PNAS Table of Contents for December 8, 2020; Vol. 117, No. 49

[PNAS] [Colloquium](/cgi/adclick/?ad=55457&adclick=true&url=https%3A%2F%2Fwww.pnas.org%2Fcc%2Farthur-m-sackler-colloquium-brain-produces-mind-by-modeling)   [December 8, 2020; Vol. 117, No. 49]( ) This Week in PNAS [In This Issue]( This week's research highlights --------------------------------------------------------------- Opinion [Opinion: Standardizing the definition of gene drive]( Luke S. Alphey, Andrea Crisanti, Filippo (Fil) Randazzo, and Omar S. Akbari Leading scientists discuss current issues. --------------------------------------------------------------- QnAs [QnAs with Catherine L. Kling]( Beth Azar Interviews with leading scientific researchers and newsmakers --------------------------------------------------------------- Profile [Profile of Se-Jin Lee]( Sandeep Ravindran The life and work of NAS members --------------------------------------------------------------- Commentaries [A Golgi-associated lipid kinase controls peripheral nerve myelination]( York Posor and Volker Haucke [A MASCOT for mosaic analysis]( Yan Yan and Tuomas Tammela [Angiosperms versus gymnosperms in the Cretaceous]( H. John B. Birks --------------------------------------------------------------- Perspective [Post-2020 biodiversity targets need to embrace climate change]( Almut Arneth, Yunne-Jai Shin, Paul Leadley, Carlo Rondinini, Elena Bukvareva, Melanie Kolb, Guy F. Midgley, Thierry Oberdorff, Ignacio Palomo, and Osamu Saito --------------------------------------------------------------- Letters [Lower Paleolithic bone handaxes and chopsticks: Tools and symbols?]( Ran Barkai [Reply to Barkai: Implications of the Konso bone handaxe]( Gen Suwa, Berhane Asfaw, Katsuhiro Sano, and Yonas Beyene [Does tocilizumab have a magical therapeutic effect on COVID-19 patients without obvious adverse reactions?]( Yong Wang, Qing Mao, and Xiangdong Zhou [Reply to Wang et al.: Tocilizumab treatment should be used in a timely manner, at suitable dose, and in suitable patients]( Xiaoling Xu, Mingfeng Han, Tiantian Li, Wei Sun, Dongsheng Wang, Binqing Fu, Yonggang Zhou, Xiaohu Zheng, Yun Yang, Xiuyong Li, Xiaohua Zhang, Aijun Pan, and Haiming Wei --------------------------------------------------------------- Physical Sciences Applied Mathematics [Local conformal autoencoder for standardized data coordinates]( Erez Peterfreund, Ofir Lindenbaum, Felix Dietrich, Tom Bertalan, Matan Gavish, Ioannis G. Kevrekidis, and Ronald R. Coifman [Moth wings are acoustic metamaterials]( Thomas R. Neil, Zhiyuan Shen, Daniel Robert, Bruce W. Drinkwater, and Marc W. Holderied Applied Physical Sciences [Global analysis of more than 50,000 SARS-CoV-2 genomes reveals epistasis between eight viral genes]( Hong-Li Zeng, Vito Dichio, Edwin Rodríguez Horta, Kaisa Thorell, and Erik Aurell Biophysics and Computational Biology [A structurally conserved human and Tetrahymena telomerase catalytic core]( Yaqiang Wang, Marcus Gallagher-Jones, Lukas Sušac, He Song, and Juli Feigon [A general model of hippocampal and dorsal striatal learning and decision making]( Jesse P. Geerts, Fabian Chersi, Kimberly L. Stachenfeld, and Neil Burgess [Inhibition of 3-phosphoinositide–dependent protein kinase 1 (PDK1) can revert cellular senescence in human dermal fibroblasts]( Sugyun An, Si-Young Cho, Junsoo Kang, Soobeom Lee, Hyung-Su Kim, Dae-Jin Min, EuiDong Son, and Kwang-Hyun Cho Chemistry [Design of a multivalent