PNAS Table of Contents for March 16, 2021; Vol. 118, No. 11 is now complete

[PNAS] [This week on the PNAS Science Sessions Podcast: Eruption of the Steamboat Geyser](/cgi/adclick/?ad=55671&adclick=true&url=https%3A%2F%2Fwww.pnas.org%2Fpage%2Fmedia%2Fpodcasts)   [March 16, 2021; Vol. 118, No. 11]( ) This Week in PNAS [In This Issue]( This week's research highlights --------------------------------------------------------------- Opinion [Opinion: Academic-humanitarian technology partnerships: an unhappy marriage?]( Louis Potter, Dikolela Kalubi, and Klaus Schönenberger Leading scientists discuss current issues --------------------------------------------------------------- QnAs [QnAs with Naoto Nagaosa]( Farooq Ahmed Interviews with leading scientific researchers and newsmakers --------------------------------------------------------------- Retrospective [Berni Julian Alder, theoretical physicist and inventor of molecular dynamics, 1925–2020]( David M. Ceperley and Stephen B. Libby --------------------------------------------------------------- Profile [Profile of James H. Hurley]( Sandeep Ravindran The life and work of NAS members --------------------------------------------------------------- Commentaries [Targeting RNA polymerase II Mediator subunits in cancer therapy]( Harinder Singh [Unifying chemical and biological perspectives of carbon accumulation in the environment]( Daniel J. Repeta [Biodiversity and community structure]( György Barabás [Linking human behaviors and infectious diseases]( Nita Bharti --------------------------------------------------------------- Perspective [From driverless dilemmas to more practical commonsense tests for automated vehicles]( Julian De Freitas, Andrea Censi, Bryant Walker Smith, Luigi Di Lillo, Sam E. Anthony, and Emilio Frazzoli --------------------------------------------------------------- Letters [Biochemical cartilage changes based on MRI-defined T2 relaxation times do not equal OA detection]( Frank W. Roemer and Ali Guermazi [Reply to Roemer and Guermazi: Early biochemical changes on MRI can predict risk of symptomatic progression]( Shinjini Kundu, Beth G. Ashinsky, Mustapha Bouhrara, Erik B. Dam, Shadpour Demehri, M. Shifat-E-Rabbi, Richard G. Spencer, Kenneth L. Urish, and Gustavo K. Rohde [Transmission of SARS-CoV-2 via fomite, especially cold chain, should not be ignored]( Weilong Ji, Xue Li, Si Chen, and Linzhu Ren --------------------------------------------------------------- Brief Report [Vaccinating the oldest against COVID-19 saves both the most lives and most years of life]( Joshua R. Goldstein, Thomas Cassidy, and Kenneth W. Wachter --------------------------------------------------------------- Physical Sciences Applied Mathematics [Neuromechanical wave resonance in jellyfish swimming]( Alexander P. Hoover, Nicole W. Xu, Brad J. Gemmell, Sean P. Colin, John H. Costello, John O. Dabiri, and Laura A. Miller Applied Physical Sciences [Retail store customer flow and COVID-19 transmission]( Robert A. Shumsky, Laurens Debo, Rebecca M. Lebeaux, Quang P. Nguyen, and Anne G. Hoen [Mesoscale networks and corresponding transitions from self-assembly of block copolymers]( Cheng-Yen Chang, Gkreti-Maria Manesi, Chih-Ying Yang, Yu-Chueh Hung, Kai-Chieh Yang, Po-Ting Chiu, Apostolos Avgeropoulos, and Rong-Ming Ho [Rapidly deployable and morphable 3D mesostructures with applications in multimodal biomedical devices]( Fan Zhang, Shupeng Li, Zhangming Shen, Xu Cheng, Zhaoguo Xue, Hang Zhang, Honglie Song, Ke Bai, Dongjia Yan, Heling Wang, Yihui Zhang, and Yonggang Huang Astronomy [Time-resolved turbulent dynamo in a laser plasma]( Archie F. A. Bott, Petros Tzeferacos, Laura Chen, Charlotte