PNAS Table of Contents for December 29, 2020; Vol. 117, No. 52 is now complete

[PNAS] [Top Ten 2020](/cgi/adclick/?ad=55495&adclick=true&url=https%3A%2F%2Fwww.pnas.org%2Fpage%2Ftoptenstories%2F2020)   [December 29, 2020; Vol. 117, No. 52]( ) This Week in PNAS [In This Issue]( This week's research highlights --------------------------------------------------------------- Inner Workings [Inner Workings: RNA-based pesticides aim to get around resistance problems]( Leah Shaffer An over-the-shoulder look at scientists at work --------------------------------------------------------------- Retrospective [François N. Diederich: Pioneer of carbon allotropes and molecular recognition]( Kendall N. Houk and J. Fraser Stoddart --------------------------------------------------------------- Profile [Profile of Raúl Padrón]( Jennifer Viegas The life and work of NAS members --------------------------------------------------------------- Commentaries [Considering network interventions]( Damon Centola [Igniting Ca2+ sparks with TRPML1]( Gerard P. Sergeant, Mark A. Hollywood, and Keith D. Thornbury [A plant surface receptor for sensing insect herbivory]( Andrea A. Gust and Thorsten Nürnberger [The spread of COVID-19 shows the importance of policy coordination]( Joshua Graff Zivin and Nicholas Sanders --------------------------------------------------------------- Perspective [The importance of “year zero” in interdisciplinary studies of climate and history]( Ulf Büntgen and Clive Oppenheimer [The mosquito taste system and disease control]( Lisa S. Baik and John R. Carlson --------------------------------------------------------------- Letters [Neuroticism may reflect emotional variability when correcting for the confound with the mean]( Mario Wenzel and Thomas Kubiak [Reply to Wenzel and Kubiak: Neuroticism is best defined by mean levels of negative emotion, not emotional variability]( Elise K. Kalokerinos, Sean C. Murphy, Peter Koval, Merijn Mestdagh, Brock Bastian, and Peter Kuppens [Is photoperiod a dominant driver of secondary growth resumption?]( Sarah C. Elmendorf and Ailene K. Ettinger [Reply to Elmendorf and Ettinger: Photoperiod plays a dominant and irreplaceable role in triggering secondary growth resumption]( Jian-Guo Huang, Filipe Campelo, Qianqian Ma, Yaling Zhang, Yves Bergeron, Annie Deslauriers, Patrick Fonti, Eryuan Liang, Harri Mäkinen, Walter Oberhuber, Cyrille B. K. Rathgeber, Roberto Tognetti, Václav Treml, Bao Yang, Lihong Zhai, Jiao-Lin Zhang, Serena Antonucci, J. Julio Camarero, Katarina Čufar, Henri E. Cuny, Martin De Luis, Alessio Giovannelli, Jožica Gričar, Andreas Gruber, Vladimír Gryc, Aylin Güney, Xiali Guo, Wei Huang, Tuula Jyske, Jakub Kašpar, Gregory King, Cornelia Krause, Audrey Lemay, Feng Liu, Fabio Lombardi, Edurne Martinez del Castillo, Hubert Morin, Cristina Nabais, Pekka Nöjd, Richard L. Peters, Peter Prislan, Antonio Saracino, Irene Swidrak, Hanuš Vavrčík, Joana Vieira, Biyun Yu, Shaokang Zhang, Qiao Zeng, Emanuele Ziaco, and Sergio Rossi --------------------------------------------------------------- Brief Report [HIV proviral DNA integration can drive T cell growth ex vivo]( John K. Yoon, Joseph R. Holloway, Daria W. Wells, Machika Kaku, David Jetton, Rebecca Brown, and John M. Coffin --------------------------------------------------------------- Physical Sciences Applied Mathematics [Robust identification of investor beliefs]( Xiaohong Chen, Lars Peter Hansen, and Peter G. Hansen Applied Physical Sciences [COVID-19 lockdown induces disease-mitigating structural changes in mobility networks]( Frank Schlosser, Benjamin