PNAS Table of Contents for March 2, 2021; Vol. 118, No. 9 is now complete

[PNAS] [Science and Culture: Expedition artists paint a picture of science exploration](/cgi/adclick/?ad=55632&adclick=true&url=https%3A%2F%2Fwww.pnas.org%2Fcontent%2F118%2F6%2Fe2026315118%3Fcct%3D1971)   [March 2, 2021; Vol. 118, No. 9]( ) This Week in PNAS [In this issue]( This week's research highlights --------------------------------------------------------------- Core Concepts [Core Concept: Integrated assessment climate policy models have proven useful, with caveats]( Gayathri Vaidyanathan A brief introduction to emerging topics in science --------------------------------------------------------------- Retrospective [Dr. Takashi Sugimura: A giant of chemical carcinogenesis]( James E. Trosko --------------------------------------------------------------- Profile [Profile of Nora J. Besansky]( Jennifer Viegas The life and work of NAS members --------------------------------------------------------------- Commentaries [Toward ecoevolutionary dynamics]( Karl Sigmund and Robert D. Holt [Monitoring epidemics: Lessons from measuring population prevalence of the coronavirus]( Samuel J. Clark and Abigail Norris Turner [Forage fish for cod and people]( Daniel S. Holland --------------------------------------------------------------- Perspectives [The quiet crossing of ocean tipping points]( Christoph Heinze, Thorsten Blenckner, Helena Martins, Dagmara Rusiecka, Ralf Döscher, Marion Gehlen, Nicolas Gruber, Elisabeth Holland, Øystein Hov, Fortunat Joos, John Brian Robin Matthews, Rolf Rødven, and Simon Wilson [Demographic perspectives on the rise of longevity]( James W. Vaupel, Francisco Villavicencio, and Marie-Pier Bergeron-Boucher --------------------------------------------------------------- Letters [Do we understand the solid-like elastic properties of confined liquids?]( Luca Angelani, Taras Bryk, Simone Capaccioli, Matteo Paoluzzi, Giancarlo Ruocco, and Walter Schirmacher [Reply to Angelani et al.: The G′ ∼ L−3 law for the elasticity of confined liquids can be proved exactly]( Alessio Zaccone and Kostya Trachenko [Caution in testing phenotypic selection]( Jianzhi Zhang and Haiqing Xu [Reply to Zhang and Xu: Environment is indeed important in any phenotypic study]( Hunter B. Fraser --------------------------------------------------------------- Brief Report [Linker domain function predicts pathogenic MLH1 missense variants]( James London, Juana Martín-López, Inho Yang, Jiaquan Liu, Jong-Bong Lee, and Richard Fishel --------------------------------------------------------------- Physical Sciences Applied Physical Sciences [Operando characterization of conductive filaments during resistive switching in Mott VO2]( Shaobo Cheng, Min-Han Lee, Xing Li, Lorenzo Fratino, Federico Tesler, Myung-Geun Han, Javier del Valle, R. C. Dynes, Marcelo J. Rozenberg, Ivan K. Schuller, and Yimei Zhu [Metastable–solid phase diagrams derived from polymorphic solidification kinetics]( Babak Sadigh, Luis Zepeda-Ruiz, and Jonathan L. Belof Biophysics and Computational Biology [Design of immunogens to elicit broadly neutralizing antibodies against HIV targeting the CD4 binding site]( Simone Conti, Kevin J. Kaczorowski, Ge Song, Katelyn Porter, Raiees Andrabi, Dennis R. Burton, Arup K. Chakraborty, and Martin Karplus Chemistry [A tandem activity-based sensing and labeling strategy enables imaging of transcellular