A. J. Palmer, Alexandra Rigby, Anthony R. Bell, Robert Bingham, Andrew Birkel, Carlo Graziani, Dustin H. Froula, Joseph Katz, Michel Koenig, Matthew W. Kunz, Chikang Li, Jena Meinecke, Francesco Miniati, Richard Petrasso, Hye-Sook Park, Bruce A. Remington, Brian Reville, J. Steven Ross, Dongsu Ryu, Dmitri Ryutov, Fredrick H. Séguin, Thomas G. White, Alexander A. Schekochihin, Donald Q. Lamb, and Gianluca Gregori Biophysics and Computational Biology [Nonlinear elasticity of biological basement membrane revealed by rapid inflation and deflation]( Hui Li, Yue Zheng, Yu Long Han, Shengqiang Cai, and Ming Guo [Revealing lineage-related signals in single-cell gene expression using random matrix theory]( Mor Nitzan and Michael P. Brenner [Protein sequence design by conformational landscape optimization]( Christoffer Norn, Basile I. M. Wicky, David Juergens, Sirui Liu, David Kim, Doug Tischer, Brian Koepnick, Ivan Anishchenko, Foldit Players, David Baker, and Sergey Ovchinnikov [Unveiling the “invisible” druggable conformations of GDP-bound inactive Ras]( Dan Liu, Yunyun Mao, Xue Gu, Yang Zhou, and Dong Long [Membrane bending by protein phase separation]( Feng Yuan, Haleh Alimohamadi, Brandon Bakka, Andrea N. Trementozzi, Kasey J. Day, Nicolas L. Fawzi, Padmini Rangamani, and Jeanne C. Stachowiak [The intracellular environment affects protein–protein interactions]( Shannon L. Speer, Wenwen Zheng, Xin Jiang, I-Te Chu, Alex J. Guseman, Maili Liu, Gary J. Pielak, and Conggang Li [POLArIS, a versatile probe for molecular orientation, revealed actin filaments associated with microtubule asters in early embryos]( Ayana Sugizaki, Keisuke Sato, Kazuyoshi Chiba, Kenta Saito, Masahiko Kawagishi, Yuri Tomabechi, Shalin B. Mehta, Hirokazu Ishii, Naoki Sakai, Mikako Shirouzu, Tomomi Tani, and Sumio Terada Chemistry [Photosynthesis tunes quantum-mechanical mixing of electronic and vibrational states to steer exciton energy transfer]( Jacob S. Higgins, Lawson T. Lloyd, Sara H. Sohail, Marco A. Allodi, John P. Otto, Rafael G. Saer, Ryan E. Wood, Sara C. Massey, Po-Chieh Ting, Robert E. Blankenship, and Gregory S. Engel [Postbiosynthetic modification of a precursor to the nitrogenase iron–molybdenum cofactor]( Suppachai Srisantitham, Edward D. Badding, and Daniel L. M. Suess [Ultrafast nanometric imaging of energy flow within and between single carbon dots]( Huy A. Nguyen, Indrajit Srivastava, Dipanjan Pan, and Martin Gruebele [Identification of earth-abundant materials for selective dehydrogenation of light alkanes to olefins]( Tao Wang, Guomin Li, Xinjiang Cui, and Frank Abild-Pedersen [Role of intramolecular hydrogen bonds in promoting electron flow through amino acid and oligopeptide conjugates]( Rafał Orłowski, John A. Clark, James B. Derr, Eli M. Espinoza, Maximilian F. Mayther, Olga Staszewska-Krajewska, Jay R. Winkler, Hanna Jędrzejewska, Agnieszka Szumna, Harry B. Gray, Valentine I. Vullev, and Daniel T. Gryko [Synthetic heparan sulfate standards and machine learning facilitate the development of solid-state nanopore analysis]( Ke Xia, James T. Hagan, Li Fu, Brian S. Sheetz, Somdatta Bhattacharya, Fuming Zhang, Jason R. Dwyer, and Robert J. Linhardt [Photoinduced hole hopping through tryptophans in proteins]( Stanislav Záliš, Jan Heyda, Filip Šebesta, Jay R. Winkler, Harry B. Gray, and Antonín Vlček Computer Sciences [Bots are less central than verified accounts during contentious political events]( Sandra González-Bailón and Manlio De Domenico Earth, Atmospheric, and Planetary Sciences [Archaeomagnetic results from Cambodia in Southeast Asia: Evidence for possible low-latitude flux expulsion]( Shuhui Cai, Rashida Doctor, Lisa Tauxe, Mitch