[PNAS] [PNAS News Feature: Keeping Black Students in STEM. Read More.](/cgi/adclick/?ad=55907&adclick=true&url=https%3A%2F%2Fwww.pnas.org%2Fcontent%2F118%2F23%2Fe2108401118) Â [June 15, 2021; Vol. 118, No. 24](
) This Week in PNAS
[In This Issue]( This week's research highlights
--------------------------------------------------------------- Opinion
[Opinion: How to ensure regulations don’t stymie much-needed COVID-19 point-of-care testing](
Clare Rock and Jonathan Zenilman
Leading scientists discuss current issues
--------------------------------------------------------------- Commentaries
[How membrane receptors tread the fine balance between symbiosis and immunity signaling](
Chai Hao Chiu and Uta Paszkowski
[Swimming in circles can lead to exotic hyperuniform states of active living matter](
Salvatore Torquato
[Faulty ribosome biogenesis underlies the ribosomopathy alopecia, neurological defects, endocrinopathy (ANE) syndrome](
Jennifer L. Gerton --------------------------------------------------------------- Perspective
[The US Department of Justice stumbles on visual perception](
Thomas D. Albright --------------------------------------------------------------- Letters
[Do crystallographic XFEL data support binding of a water molecule to the oxygen-evolving complex of photosystem II exposed to two flashes of light?](
Jimin Wang, William H. Armstrong, and Victor S. Batista
[Reply to Wang et al.: Clear evidence of binding of Ox to the oxygen-evolving complex of photosystem II is best observed in the omit map](
Mohamed Ibrahim, Nigel W. Moriarty, Jan Kern, James M. Holton, Aaron S. Brewster, Asmit Bhowmick, Uwe Bergmann, Athina Zouni, Johannes Messinger, Vittal K. Yachandra, Junko Yano, Holger Dobbek, Nicholas K. Sauter, and Paul D. Adams --------------------------------------------------------------- Brief Report
[Early life stress is associated with earlier emergence of permanent molars](
Cassidy L. McDermott, Katherine Hilton, Anne T. Park, Ursula A. Tooley, Austin L. Boroshok, Muralidhar Mupparapu, JoAnna M. Scott, Erin E. Bumann, and Allyson P. Mackey --------------------------------------------------------------- Physical Sciences
Applied Physical Sciences
[Superelastic oxide micropillars enabled by surface tension–modulated 90° domain switching with excellent fatigue resistance](
Yingwei Li, Kangjie Chu, Chang Liu, Peng Jiang, Ke Qu, Peng Gao, Jie Wang, Fuzeng Ren, Qingping Sun, Longqing Chen, and Jiangyu Li Earth, Atmospheric, and Planetary Sciences
[Anthropogenic lead pervasive in Canadian Arctic seawater](
Joan De Vera, Priyanka Chandan, Paulina Pinedo-González, Seth G. John, Sarah L. Jackson, Jay T. Cullen, Manuel Colombo, Kristin J. Orians, and Bridget A. Bergquist
[Asteroid break-ups and meteorite delivery to Earth the past 500 million years](
Fredrik Terfelt and Birger Schmitz Engineering
[Torsional fracture of viscoelastic liquid bridges](
San To Chan, Frank P. A. van Berlo, Hammad A. Faizi, Atsushi Matsumoto, Simon J. Haward, Patrick D. Anderson, and Amy Q. Shen --------------------------------------------------------------- Social Sciences
Environmental Sciences
[Measuring social equity in urban energy use and interventions using fine-scale data](
Kangkang Tong, Anu Ramaswami, Corey (Kewei) Xu, Richard Feiock, Patrick Schmitz, and Michael Ohlsen Psychological and Cognitive Sciences