hydrogen peroxide signaling]( Hidefumi Iwashita, Erika Castillo, Marco S. Messina, Raymond A. Swanson, and Christopher J. Chang [Primitive selection of the fittest emerging through functional synergy in nucleopeptide networks]( Anil Kumar Bandela, Nathaniel Wagner, Hava Sadihov, Sara Morales-Reina, Agata Chotera-Ouda, Kingshuk Basu, Rivka Cohen-Luria, Andrés de la Escosura, and Gonen Ashkenasy [Effects of fluorinated solvents on electrolyte solvation structures and electrode/electrolyte interphases for lithium metal batteries]( Xia Cao, Peiyuan Gao, Xiaodi Ren, Lianfeng Zou, Mark H. Engelhard, Bethany E. Matthews, Jiangtao Hu, Chaojiang Niu, Dianying Liu, Bruce W. Arey, Chongmin Wang, Jie Xiao, Jun Liu, Wu Xu, and Ji-Guang Zhang [Continuous electrochemical water splitting from natural water sources via forward osmosis]( Samuel S. Veroneau and Daniel G. Nocera Computer Sciences [The echo chamber effect on social media]( Matteo Cinelli, Gianmarco De Francisci Morales, Alessandro Galeazzi, Walter Quattrociocchi, and Michele Starnini [The inverse variance–flatness relation in stochastic gradient descent is critical for finding flat minima]( Yu Feng and Yuhai Tu Earth, Atmospheric, and Planetary Sciences [African burned area and fire carbon emissions are strongly impacted by small fires undetected by coarse resolution satellite data]( Ruben Ramo, Ekhi Roteta, Ioannis Bistinas, Dave van Wees, Aitor Bastarrika, Emilio Chuvieco, and Guido R. van der Werf [Risk of tipping the overturning circulation due to increasing rates of ice melt]( Johannes Lohmann and Peter D. Ditlevsen [Sea spray aerosol concentration modulated by sea surface temperature]( Shang Liu, Cheng-Cheng Liu, Karl D. Froyd, Gregory P. Schill, Daniel M. Murphy, T. Paul Bui, Jonathan M. Dean-Day, Bernadett Weinzierl, Maximilian Dollner, Glenn S. Diskin, Gao Chen, and Ru-Shan Gao [Controls on the size distributions of shallow landslides]( Dino G. Bellugi, David G. Milledge, Kurt M. Cuffey, William E. Dietrich, and Laurel G. Larsen Engineering [Neural interfacing architecture enables enhanced motor control and residual limb functionality postamputation]( Shriya S. Srinivasan, Samantha Gutierrez-Arango, Ashley Chia-En Teng, Erica Israel, Hyungeun Song, Zachary Keith Bailey, Matthew J. Carty, Lisa E. Freed, and Hugh M. Herr [T cells selectively filter oscillatory signals on the minutes timescale]( Geoff P. O’Donoghue, Lukasz J. Bugaj, Warren Anderson, Kyle G. Daniels, David J. Rawlings, and Wendell A. Lim [Hard X-ray omnidirectional differential phase and dark-field imaging]( Hongchang Wang and Kawal Sawhney --------------------------------------------------------------- Social Sciences Economic Sciences [Lifestyle and mental health disruptions during COVID-19]( Osea Giuntella, Kelly Hyde, Silvia Saccardo, and Sally Sadoff [The effects of school closures on SARS-CoV-2 among parents and teachers]( Jonas Vlachos, Edvin Hertegård, and Helena B. Svaleryd Political Sciences [Lawmakers' use of scientific evidence can be improved]( D. Max Crowley, J. Taylor Scott, Elizabeth C. Long, Lawrie Green, Azaliah Israel, Lauren Supplee, Elizabeth Jordan, Kathryn Oliver, Shannon Guillot-Wright, Brittany Gay, Rachel Storace, Naomi Torres-Mackie, Yolanda Murphy, Sandra Donnay, Jenna Reardanz, Rebecca Smith, Kristina McGuire, Elizabeth Baker, Ana Antonopoulos, Mary McCauley, and Cagla Giray Psychological and Cognitive Sciences [The echo chamber effect on social media]( Matteo Cinelli, Gianmarco De Francisci Morales, Alessandro Galeazzi, Walter Quattrociocchi, and Michele Starnini [Probabilistic pragmatics explains gradience and focality in natural language quantification]( Bob van Tiel, Michael Franke, and Uli Sauerland [Heritability of individualized cortical network topography]( Kevin M. Anderson, Tian Ge, Ru Kong, Lauren M. Patrick, R. Nathan Spreng, Mert R. Sabuncu, B. T. Thomas Yeo, and Avram J. Holmes --------------------------------------------------------------- Biological Sciences Applied Biological Sciences [Acetogenic bacteria utilize light-driven electrons as an energy source for autotrophic growth]( Sangrak Jin, Yale Jeon, Min Soo Jeon, Jongoh Shin, Yoseb Song, Seulgi Kang, Jiyun Bae, Suhyung Cho, Jung-Kul Lee, Dong Rip Kim, and Byung-Kwan Cho Biochemistry [A tandem activity-based sensing and labeling strategy enables imaging of transcellular hydrogen peroxide signaling]( Hidefumi Iwashita, Erika Castillo, Marco S. Messina, Raymond A. Swanson, and Christopher J. Chang [Real-time measurements of aminoglycoside effects on protein synthesis in live cells]( Javier Aguirre Rivera, Jimmy Larsson, Ivan L. Volkov, A. Carolin Seefeldt, Suparna Sanyal, and Magnus Johansson [Discovery and characterization of bromodomain 2–specific inhibitors of BRDT]( Zhifeng Yu, Angela F. Ku, Justin L. Anglin, Rajesh Sharma, Melek Nihan Ucisik, John C. Faver, Feng Li, Pranavanand Nyshadham, Nicholas Simmons, Kiran L. Sharma, Sureshbabu Nagarajan, Kevin Riehle, Gundeep Kaur, Banumathi Sankaran, Marta Storl-Desmond, Stephen S. Palmer, Damian W. Young, Choel Kim, and Martin M. Matzuk Biophysics and Computational Biology [Primitive selection of the fittest emerging through functional synergy in nucleopeptide networks]( Anil Kumar Bandela, Nathaniel Wagner, Hava Sadihov, Sara Morales-Reina, Agata Chotera-Ouda, Kingshuk Basu, Rivka Cohen-Luria, Andrés de la Escosura, and Gonen Ashkenasy [Unfolded and intermediate states of PrP play a key role in the mechanism of action of an antiprion chaperone]( Rafayel Petrosyan, Shubhadeep Patra, Negar Rezajooei, Craig R. Garen, and Michael T. Woodside [Structure of a bacterial OapB protein with its OLE RNA target gives insights into the architecture of the OLE ribonucleoprotein complex]( Yang Yang, Kimberly A. Harris, Danielle L. Widner, and Ronald R. Breaker Cell Biology [Compartmentalization of phosphatidylinositol 4,5-bisphosphate metabolism into plasma membrane liquid-ordered/raft domains]( Jongyun Myeong, Cheon-Gyu Park, Byung-Chang Suh, and Bertil Hille Developmental Biology [The zebrafish grime mutant uncovers an evolutionarily conserved role for Tmem161b in the control of cardiac rhythm]( Charlotte D. Koopman, Jessica De Angelis, Swati P. Iyer, Arie O. Verkerk, Jason Da Silva, Geza Berecki, Angela Jeanes, Gregory J. Baillie, Scott Paterson, Veronica Uribe, Ophelia V. Ehrlich, Samuel D. Robinson, Laurence Garric, Steven Petrou, Cas Simons, Irina Vetter, Benjamin M. Hogan, Teun P. de Boer, Jeroen Bakkers, and Kelly A. Smith Ecology [Planktivores as trophic drivers of global coral reef fish diversity patterns]( Alexandre C. Siqueira, Renato A. Morais, David R. Bellwood, and Peter F. Cowman Environmental Sciences [African burned area and fire carbon emissions are strongly impacted by small fires undetected by coarse resolution satellite data]( Ruben Ramo, Ekhi