PNAS Table of Contents for September 28, 2021; Vol. 118, No. 39 is now complete

[PNAS] [This week on the PNAS Science Sessions Podcast: Racial and ethnic disparities in pollutant exposure. Listen here.](/cgi/adclick/?ad=56105&adclick=true&url=https%3A%2F%2Fwww.pnas.org%2Fpage%2Fmedia%2Fpodcasts%23racial-ethnic-disparities)   [September 28, 2021; Vol. 118, No. 39]( ) This Week in PNAS [In This Issue]( This week's research highlights --------------------------------------------------------------- Profile [Cracking the Clock: Ronald J. Konopka and Seymour Benzer]( Matthew Hardcastle The life and work of NAS members --------------------------------------------------------------- Commentaries [Origin, transmission, and evolution of plague over 400 y in Europe]( Rémi Barbieri [Model and modelers provide an insight into pairing of homologous DNA duplexes]( David E. A. Catcheside --------------------------------------------------------------- Perspective [The 50th anniversary of the Konopka and Benzer 1971 paper in PNAS: “Clock Mutants of Drosophila melanogaster”]( Joseph S. Takahashi [Can we get human nature right?]( Iris Berent --------------------------------------------------------------- Letters [How the unvaccinated threaten the vaccinated for COVID-19: A Darwinian perspective]( Emanuel Goldman [Physiological cyanide concentrations do not stimulate mitochondrial cytochrome c oxidase activity]( Flavia Giamogante, Tito Calì, and Francesco Malatesta [Reply to Giamogante et al.: The effect of low cyanide on O2 consumption is best observed in physiological, rather than reductionist, systems]( Karim Zuhra and Csaba Szabo --------------------------------------------------------------- Physical Sciences Applied Mathematics [The discrete-time Kermack–McKendrick model: A versatile and computationally attractive framework for modeling epidemics]( Odo Diekmann, Hans G. Othmer, Robert Planqué, and Martin C. J. Bootsma [Deep learning for early warning signals of tipping points]( Thomas M. Bury, R. I. Sujith, Induja Pavithran, Marten Scheffer, Timothy M. Lenton, Madhur Anand, and Chris T. Bauch Applied Physical Sciences [Edge current and pairing order transition in chiral bacterial vortices]( Kazusa Beppu, Ziane Izri, Tasuku Sato, Yoko Yamanishi, Yutaka Sumino, and Yusuke T. Maeda Biophysics and Computational Biology [Shear-induced orientational ordering in an active glass former]( Rituparno Mandal and Peter Sollich [O to bR transition in bacteriorhodopsin occurs through a proton hole mechanism]( Denis Maag, Thilo Mast, Marcus Elstner, Qiang Cui, and Tomáš Kubař Chemistry [Nanosecond heme-to-heme electron transfer rates in a multiheme cytochrome nanowire reported by a spectrally unique His/Met-ligated heme]( Jessica H. van Wonderen, Katrin Adamczyk, Xiaojing Wu, Xiuyun Jiang, Samuel E. H. Piper, Christopher R. Hall, Marcus J. Edwards, Thomas A. Clarke, Huijie Zhang, Lars J. C. Jeuken, Igor V. Sazanovich, Michael Towrie, Jochen Blumberger, Stephen R. Meech, and Julea N. Butt [Electrophilic aromatic substitution reactions of compounds with Craig-Möbius aromaticity]( Yuanting Cai, Yuhui Hua, Zhengyu Lu, Qing Lan, Zuzhang Lin, Jiawei Fei, Zhixin Chen, Hong Zhang, and Haiping Xia [Self-catalytic growth of one-dimensional materials within dislocations in gold]( Lotan Portal, Iryna