PNAS Table of Contents for March 9, 2021; Vol. 118, No. 10 is now complete

[PNAS]   [March 9, 2021; Vol. 118, No. 10]( ) This Week in PNAS [In This Issue]( This week's research highlights --------------------------------------------------------------- News Feature [News Feature: A sea in the Amazon]( Amy McDermott An in-depth look at trending science issues --------------------------------------------------------------- Retrospective [Kathryn Anderson, grand dame of developmental biology]( Ushma S. Neill and Joan Massagué --------------------------------------------------------------- Profile [Profile of Michael Manga]( Brian Doctrow The life and work of NAS members --------------------------------------------------------------- Commentaries [A metagenomics approach to investigate microbiome sociobiology]( Sandra B. Andersen and Jonas Schluter [Rapid emergence of virus–host mutualism under stress]( Valerian V. Dolja [How old are the oldest Homo sapiens in Far East Asia?]( Jean-Jacques Hublin --------------------------------------------------------------- Perspective [The inflated significance of neutral genetic diversity in conservation genetics]( João C. Teixeira and Christian D. Huber --------------------------------------------------------------- Letters [Infection curves on small-world networks are linear only in the vicinity of the critical point]( Łukasz Kuśmierz and Taro Toyoizumi [Reply to Kuśmierz and Toyoizumi: A network-based explanation of why most COVID-19 infection curves are linear]( Stefan Thurner, Peter Klimek, and Rudolf Hanel [Conflicting shape percepts explained by perception cognition distinction]( Paul Linton [Richer color vocabulary is correlated with color memory, but its relation to perception is unknown]( Shiri Lev-Ari [Reply to Lev-Ari: Operational definition of “color perception”; which task represents the concept better?]( Arash Afraz and Maryam Hasantash --------------------------------------------------------------- Brief Report [Homozygous IL37 mutation associated with infantile inflammatory bowel disease]( Zinan Z. Zhang, Yu Zhang, Tingyan He, Colin L. Sweeney, Safa Baris, Elif Karakoc-Aydiner, Yikun Yao, Deniz Ertem, Helen F. Matthews, Claudia Gonzaga-Jauregui, Harry L. Malech, Helen C. Su, Ahmet Ozen, Kenneth G. C. Smith, and Michael J. Lenardo --------------------------------------------------------------- Physical Sciences Applied Physical Sciences [Theory of bulk photovoltaic effect in Anderson insulator]( Hiroaki Ishizuka and Naoto Nagaosa [Cell cycle–dependent active stress drives epithelia remodeling]( John Devany, Daniel M. Sussman, Takaki Yamamoto, M. Lisa Manning, and Margaret L. Gardel [Chemically controlled pattern formation in self-oscillating elastic shells]( Siyu Li, Daniel A. Matoz-Fernandez, Aaveg Aggarwal, and Monica Olvera de la Cruz [Anomalous mechanics of Zn2+-modified fibrin networks]( Jing Xia, Li-Heng Cai, Huayin Wu, Frederick C. MacKintosh, and David A. Weitz Biophysics and Computational Biology [The mechanics and dynamics of cancer cells sensing noisy 3D contact guidance]( Jihan Kim, Yuansheng Cao, Christopher Eddy, Youyuan Deng, Herbert Levine, Wouter-Jan Rappel, and Bo Sun [Emergent robustness of bacterial quorum sensing in fluid flow]( Mohit P. Dalwadi and Philip Pearce [Nonequilibrium dynamics and action at a distance in transcriptionally driven DNA supercoiling]( Yair A. G. Fosado, Davide Michieletto, Chris A. Brackley, and Davide Marenduzzo Chemistry [Boronic acid with high oxidative stability and utility in biological contexts]( Brian J. Graham, Ian W. Windsor, Brian Gold, and Ronald T. Raines [Anomalous nanoparticle surface diffusion in LCTEM is revealed by deep learning-assisted analysis]( Vida Jamali, Cory Hargus, Assaf Ben-Moshe, Amirali Aghazadeh, Hyun Dong Ha, Kranthi K. Mandadapu, and A. Paul Alivisatos [Mesoscopic protein-rich clusters host the nucleation of mutant p53 amyloid fibrils]( David S. Yang, Arash Saeedi, Aram Davtyan, Mohsen Fathi, Michael B. Sherman, Mohammad S. Safari, Alena Klindziuk, Michelle C. Barton, Navin Varadarajan, Anatoly B. Kolomeisky, and Peter G. Vekilov [Three-step nucleation of metal–organic framework nanocrystals]( Xiangwen Liu, See Wee Chee, Sanoj Raj, Michal Sawczyk, Petr Král, and Utkur Mirsaidov [Chemical evidence for the persistence of wine production and trade in Early Medieval Islamic Sicily]( Léa Drieu, Paola Orecchioni, Claudio Capelli, Antonino Meo, Jasmine Lundy, Viva Sacco, Lucia Arcifa, Alessandra Molinari, Martin Carver, and Oliver E. Craig [Lipid nanoparticle-mediated codelivery of Cas9 mRNA and single-guide RNA achieves liver-specific in vivo genome editing of Angptl3]( Min Qiu, Zachary Glass, Jinjin Chen, Mary Haas, Xin Jin, Xuewei Zhao, Xuehui Rui, Zhongfeng Ye, Yamin Li, Feng Zhang, and Qiaobing Xu [Bepridil is potent against SARS-CoV-2 in vitro]( Erol C. Vatansever, Kai S. Yang, Aleksandra K. Drelich, Kaci C. Kratch, Chia-Chuan Cho, Kempaiah Rayavara Kempaiah, Jason C. Hsu, Drake M. Mellott, Shiqing Xu, Chien-Te K. Tseng, and Wenshe Ray Liu [Shape changes and cooperativity in the folding of the central domain of the 16S ribosomal RNA]( Naoto Hori, Natalia A. Denesyuk, and D. Thirumalai [Seipin accumulates and traps diacylglycerols and triglycerides in its ring-like structure]( Valeria Zoni, Rasha Khaddaj, Ivan Lukmantara, Wataru Shinoda, Hongyuan Yang, Roger Schneiter, and Stefano Vanni Earth, Atmospheric, and Planetary Sciences [Ozone pollution in the North China Plain spreading into the late-winter haze season]( Ke Li, Daniel J. Jacob, Hong Liao, Yulu Qiu, Lu Shen, Shixian Zhai, Kelvin H. Bates, Melissa P. Sulprizio, Shaojie Song, Xiao Lu, Qiang Zhang, Bo Zheng, Yuli Zhang, Jinqiang Zhang, Hyun Chul Lee, and Su Keun Kuk [Simple stochastic model for geomagnetic excursions and reversals reproduces the temporal asymmetry of the axial dipole moment]( Alberto Molina-Cardín, Luis Dinis, and María Luisa Osete [Source apportionment of methane escaping the subsea permafrost system in the outer Eurasian Arctic Shelf]( Julia Steinbach, Henry Holmstrand, Kseniia Shcherbakova, Denis Kosmach, Volker Brüchert, Natalia Shakhova, Anatoly Salyuk, Célia J. Sapart, Denis Chernykh, Riko Noormets, Igor Semiletov, and Örjan Gustafsson Engineering [Elastic amplification of the Rayleigh–Taylor instability in solidifying melts]( Etienne Jambon-Puillet, Matthieu Royer Piéchaud, and P.-T. Brun [How the growth of ice depends on the fluid dynamics underneath]( Ziqi Wang, Enrico Calzavarini, Chao Sun, and Federico Toschi Physics [Encoding memory in tube diameter hierarchy of living flow network]( Mirna Kramar and Karen Alim [Γ valley transition metal dichalcogenide moiré bands]( Mattia Angeli and Allan H. MacDonald [Machine learning active-nematic hydrodynamics]( Jonathan Colen, Ming Han, Rui Zhang, Steven A. Redford, Linnea M. Lemma, Link Morgan, Paul V. Ruijgrok, Raymond Adkins, Zev Bryant, Zvonimir Dogic, Margaret L. Gardel, Juan J. de Pablo, and Vincenzo Vitelli [Designing self-assembling kinetics with differentiable statistical physics models]( Carl P. Goodrich, Ella M. King, Samuel S. Schoenholz, Ekin D. Cubuk, and Michael P. Brenner [Non–line-of-sight imaging over 1.43 km]( Cheng Wu, Jianjiang Liu, Xin Huang, Zheng-Ping