Hendrickson, Quan Hua, Stéphanie Leroy, and Kaseka Phon [A 4,565-My-old andesite from an extinct chondritic protoplanet]( Jean-Alix Barrat, Marc Chaussidon, Akira Yamaguchi, Pierre Beck, Johan Villeneuve, David J. Byrne, Michael W. Broadley, and Bernard Marty Engineering [Hexokinase 2 discerns a novel circulating tumor cell population associated with poor prognosis in lung cancer patients]( Liu Yang, Xiaowei Yan, Jie Chen, Qiong Zhan, Yingqi Hua, Shili Xu, Ziming Li, Zhuo Wang, Yu Dong, Dongqing Zuo, Min Xue, Yin Tang, Harvey R. Herschman, Shun Lu, Qihui Shi, and Wei Wei [Quadruple ultrasound, photoacoustic, optical coherence, and fluorescence fusion imaging with a transparent ultrasound transducer]( Jeongwoo Park, Byullee Park, Tae Yeong Kim, Sungjin Jung, Woo June Choi, Joongho Ahn, Dong Hee Yoon, Jeongho Kim, Seungwan Jeon, Donghyun Lee, Uijung Yong, Jinah Jang, Won Jong Kim, Hong Kyun Kim, Unyong Jeong, Hyung Ham Kim, and Chulhong Kim [Modeling programmable drug delivery in bioelectronics with electrochemical actuation]( Raudel Avila, Chenhang Li, Yeguang Xue, John A. Rogers, and Yonggang Huang Environmental Sciences [Legume–microbiome interactions unlock mineral nutrients in regrowing tropical forests]( Dimitar Z. Epihov, Kristin Saltonstall, Sarah A. Batterman, Lars O. Hedin, Jefferson S. Hall, Michiel van Breugel, Jonathan R. Leake, and David J. Beerling Mathematics [On a question of Mordell]( Andrew R. Booker and Andrew V. Sutherland Physics [Determining the nonequilibrium criticality of a Gardner transition via a hybrid study of molecular simulations and machine learning]( Huaping Li, Yuliang Jin, Ying Jiang, and Jeff Z. Y. Chen [Evidence of a liquid–liquid transition in a glass-forming ionic liquid]( Matthew A. Harris, Thomas Kinsey, Durgesh V. Wagle, Gary A. Baker, and Joshua Sangoro --------------------------------------------------------------- Social Sciences Anthropology [The evolution of altruism through war is highly sensitive to population structure and to civilian and fighter mortality]( Mark Dyble Economic Sciences [Focusing climate negotiations on a uniform common commitment can promote cooperation]( Klaus M. Schmidt and Axel Ockenfels Psychological and Cognitive Sciences [Passion matters but not equally everywhere: Predicting achievement from interest, enjoyment, and efficacy in 59 societies]( Xingyu Li, Miaozhe Han, Geoffrey L. Cohen, and Hazel Rose Markus Social Sciences [Bots are less central than verified accounts during contentious political events]( Sandra González-Bailón and Manlio De Domenico [Life expectancy in adulthood is falling for those without a BA degree, but as educational gaps have widened, racial gaps have narrowed]( Anne Case and Angus Deaton [Pandemic response policies’ democratizing effects on online learning]( Rene F. Kizilcec, Christos A. Makridis, and Katharine C. Sadowski --------------------------------------------------------------- Biological Sciences Agricultural Sciences [Quantification of Brucella abortus population structure in a natural host]( Aretha Fiebig, Catherine E. Vrentas, Thien Le, Marianne Huebner, Paola M. Boggiatto, Steven C. Olsen, and Sean Crosson Anthropology [The evolution of altruism through war is highly sensitive to population structure and to civilian and fighter mortality]( Mark Dyble Applied Biological Sciences [Hexokinase 2 discerns a novel circulating tumor cell population associated with poor prognosis in lung cancer patients]( Liu Yang, Xiaowei Yan, Jie Chen, Qiong Zhan, Yingqi Hua, Shili Xu, Ziming Li, Zhuo Wang, Yu Dong, Dongqing Zuo, Min Xue, Yin Tang, Harvey R. Herschman, Shun Lu, Qihui Shi, and Wei Wei [Neuromechanical wave resonance in jellyfish