[The impact of a lack of mathematical education on brain development and future attainment](
George Zacharopoulos, Francesco Sella, and Roi Cohen Kadosh
[Worldviews, trust, and risk perceptions shape public acceptance of COVID-19 public health measures](
Michael Siegrist and Angela Bearth
[Characterizing public perceptions of social and cultural impacts in policy decisions](
Nathan F. Dieckmann, Robin Gregory, Terre Satterfield, Marcus Mayorga, and Paul Slovic
[The balance of giving versus receiving social support and all-cause mortality in a US national sample](
Edith Chen, Phoebe H. Lam, Eric D. Finegood, Nicholas A. Turiano, Daniel K. Mroczek, and Gregory E. Miller Social Sciences
[Intracounty modeling of COVID-19 infection with human mobility: Assessing spatial heterogeneity with business traffic, age, and race](
Xiao Hou, Song Gao, Qin Li, Yuhao Kang, Nan Chen, Kaiping Chen, Jinmeng Rao, Jordan S. Ellenberg, and Jonathan A. Patz Sustainability Science
[Measuring social equity in urban energy use and interventions using fine-scale data](
Kangkang Tong, Anu Ramaswami, Corey (Kewei) Xu, Richard Feiock, Patrick Schmitz, and Michael Ohlsen
[Toward achieving persistent behavior change in household water conservation](
Vivek, Deepak Malghan, and Kanchan Mukherjee
[Language extinction triggers the loss of unique medicinal knowledge](
Rodrigo Cámara-Leret and Jordi Bascompte --------------------------------------------------------------- Biological Sciences
Biochemistry
[Hypertrophic cardiomyopathy β-cardiac myosin mutation (P710R) leads to hypercontractility by disrupting super relaxed state](
Alison Schroer Vander Roest, Chao Liu, Makenna M. Morck, Kristina Bezold Kooiker, Gwanghyun Jung, Dan Song, Aminah Dawood, Arnav Jhingran, Gaspard Pardon, Sara Ranjbarvaziri, Giovanni Fajardo, Mingming Zhao, Kenneth S. Campbell, Beth L. Pruitt, James A. Spudich, Kathleen M. Ruppel, and Daniel Bernstein
[CAP1 binds and activates adenylyl cyclase in mammalian cells](
Xuefeng Zhang, Alejandro Pizzoni, Kyoungja Hong, Nyla Naim, Chao Qi, Volodymyr Korkhov, and Daniel L. Altschuler
[A metabolic regulon reveals early and late acting enzymes in neuroactive Lycopodium alkaloid biosynthesis](
Ryan S. Nett, Yaereen Dho, Yun-Yee Low, and Elizabeth S. Sattely
[Homocysteine fibrillar assemblies display cross-talk with Alzheimer’s disease β-amyloid polypeptide](
Dorin Sade Yazdi, Dana Laor Bar-Yosef, Hanaa Adsi, Topaz Kreiser, Shahaf Sigal, Santu Bera, Dor Zaguri, Shira Shaham-Niv, Damilola S. Oluwatoba, Davide Levy, Myra Gartner, Thanh D. Do, Dan Frenkel, and Ehud Gazit Cell Biology
[Cadherin puncta are interdigitated dynamic actin protrusions necessary for stable cadherin adhesion](
John Xiao He Li, Vivian W. Tang, Kingsley A. Boateng, and William M. Brieher
[ALS- and FTD-associated missense mutations in TBK1 differentially disrupt mitophagy](
Olivia Harding, Chantell S. Evans, Junqiang Ye, Jonah Cheung, Tom Maniatis, and Erika L. F. Holzbaur Ecology
[Drivers of fatal bird collisions in an urban center](
Benjamin M. Van Doren, David E. Willard, Mary Hennen, Kyle G. Horton, Erica F. Stuber, Daniel Sheldon, Ashwin H. Sivakumar, Julia Wang, Andrew Farnsworth, and Benjamin M. Winger
[Language extinction triggers the loss of unique medicinal knowledge](
