PNAS Table of Contents for December 1, 2020; Vol. 117, No. 48

[PNAS] [Special Feature Banner](/cgi/adclick/?ad=55425&adclick=true&url=https%3A%2F%2Fwww.pnas.org%2Fcc%2Farthur-m-sackler-colloquium-brain-produces-mind-by-modeling)   [December 1, 2020; Vol. 117, No. 48]( ) This Week in PNAS [In This Issue]( This week's research highlights --------------------------------------------------------------- Opinion [Opinion: Biodiversity conservation during a global crisis: Consequences and the way forward]( Alok Bang and Suvarna Khadakkar Leading scientists discuss current issues --------------------------------------------------------------- Profile [Profile of Joel D. Blum]( Jennifer Viegas The life and work of NAS members --------------------------------------------------------------- Commentaries [Hippocampal plasticity may drive cocaine relapse]( Vanessa E. Lehmann and Paul J. Kenny [Are nearly free silanols a unifying structural determinant of silica particle toxicity?]( C. Jeffrey Brinker, Kimberly S. Butler, and Stephen H. Garofalini [In fatal COVID-19, the immune response can control the virus but kill the patient]( Arturo Casadevall and Liise-anne Pirofski [Hawks, Doves, and mongooses]( Michael L. Wilson --------------------------------------------------------------- Perspective [Ethics in field experimentation: A call to establish new standards to protect the public from unwanted manipulation and real harms]( Rose McDermott and Peter K. Hatemi --------------------------------------------------------------- Letters [Aspect ratio dependence of the ultimate-state transition in turbulent thermal convection]( Xiaozhou He, Eberhard Bodenschatz, and Guenter Ahlers [Reply to He et al.: The dependence of heat transport law on aspect ratio is still unclear]( Kartik P. Iyer, Janet D. Scheel, Jörg Schumacher, and Katepalli R. Sreenivasan [Safety concerns regarding concomitant use of tocilizumab and glucocorticoids in COVID-19 patients]( Chengliang Yang, Elizabeth Liu, and Mingyao Liu [Reply to Yang et al.: Tocilizumab treatment in COVID-19 patients needs the assessment of the disease severity and timely intervention]( Xiaoling Xu, Mingfeng Han, Tiantian Li, Wei Sun, Dongsheng Wang, Binqing Fu, Yonggang Zhou, Xiaohu Zheng, Yun Yang, Xiuyong Li, Xiaohua Zhang, Aijun Pan, and Haiming Wei --------------------------------------------------------------- Colloquium on the Science of Deep Learning Introduction [The science of deep learning]( Richard Baraniuk, David Donoho, and Matan Gavish Colloquium Papers [The unreasonable effectiveness of deep learning in artificial intelligence]( Terrence J. Sejnowski [Theoretical issues in deep networks]( Tomaso Poggio, Andrzej Banburski, and Qianli Liao [Emergent linguistic structure in artificial neural networks trained by self-supervision]( Christopher D. Manning, Kevin Clark, John Hewitt, Urvashi Khandelwal, and Omer Levy [The frontier of simulation-based inference]( Kyle Cranmer, Johann Brehmer, and Gilles Louppe [Benign overfitting in linear regression]( Peter L. Bartlett, Philip M. Long, Gábor Lugosi, and Alexander Tsigler [Understanding the role of individual units in a deep neural network]( David Bau, Jun-Yan Zhu, Hendrik Strobelt, Agata Lapedriza, Bolei Zhou, and Antonio Torralba [Fast reinforcement learning with generalized policy updates]( André Barreto, Shaobo Hou, Diana Borsa, David Silver, and Doina Precup [On instabilities of deep learning in image reconstruction and the potential costs of AI]( Vegard Antun, Francesco Renna, Clarice Poon, Ben Adcock, and Anders C. Hansen [Algorithms as discrimination detectors]( Jon Kleinberg, Jens Ludwig, Sendhil Mullainathan, and Cass R. Sunstein --------------------------------------------------------------- Brief Reports [The effect of