swimming]( Alexander P. Hoover, Nicole W. Xu, Brad J. Gemmell, Sean P. Colin, John H. Costello, John O. Dabiri, and Laura A. Miller [Retail store customer flow and COVID-19 transmission]( Robert A. Shumsky, Laurens Debo, Rebecca M. Lebeaux, Quang P. Nguyen, and Anne G. Hoen [Therapy for Argentine hemorrhagic fever in nonhuman primates with a humanized monoclonal antibody]( Larry Zeitlin, Robert W. Cross, Joan B. Geisbert, Viktoriya Borisevich, Krystle N. Agans, Abhishek N. Prasad, Sven Enterlein, M. Javad Aman, Zachary A. Bornholdt, Miles B. Brennan, Lioudmila Campbell, Do Kim, Neil Mlakar, Crystal L. Moyer, Michael H. Pauly, William Shestowsky, Kevin J. Whaley, Karla A. Fenton, and Thomas W. Geisbert Biochemistry [Synthetic heparan sulfate standards and machine learning facilitate the development of solid-state nanopore analysis]( Ke Xia, James T. Hagan, Li Fu, Brian S. Sheetz, Somdatta Bhattacharya, Fuming Zhang, Jason R. Dwyer, and Robert J. Linhardt [A conserved Ctp1/CtIP C-terminal peptide stimulates Mre11 endonuclease activity]( Aleksandar Zdravković, James M. Daley, Arijit Dutta, Tatsuya Niwa, Yasuto Murayama, Shuji Kanamaru, Kentaro Ito, Takahisa Maki, Bilge Argunhan, Masayuki Takahashi, Hideo Tsubouchi, Patrick Sung, and Hiroshi Iwasaki [The pentapeptide-repeat protein, MfpA, interacts with mycobacterial DNA gyrase as a DNA T-segment mimic]( Lipeng Feng, Julia E. A. Mundy, Clare E. M. Stevenson, Lesley A. Mitchenall, David M. Lawson, Kaixia Mi, and Anthony Maxwell [Enhanced cytarabine-induced killing in OGG1-deficient acute myeloid leukemia cells]( Nichole Owen, Irina G. Minko, Samantha A. Moellmer, Sydney K. Cammann, R. Stephen Lloyd, and Amanda K. McCullough [Archaeal Connectase is a specific and efficient protein ligase related to proteasome β subunits]( Adrian C. D. Fuchs, Moritz Ammelburg, Jörg Martin, Ruth A. Schmitz, Marcus D. Hartmann, and Andrei N. Lupas [Structural and functional dissection of reovirus capsid folding and assembly by the prefoldin-TRiC/CCT chaperone network]( Jonathan J. Knowlton, Daniel Gestaut, Boxue Ma, Gwen Taylor, Alpay Burak Seven, Alexander Leitner, Gregory J. Wilson, Sreejesh Shanker, Nathan A. Yates, B. V. Venkataram Prasad, Ruedi Aebersold, Wah Chiu, Judith Frydman, and Terence S. Dermody [Cryo-EM structure and kinetics reveal electron transfer by 2D diffusion of cytochrome c in the yeast III-IV respiratory supercomplex]( Agnes Moe, Justin Di Trani, John L. Rubinstein, and Peter Brzezinski [Clutch mechanism of chemomechanical coupling in a DNA resecting motor nuclease]( Mihaela-Carmen Unciuleac, Aviv Meir, Chaoyou Xue, Garrett M. Warren, Eric C. Greene, and Stewart Shuman [Comparative structural analysis of human Nav1.1 and Nav1.5 reveals mutational hotspots for sodium channelopathies]( Xiaojing Pan, Zhangqiang Li, Xueqin Jin, Yanyu Zhao, Gaoxingyu Huang, Xiaoshuang Huang, Zilin Shen, Yong Cao, Mengqiu Dong, Jianlin Lei, and Nieng Yan [Structure of human Nav1.5 reveals the fast inactivation-related segments as a mutational hotspot for the long QT syndrome]( Zhangqiang Li, Xueqin Jin, Tong Wu, Xin Zhao, Weipeng Wang, Jianlin Lei, Xiaojing Pan, and Nieng Yan [A synthetic 5,3-cross-link in the cell wall of rod-shaped Gram-positive bacteria]( David A. Dik, Nan Zhang, Emily J. Sturgell, Brittany B. Sanchez, Jason S. Chen, Bill Webb, Kimberly G. Vanderpool, and Peter G. Schultz Biophysics and Computational Biology [Nonlinear elasticity of biological basement membrane revealed by rapid inflation and deflation]( Hui Li, Yue Zheng, Yu Long Han, Shengqiang Cai, and Ming Guo [Membrane bending by protein phase separation]( Feng Yuan, Haleh Alimohamadi, Brandon Bakka, Andrea N. Trementozzi, Kasey J. Day, Nicolas