Li, Chao Yu, Jun-Tian Ye, Jun Zhang, Qiang Zhang, Xiankang Dou, Vivek K. Goyal, Feihu Xu, and Jian-Wei Pan [High-sensitivity heat-capacity measurements on Sr2RuO4 under uniaxial pressure]( You-Sheng Li, Naoki Kikugawa, Dmitry A. Sokolov, Fabian Jerzembeck, Alexandra S. Gibbs, Yoshiteru Maeno, Clifford W. Hicks, Jörg Schmalian, Michael Nicklas, and Andrew P. Mackenzie [Emergence of dynamic vortex glasses in disordered polar active fluids]( Amélie Chardac, Suraj Shankar, M. Cristina Marchetti, and Denis Bartolo --------------------------------------------------------------- Statistics [Integration and transfer learning of single-cell transcriptomes via cFIT]( Minshi Peng, Yue Li, Brie Wamsley, Yuting Wei, and Kathryn Roeder [Elevated cerebrospinal fluid cytokine levels in tuberculous meningitis predict survival in response to dexamethasone]( Laura J. Whitworth, Rajan Troll, Antonio J. Pagán, Francisco J. Roca, Paul H. Edelstein, Mark Troll, David M. Tobin, Nguyen Hoan Phu, Nguyen Duc Bang, Guy E. Thwaites, Nguyen Thuy Thuong Thuong, Roger F. Sewell, and Lalita Ramakrishnan --------------------------------------------------------------- Social Sciences Anthropology [Chemical evidence for the persistence of wine production and trade in Early Medieval Islamic Sicily]( Léa Drieu, Paola Orecchioni, Claudio Capelli, Antonino Meo, Jasmine Lundy, Viva Sacco, Lucia Arcifa, Alessandra Molinari, Martin Carver, and Oliver E. Craig Environmental Sciences [Human arrival and landscape dynamics in the northern Bahamas]( Patricia L. Fall, Peter J. van Hengstum, Lisa Lavold-Foote, Jeffrey P. Donnelly, Nancy A. Albury, and Anne E. Tamalavage Psychological and Cognitive Sciences [Influence of a COVID-19 vaccine’s effectiveness and safety profile on vaccination acceptance]( Robert M. Kaplan and Arnold Milstein [Stunted upward mobility in a learning environment reduces the academic benefits of growth mindsets]( Lile Jia, Chun Hui Lim, Ismaharif Ismail, and Yia Chin Tan [Do conversations end when people want them to?]( Adam M. Mastroianni, Daniel T. Gilbert, Gus Cooney, and Timothy D. Wilson --------------------------------------------------------------- Biological Sciences Agricultural Sciences [Cas9-expressing chickens and pigs as resources for genome editing in livestock]( Beate Rieblinger, Hicham Sid, Denise Duda, Tarik Bozoglu, Romina Klinger, Antonina Schlickenrieder, Kamila Lengyel, Krzysztof Flisikowski, Tatiana Flisikowska, Nina Simm, Alessandro Grodziecki, Carolin Perleberg, Andrea Bähr, Lucie Carrier, Mayuko Kurome, Valeri Zakhartchenko, Barbara Kessler, Eckhard Wolf, Lutz Kettler, Harald Luksch, Ibrahim T. Hagag, Daniel Wise, Jim Kaufman, Benedikt B. Kaufer, Christian Kupatt, Angelika Schnieke, and Benjamin Schusser [A multitaxa assessment of the effectiveness of agri-environmental schemes for biodiversity management]( Fabian A. Boetzl, Jochen Krauss, Jonathan Heinze, Hannes Hoffmann, Jan Juffa, Sebastian König, Elena Krimmer, Maren Prante, Emily A. Martin, Andrea Holzschuh, and Ingolf Steffan-Dewenter Applied Biological Sciences [Lipid nanoparticle-mediated codelivery of Cas9 mRNA and single-guide RNA achieves liver-specific in vivo genome editing of Angptl3]( Min Qiu, Zachary Glass, Jinjin Chen, Mary Haas, Xin Jin, Xuewei Zhao, Xuehui Rui, Zhongfeng Ye, Yamin Li, Feng Zhang, and Qiaobing Xu [Mutational fitness landscapes reveal genetic and structural improvement pathways for a vaccine-elicited HIV-1 broadly neutralizing antibody]( Bharat Madan, Baoshan Zhang, Kai Xu, Cara W. Chao, Sijy O’Dell, Jacy R. Wolfe, Gwo-Yu Chuang, Ahmed S. Fahad, Hui Geng, Rui Kong, Mark