tethering on the clearance rate of suspension-feeding plankton]( Anders Andersen and Thomas Kiørboe [The interplay of movement and spatiotemporal variation in transmission degrades pandemic control]( Nicholas Kortessis, Margaret W. Simon, Michael Barfield, Gregory E. Glass, Burton H. Singer, and Robert D. Holt --------------------------------------------------------------- Physical Sciences Applied Mathematics [Theoretical issues in deep networks]( Tomaso Poggio, Andrzej Banburski, and Qianli Liao [On instabilities of deep learning in image reconstruction and the potential costs of AI]( Vegard Antun, Francesco Renna, Clarice Poon, Ben Adcock, and Anders C. Hansen Applied Physical Sciences [Hyperchromatic structural color for perceptually enhanced sensing by the naked eye]( Tahmid H. Talukdar, Bria McCoy, Sarah K. Timmins, Taufiquar Khan, and Judson D. Ryckman [Heterogeneity in social and epidemiological factors determines the risk of measles outbreaks]( Paolo Bosetti, Piero Poletti, Massimo Stella, Bruno Lepri, Stefano Merler, and Manlio De Domenico Biophysics and Computational Biology [Structure and regulation of the BsYetJ calcium channel in lipid nanodiscs]( Chieh-Chin Li, Te-Yu Kao, Chu-Chun Cheng, and Yun-Wei Chiang [Structure of eukaryotic DNA polymerase δ bound to the PCNA clamp while encircling DNA]( Fengwei Zheng, Roxana E. Georgescu, Huilin Li, and Michael E. O’Donnell [Replisome bypass of a protein-based R-loop block by Pif1]( Grant D. Schauer, Lisanne M. Spenkelink, Jacob S. Lewis, Olga Yurieva, Stefan H. Mueller, Antoine M. van Oijen, and Michael E. O’Donnell [Tight and specific lanthanide binding in a de novo TIM barrel with a large internal cavity designed by symmetric domain fusion]( Shane J. Caldwell, Ian C. Haydon, Nikoletta Piperidou, Po-Ssu Huang, Matthew J. Bick, H. Sebastian Sjöström, Donald Hilvert, David Baker, and Cathleen Zeymer [An S/T motif controls reversible oligomerization of the Hsp40 chaperone DNAJB6b through subtle reorganization of a β sheet backbone]( Theodoros K. Karamanos, Vitali Tugarinov, and G. Marius Clore [Markov state modeling reveals alternative unbinding pathways for peptide–MHC complexes]( Jayvee R. Abella, Dinler Antunes, Kyle Jackson, Gregory Lizée, Cecilia Clementi, and Lydia E. Kavraki [mGreenLantern: a bright monomeric fluorescent protein with rapid expression and cell filling properties for neuronal imaging]( Benjamin C. Campbell, Elisa M. Nabel, Mitchell H. Murdock, Cristina Lao-Peregrin, Pantelis Tsoulfas, Murray G. Blackmore, Francis S. Lee, Conor Liston, Hirofumi Morishita, and Gregory A. Petsko Chemistry [Stable metal anodes enabled by a labile organic molecule bonded to a reduced graphene oxide aerogel]( Yue Gao, Daiwei Wang, Yun Kyung Shin, Zhifei Yan, Zhuo Han, Ke Wang, Md Jamil Hossain, Shuling Shen, Atif AlZahrani, Adri C. T. van Duin, Thomas E. Mallouk, and Donghai Wang [A chemical dynamics study on the gas-phase formation of triplet and singlet C5H2 carbenes]( Chao He, Galiya R. Galimova, Yuheng Luo, Long Zhao, André K. Eckhardt, Rui Sun, Alexander M. Mebel, and Ralf I. Kaiser [Absolute ion hydration free energy scale and the surface potential of water via quantum simulation]( Yu Shi and Thomas L. Beck Computer Sciences [The unreasonable effectiveness of deep learning in artificial intelligence]( Terrence J. Sejnowski [Emergent linguistic structure in artificial neural networks trained by self-supervision]( Christopher D. Manning, Kevin Clark, John Hewitt, Urvashi Khandelwal, and Omer Levy [Understanding the role of individual units in a deep neural network]( David Bau, Jun-Yan Zhu, Hendrik Strobelt, Agata Lapedriza, Bolei Zhou, and Antonio Torralba [Fast reinforcement learning with generalized policy updates]( André Barreto, Shaobo Hou, Diana Borsa, David