Polishchuk, Maria Koifman Khristosov, Alexander Katsman, and Boaz Pokroy Computer Sciences [Deep learning identifies synergistic drug combinations for treating COVID-19]( Wengong Jin, Jonathan M. Stokes, Richard T. Eastman, Zina Itkin, Alexey V. Zakharov, James J. Collins, Tommi S. Jaakkola, and Regina Barzilay Earth, Atmospheric, and Planetary Sciences [Beyond the hockey stick: Climate lessons from the Common Era]( Michael E. Mann [Potassium isotope composition of Mars reveals a mechanism of planetary volatile retention]( Zhen Tian, Tomáš Magna, James M. D. Day, Klaus Mezger, Erik E. Scherer, Katharina Lodders, Remco C. Hin, Piers Koefoed, Hannah Bloom, and Kun Wang Engineering [Neuromorphic learning with Mott insulator NiO]( Zhen Zhang, Sandip Mondal, Subhasish Mandal, Jason M. Allred, Neda Alsadat Aghamiri, Alireza Fali, Zhan Zhang, Hua Zhou, Hui Cao, Fanny Rodolakis, Jessica L. McChesney, Qi Wang, Yifei Sun, Yohannes Abate, Kaushik Roy, Karin M. Rabe, and Shriram Ramanathan [Valveless microliter combustion for densely packed arrays of powerful soft actuators]( Ronald H. Heisser, Cameron A. Aubin, Ofek Peretz, Nicholas Kincaid, Hyeon Seok An, Elizabeth M. Fisher, Sadaf Sobhani, Perrine Pepiot, Amir D. Gat, and Robert F. Shepherd [An organic transistor matrix for multipoint intracellular action potential recording]( Yasutoshi Jimbo, Daisuke Sasaki, Takashi Ohya, Sunghoon Lee, Wonryung Lee, Faezeh Arab Hassani, Tomoyuki Yokota, Katsuhisa Matsuura, Shinjiro Umezu, Tatsuya Shimizu, and Takao Someya [Transdermal vaccination via 3D-printed microneedles induces potent humoral and cellular immunity]( Cassie Caudill, Jillian L. Perry, Kimon Iliadis, Addis T. Tessema, Brian J. Lee, Beverly S. Mecham, Shaomin Tian, and Joseph M. DeSimone Physics [Emergent probability fluxes in confined microbial navigation]( Jan Cammann, Fabian Jan Schwarzendahl, Tanya Ostapenko, Danylo Lavrentovich, Oliver Bäumchen, and Marco G. Mazza [Scene statistics and noise determine the relative arrangement of receptive field mosaics]( Na Young Jun, Greg D. Field, and John Pearson --------------------------------------------------------------- Social Sciences Anthropology [Modern Siberian dog ancestry was shaped by several thousand years of Eurasian-wide trade and human dispersal]( Tatiana R. Feuerborn, Alberto Carmagnini, Robert J. Losey, Tatiana Nomokonova, Arthur Askeyev, Igor Askeyev, Oleg Askeyev, Ekaterina E. Antipina, Martin Appelt, Olga P. Bachura, Fiona Beglane, Daniel G. Bradley, Kevin G. Daly, Shyam Gopalakrishnan, Kristian Murphy Gregersen, Chunxue Guo, Andrei V. Gusev, Carleton Jones, Pavel A. Kosintsev, Yaroslav V. Kuzmin, Valeria Mattiangeli, Angela R. Perri, Andrei V. Plekhanov, Jazmín Ramos-Madrigal, Anne Lisbeth Schmidt, Dilyara Shaymuratova, Oliver Smith, Lilia V. Yavorskaya, Guojie Zhang, Eske Willerslev, Morten Meldgaard, M. Thomas P. Gilbert, Greger Larson, Love Dalén, Anders J. Hansen, Mikkel-Holger S. Sinding, and Laurent Frantz Economic Sciences [Globalization mitigates the risk of conflict caused by strategic territory]( Quentin Gallea and Dominic Rohner [Constrained public benefits from global catch share fisheries]( Abdulrahman Ben-Hasan, Santiago De La Puente, Diana Flores, Michael C. Melnychuk, Emily Tivoli, Villy Christensen, Wei Cui, and Carl J. Walters [Excess mortality from COVID and non-COVID causes in minority populations]( Christopher J. Cronin and William N. Evans [Market forces determine the distribution of a leaky function in a simple microbial community]( Sarah J. Adkins-Jablonsky, Colleen M. Clark, Spiridon E. Papoulis, Matthew D. Kuhl, and J. Jeffrey Morris Psychological and Cognitive Sciences [What we talk about when we talk about colors]( Colin R. Twomey, Gareth Roberts, David H. Brainard, and Joshua B. Plotkin [Toddlers draw broad negative inferences from wrongdoers’ moral violations]( Fransisca Ting and Renée Baillargeon [Cognitive maps of social features enable flexible inference in social networks]( Jae-Young Son, Apoorva Bhandari, and Oriel FeldmanHall [How top-down and bottom-up attention modulate risky choice]( Yonatan Vanunu, Jared M. Hotaling, Mike E. Le Pelley, and Ben R. Newell [National religiosity eases the psychological burden of poverty]( Jana B. Berkessel, Jochen E. Gebauer, Mohsen Joshanloo, Wiebke Bleidorn, Peter J. Rentfrow, Jeff Potter, and Samuel D. Gosling [The emotional and mental health impact of the murder of George Floyd on the US population]( Johannes C. Eichstaedt, Garrick T. Sherman, Salvatore Giorgi, Steven O. Roberts, Megan E. Reynolds, Lyle H. Ungar, and Sharath Chandra Guntuku Social Sciences [Gender inequities in the online dissemination of scholars’ work]( Orsolya Vásárhelyi, Igor Zakhlebin, Staša Milojević, and Emőke-Ágnes Horvát --------------------------------------------------------------- Biological Sciences Agricultural Sciences [A steady-state N balance approach for sustainable smallholder farming]( Yulong Yin, Rongfang Zhao, Yi Yang, Qingfeng Meng, Hao Ying, Kenneth G. Cassman, Wenfeng Cong, Xingshuai Tian, Kai He, Yingcheng Wang, Zhenling Cui, Xinping Chen, and Fusuo Zhang Applied Biological Sciences [Shotgun scanning glycomutagenesis: A simple and efficient strategy for constructing and characterizing neoglycoproteins]( Mingji Li, Xiaolu Zheng, Sudhanshu Shanker, Thapakorn Jaroentomeechai, Tyler D. Moeller, Sophia W. Hulbert, Ilkay Koçer, Josef Byrne, Emily C. Cox, Qin Fu, Sheng Zhang, Jason W. Labonte, Jeffrey J. Gray, and Matthew P. DeLisa Biochemistry [Elongin functions as a loading factor for Mediator at ATF6α-regulated ER stress response genes]( Yanfeng He, Shigeo Sato, Chieri Tomomori-Sato, Shiyuan Chen, Zach H. Goode, Joan W. Conaway, and Ronald C. Conaway [A membrane protein display platform for receptor interactome discovery]( Shengya Cao, Sean M. Peterson, Sören Müller, Mike Reichelt, Christian McRoberts Amador, and Nadia Martinez-Martin [Assembly and organization of the N-terminal region of mucin MUC5AC: Indications for structural and functional distinction from MUC5B]( Jerome Carpenter, Yang Wang, Richa Gupta, Yuanli Li, Prashamsha Haridass, Durai B. Subramani, Boris Reidel, Lisa Morton, Caroline Ridley, Wanda K. O’Neal, Marie-Pierre Buisine, Camille Ehre, David J. Thornton, and Mehmet Kesimer [The LarB carboxylase/hydrolase forms a transient cysteinyl-pyridine intermediate during nickel-pincer nucleotide cofactor biosynthesis]( Joel A. Rankin, Shramana Chatterjee, Zia Tariq, Satyanarayana Lagishetty, Benoît Desguin, Jian Hu, and Robert P. Hausinger [Molecular characterization of a complex of apoptosis-inducing factor 1 with cytochrome