F. Maier, Olivia Jack, David Hinrichs, Adrian Zachariae, and Dirk Brockmann Biophysics and Computational Biology [Structure, self-assembly, and properties of a truncated reflectin variant]( Mehran J. Umerani, Preeta Pratakshya, Atrouli Chatterjee, Juana A. Cerna Sanchez, Ho Shin Kim, Gregor Ilc, Matic Kovačič, Christophe Magnan, Benedetta Marmiroli, Barbara Sartori, Albert L. Kwansa, Helen Orins, Andrew W. Bartlett, Erica M. Leung, Zhijing Feng, Kyle L. Naughton, Brenna Norton-Baker, Long Phan, James Long, Alex Allevato, Jessica E. Leal-Cruz, Qiyin Lin, Pierre Baldi, Sigrid Bernstorff, Janez Plavec, Yaroslava G. Yingling, and Alon A. Gorodetsky [Mirror-image antiparallel β-sheets organize water molecules into superstructures of opposite chirality]( Ethan A. Perets, Daniel Konstantinovsky, Li Fu, Jiantao Chen, Hong-Fei Wang, Sharon Hammes-Schiffer, and Elsa C. Y. Yan [Uncovering the genetic blueprint of the C. elegans nervous system]( István A. Kovács, Dániel L. Barabási, and Albert-László Barabási Chemistry [A thermodynamic atlas of carbon redox chemical space]( Adrian Jinich, Benjamin Sanchez-Lengeling, Haniu Ren, Joshua E. Goldford, Elad Noor, Jacob N. Sanders, Daniel Segrè, and Alán Aspuru-Guzik [Quinine copolymer reporters promote efficient intracellular DNA delivery and illuminate a protein-induced unpackaging mechanism]( Craig Van Bruggen, David Punihaole, Allison R. Keith, Andrew J. Schmitz, Jakub Tolar, Renee R. Frontiera, and Theresa M. Reineke [A new ultrafast energy funneling material harvests three times more diffusive solar energy for GaInP photovoltaics]( Marcel M. Willich, Lucas Wegener, Johannes Vornweg, Manuel Hohgardt, Julia Nowak, Mario Wolter, Christoph R. Jacob, and Peter Jomo Walla [Cathodic electroorganic reaction on silicon oxide dielectric electrode]( Samuel J. Shin, Sangmee Park, Jin-Young Lee, Jae Gyeong Lee, Jeongse Yun, Dae-Woong Hwang, and Taek Dong Chung [Increasing the rate of the hydrogen evolution reaction in neutral water with protic buffer electrolytes]( Kayla E. Clary, Metin Karayilan, Keelee C. McCleary-Petersen, Haley A. Petersen, Richard S. Glass, Jeffrey Pyun, and Dennis L. Lichtenberger [An isolated water droplet in the aqueous solution of a supramolecular tetrahedral cage]( Federico Sebastiani, Trandon A. Bender, Simone Pezzotti, Wan-Lu Li, Gerhard Schwaab, Robert G. Bergman, Kenneth N. Raymond, F. Dean Toste, Teresa Head-Gordon, and Martina Havenith [Fluorine assembly nanocluster breaks the shackles of immunosuppression to turn the cold tumor hot]( Zhaoting Li, Lianghan Zhu, Honghao Sun, Yuexin Shen, Dandan Hu, Wenhao Wu, Yixin Wang, Chenggen Qian, and Minjie Sun [Allosteric cooperation in a de novo-designed two-domain protein]( Fabio Pirro, Nathan Schmidt, James Lincoff, Zachary X. Widel, Nicholas F. Polizzi, Lijun Liu, Michael J. Therien, Michael Grabe, Marco Chino, Angela Lombardi, and William F. DeGrado Computer Sciences [Transforming task representations to perform novel tasks]( Andrew K. Lampinen and James L. McClelland Earth, Atmospheric, and Planetary Sciences [A hydromorphic reevaluation of the forgotten river civilizations of Central Asia]( Willem H. J. Toonen, Mark G. Macklin, Giles Dawkes, Julie A. Durcan, Max Leman, Yevgeniy Nikolayev, and Alexandr Yegorov [A Middle Eocene lowland humid subtropical “Shangri-La” ecosystem in central Tibet]( Tao Su, Robert A. Spicer, Fei-Xiang Wu, Alexander Farnsworth, Jian Huang, Cédric Del Rio, Tao Deng, Lin Ding, Wei-Yu-Dong Deng, Yong-Jiang Huang, Alice Hughes, Lin-Bo Jia, Jian-Hua Jin, Shu-Feng Li, Shui-Qing Liang, Jia Liu, Xiao-Yan Liu, Sarah