K. Louder, Thuy Duong Nguyen, Reda Rawi, Arne Schön, Zizhang Sheng, Rajani Nimrania, Yiran Wang, Tongqing Zhou, Bob C. Lin, Nicole A. Doria-Rose, Lawrence Shapiro, Peter D. Kwong, and Brandon J. DeKosky Biochemistry [Boronic acid with high oxidative stability and utility in biological contexts]( Brian J. Graham, Ian W. Windsor, Brian Gold, and Ronald T. Raines [Bepridil is potent against SARS-CoV-2 in vitro]( Erol C. Vatansever, Kai S. Yang, Aleksandra K. Drelich, Kaci C. Kratch, Chia-Chuan Cho, Kempaiah Rayavara Kempaiah, Jason C. Hsu, Drake M. Mellott, Shiqing Xu, Chien-Te K. Tseng, and Wenshe Ray Liu [Charting the sequence-activity landscape of peptide inhibitors of translation termination]( Chetana Baliga, Tyler J. Brown, Tanja Florin, Sarah Colon, Vallari Shah, Kornelia J. Skowron, Amira Kefi, Teresa Szal, Dorota Klepacki, Terry W. Moore, Nora Vázquez-Laslop, and Alexander S. Mankin [Structural basis for recognition of distinct deaminated DNA lesions by endonuclease Q]( Ke Shi, Nicholas H. Moeller, Surajit Banerjee, Jennifer L. McCann, Michael A. Carpenter, Lulu Yin, Ramkumar Moorthy, Kayo Orellana, Daniel A. Harki, Reuben S. Harris, and Hideki Aihara [Collagen’s enigmatic, highly conserved N-glycan has an essential proteostatic function]( Rasia C. Li, Madeline Y. Wong, Andrew S. DiChiara, Azade S. Hosseini, and Matthew D. Shoulders [Structural insights into α-synuclein monomer–fibril interactions]( Pratibha Kumari, Dhiman Ghosh, Agathe Vanas, Yanick Fleischmann, Thomas Wiegand, Gunnar Jeschke, Roland Riek, and Cédric Eichmann [Chloride-dependent conformational changes in the GlyT1 glycine transporter]( Yuan-Wei Zhang, Stacy Uchendu, Vanessa Leone, Richard T. Bradshaw, Ntumba Sangwa, Lucy R. Forrest, and Gary Rudnick [Architecturally complex O-glycopeptidases are customized for mucin recognition and hydrolysis]( Benjamin Pluvinage, Elizabeth Ficko-Blean, Ilit Noach, Christopher Stuart, Nicole Thompson, Hayden McClure, Nakita Buenbrazo, Warren Wakarchuk, and Alisdair B. Boraston [Structural basis for IFN antagonism by human respiratory syncytial virus nonstructural protein 2]( Jingjing Pei, Nicole D. Wagner, Angela J. Zou, Srirupa Chatterjee, Dominika Borek, Aidan R. Cole, Preston J. Kim, Christopher F. Basler, Zbyszek Otwinowski, Michael L. Gross, Gaya K. Amarasinghe, and Daisy W. Leung Biophysics and Computational Biology [Cell cycle–dependent active stress drives epithelia remodeling]( John Devany, Daniel M. Sussman, Takaki Yamamoto, M. Lisa Manning, and Margaret L. Gardel [Encoding memory in tube diameter hierarchy of living flow network]( Mirna Kramar and Karen Alim [Shape changes and cooperativity in the folding of the central domain of the 16S ribosomal RNA]( Naoto Hori, Natalia A. Denesyuk, and D. Thirumalai [Seipin accumulates and traps diacylglycerols and triglycerides in its ring-like structure]( Valeria Zoni, Rasha Khaddaj, Ivan Lukmantara, Wataru Shinoda, Hongyuan Yang, Roger Schneiter, and Stefano Vanni [Integration and transfer learning of single-cell transcriptomes via cFIT]( Minshi Peng, Yue Li, Brie Wamsley, Yuting Wei, and Kathryn Roeder [Identification of tetracycline combinations as EphB1 tyrosine kinase inhibitors for treatment of neuropathic pain]( Mahmoud S. Ahmed, Ping Wang, Ngoc Uyen Nhi Nguyen, Yuji Nakada, Ivan Menendez-Montes, Muhammad Ismail, Robert Bachoo, Mark Henkemeyer, Hesham A. Sadek, and Enas S. Kandil [Computational studies of anaplastic lymphoma kinase mutations reveal common mechanisms of oncogenic activation]( Keshav Patil, Earl Joseph Jordan, Jin H. Park, Krishna Suresh, Courtney M. Smith, Abigail A. Lemmon, Yaël P. Mossé, Mark