c oxidase of the mitochondrial respiratory chain]( Johannes F. Hevler, Riccardo Zenezeni Chiozzi, Alfredo Cabrera-Orefice, Ulrich Brandt, Susanne Arnold, and Albert J. R. Heck [Design of proteasome inhibitors with oral efficacy in vivo against Plasmodium falciparum and selectivity over the human proteasome]( Stanley C. Xie, Riley D. Metcalfe, Hirotake Mizutani, Tanya Puhalovich, Eric Hanssen, Craig J. Morton, Yawei Du, Con Dogovski, Shih-Chung Huang, Jeffrey Ciavarri, Paul Hales, Robert J. Griffin, Lawrence H. Cohen, Bei-Ching Chuang, Sergio Wittlin, Ioanna Deni, Tomas Yeo, Kurt E. Ward, Daniel C. Barry, Boyin Liu, David L. Gillett, Benigno F. Crespo-Fernandez, Sabine Ottilie, Nimisha Mittal, Alisje Churchyard, Daniel Ferguson, Anna Caroline C. Aguiar, Rafael V. C. Guido, Jake Baum, Kirsten K. Hanson, Elizabeth A. Winzeler, Francisco-Javier Gamo, David A. Fidock, Delphine Baud, Michael W. Parker, Stephen Brand, Lawrence R. Dick, Michael D. W. Griffin, Alexandra E. Gould, and Leann Tilley Biophysics and Computational Biology [Edge current and pairing order transition in chiral bacterial vortices]( Kazusa Beppu, Ziane Izri, Tasuku Sato, Yoko Yamanishi, Yutaka Sumino, and Yusuke T. Maeda [Nanosecond heme-to-heme electron transfer rates in a multiheme cytochrome nanowire reported by a spectrally unique His/Met-ligated heme]( Jessica H. van Wonderen, Katrin Adamczyk, Xiaojing Wu, Xiuyun Jiang, Samuel E. H. Piper, Christopher R. Hall, Marcus J. Edwards, Thomas A. Clarke, Huijie Zhang, Lars J. C. Jeuken, Igor V. Sazanovich, Michael Towrie, Jochen Blumberger, Stephen R. Meech, and Julea N. Butt [Emergent probability fluxes in confined microbial navigation]( Jan Cammann, Fabian Jan Schwarzendahl, Tanya Ostapenko, Danylo Lavrentovich, Oliver Bäumchen, and Marco G. Mazza [O to bR transition in bacteriorhodopsin occurs through a proton hole mechanism]( Denis Maag, Thilo Mast, Marcus Elstner, Qiang Cui, and Tomáš Kubař [Structure of cell–cell adhesion mediated by the Down syndrome cell adhesion molecule]( Luqiang Guo, Yichun Wu, Haishuang Chang, Ze Zhang, Hua Tang, Yang Yu, Lihui Xin, Yingbin Liu, and Yongning He [Amyloid-β peptide dimers undergo a random coil to β-sheet transition in the aqueous phase but not at the neuronal membrane]( Hebah Fatafta, Mohammed Khaled, Michael C. Owen, Abdallah Sayyed-Ahmad, and Birgit Strodel Cell Biology [Necroptosis activates UPR sensors without disrupting their binding with GRP78]( Wei Liang, Weiwei Qi, Yang Geng, Linhan Wang, Jing Zhao, Kezhou Zhu, Guowei Wu, Zairong Zhang, Heling Pan, Lihui Qian, and Junying Yuan [Nuclear receptor NR5A2 negatively regulates cell proliferation and tumor growth in nervous system malignancies]( Dimitrios Gkikas, Dimitris Stellas, Alexia Polissidis, Theodora Manolakou, Maroula G. Kokotou, George Kokotos, and Panagiotis K. Politis [Thyroid hormone receptor phosphorylation regulates acute fasting-induced suppression of the hypothalamic–pituitary–thyroid axis]( Svetlana Minakhina, Vanessa De Oliveira, Sun Young Kim, Haiyan Zheng, and Fredric E. Wondisford [ATF6 is essential for human cone photoreceptor development]( Heike Kroeger, Julia M. D. Grandjean, Wei-Chieh Jerry Chiang, Daphne D. Bindels, Rebecca Mastey, Jennifer Okalova, Amanda Nguyen, Evan T. Powers, Jeffery W. Kelly, Neil J. Grimsey, Michel