L. Fawzi, Padmini Rangamani, and Jeanne C. Stachowiak [The intracellular environment affects protein–protein interactions]( Shannon L. Speer, Wenwen Zheng, Xin Jiang, I-Te Chu, Alex J. Guseman, Maili Liu, Gary J. Pielak, and Conggang Li [Photoinduced hole hopping through tryptophans in proteins]( Stanislav Záliš, Jan Heyda, Filip Šebesta, Jay R. Winkler, Harry B. Gray, and Antonín Vlček [β2-adrenoceptor ligand efficacy is tuned by a two-stage interaction with the Gαs C terminus]( Keehun Kim, Shayla Paulekas, Fredrik Sadler, Tejas M. Gupte, Michael Ritt, Matthew Dysthe, Nagarajan Vaidehi, and Sivaraj Sivaramakrishnan [The mosquito protein AEG12 displays both cytolytic and antiviral properties via a common lipid transfer mechanism]( Alexander C. Y. Foo, Peter M. Thompson, Shih-Heng Chen, Ramesh Jadi, Brianna Lupo, Eugene F. DeRose, Simrat Arora, Victoria C. Placentra, Lakshmanane Premkumar, Lalith Perera, Lars C. Pedersen, Negin Martin, and Geoffrey A. Mueller [Kinetic analysis reveals that independent nucleation events determine the progression of polyglutamine aggregation in C. elegans]( Tessa Sinnige, Georg Meisl, Thomas C. T. Michaels, Michele Vendruscolo, Tuomas P. J. Knowles, and Richard I. Morimoto [Oligomeric assembly regulating mitochondrial HtrA2 function as examined by methyl-TROSY NMR]( Yuki Toyama, Robert W. Harkness, Tim Y. T. Lee, Jason T. Maynes, and Lewis E. Kay Cell Biology [POLArIS, a versatile probe for molecular orientation, revealed actin filaments associated with microtubule asters in early embryos]( Ayana Sugizaki, Keisuke Sato, Kazuyoshi Chiba, Kenta Saito, Masahiko Kawagishi, Yuri Tomabechi, Shalin B. Mehta, Hirokazu Ishii, Naoki Sakai, Mikako Shirouzu, Tomomi Tani, and Sumio Terada [Screening for gene expression fluctuations reveals latency-promoting agents of HIV]( Yiyang Lu, Kathrin Bohn-Wippert, Patrick J. Pazerunas, Jennifer M. Moy, Harpal Singh, and Roy D. Dar [Zn2+ influx activates ERK and Akt signaling pathways]( Kelsie J. Anson, Giulia A. Corbet, and Amy E. Palmer [Zinc finger protein E4F1 cooperates with PARP-1 and BRG1 to promote DNA double-strand break repair]( Céline Moison, Jalila Chagraoui, Marie-Christine Caron, Jean-Philippe Gagné, Yan Coulombe, Guy G. Poirier, Jean-Yves Masson, and Guy Sauvageau [DNMT1 maintains metabolic fitness of adipocytes through acting as an epigenetic safeguard of mitochondrial dynamics]( Yoon Jeong Park, Sangseon Lee, Sangsoo Lim, Hahn Nahmgoong, Yul Ji, Jin Young Huh, Assim A. Alfadda, Sun Kim, and Jae Bum Kim [Super-resolution mapping of cellular double-strand break resection complexes during homologous recombination]( Donna R. Whelan and Eli Rothenberg [Thrombomodulin is essential for maintaining quiescence in vascular endothelial cells]( Hemant Giri, Sumith R. Panicker, Xiaofeng Cai, Indranil Biswas, Hartmut Weiler, and Alireza R. Rezaie Ecology [Legume–microbiome interactions unlock mineral nutrients in regrowing tropical forests]( Dimitar Z. Epihov, Kristin Saltonstall, Sarah A. Batterman, Lars O. Hedin, Jefferson S. Hall, Michiel van Breugel, Jonathan R. Leake, and David J. Beerling [Behavioral responses across a mosaic of ecosystem states restructure a sea otter–urchin trophic cascade]( Joshua G. Smith, Joseph Tomoleoni, Michelle Staedler, Sophia Lyon, Jessica Fujii, and M. Tim Tinker [Interventions can shift the thermal optimum for parasitic disease transmission]( Karena H. Nguyen, Philipp H. Boersch-Supan, Rachel B. Hartman, Sandra Y. Mendiola, Valerie J. Harwood, David J. Civitello, and Jason R. Rohr Environmental Sciences [The cyanobacterium Prochlorococcus has divergent light-harvesting antennae and may have evolved in a low-oxygen ocean]( Osvaldo