bifunctional chelator for diagnostic 64Cu PET imaging in Alzheimer’s disease]( Hong-Jun Cho, Truc T. Huynh, Buck E. Rogers, and Liviu M. Mirica [Condensing water vapor to droplets generates hydrogen peroxide]( Jae Kyoo Lee, Hyun Soo Han, Settasit Chaikasetsin, Daniel P. Marron, Robert M. Waymouth, Fritz B. Prinz, and Richard N. Zare [β-Cyclodextrin modified Pt(II) metallacycle-based supramolecular hyperbranched polymer assemblies for DOX delivery to liver cancer cells]( Wenzhuo Chen, Xuefeng Li, Chengfei Liu, Jia He, Miao Qi, Yue Sun, Bingbing Shi, Hajar Sepehrpour, Hui Li, Wei Tian, and Peter J. Stang [Photochemistry of oxidized Hg(I) and Hg(II) species suggests missing mercury oxidation in the troposphere]( Alfonso Saiz-Lopez, Oleg Travnikov, Jeroen E. Sonke, Colin P. Thackray, Daniel J. Jacob, Javier Carmona-García, Antonio Francés-Monerris, Daniel Roca-Sanjuán, A. Ulises Acuña, Juan Z. Dávalos, Carlos A. Cuevas, Martin Jiskra, Feiyue Wang, Johannes Bieser, John M. C. Plane, and Joseph S. Francisco [Cellular pathways of calcium transport and concentration toward mineral formation in sea urchin larvae]( Keren Kahil, Neta Varsano, Andrea Sorrentino, Eva Pereiro, Peter Rez, Steve Weiner, and Lia Addadi [In situ organic Fenton-like catalysis triggered by anodic polymeric intermediates for electrochemical water purification]( Dan-Ni Pei, Chang Liu, Ai-Yong Zhang, Xiao-Qiang Pan, and Han-Qing Yu [Datura quids at Pinwheel Cave, California, provide unambiguous confirmation of the ingestion of hallucinogens at a rock art site]( David W. Robinson, Kelly Brown, Moira McMenemy, Lynn Dennany, Matthew J. Baker, Pamela Allan, Caroline Cartwright, Julienne Bernard, Fraser Sturt, Elena Kotoula, Christopher Jazwa, Kristina M. Gill, Patrick Randolph-Quinney, Thomas Ash, Clare Bedford, Devlin Gandy, Matthew Armstrong, James Miles, and David Haviland [Natural hybrid silica/protein superstructure at atomic resolution]( Stefan Görlich, Abisheik John Samuel, Richard Johannes Best, Ronald Seidel, Jean Vacelet, Filip Karol Leonarski, Takashi Tomizaki, Bernd Rellinghaus, Darius Pohl, and Igor Zlotnikov [Structure of the Dietzia Mrp complex reveals molecular mechanism of this giant bacterial sodium proton pump]( Bin Li, Kaiduan Zhang, Yong Nie, Xianping Wang, Yan Zhao, Xuejun C. Zhang, and Xiao-Lei Wu Earth, Atmospheric, and Planetary Sciences [The internal structure and geodynamics of Mars inferred from a 4.2-Gyr zircon record]( Maria M. Costa, Ninna K. Jensen, Laura C. Bouvier, James N. Connelly, Takashi Mikouchi, Matthew S. A. Horstwood, Jussi-Petteri Suuronen, Frédéric Moynier, Zhengbin Deng, Arnaud Agranier, Laure A. J. Martin, Tim E. Johnson, Alexander A. Nemchin, and Martin Bizzarro [A new sea-level record for the Neogene/Quaternary boundary reveals transition to a more stable East Antarctic Ice Sheet]( Kim A. Jakob, Paul A. Wilson, Jörg Pross, Thomas H. G. Ezard, Jens Fiebig, Janne Repschläger, and Oliver Friedrich [Seasonal drought events in tropical East Asia over the last 60,000 y]( Jianping Zhang, Houyuan Lu, Jiwei Jia, Caiming Shen, Shuyun Wang, Guoqiang Chu, Luo Wang, Anning Cui, Jiaqi Liu, Naiqin Wu, and Fengjiang Li [Ancient helium and tungsten isotopic signatures preserved in mantle domains least modified by crustal recycling]( Matthew G. Jackson, Janne Blichert-Toft, Saemundur A. Halldórsson, Andrea Mundl-Petermeier, Michael Bizimis, Mark D. Kurz, Allison A. Price, Sunna Harðardóttir, Lori N. Willhite, Kresten