A. Lemmon, and Ravi Radhakrishnan [Structural insights into membrane remodeling by SNX1]( Yan Zhang, Xiaoyun Pang, Jian Li, Jiashu Xu, Victor W. Hsu, and Fei Sun [Cadherin cis and trans interactions are mutually cooperative]( Connor J. Thompson, Vinh H. Vu, Deborah E. Leckband, and Daniel K. Schwartz [A narrow ear canal reduces sound velocity to create additional acoustic inputs in a microscale insect ear]( Daniel Veitch, Emine Celiker, Sarah Aldridge, Christian Pulver, Carl D. Soulsbury, Thorin Jonsson, Charlie Woodrow, and Fernando Montealegre-Z [Raf promotes dimerization of the Ras G-domain with increased allosteric connections]( Morgan R. Packer, Jillian A. Parker, Jean K. Chung, Zhenlu Li, Young Kwang Lee, Trinity Cookis, Hugo Guterres, Steven Alvarez, Md Amin Hossain, Daniel P. Donnelly, Jeffrey N. Agar, Lee Makowski, Matthias Buck, Jay T. Groves, and Carla Mattos [Ligand effects on phase separation of multivalent macromolecules]( Kiersten M. Ruff, Furqan Dar, and Rohit V. Pappu Cell Biology [The mechanics and dynamics of cancer cells sensing noisy 3D contact guidance]( Jihan Kim, Yuansheng Cao, Christopher Eddy, Youyuan Deng, Herbert Levine, Wouter-Jan Rappel, and Bo Sun [mTORC1-chaperonin CCT signaling regulates m6A RNA methylation to suppress autophagy]( Hong-Wen Tang, Jui-Hsia Weng, Wen Xing Lee, Yanhui Hu, Lei Gu, Sungyun Cho, Gina Lee, Richard Binari, Cathleen Li, Min En Cheng, Ah-Ram Kim, Jun Xu, Zhangfei Shen, Chiwei Xu, John M. Asara, John Blenis, and Norbert Perrimon [Adaptation of pancreatic cancer cells to nutrient deprivation is reversible and requires glutamine synthetase stabilization by mTORC1]( Pei-Yun Tsai, Min-Sik Lee, Unmesh Jadhav, Insia Naqvi, Shariq Madha, Ashley Adler, Meeta Mistry, Sergey Naumenko, Caroline A. Lewis, Daniel S. Hitchcock, Frederick R. Roberts, Peter DelNero, Thomas Hank, Kim C. Honselmann, Vicente Morales Oyarvide, Mari Mino-Kenudson, Clary B. Clish, Ramesh A. Shivdasani, and Nada Y. Kalaany [CENP-A chromatin prevents replication stress at centromeres to avoid structural aneuploidy]( Simona Giunta, Solène Hervé, Ryan R. White, Therese Wilhelm, Marie Dumont, Andrea Scelfo, Riccardo Gamba, Cheng Kit Wong, Giulia Rancati, Agata Smogorzewska, Hironori Funabiki, and Daniele Fachinetti [The store-operated Ca2+ entry complex comprises a small cluster of STIM1 associated with one Orai1 channel]( Yihan Shen, Nagendra Babu Thillaiappan, and Colin W. Taylor [Metabolic supervision by PPIP5K, an inositol pyrophosphate kinase/phosphatase, controls proliferation of the HCT116 tumor cell line]( Chunfang Gu, Juan Liu, Xiaojing Liu, Haibo Zhang, Ji Luo, Huanchen Wang, Jason W. Locasale, and Stephen B. Shears [Ki-67 regulates global gene expression and promotes sequential stages of carcinogenesis]( Karim Mrouj, Nuria Andrés-Sánchez, Geronimo Dubra, Priyanka Singh, Michal Sobecki, Dhanvantri Chahar, Emile Al Ghoul, Ana Bella Aznar, Susana Prieto, Nelly Pirot, Florence Bernex, Benoit Bordignon, Cedric Hassen-Khodja, Martin Villalba, Liliana Krasinska, and Daniel Fisher Developmental Biology [Dynamics of hydraulic and contractile wave-mediated fluid transport during Drosophila oogenesis]( Jasmin Imran Alsous, Nicolas Romeo, Jonathan A. Jackson, Frank M. Mason, Jörn Dunkel, and Adam C. Martin [ASCL2 reciprocally controls key trophoblast lineage decisions during hemochorial placenta development]( Kaela M. Varberg, Khursheed Iqbal, Masanaga Muto, Mikaela E. Simon, Regan L. Scott, Keisuke Kozai, Ruhul H. Choudhury, John D. Aplin, Rebecca Biswell, Margaret Gibson, Hiroaki Okae, Takahiro Arima, Jay L. Vivian, Elin Grundberg, and Michael