Ulloa, Carlos Henríquez-Castillo, Salvador Ramírez-Flandes, Alvaro M. Plominsky, Alejandro A. Murillo, Connor Morgan-Lang, Steven J. Hallam, and Ramunas Stepanauskas Evolution [A bird-like genome from a frog: Mechanisms of genome size reduction in the ornate burrowing frog, Platyplectrum ornatum]( Sangeet Lamichhaney, Renee Catullo, J. Scott Keogh, Simon Clulow, Scott V. Edwards, and Tariq Ezaz [Ancient noeggerathialean reveals the seed plant sister group diversified alongside the primary seed plant radiation]( Jun Wang, Jason Hilton, Hermann W. Pfefferkorn, Shijun Wang, Yi Zhang, Jiri Bek, Josef Pšenička, Leyla J. Seyfullah, and David Dilcher Genetics [Genome wide association study of HTLV-1–associated myelopathy/tropical spastic paraparesis in the Japanese population]( Marina Penova, Shuji Kawaguchi, Jun-ichirou Yasunaga, Takahisa Kawaguchi, Tomoo Sato, Meiko Takahashi, Masakazu Shimizu, Mineki Saito, Kunihiro Tsukasaki, Masanori Nakagawa, Norihiro Takenouchi, Hideo Hara, Eiji Matsuura, Satoshi Nozuma, Hiroshi Takashima, Shuji Izumo, Toshiki Watanabe, Kaoru Uchimaru, Masako Iwanaga, Atae Utsunomiya, Yasuharu Tabara, Richard Paul, Yoshihisa Yamano, Masao Matsuoka, and Fumihiko Matsuda [Long-read assembly of a Great Dane genome highlights the contribution of GC-rich sequence and mobile elements to canine genomes]( Julia V. Halo, Amanda L. Pendleton, Feichen Shen, Aurélien J. Doucet, Thomas Derrien, Christophe Hitte, Laura E. Kirby, Bridget Myers, Elzbieta Sliwerska, Sarah Emery, John V. Moran, Adam R. Boyko, and Jeffrey M. Kidd Immunology and Inflammation [CD47 blockade reduces the pathologic features of experimental cerebral malaria and promotes survival of hosts with Plasmodium infection]( Laughing Bear Torrez Dulgeroff, Miranda S. Oakley, Michal C. Tal, Ying Ying Yiu, Joy Q. He, Maia Shoham, Victoria Majam, Winter A. Okoth, Pallavi Malla, Sanjai Kumar, and Irving L. Weissman [Type I interferon activation and endothelial dysfunction in caveolin-1 insufficiency-associated pulmonary arterial hypertension]( Salina Gairhe, Keytam S. Awad, Edward J. Dougherty, Gabriela A. Ferreyra, Shuibang Wang, Zu-Xi Yu, Kazuyo Takeda, Cumhur Y. Demirkale, Parizad Torabi-Parizi, Eric D. Austin, Jason M. Elinoff, and Robert L. Danner [Expansions of adaptive-like NK cells with a tissue-resident phenotype in human lung and blood]( Demi Brownlie, Marlena Scharenberg, Jeff E. Mold, Joanna Hård, Eliisa Kekäläinen, Marcus Buggert, Son Nguyen, Jennifer N. Wilson, Mamdoh Al-Ameri, Hans-Gustaf Ljunggren, Nicole Marquardt, and Jakob Michaëlsson [Acetylcholine ameliorates colitis by promoting IL-10 secretion of monocytic myeloid-derived suppressor cells through the nAChR/ERK pathway]( Wanwei Zheng, Huan Song, Zhongguang Luo, Hao Wu, Lin Chen, Yuedi Wang, Haoshu Cui, Yufei Zhang, Bangting Wang, Wenshuai Li, Yao Liu, Jun Zhang, Yiwei Chu, Feifei Luo, and Jie Liu [Involvement of cytotoxic Eomes-expressing CD4+ T cells in secondary progressive multiple sclerosis]( Ben J. E. Raveney, Wakiro Sato, Daiki Takewaki, Chenyang Zhang, Tomomi Kanazawa, Youwei Lin, Tomoko Okamoto, Manabu Araki, Yukio Kimura, Noriko Sato, Terunori Sano, Yuko Saito, Shinji Oki, and Takashi Yamamura [A specific RIP3+ subpopulation of microglia promotes retinopathy through a hypoxia-triggered necroptotic mechanism]( Chang He, Yan Liu, Zijing Huang, Ziqi Yang, Tian Zhou, Sheng Liu, Zhaozhe Hao, Jing Wang, Qiumin Feng, Yizhi Liu, Yihai Cao, and Xialin Liu [Aryl hydrocarbon receptor is essential for the pathogenesis of pulmonary arterial hypertension]( Takeshi Masaki, Makoto Okazawa, Ryotaro Asano, Tadakatsu Inagaki, Tomohiko Ishibashi, Akiko Yamagishi, Saori Umeki-Mizushima, Manami Nishimura, Yusuke