Rodrigo Cámara-Leret and Jordi Bascompte
[Unifying deterministic and stochastic ecological dynamics via a landscape-flux approach](
Li Xu, Denis Patterson, Ann Carla Staver, Simon Asher Levin, and Jin Wang Environmental Sciences
[Inactivation of common airborne antigens by perfluoroalkyl chemicals modulates early life allergic asthma](
Mengjing Wang, Qianqian Li, Meifang Hou, Louisa L. Y. Chan, Meng Liu, Soo Kai Ter, Ting Dong, Yun Xia, Sanjay H. Chotirmall, and Mingliang Fang Evolution
[Eusociality in snapping shrimps is associated with larger genomes and an accumulation of transposable elements](
Solomon T. C. Chak, Stephen E. Harris, Kristin M. Hultgren, Nicholas W. Jeffery, and Dustin R. Rubenstein
[Fifty million years of beetle evolution along the Antarctic Polar Front](
Helena P. Baird, Seunggwan Shin, Rolf G. Oberprieler, Maurice Hullé, Philippe Vernon, Katherine L. Moon, Richard H. Adams, Duane D. McKenna, and Steven L. Chown Genetics
[Accurate genomic variant detection in single cells with primary template-directed amplification](
Veronica Gonzalez-Pena, Sivaraman Natarajan, Yuntao Xia, David Klein, Robert Carter, Yakun Pang, Bridget Shaner, Kavya Annu, Daniel Putnam, Wenan Chen, Jon Connelly, Shondra Pruett-Miller, Xiang Chen, John Easton, and Charles Gawad
[The intra-S phase checkpoint directly regulates replication elongation to preserve the integrity of stalled replisomes](
Yang Liu, Lu Wang, Xin Xu, Yue Yuan, Bo Zhang, Zeyang Li, Yuchen Xie, Rui Yan, Zeqi Zheng, Jianguo Ji, Johanne M. Murray, Antony M. Carr, and Daochun Kong
[The dynamic epigenetic regulation of the inactive X chromosome in healthy human B cells is dysregulated in lupus patients](
Sarah Pyfrom, Bam Paneru, James J. Knox, Michael P. Cancro, Sylvia Posso, Jane H. Buckner, and Montserrat C. Anguera Immunology and Inflammation
[Radiation-induced neoantigens broaden the immunotherapeutic window of cancers with low mutational loads](
Danielle M. Lussier, Elise Alspach, Jeffrey P. Ward, Alexander P. Miceli, Daniele Runci, J. Michael White, Cedric Mpoy, Cora D. Arthur, Heather N. Kohlmiller, Tyler Jacks, Maxim N. Artyomov, Buck E. Rogers, and Robert D. Schreiber
[STING inhibitors target the cyclic dinucleotide binding pocket](
Ze Hong, Jiahao Mei, Chenhui Li, Guohui Bai, Munire Maimaiti, Haiyang Hu, Wenying Yu, Li Sun, Lele Zhang, Dan Cheng, Yixian Liao, Senlin Li, Yanping You, Hongbin Sun, Jing Huang, Xing Liu, Judy Lieberman, and Chen Wang Medical Sciences
[Targeting the tetraspanin CD81 reduces cancer invasion and metastasis](
Felipe Vences-Catalán, Ranjani Rajapaksa, Chiung-Chi Kuo, Caitlyn L. Miller, Anderson Lee, Vishnu C. Ramani, Stefanie S. Jeffrey, Ronald Levy, and Shoshana Levy
[Single-cell analyses of renal cell cancers reveal insights into tumor microenvironment, cell of origin, and therapy response](
Yuping Zhang, Sathiya P. Narayanan, Rahul Mannan, Gregory Raskind, Xiaoming Wang, Pankaj Vats, Fengyun Su, Noshad Hosseini, Xuhong Cao, Chandan Kumar-Sinha, Stephanie J. Ellison, Thomas J. Giordano, Todd M. Morgan, Sethuramasundaram Pitchiaya, Ajjai Alva, Rohit Mehra, Marcin Cieslik, Saravana M. Dhanasekaran, and Arul M. Chinnaiyan
[Meeting the unmet needs of clinicians from AI systems showcased for cardiology with deep-learning–based ECG analysis](