Roteta, Ioannis Bistinas, Dave van Wees, Aitor Bastarrika, Emilio Chuvieco, and Guido R. van der Werf [The effects of school closures on SARS-CoV-2 among parents and teachers]( Jonas Vlachos, Edvin Hertegård, and Helena B. Svaleryd Evolution [A machine-learning approach to map landscape connectivity in Aedes aegypti with genetic and environmental data]( Evlyn Pless, Norah P. Saarman, Jeffrey R. Powell, Adalgisa Caccone, and Giuseppe Amatulli [The battle between harvest and natural selection creates small and shy fish]( Christopher T. Monk, Dorte Bekkevold, Thomas Klefoth, Thilo Pagel, Miquel Palmer, and Robert Arlinghaus [On the evolutionary origins of host–microbe associations]( Michael Sieber, Arne Traulsen, Hinrich Schulenburg, and Angela E. Douglas Genetics [Mitochondrial hydrogen sulfide supplementation improves health in the C. elegans Duchenne muscular dystrophy model]( Rebecca A. Ellwood, Jennifer E. Hewitt, Roberta Torregrossa, Ashleigh M. Philp, Justin P. Hardee, Samantha Hughes, David van de Klashorst, Nima Gharahdaghi, Taslim Anupom, Luke Slade, Colleen S. Deane, Michael Cooke, Timothy Etheridge, Mathew Piasecki, Adam Antebi, Gordon S. Lynch, Andrew Philp, Siva A. Vanapalli, Matthew Whiteman, and Nathaniel J. Szewczyk [A genomic region associated with protection against severe COVID-19 is inherited from Neandertals]( Hugo Zeberg and Svante Pääbo Immunology and Inflammation [Immunotherapy for breast cancer using EpCAM aptamer tumor-targeted gene knockdown]( Ying Zhang, Xuemei Xie, Pourya Naderi Yeganeh, Dian-Jang Lee, David Valle-Garcia, Karla F. Meza-Sosa, Caroline Junqueira, Jiayu Su, Hongbo R. Luo, Winston Hide, and Judy Lieberman [Design of immunogens to elicit broadly neutralizing antibodies against HIV targeting the CD4 binding site]( Simone Conti, Kevin J. Kaczorowski, Ge Song, Katelyn Porter, Raiees Andrabi, Dennis R. Burton, Arup K. Chakraborty, and Martin Karplus [T cells selectively filter oscillatory signals on the minutes timescale]( Geoff P. O’Donoghue, Lukasz J. Bugaj, Warren Anderson, Kyle G. Daniels, David J. Rawlings, and Wendell A. Lim [Cross-reactivity of a pathogenic autoantibody to a tumor antigen in GABAA receptor encephalitis]( Simone M. Brändle, Manuela Cerina, Susanne Weber, Kathrin Held, Amélie F. Menke, Carmen Alcalá, David Gebert, Alexander M. Herrmann, Hannah Pellkofer, Lisa Ann Gerdes, Stefan Bittner, Frank Leypoldt, Bianca Teegen, Lars Komorowski, Tania Kümpfel, Reinhard Hohlfeld, Sven G. Meuth, Bonaventura Casanova, Nico Melzer, Eduardo Beltrán, and Klaus Dornmair [Regulation of neonatal IgA production by the maternal microbiota]( Qinghui Mu, Brianna K. Swartwout, Michael Edwards, Jing Zhu, Grace Lee, Kristin Eden, Xavier Cabana-Puig, Dylan K. McDaniel, Jiangdi Mao, Leila Abdelhamid, Rebecca M. Brock, Irving Coy Allen, Christopher M. Reilly, and Xin M. Luo [Neural stem cells secreting bispecific T cell engager to induce selective antiglioma activity]( Katarzyna C. Pituch, Markella Zannikou, Liliana Ilut, Ting Xiao, Michael Chastkofsky, Madina Sukhanova, Nicola Bertolino, Daniele Procissi, Christina Amidei, Craig M. Horbinski, Karen S. Aboody, C. David James, Maciej S. Lesniak, and Irina V. Balyasnikova [Sema7A is crucial for resolution of severe inflammation]( Andreas Körner, Alice Bernard, Julia C. Fitzgerald, Juan Carlos Alarcon-Barrera, Sarantos Kostidis, Torsten Kaussen, Martin Giera, and Valbona Mirakaj [Generating