Cozzarelli Prize Winner Front Matter --------------------------------------------------------------- This message was sent to {EMAIL}. [Unsubscribe]( from or [edit]( your subscription for this service. Or by mail: Customer Service * 973 University Avenue * Los Gatos, CA 95032 * U.S.A. Copyright © 2017 by the National Academy of Sciences