Yonatan Elul, Aviv A. Rosenberg, Assaf Schuster, Alex M. Bronstein, and Yael Yaniv Microbiology
[Translational shutdown and evasion of the innate immune response by SARS-CoV-2 NSP14 protein](
Jack Chun-Chieh Hsu, Maudry Laurent-Rolle, Joanna B. Pawlak, Craig B. Wilen, and Peter Cresswell
[Middle East respiratory syndrome coronavirus Spike protein variants exhibit geographic differences in virulence](
Lok-Yin Roy Wong, Jian Zheng, Alan Sariol, Shea Lowery, David K. Meyerholz, Tom Gallagher, and Stanley Perlman
[Starvation induces shrinkage of the bacterial cytoplasm](
Handuo Shi, Corey S. Westfall, Jesse Kao, Pascal D. Odermatt, Sarah E. Anderson, Spencer Cesar, Montana Sievert, Jeremy Moore, Carlos G. Gonzalez, Lichao Zhang, Joshua E. Elias, Fred Chang, Kerwyn Casey Huang, and Petra Anne Levin Neuroscience
[The impact of a lack of mathematical education on brain development and future attainment](
George Zacharopoulos, Francesco Sella, and Roi Cohen Kadosh
[Involvement of Scratch2 in GalR1-mediated depression-like behaviors in the rat ventral periaqueductal gray](
Yutao Yang, Yueting Li, Bo Liu, Chenchen Li, Zijin Liu, Jiahui Deng, Hanjiang Luo, Xiaoxiao Li, Jinjin Wu, Hui Li, Chuan-Yue Wang, Ming Zhao, Haohao Wu, Francois Lallemend, Per Svenningsson, Tomas G. M. Hökfelt, and Zhi-Qing David Xu
[Selective filtering of excitatory inputs to nucleus accumbens by dopamine and serotonin](
Daniel J. Christoffel, Jessica J. Walsh, Paul Hoerbelt, Boris D. Heifets, Pierre Llorach, Ricardo C. Lopez, Charu Ramakrishnan, Karl Deisseroth, and Robert C. Malenka
[Antipsychotic drugs counteract autophagy and mitophagy in multiple sclerosis](
Simone Patergnani, Massimo Bonora, Selene Ingusci, Maurizio Previati, Saverio Marchi, Silvia Zucchini, Mariasole Perrone, Mariusz R. Wieckowski, Massimiliano Castellazzi, Maura Pugliatti, Carlotta Giorgi, Michele Simonato, and Paolo Pinton Plant Biology
[TMK1-based auxin signaling regulates abscisic acid responses via phosphorylating ABI1/2 in Arabidopsis](
Jie Yang, Hang He, Yuming He, Qiaozhen Zheng, Qingzhong Li, Xin Feng, Pengcheng Wang, Guocheng Qin, Yangtao Gu, Ping Wu, Chao Peng, Shilei Sun, Yi Zhang, Mingzhang Wen, Rong Chen, Yang Zhao, and Tongda Xu Psychological and Cognitive Sciences
[Exploring the perceptual inabilities of Eurasian jays (Garrulus glandarius) using magic effects](
Elias Garcia-Pelegrin, Alexandra K. Schnell, Clive Wilkins, and Nicola S. Clayton Sustainability Science
[Drivers of fatal bird collisions in an urban center](
Benjamin M. Van Doren, David E. Willard, Mary Hennen, Kyle G. Horton, Erica F. Stuber, Daniel Sheldon, Ashwin H. Sivakumar, Julia Wang, Andrew Farnsworth, and Benjamin M. Winger --------------------------------------------------------------- Correction
[Correction for Wang et al., TLR4/MD-2 activation by a synthetic agonist with no similarity to LPS]( --------------------------------------------------------------- Editorial Expression of Concern
[Editorial Expression of Concern: New class of transcription factors controls flagellar assembly by recruiting RNA polymerase II in Chlamydomonas]( [Cover] --------------------------------------------------------------- This message was sent to {EMAIL}. [Unsubscribe]( from or [edit]( your subscription for this service.
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