Silver, and Doina Precup [Algorithms as discrimination detectors]( Jon Kleinberg, Jens Ludwig, Sendhil Mullainathan, and Cass R. Sunstein Earth, Atmospheric, and Planetary Sciences [From particle attachment to space-filling coral skeletons]( Chang-Yu Sun, Cayla A. Stifler, Rajesh V. Chopdekar, Connor A. Schmidt, Ganesh Parida, Vanessa Schoeppler, Benjamin I. Fordyce, Jack H. Brau, Tali Mass, Sylvie Tambutté, and Pupa U. P. A. Gilbert [Molecular and isotopic evidence reveals the end-Triassic carbon isotope excursion is not from massive exogenous light carbon]( Calum P. Fox, Xingqian Cui, Jessica H. Whiteside, Paul E. Olsen, Roger E. Summons, and Kliti Grice [Solar geoengineering may not prevent strong warming from direct effects of CO2 on stratocumulus cloud cover]( Tapio Schneider, Colleen M. Kaul, and Kyle G. Pressel Engineering [Dirac cones and chiral selection of elastic waves in a soft strip]( Maxime Lanoy, Fabrice Lemoult, Antonin Eddi, and Claire Prada [Ionization behavior of nanoporous polyamide membranes]( Cody L. Ritt, Jay R. Werber, Mengyi Wang, Zhongyue Yang, Yumeng Zhao, Heather J. Kulik, and Menachem Elimelech [Swimming microorganisms acquire optimal efficiency with multiple cilia]( Toshihiro Omori, Hiroaki Ito, and Takuji Ishikawa [Constitutive relationship and governing physical properties for magnetophoresis]( Ayankola O. Ayansiji, Anish V. Dighe, Andreas A. Linninger, and Meenesh R. Singh Physics [Critical point for Bose–Einstein condensation of excitons in graphite]( Jinhua Wang, Pan Nie, Xiaokang Li, Huakun Zuo, Benoît Fauqué, Zengwei Zhu, and Kamran Behnia [From antiferromagnetic and hidden order to Pauli paramagnetism in UM2Si2 compounds with 5f electron duality]( Andrea Amorese, Martin Sundermann, Brett Leedahl, Andrea Marino, Daisuke Takegami, Hlynur Gretarsson, Andrei Gloskovskii, Christoph Schlueter, Maurits W. Haverkort, Yingkai Huang, Maria Szlawska, Dariusz Kaczorowski, Sheng Ran, M. Brian Maple, Eric D. Bauer, Andreas Leithe-Jasper, Philipp Hansmann, Peter Thalmeier, Liu Hao Tjeng, and Andrea Severing [Flow-induced choking of a compliant Hele-Shaw cell]( Finn Box, Gunnar G. Peng, Draga Pihler-Puzović, and Anne Juel [Machine-learning iterative calculation of entropy for physical systems]( Amit Nir, Eran Sela, Roy Beck, and Yohai Bar-Sinai [Multiscale structural complexity of natural patterns]( Andrey A. Bagrov, Ilia A. Iakovlev, Askar A. Iliasov, Mikhail I. Katsnelson, and Vladimir V. Mazurenko [Hidden symmetries generate rigid folding mechanisms in periodic origami]( James McInerney, Bryan Gin-ge Chen, Louis Theran, Christian D. Santangelo, and D. Zeb Rocklin [Topological Weaire–Thorpe models of amorphous matter]( Quentin Marsal, Dániel Varjas, and Adolfo G. Grushin Statistics [The frontier of simulation-based inference]( Kyle Cranmer, Johann Brehmer, and Gilles Louppe [Benign overfitting in linear regression]( Peter L. Bartlett, Philip M. Long, Gábor Lugosi, and Alexander Tsigler [Methods for correcting inference based on outcomes predicted by machine learning]( Siruo Wang, Tyler H. McCormick, and Jeffrey T. Leek [Estimating and forecasting spatial population dynamics of apex predators using transnational genetic monitoring]( Richard Bischof, Cyril Milleret, Pierre Dupont, Joseph Chipperfield, Mahdieh Tourani, Andrés Ordiz, Perry de Valpine, Daniel Turek, J. Andrew Royle, Olivier Gimenez, Øystein Flagstad, Mikael Åkesson, Linn Svensson, Henrik Brøseth, and Jonas Kindberg --------------------------------------------------------------- Social Sciences Anthropology [Matriliny reverses gender disparities in inflammation and hypertension among the Mosuo of China]( Adam Z. Reynolds, Katherine Wander, Chun-Yi Sum, Mingjie Su, Melissa Emery Thompson, Paul L. Hooper, Hui Li, Mary K. Shenk, Kathrine