Breddam, Thorsten W. Becker, and Rebecca A. Fischer Engineering [Characterization, stability, and application of domain walls in flexible mechanical metamaterials]( Bolei Deng, Siqin Yu, Antonio E. Forte, Vincent Tournat, and Katia Bertoldi Sustainability Science [Green energy by recoverable triple-oxide mesostructured perovskite photovoltaics]( Avi Schneider, Ariel Efrati, Stav Alon, Maayan Sohmer, and Lioz Etgar [Natural gas shortages during the “coal-to-gas” transition in China have caused a large redistribution of air pollution in winter 2017]( Siwen Wang, Hang Su, Chuchu Chen, Wei Tao, David G. Streets, Zifeng Lu, Bo Zheng, Gregory R. Carmichael, Jos Lelieveld, Ulrich Pöschl, and Yafang Cheng --------------------------------------------------------------- Social Sciences Anthropology [Datura quids at Pinwheel Cave, California, provide unambiguous confirmation of the ingestion of hallucinogens at a rock art site]( David W. Robinson, Kelly Brown, Moira McMenemy, Lynn Dennany, Matthew J. Baker, Pamela Allan, Caroline Cartwright, Julienne Bernard, Fraser Sturt, Elena Kotoula, Christopher Jazwa, Kristina M. Gill, Patrick Randolph-Quinney, Thomas Ash, Clare Bedford, Devlin Gandy, Matthew Armstrong, James Miles, and David Haviland Environmental Sciences [Conservation cobenefits from air pollution regulation: Evidence from birds]( Yuanning Liang, Ivan Rudik, Eric Yongchen Zou, Alison Johnston, Amanda D. Rodewald, and Catherine L. Kling Political Sciences [Dogmatism manifests in lowered information search under uncertainty]( Lion Schulz, Max Rollwage, Raymond J. Dolan, and Stephen M. Fleming Psychological and Cognitive Sciences [“You” speaks to me: Effects of generic-you in creating resonance between people and ideas]( Ariana Orvell, Ethan Kross, and Susan A. Gelman [Richer color vocabulary is associated with better color memory but not color perception]( Maryam Hasantash and Arash Afraz Social Sciences [Race and ethnic variation in college students’ allostatic regulation of racism-related stress]( Jacob E. Cheadle, Bridget J. Goosby, Joseph C. Jochman, Cara C. Tomaso, Chelsea B. Kozikowski Yancey, and Timothy D. Nelson [Gender stereotypes can explain the gender-equality paradox]( Thomas Breda, Elyès Jouini, Clotilde Napp, and Georgia Thebault --------------------------------------------------------------- Biological Sciences Applied Biological Sciences [Development of cyclic peptides with potent in vivo osteogenic activity through RaPID-based affinity maturation]( Nasir K. Bashiruddin, Mikihito Hayashi, Masanobu Nagano, Yan Wu, Yukiko Matsunaga, Junichi Takagi, Tomoki Nakashima, and Hiroaki Suga Biochemistry [A structurally conserved human and Tetrahymena telomerase catalytic core]( Yaqiang Wang, Marcus Gallagher-Jones, Lukas Sušac, He Song, and Juli Feigon [Natural hybrid silica/protein superstructure at atomic resolution]( Stefan Görlich, Abisheik John Samuel, Richard Johannes Best, Ronald Seidel, Jean Vacelet, Filip Karol Leonarski, Takashi Tomizaki, Bernd Rellinghaus, Darius Pohl, and Igor Zlotnikov [The Arg/N-degron pathway targets transcription factors and regulates specific genes]( Tri T. M. Vu, Dylan C. Mitchell, Steven P. Gygi, and Alexander Varshavsky [Mutation-oriented profiling of autoinhibitory kinase conformations predicts RAF inhibitor efficacies]( Johanna E. Mayrhofer, Florian Enzler, Andreas Feichtner, Ruth Röck, Jakob Fleischmann, Andrea Raffeiner, Philipp Tschaikner, Egon Ogris, Roland G. Huber, Markus