PNAS Table of Contents for October 12, 2021; Vol. 118, No. 41 is now complete

[PNAS] [Special Feature: Tropical Forests as Key Sites of the Anthropocene. Access now.](/cgi/adclick/?ad=56140&adclick=true&url=https%3A%2F%2Fwww.pnas.org%2Fcc%2Ftropical-forests-anthropocene-special-feature)   [October 12, 2021; Vol. 118, No. 41]( ) This Week in PNAS [In This Issue]( This week's research highlights --------------------------------------------------------------- At the National Academies [The Strategic Council for Research Excellence, Integrity, and Trust]( Marcia McNutt, France A. Córdova, and David B. Allison --------------------------------------------------------------- Science and Culture [Science and Culture: Looking to “junk” food to design healthier options]( Amy McDermott How science intersects with culture --------------------------------------------------------------- Commentaries [Genomics serology to inform therapies and vaccines for arthritogenic alphaviruses]( Adolfo García-Sastre [Pathways to parasitic strategies in ants]( Heikki Helanterä [Broad tiger stripes in a small habitat patch]( Eduardo Eizirik [Education’s role in China’s demographic future]( Philip H. Rees --------------------------------------------------------------- Perspective [The overlap gap property: A topological barrier to optimizing over random structures]( David Gamarnik --------------------------------------------------------------- Letters [Intestinal dysbiosis in celiac disease: Decreased butyrate production may facilitate the onset of the disease]( Jiezhong Chen and Luis Vitetta [Reply to Chen and Vitetta: Unraveling the complex interactions among organisms in the microbiome is necessary to identify unique signatures predicting CD onset]( Maureen M. Leonard, Rita R. Colwell, and Alessio Fasano --------------------------------------------------------------- Brief Reports [Cerebral and systemic physiological effects of wearing face masks in young adults]( Jonas B. Fischer, Lisa Kobayashi Frisk, Felix Scholkmann, Raquel Delgado-Mederos, Mercedes Mayos, and Turgut Durduran [Adolescent civic engagement: Lessons from Black Lives Matter]( Arielle Baskin-Sommers, Cortney Simmons, May Conley, Shou-An Chang, Suzanne Estrada, Meghan Collins, William Pelham, Emil Beckford, Haley Mitchell-Adams, Nia Berrian, Susan F. Tapert, Dylan G. Gee, and B. J. Casey --------------------------------------------------------------- Physical Sciences Applied Mathematics [Switchover phenomenon induced by epidemic seeding on geometric networks]( Gergely Ódor, Domonkos Czifra, Júlia Komjáthy, László Lovász, and Márton Karsai [Multiparameter persistent homology landscapes identify immune cell spatial patterns in tumors]( Oliver Vipond, Joshua A. Bull, Philip S. Macklin, Ulrike Tillmann, Christopher W. Pugh, Helen M. Byrne, and Heather A. Harrington Applied Physical Sciences [Making ab initio QED functional(s): Nonperturbative and photon-free effective frameworks for strong light–matter coupling]( Christian Schäfer, Florian Buchholz, Markus Penz, Michael Ruggenthaler, and Angel Rubio [Attractive forces slow contact formation between deformable bodies underwater]( Mengyue Sun, Nityanshu Kumar, Ali Dhinojwala, and Hunter King Biophysics and Computational Biology [Understanding cytoskeletal avalanches using mechanical stability analysis]( Carlos Floyd, Herbert Levine, Christopher Jarzynski, and Garegin A. Papoian Chemistry [Voltage cycling process for the electroconversion of biomass-derived polyols]( Dohyung Kim, Chengshuang Zhou, Miao Zhang, and Matteo Cargnello [Tubular lysosomes