Sherlock, Teresa Spicer, Gaurav Srivastava, He Tang, Paul Valdes, Teng-Xiang Wang, Mike Widdowson, Meng-Xiao Wu, Yao-Wu Xing, Cong-Li Xu, Jian Yang, Cong Zhang, Shi-Tao Zhang, Xin-Wen Zhang, Fan Zhao, and Zhe-Kun Zhou [Vitamin B12-dependent biosynthesis ties amplified 2-methylhopanoid production during oceanic anoxic events to nitrification]( Felix J. Elling, Jordon D. Hemingway, Thomas W. Evans, Jenan J. Kharbush, Eva Spieck, Roger E. Summons, and Ann Pearson [Vapor isotopic evidence for the worsening of winter air quality by anthropogenic combustion-derived water]( Meng Xing, Weiguo Liu, Xia Li, Weijian Zhou, Qiyuan Wang, Jie Tian, Xiaofei Li, Xuexi Tie, Guohui Li, Junji Cao, Huiming Bao, and Zhisheng An [Rapid hydrolysis of tertiary isoprene nitrate efficiently removes NOx from the atmosphere]( Krystal T. Vasquez, John D. Crounse, Benjamin C. Schulze, Kelvin H. Bates, Alexander P. Teng, Lu Xu, Hannah M. Allen, and Paul O. Wennberg [Predicting long-term dynamics of soil salinity and sodicity on a global scale]( Amirhossein Hassani, Adisa Azapagic, and Nima Shokri [Rapid dark aging of biomass burning as an overlooked source of oxidized organic aerosol]( John K. Kodros, Dimitrios K. Papanastasiou, Marco Paglione, Mauro Masiol, Stefania Squizzato, Kalliopi Florou, Ksakousti Skyllakou, Christos Kaltsonoudis, Athanasios Nenes, and Spyros N. Pandis [Coupled impacts of sea ice variability and North Pacific atmospheric circulation on Holocene hydroclimate in Arctic Alaska]( Ellie Broadman, Darrell S. Kaufman, Andrew C. G. Henderson, Irene Malmierca-Vallet, Melanie J. Leng, and Jack H. Lacey [Bistability in the redox chemistry of sediments and oceans]( Sebastiaan J. van de Velde, Christopher T. Reinhard, Andy Ridgwell, and Filip J. R. Meysman [Stem water cryogenic extraction biases estimation in deuterium isotope composition of plant source water]( Yongle Chen, Brent R. Helliker, Xianhui Tang, Fang Li, Youping Zhou, and Xin Song Engineering [Deep learning extended depth-of-field microscope for fast and slide-free histology]( Lingbo Jin, Yubo Tang, Yicheng Wu, Jackson B. Coole, Melody T. Tan, Xuan Zhao, Hawraa Badaoui, Jacob T. Robinson, Michelle D. Williams, Ann M. Gillenwater, Rebecca R. Richards-Kortum, and Ashok Veeraraghavan [Operando measurement of lattice strain in internal combustion engine components by neutron diffraction]( Martin L. Wissink, Yan Chen, Matthew J. Frost, Scott J. Curran, Orlando Rios, Zachary C. Sims, David Weiss, Eric T. Stromme, and Ke An [Universal features of annealing and aging in compaction of granular piles]( Paula A. Gago and Stefan Boettcher [Grain-boundary topological phase transitions]( Kongtao Chen, David J. Srolovitz, and Jian Han Mathematics [A non-diagonalizable pure state]( Piotr Koszmider Physics [Physical mechanisms of amyloid nucleation on fluid membranes]( Johannes Krausser, Tuomas P. J. Knowles, and Anđela Šarić [Nonadiabatic coupling of the dynamical structure to the superconductivity in YSr2Cu2.75Mo0.25O7.54 and Sr2CuO3.3]( Steven D. Conradson, Theodore H. Geballe, Chang-Qing Jin, Li-Peng Cao, Andrea Gauzzi, Maarit Karppinen, Gianguido Baldinozzi, Wen-Min Li, Edmondo Gilioli, Jack M. Jiang, Matthew Latimer, Oliver Mueller, and Venera Nasretdinova [Two-boson quantum interference in time]( Nicolas J. Cerf and Michael G. Jabbour Statistics [A polynomial algorithm for best-subset selection problem]( Junxian Zhu, Canhong Wen, Jin Zhu, Heping Zhang, and Xueqin Wang --------------------------------------------------------------- Social Sciences Anthropology [Archaeological Central American maize genomes