J. Soares [Progenitor cell diversity in the developing mouse neocortex]( Xiangbin Ruan, Bowei Kang, Cai Qi, Wenhe Lin, Jingshu Wang, and Xiaochang Zhang [Primary sex determination in birds depends on DMRT1 dosage, but gonadal sex does not determine adult secondary sex characteristics]( Jason Ioannidis, Gunes Taylor, Debiao Zhao, Long Liu, Alewo Idoko-Akoh, Daoqing Gong, Robin Lovell-Badge, Silvana Guioli, Mike J. McGrew, and Michael Clinton [Lipid droplets in mammalian eggs are utilized during embryonic diapause]( Roberta Arena, Simona Bisogno, Łukasz Gąsior, Joanna Rudnicka, Laura Bernhardt, Thomas Haaf, Federica Zacchini, Michał Bochenek, Kinga Fic, Ewelina Bik, Małgorzata Barańska, Anna Bodzoń-Kułakowska, Piotr Suder, Joanna Depciuch, Artur Gurgul, Zbigniew Polański, and Grażyna E. Ptak Ecology [Evolutionary relationships between drought-related traits and climate shape large hydraulic safety margins in western North American oaks]( Robert P. Skelton, Leander D. L. Anderegg, Jessica Diaz, Matthew M. Kling, Prahlad Papper, Laurent J. Lamarque, Sylvain Delzon, Todd E. Dawson, and David D. Ackerly [Selective constraints on global plankton dispersal]( Ben A. Ward, B. B. Cael, Sinead Collins, and C. Robert Young Evolution [Deep time diversity and the early radiations of birds]( Yilun Yu, Chi Zhang, and Xing Xu [Dual oxidase enables insect gut symbiosis by mediating respiratory network formation]( Seonghan Jang, Peter Mergaert, Tsubasa Ohbayashi, Kota Ishigami, Shuji Shigenobu, Hideomi Itoh, and Yoshitomo Kikuchi [Adaptive evolution of hybrid bacteria by horizontal gene transfer]( Jeffrey J. Power, Fernanda Pinheiro, Simone Pompei, Viera Kovacova, Melih Yüksel, Isabel Rathmann, Mona Förster, Michael Lässig, and Berenike Maier Genetics [Discordant clinical features of identical hypertrophic cardiomyopathy twins]( Giuliana G. Repetti, Yuri Kim, Alexandre C. Pereira, Jodie Ingles, Mark W. Russell, Neal K. Lakdawala, Carolyn Y. Ho, Sharlene Day, Christopher Semsarian, Barbara McDonough, Steven R. DePalma, Daniel Quiat, Eric M. Green, Christine E. Seidman, and J. G. Seidman [A versatile platform for locus-scale genome rewriting and verification]( Ran Brosh, Jon M. Laurent, Raquel Ordoñez, Emily Huang, Megan S. Hogan, Angela M. Hitchcock, Leslie A. Mitchell, Sudarshan Pinglay, John A. Cadley, Raven D. Luther, David M. Truong, Jef D. Boeke, and Matthew T. Maurano [The imprinted lncRNA Peg13 regulates sexual preference and the sex-specific brain transcriptome in mice]( Maryam Keshavarz and Diethard Tautz [Up-regulation of miR-34b/c by JNK and FOXO3 protects from liver fibrosis]( Pasquale Piccolo, Rosa Ferriero, Anna Barbato, Sergio Attanasio, Marcello Monti, Claudia Perna, Florie Borel, Patrizia Annunziata, Annamaria Carissimo, Rossella De Cegli, Luca Quagliata, Luigi M. Terracciano, Chantal Housset, Jeffrey H. Teckman, Christian Mueller, and Nicola Brunetti-Pierri [Comparative parallel analysis of RNA ends identifies mRNA substrates of a tRNA splicing endonuclease-initiated mRNA decay pathway]( Jennifer E. Hurtig, Michelle A. Steiger, Vinay K. Nagarajan, Tao Li, Ti-Chun Chao, Kuang-Lei Tsai, and Ambro van Hoof [Genome-wide shifts in climate-related variation underpin responses to selective breeding in a widespread conifer]( Ian R. MacLachlan, Tegan K. McDonald, Brandon M. Lind, Loren H. Rieseberg, Sam Yeaman, and Sally N. Aitken Immunology and Inflammation [An in vivo method for diversifying the functions of therapeutic antibodies]( Ming Tian, Hwei-Ling Cheng, Michael T. Kimble, Kelly McGovern, Peyton Waddicor, Yiwei Chen, Elizabeth Cantor, Mengting Qiu, Marie-Elen