harbor active ion gradients and poise macrophages for phagocytosis]( Bhavyashree Suresh, Anand Saminathan, Kasturi Chakraborty, Matthew Zajac, Chang Cui, Lev Becker, and Yamuna Krishnan Earth, Atmospheric, and Planetary Sciences [Recent increases in tropical cyclone precipitation extremes over the US east coast]( Justin T. Maxwell, Joshua C. Bregy, Scott M. Robeson, Paul A. Knapp, Peter T. Soulé, and Valerie Trouet [Decreasing Phanerozoic extinction intensity as a consequence of Earth surface oxygenation and metazoan ecophysiology]( Richard G. Stockey, Alexandre Pohl, Andy Ridgwell, Seth Finnegan, and Erik A. Sperling [Hurricane annual cycle controlled by both seeds and genesis probability]( Wenchang Yang, Tsung-Lin Hsieh, and Gabriel A. Vecchi [Evidence for massive and recurrent toxic blooms of Alexandrium catenella in the Alaskan Arctic]( Donald M. Anderson, Evangeline Fachon, Robert S. Pickart, Peigen Lin, Alexis D. Fischer, Mindy L. Richlen, Victoria Uva, Michael L. Brosnahan, Leah McRaven, Frank Bahr, Kathi Lefebvre, Jacqueline M. Grebmeier, Seth L. Danielson, Yihua Lyu, and Yuri Fukai [Climate change facilitated the early colonization of the Azores Archipelago during medieval times]( Pedro M. Raposeiro, Armand Hernández, Sergi Pla-Rabes, Vítor Gonçalves, Roberto Bao, Alberto Sáez, Timothy Shanahan, Mario Benavente, Erik J. de Boer, Nora Richter, Verónica Gordon, Helena Marques, Pedro M. Sousa, Martín Souto, Miguel G. Matias, Nicole Aguiar, Cátia Pereira, Catarina Ritter, María Jesús Rubio, Marina Salcedo, David Vázquez-Loureiro, Olga Margalef, Linda A. Amaral-Zettler, Ana Cristina Costa, Yongsong Huang, Jacqueline F. N. van Leeuwen, Pere Masqué, Ricardo Prego, Ana Carolina Ruiz-Fernández, Joan-Albert Sanchez-Cabeza, Ricardo Trigo, and Santiago Giralt Engineering [Detecting insulitis in type 1 diabetes with ultrasound phase-change contrast agents]( David G. Ramirez, Mark Ciccaglione, Awaneesh K. Upadhyay, Vinh T. Pham, Mark A. Borden, and Richard K. P. Benninger Sustainability Science [Global urban population exposure to extreme heat]( Cascade Tuholske, Kelly Caylor, Chris Funk, Andrew Verdin, Stuart Sweeney, Kathryn Grace, Pete Peterson, and Tom Evans --------------------------------------------------------------- Social Sciences Psychological and Cognitive Sciences [Eighteen-month-old infants represent nonlocal syntactic dependencies]( Laurel Perkins and Jeffrey Lidz Social Sciences [Slowed canonical progress in large fields of science]( Johan S. G. Chu and James A. Evans Sustainability Science [Global urban population exposure to extreme heat]( Cascade Tuholske, Kelly Caylor, Chris Funk, Andrew Verdin, Stuart Sweeney, Kathryn Grace, Pete Peterson, and Tom Evans --------------------------------------------------------------- Biological Sciences Applied Biological Sciences [Releasing incompatible males drives strong suppression across populations of wild and Wolbachia-carrying Aedes aegypti in Australia]( Nigel W. Beebe, Dan Pagendam, Brendan J. Trewin, Andrew Boomer, Matt Bradford, Andrew Ford, Catherine Liddington, Artiom Bondarenco, Paul J. De Barro, Joshua Gilchrist, Christopher Paton, Kyran M. Staunton, Brian Johnson, Andrew J. Maynard, Gregor J. Devine, Leon E. Hugo, Gordana Rasic, Helen Cook, Peter Massaro, Nigel Snoad, Jacob E. Crawford, Bradley J. White, Zhiyong Xi, and Scott A. Ritchie Biochemistry [Phospholipase Cγ2 regulates endocannabinoid and eicosanoid networks in innate immune cells]( Hui Jing, Alex Reed, Olesya A. Ulanovskaya, Jan-Sebastian Grigoleit, Dylan M. Herbst, Cassandra L. Henry, Haoxin Li, Sabrina