suggest ancient gene flow from South America]( Logan Kistler, Heather B. Thakar, Amber M. VanDerwarker, Alejandra Domic, Anders Bergström, Richard J. George, Thomas K. Harper, Robin G. Allaby, Kenneth Hirth, and Douglas J. Kennett Economic Sciences [Robust identification of investor beliefs]( Xiaohong Chen, Lars Peter Hansen, and Peter G. Hansen [Testing the drift-diffusion model]( Drew Fudenberg, Whitney Newey, Philipp Strack, and Tomasz Strzalecki Environmental Sciences [A hydromorphic reevaluation of the forgotten river civilizations of Central Asia]( Willem H. J. Toonen, Mark G. Macklin, Giles Dawkes, Julie A. Durcan, Max Leman, Yevgeniy Nikolayev, and Alexandr Yegorov Psychological and Cognitive Sciences [Transforming task representations to perform novel tasks]( Andrew K. Lampinen and James L. McClelland [Similarity in functional brain connectivity at rest predicts interpersonal closeness in the social network of an entire village]( Ryan Hyon, Yoosik Youm, Junsol Kim, Jeanyung Chey, Seyul Kwak, and Carolyn Parkinson [Heading perception depends on time-varying evolution of optic flow]( Charlie S. Burlingham and David J. Heeger Social Sciences [COVID-19 lockdown induces disease-mitigating structural changes in mobility networks]( Frank Schlosser, Benjamin F. Maier, Olivia Jack, David Hinrichs, Adrian Zachariae, and Dirk Brockmann Sustainability Science [Evaluating sustainable development policies in rural coastal economies]( Amanda R. Lindsay, James N. Sanchirico, Ted E. Gilliland, Rohani Ambo-Rappe, J. Edward Taylor, Nils C. Krueck, and Peter J. Mumby --------------------------------------------------------------- Biological Sciences Agricultural Sciences [Engineering 6-phosphogluconate dehydrogenase improves grain yield in heat-stressed maize]( Camila Ribeiro, Tracie A. Hennen-Bierwagen, Alan M. Myers, Kenneth Cline, and A. Mark Settles Biochemistry [Structure, self-assembly, and properties of a truncated reflectin variant]( Mehran J. Umerani, Preeta Pratakshya, Atrouli Chatterjee, Juana A. Cerna Sanchez, Ho Shin Kim, Gregor Ilc, Matic Kovačič, Christophe Magnan, Benedetta Marmiroli, Barbara Sartori, Albert L. Kwansa, Helen Orins, Andrew W. Bartlett, Erica M. Leung, Zhijing Feng, Kyle L. Naughton, Brenna Norton-Baker, Long Phan, James Long, Alex Allevato, Jessica E. Leal-Cruz, Qiyin Lin, Pierre Baldi, Sigrid Bernstorff, Janez Plavec, Yaroslava G. Yingling, and Alon A. Gorodetsky [A thermodynamic atlas of carbon redox chemical space]( Adrian Jinich, Benjamin Sanchez-Lengeling, Haniu Ren, Joshua E. Goldford, Elad Noor, Jacob N. Sanders, Daniel Segrè, and Alán Aspuru-Guzik [Transcriptional readout of neuronal activity via an engineered Ca2+-activated protease]( Mateo I. Sanchez, Quynh-Anh Nguyen, Wenjing Wang, Ivan Soltesz, and Alice Y. Ting [A general fragment-based approach to identify and optimize bioactive ligands targeting RNA]( Blessy M. Suresh, Weichao Li, Peiyuan Zhang, Kye Won Wang, Ilyas Yildirim, Christopher G. Parker, and Matthew D. Disney [Assessment of enzyme active site positioning and tests of catalytic mechanisms through X-ray–derived conformational ensembles]( Filip Yabukarski, Justin T. Biel, Margaux M. Pinney, Tzanko Doukov, Alexander S. Powers, James S. Fraser, and Daniel Herschlag [Towards the molecular architecture of the peroxisomal receptor docking complex]( Pascal Lill, Tobias Hansen, Daniel Wendscheck, Bjoern Udo Klink, Tomasz Jeziorek, Dimitrios Vismpas, Jonas Miehling, Julian Bender, Andreas Schummer, Friedel Drepper, Wolfgang Girzalsky, Bettina Warscheid, Ralf Erdmann, and Christos Gatsogiannis [Sulfated