tumor-selective conditionally active biologic anti-CTLA4 antibodies via protein-associated chemical switches]( Hwai Wen Chang, Gerhard Frey, Haizhen Liu, Charles Xing, Lawrence Steinman, William J. Boyle, and Jay M. Short [ELF3 activated by a superenhancer and an autoregulatory feedback loop is required for high-level HLA-C expression on extravillous trophoblasts]( Qin Li, Torsten B. Meissner, Fang Wang, Ziming Du, Sai Ma, Sarika Kshirsagar, Tamara Tilburgs, Jason D. Buenrostro, Motonari Uesugi, and Jack L. Strominger Medical Sciences [Hard X-ray omnidirectional differential phase and dark-field imaging]( Hongchang Wang and Kawal Sawhney [A circulating, disease-specific, mechanism-linked biomarker for ATTR polyneuropathy diagnosis and response to therapy prediction]( Xin Jiang, Richard Labaudinière, Joel N. Buxbaum, Cecília Monteiro, Marta Novais, Teresa Coelho, and Jeffery W. Kelly [Depletion of H3K36me2 recapitulates epigenomic and phenotypic changes induced by the H3.3K36M oncohistone mutation]( Kartik N. Rajagopalan, Xiao Chen, Daniel N. Weinberg, Haifen Chen, Jacek Majewski, C. David Allis, and Chao Lu [Glucagon blockade restores functional β-cell mass in type 1 diabetic mice and enhances function of human islets]( May-Yun Wang, E. Danielle Dean, Ezekiel Quittner-Strom, Yi Zhu, Kamrul H. Chowdhury, Zhuzhen Zhang, Shangang Zhao, Na Li, Reshing Ye, Young Lee, Yiyi Zhang, Shiuhwei Chen, Xinxin Yu, Derek C. Leonard, Greg Poffenberger, Alison Von Deylen, S. Kay McCorkle, Amnon Schlegel, Kyle W. Sloop, Alexander M. Efanov, Ruth E. Gimeno, Philipp E. Scherer, Alvin C. Powers, Roger H. Unger, and William L. Holland Microbiology [Molecular bases of an alternative dual-enzyme system for light color acclimation of marine Synechococcus cyanobacteria]( Théophile Grébert, Adam A. Nguyen, Suman Pokhrel, Kes Lynn Joseph, Morgane Ratin, Louison Dufour, Bo Chen, Allissa M. Haney, Jonathan A. Karty, Jonathan C. Trinidad, Laurence Garczarek, Wendy M. Schluchter, David M. Kehoe, and Frédéric Partensky [The effect of the D614G substitution on the structure of the spike glycoprotein of SARS-CoV-2]( Donald J. Benton, Antoni G. Wrobel, Chloë Roustan, Annabel Borg, Pengqi Xu, Stephen R. Martin, Peter B. Rosenthal, John J. Skehel, and Steven J. Gamblin [Bromodomain proteins regulate human cytomegalovirus latency and reactivation allowing epigenetic therapeutic intervention]( Ian J. Groves, Sarah E. Jackson, Emma L. Poole, Aharon Nachshon, Batsheva Rozman, Michal Schwartz, Rab K. Prinjha, David F. Tough, John H. Sinclair, and Mark R. Wills Neuroscience [Neural interfacing architecture enables enhanced motor control and residual limb functionality postamputation]( Shriya S. Srinivasan, Samantha Gutierrez-Arango, Ashley Chia-En Teng, Erica Israel, Hyungeun Song, Zachary Keith Bailey, Matthew J. Carty, Lisa E. Freed, and Hugh M. Herr [TIA1 potentiates tau phase separation and promotes generation of toxic oligomeric tau]( Peter E. A. Ash, Shuwen Lei, Jenifer Shattuck, Samantha Boudeau, Yari Carlomagno, Maria Medalla, Bryce L. Mashimo, Guillermo Socorro, Louloua F. A. Al-Mohanna, Lulu Jiang, Muhammet M. Öztürk, Mark Knobel, Pavel Ivanov, Leonard Petrucelli, Susanne Wegmann, Nicholas M. Kanaan, and Benjamin Wolozin [Rapid Ca2+ channel accumulation contributes to cAMP-mediated increase in transmission at hippocampal mossy fiber synapses]( Ryota Fukaya, Marta Maglione, Stephan J. Sigrist, and