Michaelides, Joseph Carroll, R. Luke Wiseman, and Jonathan H. Lin [Cell–cell contact landscapes in Xenopus gastrula tissues]( Debanjan Barua, Martina Nagel, and Rudolf Winklbauer [Interleukin-6 mediates PSAT1 expression and serine metabolism in TSC2-deficient cells]( Ji Wang, Harilaos Filippakis, Thomas Hougard, Heng Du, Chenyang Ye, Heng-Jia Liu, Long Zhang, Khadijah Hindi, Shefali Bagwe, Julie Nijmeh, John M. Asara, Wei Shi, Souheil El-Chemaly, Elizabeth P. Henske, and Hilaire C. Lam Developmental Biology [Juvenile hormone signaling promotes ovulation and maintains egg shape by inducing expression of extracellular matrix genes]( Wei Luo, Suning Liu, Wenqiang Zhang, Liu Yang, Jianhua Huang, Shutang Zhou, Qili Feng, Subba Reddy Palli, Jian Wang, Siegfried Roth, and Sheng Li [Ttc30a affects tubulin modifications in a model for ciliary chondrodysplasia with polycystic kidney disease]( Maike Getwan, Anselm Hoppmann, Pascal Schlosser, Kelli Grand, Weiting Song, Rebecca Diehl, Sophie Schroda, Florian Heeg, Konstantin Deutsch, Friedhelm Hildebrandt, Ekkehart Lausch, Anna Köttgen, and Soeren S. Lienkamp Ecology [Deep learning for early warning signals of tipping points]( Thomas M. Bury, R. I. Sujith, Induja Pavithran, Marten Scheffer, Timothy M. Lenton, Madhur Anand, and Chris T. Bauch [Biodiversity of coral reef cryptobiota shuffles but does not decline under the combined stressors of ocean warming and acidification]( Molly A. Timmers, Christopher P. Jury, Jan Vicente, Keisha D. Bahr, Maryann K. Webb, and Robert J. Toonen [Congruent trophic pathways underpin global coral reef food webs]( Chloé Pozas-Schacre, Jordan M. Casey, Simon J. Brandl, Michel Kulbicki, Mireille Harmelin-Vivien, Giovanni Strona, and Valeriano Parravicini Evolution [Market forces determine the distribution of a leaky function in a simple microbial community]( Sarah J. Adkins-Jablonsky, Colleen M. Clark, Spiridon E. Papoulis, Matthew D. Kuhl, and J. Jeffrey Morris [A single mutation weakens symbiont-induced reproductive manipulation through reductions in deubiquitylation efficiency]( John F. Beckmann, Kelley Van Vaerenberghe, Daniel E. Akwa, and Brandon S. Cooper Genetics [Modern Siberian dog ancestry was shaped by several thousand years of Eurasian-wide trade and human dispersal]( Tatiana R. Feuerborn, Alberto Carmagnini, Robert J. Losey, Tatiana Nomokonova, Arthur Askeyev, Igor Askeyev, Oleg Askeyev, Ekaterina E. Antipina, Martin Appelt, Olga P. Bachura, Fiona Beglane, Daniel G. Bradley, Kevin G. Daly, Shyam Gopalakrishnan, Kristian Murphy Gregersen, Chunxue Guo, Andrei V. Gusev, Carleton Jones, Pavel A. Kosintsev, Yaroslav V. Kuzmin, Valeria Mattiangeli, Angela R. Perri, Andrei V. Plekhanov, Jazmín Ramos-Madrigal, Anne Lisbeth Schmidt, Dilyara Shaymuratova, Oliver Smith, Lilia V. Yavorskaya, Guojie Zhang, Eske Willerslev, Morten Meldgaard, M. Thomas P. Gilbert, Greger Larson, Love Dalén, Anders J. Hansen, Mikkel-Holger S. Sinding, and Laurent Frantz [The conserved fertility factor SPACA4/Bouncer has divergent modes of action in vertebrate fertilization]( Yoshitaka Fujihara, Sarah Herberg, Andreas Blaha, Karin Panser, Kiyonori Kobayashi, Tamara Larasati, Maria Novatchkova, Hans-Christian Theussl, Olga Olszanska, Masahito Ikawa, and Andrea Pauli [Extracellular matrix protein N-glycosylation