Hartl, Rainer Schneider, Jakob Troppmair, Omar Torres-Quesada, and Eduard Stefan [The SERCA residue Glu340 mediates interdomain communication that guides Ca2+ transport]( Maxwell M. G. Geurts, Johannes D. Clausen, Bertrand Arnou, Cédric Montigny, Guillaume Lenoir, Robin A. Corey, Christine Jaxel, Jesper V. Møller, Poul Nissen, Jens Peter Andersen, Marc le Maire, and Maike Bublitz [Hsp40 proteins phase separate to chaperone the assembly and maintenance of membraneless organelles]( Jinge Gu, Zhenying Liu, Shengnan Zhang, Yichen Li, Wencheng Xia, Chen Wang, Huaijiang Xiang, Zhijun Liu, Li Tan, Yanshan Fang, Cong Liu, and Dan Li Biophysics and Computational Biology [Moth wings are acoustic metamaterials]( Thomas R. Neil, Zhiyuan Shen, Daniel Robert, Bruce W. Drinkwater, and Marc W. Holderied [Discovery of Marburg virus neutralizing antibodies from virus-naïve human antibody repertoires using large-scale structural predictions]( Nina G. Bozhanova, Amandeep K. Sangha, Alexander M. Sevy, Pavlo Gilchuk, Kai Huang, Rachel S. Nargi, Joseph X. Reidy, Andrew Trivette, Robert H. Carnahan, Alexander Bukreyev, James E. Crowe Jr, and Jens Meiler [Robust folding of a de novo designed ideal protein even with most of the core mutated to valine]( Rie Koga, Mami Yamamoto, Takahiro Kosugi, Naohiro Kobayashi, Toshihiko Sugiki, Toshimichi Fujiwara, and Nobuyasu Koga [Mapping transmembrane binding partners for E-cadherin ectodomains]( Omer Shafraz, Bin Xie, Soichiro Yamada, and Sanjeevi Sivasankar Cell Biology [Structure of the Dietzia Mrp complex reveals molecular mechanism of this giant bacterial sodium proton pump]( Bin Li, Kaiduan Zhang, Yong Nie, Xianping Wang, Yan Zhao, Xuejun C. Zhang, and Xiao-Lei Wu [Chemical mutagenesis of a GPCR ligand: Detoxifying “inflammo-attraction” to direct therapeutic stem cell migration]( Jean-Pyo Lee, Runquan Zhang, Maocai Yan, Srinivas Duggineni, Dustin R. Wakeman, Walter L. Niles, Yongmei Feng, Justin Chen, Milton H. Hamblin, Edward B. Han, Rodolfo Gonzalez, Xiao Fang, Yinsong Zhu, Juan Wang, Yan Xu, David A. Wenger, Thomas N. Seyfried, Jing An, Richard L. Sidman, Ziwei Huang, and Evan Y. Snyder [Oncogenic activation of PI3K-AKT-mTOR signaling suppresses ferroptosis via SREBP-mediated lipogenesis]( Junmei Yi, Jiajun Zhu, Jiao Wu, Craig B. Thompson, and Xuejun Jiang [ATP13A2-mediated endo-lysosomal polyamine export counters mitochondrial oxidative stress]( Stephanie Vrijsen, Laura Besora-Casals, Sarah van Veen, Jeffrey Zielich, Chris Van den Haute, Norin Nabil Hamouda, Christian Fischer, Bart Ghesquière, Ivailo Tournev, Patrizia Agostinis, Veerle Baekelandt, Jan Eggermont, Eric Lambie, Shaun Martin, and Peter Vangheluwe [Circadian regulation of muscle growth independent of locomotor activity]( Jeffrey J. Kelu, Tapan G. Pipalia, and Simon M. Hughes Developmental Biology [Reversal of autoimmunity by mixed chimerism enables reactivation of β cells and transdifferentiation of α cells in diabetic NOD mice]( Shanshan Tang, Mingfeng Zhang, Samuel Zeng, Yaxun Huang, Melissa Qin, Ubaydah Nasri, Pere Santamaria, Arthur D. Riggs, Liang Jin, and Defu Zeng [Chromatin topology and the timing of enhancer function at the HoxD locus]( Eddie Rodríguez-Carballo, Lucille Lopez-Delisle, Andréa Willemin, Leonardo Beccari, Sandra Gitto, Bénédicte Mascrez, and Denis Duboule Ecology [Conservation cobenefits from air pollution regulation: Evidence from birds]( Yuanning Liang, Ivan Rudik, Eric Yongchen Zou, Alison