glycosaminoglycans mediate prion-like behavior of p53 aggregates]( Naoyuki Iwahashi, Midori Ikezaki, Taro Nishikawa, Norihiro Namba, Takashi Ohgita, Hiroyuki Saito, Yoshito Ihara, Toshinori Shimanouchi, Kazuhiko Ino, Kenji Uchimura, and Kazuchika Nishitsuji [Pyridoxal kinase inhibition by artemisinins down-regulates inhibitory neurotransmission]( Vikram Babu Kasaragod, Anabel Pacios-Michelena, Natascha Schaefer, Fang Zheng, Nicole Bader, Christian Alzheimer, Carmen Villmann, and Hermann Schindelin Biophysics and Computational Biology [Mirror-image antiparallel β-sheets organize water molecules into superstructures of opposite chirality]( Ethan A. Perets, Daniel Konstantinovsky, Li Fu, Jiantao Chen, Hong-Fei Wang, Sharon Hammes-Schiffer, and Elsa C. Y. Yan [Physical mechanisms of amyloid nucleation on fluid membranes]( Johannes Krausser, Tuomas P. J. Knowles, and Anđela Šarić [Allosteric cooperation in a de novo-designed two-domain protein]( Fabio Pirro, Nathan Schmidt, James Lincoff, Zachary X. Widel, Nicholas F. Polizzi, Lijun Liu, Michael J. Therien, Michael Grabe, Marco Chino, Angela Lombardi, and William F. DeGrado [Widespread occurrence of the droplet state of proteins in the human proteome]( Maarten Hardenberg, Attila Horvath, Viktor Ambrus, Monika Fuxreiter, and Michele Vendruscolo [Actin-ring segment switching drives nonadhesive gap closure]( Qiong Wei, Xuechen Shi, Tiankai Zhao, Pingqiang Cai, Tianwu Chen, Yao Zhang, Changjin Huang, Jian Yang, Xiaodong Chen, and Sulin Zhang [Locking mixed-lineage kinase domain-like protein in its auto-inhibited state prevents necroptosis]( Martin Rübbelke, Dennis Fiegen, Margit Bauer, Florian Binder, James Hamilton, Jim King, Sven Thamm, Herbert Nar, and Markus Zeeb Cell Biology [Snx14 proximity labeling reveals a role in saturated fatty acid metabolism and ER homeostasis defective in SCAR20 disease]( Sanchari Datta, Jade Bowerman, Hanaa Hariri, Rupali Ugrankar, Kaitlyn M. Eckert, Chase Corley, Gonçalo Vale, Jeffrey G. McDonald, and W. Mike Henne [Adipocytes promote breast tumorigenesis through TAZ-dependent secretion of Resistin]( Yuhao Gao, Xiaosong Chen, Qing He, Ryan C. Gimple, Yajin Liao, Liang Wang, Rong Wu, Qi Xie, Jeremy N. Rich, Kunwei Shen, and Zengqiang Yuan Developmental Biology [Post-transcriptional tuning of FGF signaling mediates neural crest induction]( Jacqueline Copeland and Marcos Simoes-Costa Ecology [A Middle Eocene lowland humid subtropical “Shangri-La” ecosystem in central Tibet]( Tao Su, Robert A. Spicer, Fei-Xiang Wu, Alexander Farnsworth, Jian Huang, Cédric Del Rio, Tao Deng, Lin Ding, Wei-Yu-Dong Deng, Yong-Jiang Huang, Alice Hughes, Lin-Bo Jia, Jian-Hua Jin, Shu-Feng Li, Shui-Qing Liang, Jia Liu, Xiao-Yan Liu, Sarah Sherlock, Teresa Spicer, Gaurav Srivastava, He Tang, Paul Valdes, Teng-Xiang Wang, Mike Widdowson, Meng-Xiao Wu, Yao-Wu Xing, Cong-Li Xu, Jian Yang, Cong Zhang, Shi-Tao Zhang, Xin-Wen Zhang, Fan Zhao, and Zhe-Kun Zhou [Stimulation of soil respiration by elevated CO2 is enhanced under nitrogen limitation in a decade-long grassland study]( Qun Gao, Gangsheng Wang, Kai Xue, Yunfeng Yang, Jianping Xie, Hao Yu, Shijie Bai, Feifei Liu, Zhili He, Daliang Ning, Sarah E. Hobbie, Peter B. Reich, and Jizhong Zhou [Communication hubs of an asocial cat are the source of a human–carnivore conflict and key to its solution]( Joerg Melzheimer, Sonja K. Heinrich, Bernd Wasiolka, Rebekka Mueller, Susanne Thalwitzer, Ivan Palmegiani, Annika Weigold, Ruben Portas, Ralf Roeder, Miha Krofel, Heribert Hofer, and Bettina Wachter [Divergence of Arctic shrub growth associated with sea ice