mediates immune self-tolerance in Drosophila melanogaster]( Nathan T. Mortimer, Mary L. Fischer, Ashley L. Waring, Pooja KR, Balint Z. Kacsoh, Susanna E. Brantley, Erin S. Keebaugh, Joshua Hill, Chris Lark, Julia Martin, Pravleen Bains, Jonathan Lee, Alysia D. Vrailas-Mortimer, and Todd A. Schlenke Immunology and Inflammation [Transdermal vaccination via 3D-printed microneedles induces potent humoral and cellular immunity]( Cassie Caudill, Jillian L. Perry, Kimon Iliadis, Addis T. Tessema, Brian J. Lee, Beverly S. Mecham, Shaomin Tian, and Joseph M. DeSimone [Trapping or slowing the diffusion of T cell receptors at close contacts initiates T cell signaling]( Kevin Y. Chen, Edward Jenkins, Markus Körbel, Aleks Ponjavic, Anna H. Lippert, Ana Mafalda Santos, Nicole Ashman, Caitlin O'Brien-Ball, Jemma McBride, David Klenerman, and Simon J. Davis [Selective depletion of a CD64-expressing phagocyte subset mediates protection against toxic kidney injury and failure]( Natallia Salei, Xingqi Ji, Dalia Pakalniškytė, Vanessa Kuentzel, Stephan Rambichler, Na Li, Markus Moser, Katja Steiger, Thorsten Buch, Hans-Joachim Anders, and Barbara U. Schraml [The ATP-hydrolyzing ectoenzyme E-NTPD8 attenuates colitis through modulation of P2X4 receptor–dependent metabolism in myeloid cells]( Haruka Tani, Bo Li, Takashi Kusu, Ryu Okumura, Junichi Nishimura, Daisuke Okuzaki, Daisuke Motooka, Shoya Arakawa, Asuka Mori, Terukazu Yoshihara, Takayuki Ogino, Shih-Han Tsai, Yoki Furuta, Masato Muneta, Shota Nakamura, Eiichiro Fukusaki, Kimiko Yamamoto, Hideo Yagita, Hisako Kayama, and Kiyoshi Takeda [Interprotomer disulfide-stabilized variants of the human metapneumovirus fusion glycoprotein induce high titer-neutralizing responses]( Guillaume B. E. Stewart-Jones, Jason Gorman, Li Ou, Baoshan Zhang, M. Gordon Joyce, Lijuan Yang, Cheng Cheng, Gwo-Yu Chuang, Kathryn E. Foulds, Wing-Pui Kong, Adam S. Olia, Mallika Sastry, Chen-Hsiang Shen, John-Paul Todd, Yaroslav Tsybovsky, Raffaello Verardi, Yongping Yang, Peter L. Collins, Davide Corti, Antonio Lanzavecchia, Diana G. Scorpio, John R. Mascola, Ursula J. Buchholz, and Peter D. Kwong [Distinct single-component adjuvants steer human DC-mediated T-cell polarization via Toll-like receptor signaling toward a potent antiviral immune response]( Laura Roßmann, Katrin Bagola, Tharshana Stephen, Anna-Lisa Gerards, Bianca Walber, Anja Ullrich, Stefan Schülke, Christel Kamp, Ingo Spreitzer, Milena Hasan, Brigitte David-Watine, Spencer L. Shorte, Max Bastian, and Ger van Zandbergen [TCRβ rearrangements without a D segment are common, abundant, and public]( Peter C. de Greef and Rob J. de Boer [Translational targeting of inflammation and fibrosis in frozen shoulder: Molecular dissection of the T cell/IL-17A axis]( Moeed Akbar, Lindsay A. N. Crowe, Michael McLean, Emma Garcia-Melchor, Lucy MacDonald, Kristyn Carter, Umberto G. Fazzi, David Martin, Angus Arthur, James H. Reilly, Iain B. McInnes, and Neal L. Millar [The molecular characterization of antibody binding to a superantigen-like protein from a commensal microbe]( Marta T. Borowska, Christoph Drees, Alexander E. Yarawsky, Mayuri Viswanathan, Sean M. Ryan, Jeffrey J. Bunker, Andrew B. Herr, Albert Bendelac, and Erin J. Adams Medical Sciences [Tetraspanin 6 is a regulator of carcinogenesis in