Barbas, Jason Germain, Kim Masuda, and Benjamin F. Cravatt [High-risk human papillomavirus-18 uses an mRNA sequence to synthesize oncoprotein E6 in tumors]( Alejandra García, Giovanna Maldonado, José L. González, Yuri Svitkin, David Cantú, Alejandro García-Carrancá, Nahum Sonenberg, and Greco Hernández [Selective promiscuity in the binding of E. coli Hsp70 to an unfolded protein]( Eugenia M. Clerico, Alexandra K. Pozhidaeva, Rachel M. Jansen, Can Özden, Joseph M. Tilitsky, and Lila M. Gierasch [Cryo-EM structure determination of small proteins by nanobody-binding scaffolds (Legobodies)]( Xudong Wu and Tom A. Rapoport Biophysics and Computational Biology [Multiparameter persistent homology landscapes identify immune cell spatial patterns in tumors]( Oliver Vipond, Joshua A. Bull, Philip S. Macklin, Ulrike Tillmann, Christopher W. Pugh, Helen M. Byrne, and Heather A. Harrington [Understanding cytoskeletal avalanches using mechanical stability analysis]( Carlos Floyd, Herbert Levine, Christopher Jarzynski, and Garegin A. Papoian [Asymmetric protonation of glutamate residues drives a preferred transport pathway in EmrE]( Jianping Li, Ampon Sae Her, and Nathaniel J. Traaseth [Structural basis of rotavirus RNA chaperone displacement and RNA annealing]( Jack P. K. Bravo, Kira Bartnik, Luca Venditti, Julia Acker, Emma H. Gail, Alice Colyer, Chen Davidovich, Don C. Lamb, Roman Tuma, Antonio N. Calabrese, and Alexander Borodavka Cell Biology [Tubular lysosomes harbor active ion gradients and poise macrophages for phagocytosis]( Bhavyashree Suresh, Anand Saminathan, Kasturi Chakraborty, Matthew Zajac, Chang Cui, Lev Becker, and Yamuna Krishnan [Integrated spatial multiomics reveals fibroblast fate during tissue repair]( Deshka S. Foster, Michael Januszyk, Kathryn E. Yost, Malini S. Chinta, Gunsagar S. Gulati, Alan T. Nguyen, Austin R. Burcham, Ankit Salhotra, R. Chase Ransom, Dominic Henn, Kellen Chen, Shamik Mascharak, Karen Tolentino, Ashley L. Titan, R. Ellen Jones, Oscar da Silva, W. Tripp Leavitt, Clement D. Marshall, Heather E. des Jardins-Park, Michael S. Hu, Derrick C. Wan, Gerlinde Wernig, Dhananjay Wagh, John Coller, Jeffrey A. Norton, Geoffrey C. Gurtner, Aaron M. Newman, Howard Y. Chang, and Michael T. Longaker Ecology [Large herbivores suppress liana infestation in an African savanna]( Tyler C. Coverdale, Ryan D. O’Connell, Matthew C. Hutchinson, Amanda Savagian, Tyler R. Kartzinel, Todd M. Palmer, Jacob R. Goheen, David J. Augustine, Mahesh Sankaran, Corina E. Tarnita, and Robert M. Pringle [Relict inland mangrove ecosystem reveals Last Interglacial sea levels]( Octavio Aburto-Oropeza, Carlos Manuel Burelo-Ramos, Exequiel Ezcurra, Paula Ezcurra, Claudia L. Henriquez, Sula E. Vanderplank, and Felipe Zapata [Capacity of soil bacteria to reach the phyllosphere and convergence of floral communities despite soil microbiota variation]( Julien Massoni, Miriam Bortfeld-Miller, Alex Widmer, and Julia A. Vorholt Environmental Sciences [Evidence for massive and recurrent toxic blooms of Alexandrium catenella in the Alaskan Arctic]( Donald M. Anderson, Evangeline Fachon, Robert S. Pickart, Peigen Lin, Alexis D. Fischer, Mindy L. Richlen, Victoria Uva, Michael L. Brosnahan, Leah McRaven, Frank Bahr, Kathi Lefebvre, Jacqueline M. Grebmeier, Seth L. Danielson, Yihua Lyu, and Yuri Fukai [Climate change facilitated the early colonization of the Azores Archipelago during medieval times]( Pedro M. Raposeiro, Armand Hernández, Sergi Pla-Rabes, Vítor Gonçalves, Roberto Bao, Alberto Sáez, Timothy Shanahan, Mario Benavente, Erik J. de Boer, Nora Richter, Verónica