Johnston, Amanda D. Rodewald, and Catherine L. Kling [Ultrahigh foraging rates of Baikal seals make tiny endemic amphipods profitable in Lake Baikal]( Yuuki Y. Watanabe, Eugene A. Baranov, and Nobuyuki Miyazaki [Differences in spatial versus temporal reaction norms for spring and autumn phenological events]( Maria del Mar Delgado, Tomas Roslin, Gleb Tikhonov, Evgeniy Meyke, Coong Lo, Eliezer Gurarie, Marina Abadonova, Ozodbek Abduraimov, Olga Adrianova, Tatiana Akimova, Muzhigit Akkiev, Aleksandr Ananin, Elena Andreeva, Natalia Andriychuk, Maxim Antipin, Konstantin Arzamascev, Svetlana Babina, Miroslav Babushkin, Oleg Bakin, Anna Barabancova, Inna Basilskaja, Nina Belova, Natalia Belyaeva, Tatjana Bespalova, Evgeniya Bisikalova, Anatoly Bobretsov, Vladimir Bobrov, Vadim Bobrovskyi, Elena Bochkareva, Gennady Bogdanov, Vladimir Bolshakov, Svetlana Bondarchuk, Evgeniya Bukharova, Alena Butunina, Yuri Buyvolov, Anna Buyvolova, Yuri Bykov, Elena Chakhireva, Olga Chashchina, Nadezhda Cherenkova, Sergej Chistjakov, Svetlana Chuhontseva, Evgeniy A. Davydov, Viktor Demchenko, Elena Diadicheva, Aleksandr Dobrolyubov, Ludmila Dostoyevskaya, Svetlana Drovnina, Zoya Drozdova, Akynaly Dubanaev, Yuriy Dubrovsky, Sergey Elsukov, Lidia Epova, Olga S. Ermakova, Olga Ermakova, Aleksandra Esengeldenova, Oleg Evstigneev, Irina Fedchenko, Violetta Fedotova, Tatiana Filatova, Sergey Gashev, Anatoliy Gavrilov, Irina Gaydysh, Dmitrij Golovcov, Nadezhda Goncharova, Elena Gorbunova, Tatyana Gordeeva, Vitaly Grishchenko, Ludmila Gromyko, Vladimir Hohryakov, Alexander Hritankov, Elena Ignatenko, Svetlana Igosheva, Uliya Ivanova, Natalya Ivanova, Yury Kalinkin, Evgeniya Kaygorodova, Fedor Kazansky, Darya Kiseleva, Anastasia Knorre, Leonid Kolpashikov, Evgenii Korobov, Helen Korolyova, Natalia Korotkikh, Gennadiy Kosenkov, Sergey Kossenko, Elvira Kotlugalyamova, Evgeny Kozlovsky, Vladimir Kozsheechkin, Alla Kozurak, Irina Kozyr, Aleksandra Krasnopevtseva, Sergey Kruglikov, Olga Kuberskaya, Aleksey Kudryavtsev, Elena Kulebyakina, Yuliia Kulsha, Margarita Kupriyanova, Murad Kurbanbagamaev, Anatoliy Kutenkov, Nadezhda Kutenkova, Nadezhda Kuyantseva, Andrey Kuznetsov, Evgeniy Larin, Pavel Lebedev, Kirill Litvinov, Natalia Luzhkova, Azizbek Mahmudov, Lidiya Makovkina, Viktor Mamontov, Svetlana Mayorova, Irina Megalinskaja, Artur Meydus, Aleksandr Minin, Oleg Mitrofanov, Mykhailo Motruk, Aleksandr Myslenkov, Nina Nasonova, Natalia Nemtseva, Irina Nesterova, Tamara Nezdoliy, Tatyana Niroda, Tatiana Novikova, Darya Panicheva, Alexey Pavlov, Klara Pavlova, Polina Van, Sergei Podolski, Natalja Polikarpova, Tatiana Polyanskaya, Igor Pospelov, Elena Pospelova, Ilya Prokhorov, Irina Prokosheva, Lyudmila Puchnina, Ivan Putrashyk, Julia Raiskaya, Yuri Rozhkov, Olga Rozhkova, Marina Rudenko, Irina Rybnikova, Svetlana Rykova, Miroslava Sahnevich, Alexander Samoylov, Valeri Sanko, Inna Sapelnikova, Sergei Sazonov, Zoya Selyunina, Ksenia Shalaeva, Maksim Shashkov, Anatoliy Shcherbakov, Vasyl Shevchyk, Sergej Shubin, Elena Shujskaja, Rustam Sibgatullin, Natalia Sikkila, Elena Sitnikova, Andrei Sivkov, Nataliya Skok, Svetlana Skorokhodova, Elena Smirnova, Galina Sokolova, Vladimir Sopin, Yurii Spasovski, Serg ei Stepanov, Vitalіy Stratiy, Violetta Strekalovskaya, Alexander Sukhov, Guzalya Suleymanova, Lilija Sultangareeva, Viktorija Teleganova, Viktor Teplov, Valentina Teplova, Tatiana Tertitsa, Vladislav Timoshkin, Dmitry Tirski, Andrej Tolmachev, Aleksey