Manabe, Hatsue Ishibashi-Ueda, Manabu Shirai, Hirotsugu Tsuchimochi, James T Pearson, Atsushi Kumanogoh, Yasushi Sakata, Takeshi Ogo, Tadamitsu Kishimoto, and Yoshikazu Nakaoka Medical Sciences [Quadruple ultrasound, photoacoustic, optical coherence, and fluorescence fusion imaging with a transparent ultrasound transducer]( Jeongwoo Park, Byullee Park, Tae Yeong Kim, Sungjin Jung, Woo June Choi, Joongho Ahn, Dong Hee Yoon, Jeongho Kim, Seungwan Jeon, Donghyun Lee, Uijung Yong, Jinah Jang, Won Jong Kim, Hong Kyun Kim, Unyong Jeong, Hyung Ham Kim, and Chulhong Kim [Decidual cell FKBP51–progesterone receptor binding mediates maternal stress–induced preterm birth]( Ozlem Guzeloglu-Kayisli, Nihan Semerci, Xiaofang Guo, Kellie Larsen, Asli Ozmen, Sefa Arlier, Duygu Mutluay, Chinedu Nwabuobi, Bradley Sipe, Irina Buhimschi, Catalin Buhimschi, Frederick Schatz, Umit A. Kayisli, and Charles J. Lockwood [A functional screen identifies transcriptional networks that regulate HIV-1 and HIV-2]( Kyle D. Pedro, Luis M. Agosto, Jared A. Sewell, Kimberly A. Eberenz, Xianbao He, Juan I. Fuxman Bass, and Andrew J. Henderson [Genetic deletion of Nox4 enhances cancerogen-induced formation of solid tumors]( Valeska Helfinger, Florian Freiherr von Gall, Nina Henke, Michael M. Kunze, Tobias Schmid, Flavia Rezende, Juliana Heidler, Ilka Wittig, Heinfried H. Radeke, Viola Marschall, Karen Anderson, Ajay M. Shah, Simone Fulda, Bernhard Brüne, Ralf P. Brandes, and Katrin Schröder [Therapeutic targeting of FOS in mutant TERT cancers through removing TERT suppression of apoptosis via regulating survivin and TRAIL-R2]( Rengyun Liu, Jie Tan, Xiaopei Shen, Ke Jiang, Chaoqun Wang, Guangwu Zhu, and Mingzhao Xing [Loss of expression of both miR-15/16 loci in CML transition to blast crisis]( Francesca Lovat, Pierluigi Gasparini, Giovanni Nigita, Karilyn Larkin, John C. Byrd, Mark D. Minden, Michael Andreeff, Bing Z. Carter, and Carlo M. Croce Microbiology [Primary differentiated respiratory epithelial cells respond to apical measles virus infection by shedding multinucleated giant cells]( Wen-Hsuan W. Lin, Annie J. Tsay, Erin N. Lalime, Andrew Pekosz, and Diane E. Griffin [Antigenic cartography reveals complexities of genetic determinants that lead to antigenic differences among pandemic GII.4 noroviruses]( Joseph A. Kendra, Kentaro Tohma, Lauren A. Ford-Siltz, Cara J. Lepore, and Gabriel I. Parra [The diversity and evolution of microbial dissimilatory phosphite oxidation]( Sophia D. Ewens, Alexa F. S. Gomberg, Tyler P. Barnum, Mikayla A. Borton, Hans K. Carlson, Kelly C. Wrighton, and John D. Coates [Limitation of phosphate assimilation maintains cytoplasmic magnesium homeostasis]( Roberto E. Bruna, Christopher G. Kendra, Eduardo A. Groisman, and Mauricio H. Pontes [Visualizing active viral infection reveals diverse cell fates in synchronized algal bloom demise]( Flora Vincent, Uri Sheyn, Ziv Porat, Daniella Schatz, and Assaf Vardi Neuroscience [Cytokine receptor clustering in sensory neurons with an engineered cytokine fusion protein triggers unique pain resolution pathways]( Judith Prado, Remco H. S. Westerink, Jelena Popov-Celeketic, Cristine Steen-Louws, Aridaman Pandit, Sabine Versteeg, Wouter van de Worp, Deon H. A. J. Kanters, Kris A. Reedquist, Leo Koenderman, C. Erik Hack, and Niels Eijkelkamp [Unique molecular characteristics and microglial origin of Kv1.3 channel–positive brain myeloid cells in Alzheimer’s disease]( Supriya Ramesha, Sruti Rayaprolu, Christine A. Bowen, Cynthia R. Giver, Sara Bitarafan, Hai M. Nguyen, Tianwen Gao, Michael J. Chen, Ngozi Nwabueze, Eric B. Dammer, Amanda K. Engstrom, Hailian Xiao, Andrea Pennati, Nicholas T. Seyfried, David