colorectal cancer]( Regina Andrijes, Rahul K. Hejmadi, Matthew Pugh, Sundaresan Rajesh, Vera Novitskaya, Maha Ibrahim, Michael Overduin, Chris Tselepis, Gary W. Middleton, Balázs Győrffy, Andrew D. Beggs, and Fedor Berditchevski [Model-driven mitigation measures for reopening schools during the COVID-19 pandemic]( Ryan Seamus McGee, Julian R. Homburger, Hannah E. Williams, Carl T. Bergstrom, and Alicia Y. Zhou [Functional succinate dehydrogenase deficiency is a common adverse feature of clear cell renal cancer]( Ritesh K. Aggarwal, Rebecca A. Luchtel, Venkata Machha, Alexander Tischer, Yiyu Zou, Kith Pradhan, Nadia Ashai, Nandini Ramachandra, Joseph M. Albanese, Jung-in Yang, Xiaoyang Wang, Srinivas Aluri, Shanisha Gordon, Ahmed Aboumohamed, Benjamin A. Gartrell, Sassan Hafizi, James Pullman, and Niraj Shenoy Microbiology [Orthogonal genome-wide screens of bat cells identify MTHFD1 as a target of broad antiviral therapy]( Danielle E. Anderson, Jin Cui, Qian Ye, Baoying Huang, Ya Tan, Chao Jiang, Wenhong Zu, Jing Gong, Weiqiang Liu, So Young Kim, Biao Guo Yan, Kristmundur Sigmundsson, Xiao Fang Lim, Fei Ye, Peihua Niu, Aaron T. Irving, Haoyu Zhang, Yefeng Tang, Xuming Zhou, Yu Wang, Wenjie Tan, Lin-Fa Wang, and Xu Tan [The transcription regulator BrsR serves as a network hub of natural competence protein–protein interactions in Streptococcus mutans]( Hua Qin, Zhengzhong Zou, David Anderson, Yu Sang, Dustin Higashi, Jens Kreth, and Justin Merritt [The citron homology domain as a scaffold for Rho1 signaling]( Sergio G. Bartual, Wenfan Wei, Yao Zhou, Veronica M. Pravata, Wenxia Fang, Kaizhou Yan, Andrew T. Ferenbach, Deborah E. A. Lockhart, and Daan M. F. van Aalten Neuroscience [Scene statistics and noise determine the relative arrangement of receptive field mosaics]( Na Young Jun, Greg D. Field, and John Pearson [D-cysteine is an endogenous regulator of neural progenitor cell dynamics in the mammalian brain]( Evan R. Semenza, Maged M. Harraz, Efrat Abramson, Adarsha P. Malla, Chirag Vasavda, Moataz M. Gadalla, Michael D. Kornberg, Solomon H. Snyder, and Robin Roychaudhuri [The Clp1 R140H mutation alters tRNA metabolism and mRNA 3′ processing in mouse models of pontocerebellar hypoplasia]( Caitlin E. Monaghan, Scott I. Adamson, Mridu Kapur, Jeffrey H. Chuang, and Susan L. Ackerman [Critical Period After Stroke Study (CPASS): A phase II clinical trial testing an optimal time for motor recovery after stroke in humans]( Alexander W. Dromerick, Shashwati Geed, Jessica Barth, Kathaleen Brady, Margot L. Giannetti, Abigail Mitchell, Matthew A. Edwardson, Ming T. Tan, Yizhao Zhou, Elissa L. Newport, and Dorothy F. Edwards [Tuned vibration modes in a miniature hearing organ: Insights from the bushcricket]( Anna Vavakou, Jan Scherberich, Manuela Nowotny, and Marcel van der Heijden [Dim light in the evening causes coordinated realignment of circadian rhythms, sleep, and short-term memory]( Shu K. E. Tam, Laurence A. Brown, Tatiana S. Wilson, Selma Tir, Angus S. Fisk, Carina A. Pothecary, Vincent van der Vinne, Russell G. Foster, Vladyslav V. Vyazovskiy, David M. Bannerman, Mary E. Harrington, and Stuart N. Peirson [Follistatin mediates learning and synaptic plasticity via regulation of Asic4 expression in the hippocampus]( Yu-Ju Chen, Shin-Meng Deng, Hui-Wen Chen, Chi-Hui