decline]( Agata Buchwal, Patrick F. Sullivan, Marc Macias-Fauria, Eric Post, Isla H. Myers-Smith, Julienne C. Stroeve, Daan Blok, Ken D. Tape, Bruce C. Forbes, Pascale Ropars, Esther Lévesque, Bo Elberling, Sandra Angers-Blondin, Joseph S. Boyle, Stéphane Boudreau, Noémie Boulanger-Lapointe, Cassandra Gamm, Martin Hallinger, Grzegorz Rachlewicz, Amanda Young, Pentti Zetterberg, and Jeffrey M. Welker Environmental Sciences [Stem water cryogenic extraction biases estimation in deuterium isotope composition of plant source water]( Yongle Chen, Brent R. Helliker, Xianhui Tang, Fang Li, Youping Zhou, and Xin Song [Crop wild relatives of the United States require urgent conservation action]( Colin K. Khoury, Daniel Carver, Stephanie L. Greene, Karen A. Williams, Harold A. Achicanoy, Melanie Schori, Blanca León, John H. Wiersema, and Anne Frances [Global tree-ring analysis reveals rapid decrease in tropical tree longevity with temperature]( Giuliano Maselli Locosselli, Roel J. W. Brienen, Melina de Souza Leite, Manuel Gloor, Stefan Krottenthaler, Alexandre A. de Oliveira, Jonathan Barichivich, Dieter Anhuf, Gregorio Ceccantini, Jochen Schöngart, and Marcos Buckeridge Evolution [Low potential for evolutionary rescue from climate change in a tropical fish]( Rachael Morgan, Mette H. Finnøen, Henrik Jensen, Christophe Pélabon, and Fredrik Jutfelt [Natural selection maintains species despite frequent hybridization in the desert shrub Encelia]( Christopher T. DiVittorio, Sonal Singhal, Adam B. Roddy, Felipe Zapata, David D. Ackerly, Bruce G. {NAME}, Craig R. Brodersen, Alberto Búrquez, Paul V. A. Fine, Mayra Padilla Flores, Elizabeth Solis, Jaime Morales-Villavicencio, David Morales-Arce, and Donald W. Kyhos [Histone variants in archaea and the evolution of combinatorial chromatin complexity]( Kathryn M. Stevens, Jacob B. Swadling, Antoine Hocher, Corinna Bang, Simonetta Gribaldo, Ruth A. Schmitz, and Tobias Warnecke [Evolutionary determinism and convergence associated with water-column transitions in marine fishes]( Melissa Rincon-Sandoval, Emanuell Duarte-Ribeiro, Aaron M. Davis, Aintzane Santaquiteria, Lily C. Hughes, Carole C. {NAME}, Luisángely Soto-Torres, Arturo Acero P., H. J. Walker Jr, Kent E. Carpenter, Marcus Sheaves, Guillermo Ortí, Dahiana Arcila, and Ricardo Betancur-R. Genetics [Archaeological Central American maize genomes suggest ancient gene flow from South America]( Logan Kistler, Heather B. Thakar, Amber M. VanDerwarker, Alejandra Domic, Anders Bergström, Richard J. George, Thomas K. Harper, Robin G. Allaby, Kenneth Hirth, and Douglas J. Kennett [HyPR-seq: Single-cell quantification of chosen RNAs via hybridization and sequencing of DNA probes]( Jamie L. Marshall, Benjamin R. Doughty, Vidya Subramanian, Philine Guckelberger, Qingbo Wang, Linlin M. Chen, Samuel G. Rodriques, Kaite Zhang, Charles P. Fulco, Joseph Nasser, Elizabeth J. Grinkevich, Teia Noel, Sarah Mangiameli, Drew T. Bergman, Anna Greka, Eric S. Lander, Fei Chen, and Jesse M. Engreitz [Direct quantification of in vivo mutagenesis and carcinogenesis using duplex sequencing]( Charles C. Valentine III, Robert R. Young, Mark R. Fielden, Rohan Kulkarni, Lindsey N. Williams, Tan Li, Sheroy Minocherhomji, and Jesse J. Salk [Efficient photoactivatable Dre recombinase for cell type-specific spatiotemporal control of genome engineering in the mouse]( Huiying Li, Qiansen Zhang, Yiran Gu, Yingyin Wu, Yamei Wang, Liren Wang, Shijie Feng, Yaqiang Hu, Yansen Zheng, Yongmei Li, Haifeng Ye, Bin Zhou, Longnian Lin, Mingyao Liu, Huaiyu Yang, and Dali Li [DNA polymerase ι compensates for