Gordon, Helena Marques, Pedro M. Sousa, Martín Souto, Miguel G. Matias, Nicole Aguiar, Cátia Pereira, Catarina Ritter, María Jesús Rubio, Marina Salcedo, David Vázquez-Loureiro, Olga Margalef, Linda A. Amaral-Zettler, Ana Cristina Costa, Yongsong Huang, Jacqueline F. N. van Leeuwen, Pere Masqué, Ricardo Prego, Ana Carolina Ruiz-Fernández, Joan-Albert Sanchez-Cabeza, Ricardo Trigo, and Santiago Giralt Genetics [BRCA1/Trp53 heterozygosity and replication stress drive esophageal cancer development in a mouse model]( Ye He, Joshua Rivera, Miklos Diossy, Haohui Duan, Christian Bowman-Colin, Rachel Reed, Rebecca Jennings, Jesse Novak, Stevenson V. Tran, Elizabeth F. Cohen, David Szuts, Anita Giobbie-Hurder, Roderick T. Bronson, Adam J. Bass, Sabina Signoretti, Zoltan Szallasi, David M. Livingston, and Shailja Pathania [Cis-acting mutation affecting GJA5 transcription is underlying the Melanotic within-feather pigmentation pattern in chickens]( Jingyi Li, Mi-Ok Lee, Junfeng Chen, Brian W. Davis, Benjamin J. Dorshorst, Paul B. Siegel, Masafumi Inaba, Ting-Xin Jiang, Cheng-Ming Chuong, and Leif Andersson [Context-specific regulation of lysosomal lipolysis through network-level diverting of transcription factor interactions]( Vinod K. Mony, Anna Drangowska-Way, Reka Albert, Emma Harrison, Abbas Ghaddar, Mary Kate Horak, Wenfan Ke, and Eyleen J. O’Rourke [Hinfp is a guardian of the somatic genome by repressing transposable elements]( Niraj K. Nirala, Qi Li, Prachi N. Ghule, Hsi-Ju Chen, Rui Li, Lihua Julie Zhu, Ruijia Wang, Nicholas P. Rice, Junhao Mao, Janet L. Stein, Gary S. Stein, Andre J. van Wijnen, and Y. Tony Ip Immunology and Inflammation [Robust and prototypical immune responses toward influenza vaccines in the high-risk group of Indigenous Australians]( Luca Hensen, Thi H. O. Nguyen, Louise C. Rowntree, Timon Damelang, Marios Koutsakos, Malet Aban, Aeron Hurt, Kim L. Harland, Maria Auladell, Carolien E. van de Sandt, Anngie Everitt, Cath Blacker, Damian A. Oyong, Jessica R. Loughland, Jessica R. Webb, Bruce D. Wines, P. Mark Hogarth, Katie L. Flanagan, Magdalena Plebanski, Adam Wheatley, Amy W. Chung, Stephen J. Kent, Adrian Miller, E. Bridie Clemens, Peter C. Doherty, Jane Nelson, Jane Davies, Steven Y. C. Tong, and Katherine Kedzierska [Human islet T cells are highly reactive to preproinsulin in type 1 diabetes]( Amanda M. Anderson, Laurie G. Landry, Aimon A. Alkanani, Laura Pyle, Alvin C. Powers, Mark A. Atkinson, Clayton E. Mathews, Bart O. Roep, Aaron W. Michels, and Maki Nakayama [Vasoactive intestinal peptide promotes host defense against enteric pathogens by modulating the recruitment of group 3 innate lymphoid cells]( Hong Bing Yu, Hyungjun Yang, Joannie M. Allaire, Caixia Ma, Franziska A. Graef, Arthur Mortha, Qiaochu Liang, Else S. Bosman, Gregor S. Reid, James A. Waschek, Lisa C. Osborne, Harry Sokol, Bruce A. Vallance, and Kevan Jacobson [Cis-acting lnc-Cxcl2 restrains neutrophil-mediated lung inflammation by inhibiting epithelial cell CXCL2 expression in virus infection]( Shuo Liu, Jiaqi Liu, Xue Yang, Minghong Jiang, Qingqing Wang, Lianfeng Zhang, Yuanwu Ma, Zhongyang Shen, Zhigang Tian, and Xuetao Cao [Eicosanoid regulation of debris-stimulated metastasis]( Jianjun Deng, Haixia Yang, Victoria M. Haak, Jun Yang, Franciele C. Kipper, Chantal Barksdale, Sung Hee Hwang, Allison Gartung, Diane R. Bielenberg, Selvakumar Subbian, Koc-Kan Ho, Xiang Ye, Daidi Fan, Yongkui Sun, Bruce D. Hammock, and Dipak Panigrahy [Single-cell profiling reveals the importance of CXCL13/CXCR5 axis biology in lymphocyte-rich classic Hodgkin