Tomilin, Ludmila Tselishcheva, Mirabdulla Turgunov, Yurij Tyukh, Vladimir Van, Elena Ershkova, Aleksander Vasin, Aleksandra Vasina, Anatoliy Vekliuk, Lidia Vetchinnikova, Vladislav Vinogradov, Nikolay Volodchenkov, Inna Voloshina, Tura Xoliqov, Eugenia Yablonovska-Grishchenko, Vladimir Yakovlev, Marina Yakovleva, Oksana Yantser, Yurij Yarema, Andrey Zahvatov, Valery Zakharov, Nicolay Zelenetskiy, Anatolii Zheltukhin, Tatyana Zubina, Juri Kurhinen, and Otso Ovaskainen Environmental Sciences [Triclosan leads to dysregulation of the metabolic regulator FGF21 exacerbating high fat diet-induced nonalcoholic fatty liver disease]( Mei-Fei Yueh, Feng He, Chen Chen, Catherine Vu, Anupriya Tripathi, Rob Knight, Michael Karin, Shujuan Chen, and Robert H. Tukey Evolution [Mycena genomes resolve the evolution of fungal bioluminescence]( Huei-Mien Ke, Hsin-Han Lee, Chan-Yi Ivy Lin, Yu-Ching Liu, Min R. Lu, Jo-Wei Allison Hsieh, Chiung-Chih Chang, Pei-Hsuan Wu, Meiyeh Jade Lu, Jeng-Yi Li, Gaus Shang, Rita Jui-Hsien Lu, László G. Nagy, Pao-Yang Chen, Hsiao-Wei Kao, and Isheng Jason Tsai Genetics [Ultrarare heterozygous pathogenic variants of genes causing dominant forms of early-onset deafness underlie severe presbycusis]( Sophie Boucher, Fabienne Wong Jun Tai, Sedigheh Delmaghani, Andrea Lelli, Amrit Singh-Estivalet, Typhaine Dupont, Magali Niasme-Grare, Vincent Michel, Nicolas Wolff, Amel Bahloul, Yosra Bouyacoub, Didier Bouccara, Bernard Fraysse, Olivier Deguine, Lionel Collet, Hung Thai-Van, Eugen Ionescu, Jean-Louis Kemeny, Fabrice Giraudet, Jean-Pierre Lavieille, Arnaud Devèze, Anne-Laure Roudevitch-Pujol, Christophe Vincent, Christian Renard, Valérie Franco-Vidal, Claire Thibult-Apt, Vincent Darrouzet, Eric Bizaguet, Arnaud Coez, Hugues Aschard, Nicolas Michalski, Gaëlle M. Lefevre, Anne Aubois, Paul Avan, Crystel Bonnet, and Christine Petit [KRAB zinc finger protein diversification drives mammalian interindividual methylation variability]( Tessa M. Bertozzi, Jessica L. Elmer, Todd S. Macfarlan, and Anne C. Ferguson-Smith [Decreased mechanotransduction prevents nuclear collapse in a Caenorhabditis elegans laminopathy]( Gabriela Huelgas-Morales, Mark Sanders, Gemechu Mekonnen, Tatsuya Tsukamoto, and David Greenstein Immunology and Inflammation [Retinol binding protein 4 primes the NLRP3 inflammasome by signaling through Toll-like receptors 2 and 4]( Pedro M. Moraes-Vieira, Mark M. Yore, Alexandra Sontheimer-Phelps, Angela Castoldi, Julie Norseen, Pratik Aryal, Kotryna Simonyté Sjödin , and Barbara B. Kahn [Cytocidal macrophages in symbiosis with CD4 and CD8 T cells cause acute diabetes following checkpoint blockade of PD-1 in NOD mice]( Hao Hu, Pavel N. Zakharov, Orion J. Peterson, and Emil R. Unanue [TAO-kinase 3 governs the terminal differentiation of NOTCH2-dependent splenic conventional dendritic cells]( Matthias Vanderkerken, Bastiaan Maes, Lana Vandersarren, Wendy Toussaint, Kim Deswarte, Manon Vanheerswynghels, Philippe Pouliot, Liesbet Martens, Sofie Van Gassen, Connie M. Arthur, Margaret E. Kirkling, Boris Reizis, Daniel Conrad, Sean Stowell, Hamida Hammad, and Bart N. Lambrecht [The Ig heavy chain protein but not its message controls early B cell development]( Muhammad Assad Aslam, Mir Farshid Alemdehy, Bingtao Hao, Peter H. L. Krijger, Colin E. J. Pritchard, Iris de Rink, Fitriari Izzatunnisa Muhaimin, Ika Nurzijah, Martijn van Baalen, Ron M. Kerkhoven, Paul C. M. van den Berk, Jane A. Skok, and Heinz Jacobs