Fanconi anemia pathway deficiency by countering DNA replication stress]( Rui Wang, Walter F. Lenoir, Chao Wang, Dan Su, Megan McLaughlin, Qianghua Hu, Xi Shen, Yanyan Tian, Naeh Klages-Mundt, Erica Lynn, Richard D. Wood, Junjie Chen, Traver Hart, and Lei Li Immunology and Inflammation [FXR mediates T cell-intrinsic responses to reduced feeding during infection]( Clarissa Campbell, Francois Marchildon, Anthony J. Michaels, Naofumi Takemoto, Joris van der Veeken, Michail Schizas, Yuri Pritykin, Christina S. Leslie, Andrew M. Intlekofer, Paul Cohen, and Alexander Y. Rudensky [IBEX: A versatile multiplex optical imaging approach for deep phenotyping and spatial analysis of cells in complex tissues]( Andrea J. Radtke, Evelyn Kandov, Bradley Lowekamp, Emily Speranza, Colin J. Chu, Anita Gola, Nishant Thakur, Rochelle Shih, Li Yao, Ziv Rafael Yaniv, Rebecca T. Beuschel, Juraj Kabat, Joshua Croteau, Jeremy Davis, Jonathan M. Hernandez, and Ronald N. Germain Medical Sciences [Heterozygous germline BLM mutations increase susceptibility to asbestos and mesothelioma]( Angela Bononi, Keisuke Goto, Guntulu Ak, Yoshie Yoshikawa, Mitsuru Emi, Sandra Pastorino, Lorenzo Carparelli, Angelica Ferro, Masaki Nasu, Jin-Hee Kim, Joelle S. Suarez, Ronghui Xu, Mika Tanji, Yasutaka Takinishi, Michael Minaai, Flavia Novelli, Ian Pagano, Giovanni Gaudino, Harvey I. Pass, Joanna Groden, Joseph J. Grzymski, Muzaffer Metintas, Muhittin Akarsu, Betsy Morrow, Raffit Hassan, Haining Yang, and Michele Carbone [Machine-learning–driven biomarker discovery for the discrimination between allergic and irritant contact dermatitis]( Vittorio Fortino, Lukas Wisgrill, Paulina Werner, Sari Suomela, Nina Linder, Erja Jalonen, Alina Suomalainen, Veer Marwah, Mia Kero, Maria Pesonen, Johan Lundin, Antti Lauerma, Kristiina Aalto-Korte, Dario Greco, Harri Alenius, and Nanna Fyhrquist [The ABL2 kinase regulates an HSF1-dependent transcriptional program required for lung adenocarcinoma brain metastasis]( Jacob P. Hoj, Benjamin Mayro, and Ann Marie Pendergast Microbiology [Vitamin B12-dependent biosynthesis ties amplified 2-methylhopanoid production during oceanic anoxic events to nitrification]( Felix J. Elling, Jordon D. Hemingway, Thomas W. Evans, Jenan J. Kharbush, Eva Spieck, Roger E. Summons, and Ann Pearson [Rewiring the specificity of extracytoplasmic function sigma factors]( Horia Todor, Hendrik Osadnik, Elizabeth A. Campbell, Kevin S. Myers, Hao Li, Timothy J. Donohue, and Carol A. Gross [An in vivo atlas of host–pathogen transcriptomes during Streptococcus pneumoniae colonization and disease]( Adonis D’Mello, Ashleigh N. Riegler, Eriel Martínez, Sarah M. Beno, Tiffany D. Ricketts, Ellen F. Foxman, Carlos J. Orihuela, and Hervé Tettelin [Identification of novel targets of azithromycin activity against Pseudomonas aeruginosa grown in physiologically relevant media]( Corrie R. Belanger, Amy Huei-Yi Lee, Daniel Pletzer, Bhavjinder Kaur Dhillon, Reza Falsafi, and Robert E. W. Hancock [Identification of Z nucleotides as an ancient signal for two-component system activation in bacteria]( Oscar J. Vázquez-Ciros, Adrián F. Alvarez, and Dimitris Georgellis [The β-encapsulation cage of rearrangement hotspot (Rhs) effectors is required for type VI secretion]( Sonya L. Donato, Christina M. Beck, Fernando Garza-Sánchez, Steven J. Jensen, Zachary C. Ruhe, David A. Cunningham, Ian Singleton, David A. Low, and Christopher S. Hayes [Exopolysaccharide defects cause hyper-thymineless death in Escherichia coli via massive loss of chromosomal DNA and cell lysis]( T. V. Pritha Rao and Andrei Kuzminov [Macrophage