Tuchel, Mai Dao, and Frederick W. Alt [Sialoglycan recognition is a common connection linking acidosis, zinc, and HMGB1 in sepsis]( Shoib S. Siddiqui, Chirag Dhar, Venkatasubramaniam Sundaramurthy, Aniruddha Sasmal, Hai Yu, Esther Bandala-Sanchez, Miaomiao Li, Xiaoxiao Zhang, Xi Chen, Leonard C. Harrison, Ding Xu, and Ajit Varki [Pericytes regulate vascular immune homeostasis in the CNS]( Orsolya Török, Bettina Schreiner, Johanna Schaffenrath, Hsing-Chuan Tsai, Upasana Maheshwari, Sebastian A. Stifter, Christina Welsh, Ana Amorim, Sucheta Sridhar, Sebastian G. Utz, Wiebke Mildenberger, Sina Nassiri, Mauro Delorenzi, Adriano Aguzzi, May H. Han, Melanie Greter, Burkhard Becher, and Annika Keller [Targeting tumor-derived NLRP3 reduces melanoma progression by limiting MDSCs expansion]( Isak W. Tengesdal, Dinoop R. Menon, Douglas G. Osborne, Charles P. Neff, Nicholas E. Powers, Fabia Gamboni, Adolfo G. Mauro, Angelo D’Alessandro, Davide Stefanoni, Morkos A. Henen, Taylor S. Mills, Dennis M. De Graaf, Tania Azam, Beat Vogeli, Brent E. Palmer, Eric M. Pietras, James DeGregori, Aik-Choon Tan, Leo A. B. Joosten, Mayumi Fujita, Charles A. Dinarello, and Carlo Marchetti [Local induction of bladder Th1 responses to combat urinary tract infections]( Jianxuan Wu, Chunjing Bao, R. Lee Reinhardt, and Soman N. Abraham [TAp73 represses NF-κB–mediated recruitment of tumor-associated macrophages in breast cancer]( Johanna Wolfsberger, Habib A. M. Sakil, Leilei Zhou, Niek van Bree, Elena Baldisseri, Sabrina de Souza Ferreira, Veronica Zubillaga, Marina Stantic, Nicolas Fritz, Johan Hartman, Charlotte Rolny, and Margareta T. Wilhelm [Host genetic control of natural killer cell diversity revealed in the Collaborative Cross]( Magali S. J. Dupont, Vincent Guillemot, Pascal Campagne, Nicolas Serafini, Solenne Marie, Xavier Montagutelli, James P. Di Santo, and Christian A. J. Vosshenrich [IDO1 scavenges reactive oxygen species in myeloid-derived suppressor cells to prevent graft-versus-host disease]( Ji-Min Ju, Giri Nam, Young-Kwan Lee, Minho Jung, Hanna Chang, Woojin Kim, Woo Jeong Shon, Ji Young Lim, Joo Young Kim, Jun Chang, Chang Ki Min, Dong-Sup Lee, Kyungho Choi, Dong-Mi Shin, and Eun Young Choi [Cysteinyl-specialized proresolving mediators link resolution of infectious inflammation and tissue regeneration via TRAF3 activation]( Nan Chiang, Xavier de la Rosa, Stephania Libreros, Hui Pan, Jonathan M. Dreyfuss, and Charles N. Serhan [Human DNA methylation signatures differentiate persistent from resolving MRSA bacteremia]( Yu-Ling Chang, Maura Rossetti, David W. Gjertson, Liudmilla Rubbi, Michael Thompson, Dennis J. Montoya, Marco Morselli, Felicia Ruffin, Alexander Hoffmann, Matteo Pellegrini, Vance G. Fowler Jr, Michael R. Yeaman, Elaine F. Reed, and with the MRSA Systems Immunology Group Medical Sciences [Influence of a COVID-19 vaccine’s effectiveness and safety profile on vaccination acceptance]( Robert M. Kaplan and Arnold Milstein [Elevated cerebrospinal fluid cytokine levels in tuberculous meningitis predict survival in response to dexamethasone]( Laura J. Whitworth, Rajan Troll, Antonio J. Pagán, Francisco J. Roca, Paul H. Edelstein, Mark Troll, David M. Tobin, Nguyen Hoan Phu, Nguyen Duc Bang, Guy E. Thwaites, Nguyen Thuy Thuong Thuong, Roger F. Sewell, and Lalita Ramakrishnan [Pathogenic LRRK2 regulates ciliation probability upstream of tau tubulin kinase 2 via Rab10 and RILPL1 proteins]( Yuriko Sobu, Paulina S. Wawro, Herschel S. Dhekne, Wondwossen M. Yeshaw, and Suzanne R. Pfeffer Microbiology [Transcriptional heterogeneity and tightly regulated changes in gene expression during