Medical Sciences [A steroid receptor coactivator stimulator (MCB-613) attenuates adverse remodeling after myocardial infarction]( Lisa K. Mullany, Aarti D. Rohira, John P. Leach, Jong H. Kim, Tanner O. Monroe, Andrea R. Ortiz, Brittany Stork, M. Waleed Gaber, Poonam Sarkar, Andrew G. Sikora, Todd K. Rosengart, Brian York, Yongcheng Song, Clifford C. Dacso, David M. Lonard, James F. Martin, and Bert W. O’Malley [Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors]( Rachel P. M. Abrams, Adam Yasgar, Tadahisa Teramoto, Myoung-Hwa Lee, Dorjbal Dorjsuren, Richard T. Eastman, Nasir Malik, Alexey V. Zakharov, Wenxue Li, Muzna Bachani, Kyle Brimacombe, Joseph P. Steiner, Matthew D. Hall, Anuradha Balasubramanian, Ajit Jadhav, Radhakrishnan Padmanabhan, Anton Simeonov, and Avindra Nath Microbiology [Designer broad-spectrum polyimidazolium antibiotics]( Wenbin Zhong, Zhenyu Shi, Surendra H. Mahadevegowda, Bo Liu, Kaixi Zhang, Chong Hui Koh, Lin Ruan, Yahua Chen, Merve S. Zeden, Carmen J. E. Pee, Kalisvar Marimuthu, Partha Pratim De, Oon Tek Ng, Yabin Zhu, Yonggui Robin Chi, Paula T. Hammond, Liang Yang, Yunn-Hwen Gan, Kevin Pethe, E. Peter Greenberg, Angelika Gründling, and Mary B. Chan-Park [Capillary leakage provides nutrients and antioxidants for rapid pneumococcal proliferation in influenza-infected lower airways]( Vicky Sender, Karina Hentrich, Anuj Pathak, Alicia Tan Qian Ler, Bethel Tesfai Embaie, Susanna L. Lundström, Massimiliano Gaetani, Jan Bergstrand, Rei Nakamoto, Lok-To Sham, Jerker Widengren, Staffan Normark, and Birgitta Henriques-Normark [A peptide of a type I toxin−antitoxin system induces Helicobacter pylori morphological transformation from spiral shape to coccoids]( Lamya El Mortaji, Alejandro Tejada-Arranz, Aline Rifflet, Ivo G. Boneca, Gérard Pehau-Arnaudet, J. Pablo Radicella, Stéphanie Marsin, and Hilde De Reuse [Unbiased optical mapping of telomere-integrated endogenous human herpesvirus 6]( Darren J. Wight, Giulia Aimola, Amr Aswad, Chi-Yu Jill Lai, Christian Bahamon, Karl Hong, Joshua A. Hill, and Benedikt B. Kaufer [Studies in bank voles reveal strain differences between chronic wasting disease prions from Norway and North America]( Romolo Nonno, Michele A. Di Bari, Laura Pirisinu, Claudia D’Agostino, Ilaria Vanni, Barbara Chiappini, Stefano Marcon, Geraldina Riccardi, Linh Tran, Turid Vikøren, Jørn Våge, Knut Madslien, Gordon Mitchell, Glenn C. Telling, Sylvie L. Benestad, and Umberto Agrimi Neuroscience [Design of a multivalent bifunctional chelator for diagnostic 64Cu PET imaging in Alzheimer’s disease]( Hong-Jun Cho, Truc T. Huynh, Buck E. Rogers, and Liviu M. Mirica [A general model of hippocampal and dorsal striatal learning and decision making]( Jesse P. Geerts, Fabian Chersi, Kimberly L. Stachenfeld, and Neil Burgess [Synaptotagmin-7 deficiency induces mania-like behavioral abnormalities through attenuating GluN2B activity]( Qiu-Wen Wang, Si-Yao Lu, Yao-Nan Liu, Yun Chen, Hui Wei, Wei Shen, Yan-Fen Chen, Chong-Lei Fu, Ying-Han Wang, Anbang Dai, Xuan Huang, Fred H. Gage, Qi Xu, and Jun Yao [High-resolution mouse subventricular zone stem-cell niche transcriptome reveals features of lineage, anatomy, and aging]( Xuanhua P. Xie, Dan R. Laks, Daochun Sun, Asaf Poran, Ashley M. Laughney, Zilai Wang, Jessica Sam, German Belenguer, Isabel Fariñas, Olivier Elemento, Xiuping Zhou, and Luis F. Parada [Layer and rhythm specificity for predictive routing]( André M. Bastos, Mikael Lundqvist, Ayan