Tsao, Wei-Ting Chen, Sin-Jhong Cheng, Hsien-Sung Huang, Bertrand Chin-Ming Tan, Martin M. Matzuk, Jonathan Flint, and Guo-Jen Huang [Norrie disease protein is essential for cochlear hair cell maturation]( Yushi Hayashi, Hao Chiang, ChunJie Tian, Artur A. Indzhykulian, and Albert S. B. Edge Pharmacology [Deep learning identifies synergistic drug combinations for treating COVID-19]( Wengong Jin, Jonathan M. Stokes, Richard T. Eastman, Zina Itkin, Alexey V. Zakharov, James J. Collins, Tommi S. Jaakkola, and Regina Barzilay Plant Biology [Transposition and duplication of MADS-domain transcription factor genes in annual and perennial Arabis species modulates flowering]( Eva Madrid, Edouard Severing, Elisa de Ansorena, Christiane Kiefer, Luise Brand, Rafael Martinez-Gallegos, Stefan Woetzel, Ulla Kemi, Wen-Biao Jiao, Korbinian Schneeberger, and George Coupland [IRON MAN interacts with BRUTUS to maintain iron homeostasis in Arabidopsis]( Yang Li, Cheng Kai Lu, Chen Yang Li, Ri Hua Lei, Meng Na Pu, Jun Hui Zhao, Feng Peng, Hua Qian Ping, Dan Wang, and Gang Liang [Suberin plasticity to developmental and exogenous cues is regulated by a set of MYB transcription factors]( Vinay Shukla, Jian-Pu Han, Fabienne Cléard, Linnka Lefebvre-Legendre, Kay Gully, Paulina Flis, Alice Berhin, Tonni G. Andersen, David E. Salt, Christiane Nawrath, and Marie Barberon [Bacterial rhamnolipids and their 3-hydroxyalkanoate precursors activate Arabidopsis innate immunity through two independent mechanisms]( Romain Schellenberger, Jérôme Crouzet, Arvin Nickzad, Lin-Jie Shu, Alexander Kutschera, Tim Gerster, Nicolas Borie, Corinna Dawid, Maude Cloutier, Sandra Villaume, Sandrine Dhondt-Cordelier, Jane Hubert, Sylvain Cordelier, Florence Mazeyrat-Gourbeyre, Christian Schmid, Marc Ongena, Jean-Hugues Renault, Arnaud Haudrechy, Thomas Hofmann, Fabienne Baillieul, Christophe Clément, Cyril Zipfel, Charles Gauthier, Eric Déziel, Stefanie Ranf, and Stéphan Dorey Population Biology [High frequency of an otherwise rare phenotype in a small and isolated tiger population]( Vinay Sagar, Christopher B. Kaelin, Meghana Natesh, P. Anuradha Reddy, Rajesh K. Mohapatra, Himanshu Chhattani, Prachi Thatte, Srinivas Vaidyanathan, Suvankar Biswas, Supriya Bhatt, Shashi Paul, Yadavendradev V. Jhala, Mayank M. Verma, Bivash Pandav, Samrat Mondol, Gregory S. Barsh, Debabrata Swain, and Uma Ramakrishnan Psychological and Cognitive Sciences [What we talk about when we talk about colors]( Colin R. Twomey, Gareth Roberts, David H. Brainard, and Joshua B. Plotkin --------------------------------------------------------------- Corrections [Correction for Grange et al., Ranking the risk of animal-to-human spillover for newly discovered viruses]( [Correction for Sang et al., Dual functions for OVAAL in initiation of RAF/MEK/ERK prosurvival signals and evasion of p27-mediated cellular senescence]( [Correction for Hsu et al., CHD7 and Runx1 interaction provides a braking mechanism for hematopoietic differentiation]( [Cover] --------------------------------------------------------------- This message was sent to {EMAIL}. [Unsubscribe]( from or [edit]( your subscription for this service. Or by mail: Customer Service * 15575-A Los Gatos Blvd * Los Gatos, CA 95032 * U.S.A. 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