LC3-associated phagocytosis is an immune defense against Streptococcus pneumoniae that diminishes with host aging]( Megumi Inomata, Shuying Xu, Pallavi Chandra, Simin N. Meydani, Genzou Takemura, Jennifer A. Philips, and John M. Leong Neuroscience [A 2020 view of tension-based cortical morphogenesis]( David C. Van Essen [Similarity in functional brain connectivity at rest predicts interpersonal closeness in the social network of an entire village]( Ryan Hyon, Yoosik Youm, Junsol Kim, Jeanyung Chey, Seyul Kwak, and Carolyn Parkinson [Uncovering the genetic blueprint of the C. elegans nervous system]( István A. Kovács, Dániel L. Barabási, and Albert-László Barabási [Poststroke acute dysexecutive syndrome, a disorder resulting from minor stroke due to disruption of network dynamics]( Elisabeth B. Marsh, Christian Brodbeck, Rafael H. Llinas, Dania Mallick, Joshua P. Kulasingham, Jonathan Z. Simon, and Rodolfo R. Llinás [Hidden proteome of synaptic vesicles in the mammalian brain]( Zacharie Taoufiq, Momchil Ninov, Alejandro Villar-Briones, Han-Ying Wang, Toshio Sasaki, Michael C. Roy, Francois Beauchain, Yasunori Mori, Tomofumi Yoshida, Shigeo Takamori, Reinhard Jahn, and Tomoyuki Takahashi [Inhibition of GCK-IV kinases dissociates cell death and axon regeneration in CNS neurons]( Amit K. Patel, Risa M. Broyer, Cassidy D. Lee, Tianlun Lu, Mikaela J. Louie, Anna La Torre, Hassan Al-Ali, Mai T. Vu, Katherine L. Mitchell, Karl J. Wahlin, Cynthia A. Berlinicke, Vinod Jaskula-Ranga, Yang Hu, Xin Duan, Santiago Vilar, John L. Bixby, Robert N. Weinreb, Vance P. Lemmon, Donald J. Zack, and Derek S. Welsbie [Biotin rescues mitochondrial dysfunction and neurotoxicity in a tauopathy model]( Kelly M. Lohr, Bess Frost, Clemens Scherzer, and Mel B. Feany [Disturbed glucose and pyruvate metabolism in glaucoma with neuroprotection by pyruvate or rapamycin]( Jeffrey M. Harder, Chelsea Guymer, John P. M. Wood, Evangelia Daskalaki, Glyn Chidlow, Chi Zhang, Revathi Balasubramanian, Brynn H. Cardozo, Nicole E. Foxworth, Kelly E. Deering, Tionna B. Ouellette, Christa Montgomery, Craig E. Wheelock, Robert J. Casson, Pete A. Williams, and Simon W. M. John [Human embryonic stem cell-derived organoid retinoblastoma reveals a cancerous origin]( Hui Liu, Yan Zhang, You-You Zhang, Yan-Ping Li, Zi-Qi Hua, Chang-Jun Zhang, Kun-Chao Wu, Fulong Yu, Yaru Zhang, Jianzhong Su, and Zi-Bing Jin [Synaptic plasticity rules with physiological calcium levels]( Yanis Inglebert, Johnatan Aljadeff, Nicolas Brunel, and Dominique Debanne [Axon morphology is modulated by the local environment and impacts the noninvasive investigation of its structure–function relationship]( Mariam Andersson, Hans Martin Kjer, Jonathan Rafael-Patino, Alexandra Pacureanu, Bente Pakkenberg, Jean-Philippe Thiran, Maurice Ptito, Martin Bech, Anders Bjorholm Dahl, Vedrana Andersen Dahl, and Tim B. 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Gove --------------------------------------------------------------- Corrections [Correction for Ornes, Inner Workings: Physicists look to a new telescope to understand neutron stars and matter at the extremes]( [Correction for Vandvik et al., Biotic rescaling reveals importance of species interactions for variation in biodiversity responses to climate change]( [Cover] --------------------------------------------------------------- This message was sent to {EMAIL}. [Unsubscribe]( from or [edit]( your subscription for this service. Or by mail: Customer Service * 15575-A Los Gatos Blvd * Los Gatos, CA 95032 * U.S.A. Copyright © 2020 by the National Academy of Sciences