J. Katz, Jacques Galipeau, Heike Wulff, Edmund K. Waller, Levi B. Wood, Allan I. Levey, and Srikant Rangaraju [Spatio-temporal heterogeneity in hippocampal metabolism in control and epilepsy conditions]( Giulio E. Brancati, Chahinaz Rawas, Antoine Ghestem, Christophe Bernard, and Anton I. Ivanov [Dlk1 dosage regulates hippocampal neurogenesis and cognition]( Raquel Montalbán-Loro, Glenda Lassi, Anna Lozano-Ureña, Ana Perez-Villalba, Esteban Jiménez-Villalba, Marika Charalambous, Giorgio Vallortigara, Alexa E. Horner, Lisa M. Saksida, Timothy J. Bussey, José Luis Trejo, Valter Tucci, Anne C. Ferguson-Smith, and Sacri R. Ferrón [A unique C2 domain at the C terminus of Munc13 promotes synaptic vesicle priming]( Murugesh Padmanarayana, Haowen Liu, Francesco Michelassi, Lei Li, Daniel Betensky, Matthew J. Dominguez, R. Bryan Sutton, Zhitao Hu, and Jeremy S. Dittman [Noninvasive neuromagnetic single-trial analysis of human neocortical population spikes]( Gunnar Waterstraat, Rainer Körber, Jan-Hendrik Storm, and Gabriel Curio [Disruption of neonatal Purkinje cell function underlies injury-related learning deficits]( Aaron Sathyanesan, Panagiotis Kratimenos, and Vittorio Gallo [Dual-process brain mitochondria isolation preserves function and clarifies protein composition]( Maria F. Noterman, Kalyani Chaubey, Kristi Lin-Rahardja, Anjali M. Rajadhyaksha, Andrew A. Pieper, and Eric B. Taylor [S-nitrosylated TDP-43 triggers aggregation, cell-to-cell spread, and neurotoxicity in hiPSCs and in vivo models of ALS/FTD]( Elaine Pirie, Chang-ki Oh, Xu Zhang, Xuemei Han, Piotr Cieplak, Henry R. Scott, Amanda K. Deal, Swagata Ghatak, Fernando J. Martinez, Gene W. Yeo, John R. Yates III, Tomohiro Nakamura, and Stuart A. Lipton [Distinct functional developments of surviving and eliminated presynaptic terminals]( Mitsuharu Midorikawa and Mariko Miyata [Early fMRI responses to somatosensory and optogenetic stimulation reflect neural information flow]( Won Beom Jung, Geun Ho Im, Haiyan Jiang, and Seong-Gi Kim Physiology [Progesterone receptor isoform B regulates the Oxtr-Plcl2-Trpc3 pathway to suppress uterine contractility]( Mary C. Peavey, San-Pin Wu, Rong Li, Jian Liu, Olivia M. Emery, Tianyuan Wang, Lecong Zhou, Margeaux Wetendorf, Chandra Yallampalli, William E. Gibbons, John P. Lydon, and Francesco J. DeMayo Plant Biology [Photosynthesis tunes quantum-mechanical mixing of electronic and vibrational states to steer exciton energy transfer]( Jacob S. Higgins, Lawson T. Lloyd, Sara H. Sohail, Marco A. Allodi, John P. Otto, Rafael G. Saer, Ryan E. Wood, Sara C. Massey, Po-Chieh Ting, Robert E. Blankenship, and Gregory S. 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Lampugnani, Xin-Fu Yan, Ghazanfar Abbas Khan, Wuan Geok Saw, Patrick Hannah, Feng Qian, Jacob Calabria, Yansong Miao, Gerhard Grüber, Staffan Persson, and Yong-Gui Gao Systems Biology [Molecular switch architecture determines response properties of signaling pathways]( Khem Raj Ghusinga, Roger D. Jones, Alan M. Jones, and Timothy C. Elston --------------------------------------------------------------- Corrections [Correction for Zaki et al., Time-reversal symmetry breaking in the Fechalcogenide superconductors]( [Correction for Kerelsky et al., Moiréless correlations in ABCA graphene]( [Correction for Finlay et al., The hygiene hypothesis, the COVID pandemic, and consequences for the human microbiome]( [Correction for Jensen et al., Multiple cannabinoid signaling cascades powerfully suppress recurrent excitation in the hippocampus]( [Cover] --------------------------------------------------------------- This message was sent to {EMAIL}. 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