Plasmodium berghei sporozoite development]( Haikel N. Bogale, Tales V. Pascini, Sachie Kanatani, Juliana M. Sá, Thomas E. Wellems, Photini Sinnis, Joel Vega-Rodríguez, and David Serre [Structural basis for a bacterial Pip system plant effector recognition protein]( Shukun Luo, Bruna G. Coutinho, Prikshat Dadhwal, Yasuhiro Oda, Jiahong Ren, Amy L. Schaefer, E. Peter Greenberg, Caroline S. Harwood, and Liang Tong [Kaposi’s sarcoma herpesvirus is associated with osteosarcoma in Xinjiang populations]( Qian Chen, Jiangtao Chen, Yuqing Li, Dawei Liu, Yan Zeng, Zheng Tian, Akbar Yunus, Yong Yang, Jie Lu, Xinghua Song, and Yan Yuan [Evaluating the potential efficacy and limitations of a phage for joint antibiotic and phage therapy of Staphylococcus aureus infections]( Brandon A. Berryhill, Douglas L. Huseby, Ingrid C. McCall, Diarmaid Hughes, and Bruce R. Levin [Phytophthora sojae effector Avr1d functions as an E2 competitor and inhibits ubiquitination activity of GmPUB13 to facilitate infection]( Yachun Lin, Qinli Hu, Jia Zhou, Weixiao Yin, Deqiang Yao, Yuanyuan Shao, Yao Zhao, Baodian Guo, Yeqiang Xia, Qian Chen, Yan Wang, Wenwu Ye, Qi Xie, Brett M. Tyler, Weiman Xing, and Yuanchao Wang [N6-methyladenosine modification of HCV RNA genome regulates cap-independent IRES-mediated translation via YTHDC2 recognition]( Geon-Woo Kim and Aleem Siddiqui [HIV-1 cores retain their integrity until minutes before uncoating in the nucleus]( Chenglei Li, Ryan C. Burdick, Kunio Nagashima, Wei-Shau Hu, and Vinay K. Pathak [NF-κB–induced R-loop accumulation and DNA damage select for nucleotide excision repair deficiencies in adult T cell leukemia]( Yunlong He, Nagesh Pasupala, Huijun Zhi, Batsuhk Dorjbal, Imran Hussain, Hsiu-Ming Shih, Sharmistha Bhattacharyya, Roopa Biswas, Milos Miljkovic, Oliver John Semmes, Thomas A. Waldmann, Andrew L. Snow, and Chou-Zen Giam Neuroscience [Drosophila clock cells use multiple mechanisms to transmit time-of-day signals in the brain]( Annika F. Barber, Shi Yi Fong, Anna Kolesnik, Michael Fetchko, and Amita Sehgal [Monocyte markers correlate with immune and neuronal brain changes in REM sleep behavior disorder]( Kristine Farmen, Sara K. Nissen, Morten G. Stokholm, Alex Iranzo, Karen Østergaard, Mónica Serradell, Marit Otto, Kristina B. Svendsen, Alicia Garrido, Dolores Vilas, Per Borghammer, Joan Santamaria, Arne Møller, Carles Gaig, David J. Brooks, Eduardo Tolosa, Nicola Pavese, and Marina Romero-Ramos [Complexity and graded regulation of neuronal cell-type–specific alternative splicing revealed by single-cell RNA sequencing]( Huijuan Feng, Daniel F. Moakley, Shuonan Chen, Melissa G. 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Dalwadi and Philip Pearce --------------------------------------------------------------- Corrections [Correction for Moser et al., Cryo-SOFI enabling low-dose super-resolution correlative light and electron cryo-microscopy]( [Correction for Han et al., Mechanistic approaches for chemically modifying the coordination sphere of copper–amyloid-β complexes]( [Correction for Kessler et al., De novo mutations across 1,465 diverse genomes reveal mutational insights and reductions in the Amish founder population]( [Correction for Abas et al., Naphthylphthalamic acid associates with and inhibits PIN auxin transporters]( [Cover] --------------------------------------------------------------- This message was sent to {EMAIL}. [Unsubscribe]( from or [edit]( your subscription for this service. Or by mail: Customer Service * 15575-A Los Gatos Blvd * Los Gatos, CA 95032 * U.S.A. Copyright © 2021 by the National Academy of Sciences