S. Waite, Nancy Kopell, and Earl K. Miller [Structure–function subsystem models of female and male forebrain networks integrating cognition, affect, behavior, and bodily functions]( Larry W. Swanson, Joel D. Hahn, and Olaf Sporns [Distinct neural ensemble response statistics are associated with recognition and discrimination of natural sound textures]( Xiu Zhai, Fatemeh Khatami, Mina Sadeghi, Fengrong He, Heather L. Read, Ian H. Stevenson, and Monty A. Escabí [Bumblebees perceive the spatial layout of their environment in relation to their body size and form to minimize inflight collisions]( Sridhar Ravi, Tim Siesenop, Olivier Bertrand, Liang Li, Charlotte Doussot, William H. Warren, Stacey A. Combes, and Martin Egelhaaf Physiology [Functional redundancy of type I and type II receptors in the regulation of skeletal muscle growth by myostatin and activin A]( Se-Jin Lee, Adam Lehar, Yewei Liu, Chi Hai Ly, Quynh-Mai Pham, Michael Michaud, Renata Rydzik, Daniel W. Youngstrom, Michael M. Shen, Vesa Kaartinen, Emily L. Germain-Lee, and Thomas A. Rando [Race and ethnic variation in college students’ allostatic regulation of racism-related stress]( Jacob E. Cheadle, Bridget J. Goosby, Joseph C. Jochman, Cara C. Tomaso, Chelsea B. Kozikowski Yancey, and Timothy D. Nelson Plant Biology [The Arabidopsis NRT1/PTR FAMILY protein NPF7.3/NRT1.5 is an indole-3-butyric acid transporter involved in root gravitropism]( Shunsuke Watanabe, Naoki Takahashi, Yuri Kanno, Hiromi Suzuki, Yuki Aoi, Noriko Takeda-Kamiya, Kiminori Toyooka, Hiroyuki Kasahara, Ken-ichiro Hayashi, Masaaki Umeda, and Mitsunori Seo [A receptor-like protein mediates plant immune responses to herbivore-associated molecular patterns]( Adam D. Steinbrenner, Maria Muñoz-Amatriaín, Antonio F. Chaparro, Jessica Montserrat Aguilar-Venegas, Sassoum Lo, Satohiro Okuda, Gaetan Glauser, Julien Dongiovanni, Da Shi, Marlo Hall, Daniel Crubaugh, Nicholas Holton, Cyril Zipfel, Ruben Abagyan, Ted C. J. Turlings, Timothy J. Close, Alisa Huffaker, and Eric A. Schmelz Population Biology [Global analysis of more than 50,000 SARS-CoV-2 genomes reveals epistasis between eight viral genes]( Hong-Li Zeng, Vito Dichio, Edwin Rodríguez Horta, Kaisa Thorell, and Erik Aurell Psychological and Cognitive Sciences [Dogmatism manifests in lowered information search under uncertainty]( Lion Schulz, Max Rollwage, Raymond J. Dolan, and Stephen M. Fleming Systems Biology [Inhibition of 3-phosphoinositide–dependent protein kinase 1 (PDK1) can revert cellular senescence in human dermal fibroblasts]( Sugyun An, Si-Young Cho, Junsoo Kang, Soobeom Lee, Hyung-Su Kim, Dae-Jin Min, EuiDong Son, and Kwang-Hyun Cho --------------------------------------------------------------- Corrections [Correction for Ciaravella et al., X-ray processing of a realistic ice mantle can explain the gas abundances in protoplanetary disks]( [Correction for Kessler et al., Victorin, the host-selective cyclic peptide toxin from the oat pathogen Cochliobolus victoriae, is ribosomally encoded]( [Correction for You et al., HERES, a lncRNA that regulates canonical and noncanonical Wnt signaling pathways via interaction with EZH2]( [Correction for Allen et al., A comparative genomics approach identifies contact-dependent growth inhibition as a virulence determinant]( [Cover] --------------------------------------------------------------- This message was sent to {EMAIL}. 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