Takeshi Sakaba [Chemokine CCL5 promotes robust optic nerve regeneration and mediates many of the effects of CNTF gene therapy]( Lili Xie, Yuqin Yin, and Larry Benowitz [The amino-terminal domain of GluA1 mediates LTP maintenance via interaction with neuroplastin-65]( Chao-Hua Jiang, Mengping Wei, Chen Zhang, and Yun Stone Shi [An increase in dendritic plateau potentials is associated with experience-dependent cortical map reorganization]( Stéphane Pagès, Nicolas Chenouard, Ronan Chéreau, Vladimir Kouskoff, Frédéric Gambino, and Anthony Holtmaat [Unique dynamics and exocytosis properties of GABAergic synaptic vesicles revealed by three-dimensional single vesicle tracking]( Chungwon Park, Xingxiang Chen, Chong-Li Tian, Gyu Nam Park, Nicolas Chenouard, Hunki Lee, Xin Yi Yeo, Sangyong Jung, Richard W. Tsien, Guo-Qiang Bi, and Hyokeun Park Pharmacology [Gatorbulin-1, a distinct cyclodepsipeptide chemotype, targets a seventh tubulin pharmacological site]( Susan Matthew, Qi-Yin Chen, Ranjala Ratnayake, Charles S. Fermaintt, Daniel Lucena-Agell, Francesca Bonato, Andrea E. Prota, Seok Ting Lim, Xiaomeng Wang, J. Fernando Díaz, April L. Risinger, Valerie J. Paul, Maria Ángela Oliva, and Hendrik Luesch Physiology [Oviposition-promoting pars intercerebralis neurons show period-dependent photoperiodic changes in their firing activity in the bean bug]( Masaharu Hasebe and Sakiko Shiga Population Biology [The origin and early spread of SARS-CoV-2 in Europe]( Sarah A. Nadeau, Timothy G. Vaughan, Jérémie Scire, Jana S. Huisman, and Tanja Stadler [Quantifying asymptomatic infection and transmission of COVID-19 in New York City using observed cases, serology, and testing capacity]( Rahul Subramanian, Qixin He, and Mercedes Pascual Psychological and Cognitive Sciences [Heritability of individualized cortical network topography]( Kevin M. Anderson, Tian Ge, Ru Kong, Lauren M. Patrick, R. Nathan Spreng, Mert R. Sabuncu, B. T. Thomas Yeo, and Avram J. Holmes Systems Biology [Intracellular pathways for lignin catabolism in white-rot fungi]( Carlos del Cerro, Erika Erickson, Tao Dong, Allison R. Wong, Elizabeth K. Eder, Samuel O. Purvine, Hugh D. Mitchell, Karl K. Weitz, Lye Meng Markillie, Meagan C. Burnet, David W. Hoyt, Rosalie K. Chu, Jan-Fang Cheng, Kelsey J. Ramirez, Rui Katahira, Wei Xiong, Michael E. Himmel, Venkataramanan Subramanian, Jeffrey G. Linger, and Davinia Salvachúa --------------------------------------------------------------- Corrections [Correction for Kim et al., Prediction of Alzheimer’s disease-specific phospholipase c gamma-1 SNV by deep learning-based approach for high-throughput screening]( [Correction for Alam et al., Upregulation of reduced folate carrier by vitamin D enhances brain folate uptake in mice lacking folate receptor alpha]( --------------------------------------------------------------- SI Corrections [Correction to Supporting Information for Chibaya et al., Mdm2 phosphorylation by Akt regulates the p53 response to oxidative stress to promote cell proliferation and tumorigenesis]( [Correction to Supporting Information for Senior et al., Global associations between macronutrient supply and age-specific mortality]( [Cover] --------------------------------------------------------------- This message was sent to {EMAIL}. [Unsubscribe]( from or [edit]( your subscription for this service. 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