lymphoma]( Tomohiro Aoki, Lauren C. Chong, Katsuyoshi Takata, Katy Milne, Ashley Marshall, Elizabeth A. Chavez, Tomoko Miyata-Takata, Susana Ben-Neriah, Doria Unrau, Adele Telenius, Merrill Boyle, Andrew P. Weng, Kerry J. Savage, David W. Scott, Pedro Farinha, Sohrab P. Shah, Brad H. Nelson, and Christian Steidl Medical Sciences [Detecting insulitis in type 1 diabetes with ultrasound phase-change contrast agents]( David G. Ramirez, Mark Ciccaglione, Awaneesh K. Upadhyay, Vinh T. Pham, Mark A. Borden, and Richard K. P. Benninger [Identification of fluoxetine as a direct NLRP3 inhibitor to treat atrophic macular degeneration]( Meenakshi Ambati, Ivana Apicella, Shao-bin Wang, Siddharth Narendran, Hannah Leung, Felipe Pereira, Yosuke Nagasaka, Peirong Huang, Akhil Varshney, Kirstie L. Baker, Kenneth M. Marion, Mehrdad Shadmehr, Cliff I. Stains, Brian C. Werner, Srinivas R. Sadda, Ethan W. Taylor, S. Scott Sutton, Joseph Magagnoli, and Bradley D. Gelfand [Interventional real-time optical imaging guidance for complete tumor ablation]( Xuefeng Kan, Feng Zhang, Guanhui Zhou, Hongxiu Ji, Wayne Monsky, Christopher Ingraham, Chuansheng Zheng, and Xiaoming Yang Microbiology [Analysis of SARS-CoV-2 infection dynamic in vivo using reporter-expressing viruses]( Chengjin Ye, Kevin Chiem, Jun-Gyu Park, Jesus A. Silvas, Desarey Morales Vasquez, Julien Sourimant, Michelle J. Lin, Alexander L. Greninger, Richard K. Plemper, Jordi B. Torrelles, James J. Kobie, Mark R. Walter, Juan Carlos de la Torre, and Luis Martinez-Sobrido [Structural and mechanistic insights into the complexes formed by Wolbachia cytoplasmic incompatibility factors]( Yunjie Xiao, Hongli Chen, Haofeng Wang, Mengwen Zhang, Xia Chen, Jason M. Berk, Lilin Zhang, Yi Wei, Wenling Li, Wen Cui, Fenghua Wang, Qianfan Wang, Can Cui, Ting Li, Cheng Chen, Sheng Ye, Lei Zhang, Xiaoyun Ji, Jinhai Huang, Wei Wang, Zefang Wang, Mark Hochstrasser, and Haitao Yang [Phytoplankton exudates and lysates support distinct microbial consortia with specialized metabolic and ecophysiological traits]( Brandon Kieft, Zhou Li, Samuel Bryson, Robert L. Hettich, Chongle Pan, Xavier Mayali, and Ryan S. Mueller Population Biology [Spillover, hybridization, and persistence in schistosome transmission dynamics at the human–animal interface]( Anna Borlase, James W. Rudge, Elsa Léger, Nicolas D. Diouf, Cheikh B. Fall, Samba D. Diop, Stefano Catalano, Mariama Sène, and Joanne P. Webster Systems Biology [Continuous variable responses and signal gating form kinetic bases for pulsatile insulin signaling and emergence of resistance]( Namrata Shukla, Shantanu Kadam, Ranjith Padinhateeri, and Ullas Kolthur-Seetharam --------------------------------------------------------------- Corrections [Correction for Froitzheim et al., Methane release from carbonate rock formations in the Siberian permafrost area during and after the 2020 heat wave]( [Correction for Whitworth et al., Elevated cerebrospinal fluid cytokine levels in tuberculous meningitis predict survival in response to dexamethasone]( [Correction for Wang et al., Genome-wide screen identifies curli amyloid fibril as a bacterial component promoting host neurodegeneration]( --------------------------------------------------------------- SI Correction [Correction to Supporting Information for Walton et al., In vitro selection of ribozyme ligases that use prebiotically plausible 2-aminoimidazole–activated substrates]( [Cover] --------------------------------------------------------------- This message was sent to {EMAIL}. 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