E. Starkweather, Tami Blumenfield, and Siobhán M. Mattison Psychological and Cognitive Sciences [Reconciling print-size and display-size constraints on reading]( Nilsu Atilgan, Ying-Zi Xiong, and Gordon E. Legge Social Sciences [Network interventions for managing the COVID-19 pandemic and sustaining economy]( Akihiro Nishi, George Dewey, Akira Endo, Sophia Neman, Sage K. Iwamoto, Michael Y. Ni, Yusuke Tsugawa, Georgios Iosifidis, Justin D. Smith, and Sean D. Young [The social patterning of autism diagnoses reversed in California between 1992 and 2018]( Alix S. Winter, Christine Fountain, Keely Cheslack-Postava, and Peter S. Bearman [The confidence gap predicts the gender pay gap among STEM graduates]( Adina D. Sterling, Marissa E. Thompson, Shiya Wang, Abisola Kusimo, Shannon Gilmartin, and Sheri Sheppard [The changing geography of social mobility in the United States]( Dylan Shane Connor and Michael Storper Sustainability Science [Consequences of seafood mislabeling for marine populations and fisheries management]( Kailin Kroetz, Gloria M. Luque, Jessica A. Gephart, Sunny L. Jardine, Patrick Lee, Katrina Chicojay Moore, Cassandra Cole, Andrew Steinkruger, and C. Josh Donlan --------------------------------------------------------------- Biological Sciences Anthropology [Matriliny reverses gender disparities in inflammation and hypertension among the Mosuo of China]( Adam Z. Reynolds, Katherine Wander, Chun-Yi Sum, Mingjie Su, Melissa Emery Thompson, Paul L. Hooper, Hui Li, Mary K. Shenk, Kathrine E. Starkweather, Tami Blumenfield, and Siobhán M. Mattison Applied Biological Sciences [Glutaric acid production by systems metabolic engineering of an l-lysine–overproducing Corynebacterium glutamicum]( Taehee Han, Gi Bae Kim, and Sang Yup Lee [Delivery of muscle-derived exosomal miRNAs induced by HIIT improves insulin sensitivity through down-regulation of hepatic FoxO1 in mice]( Carlos Castaño, Mercedes Mirasierra, Mario Vallejo, Anna Novials, and Marcelina Párrizas Biochemistry [Structure and regulation of the BsYetJ calcium channel in lipid nanodiscs]( Chieh-Chin Li, Te-Yu Kao, Chu-Chun Cheng, and Yun-Wei Chiang [Structure of eukaryotic DNA polymerase δ bound to the PCNA clamp while encircling DNA]( Fengwei Zheng, Roxana E. Georgescu, Huilin Li, and Michael E. O’Donnell [Replisome bypass of a protein-based R-loop block by Pif1]( Grant D. Schauer, Lisanne M. Spenkelink, Jacob S. Lewis, Olga Yurieva, Stefan H. Mueller, Antoine M. van Oijen, and Michael E. O’Donnell [Tight and specific lanthanide binding in a de novo TIM barrel with a large internal cavity designed by symmetric domain fusion]( Shane J. Caldwell, Ian C. Haydon, Nikoletta Piperidou, Po-Ssu Huang, Matthew J. Bick, H. Sebastian Sjöström, Donald Hilvert, David Baker, and Cathleen Zeymer [Structure-function analysis of microRNA 3′-end trimming by Nibbler]( Wei Xie, Ivica Sowemimo, Rippei Hayashi, Juncheng Wang, Thomas R. Burkard, Julius Brennecke, Stefan L. Ameres, and Dinshaw J. Patel [Crystal structure of a guanine nucleotide exchange factor encoded by the scrub typhus pathogen Orientia tsutsugamushi]( Christopher Lim, Jason M. Berk, Alyssa Blaise, Josie Bircher, Anthony J. Koleske, Mark Hochstrasser, and Yong Xiong [NAP1-Related Protein 1 (NRP1) has multiple interaction modes for chaperoning histones H2A-H2B]( Qiang Luo, Baihui Wang, Zhen Wu, Wen Jiang, Yueyue Wang, Kangxi Du, Nana Zhou, Lina Zheng, Jianhua Gan, Wen-Hui Shen, Jinbiao Ma, and Aiwu Dong [FMRP links optimal codons to mRNA stability in neurons]( Huan Shu, Elisa Donnard, Botao Liu, Suna Jung, Ruijia Wang, and Joel D. Richter [Mobile loop dynamics in adenosyltransferase control binding and reactivity of coenzyme B12]( Romila Mascarenhas, Markus Ruetz, Liam McDevitt, Markos Koutmos, and Ruma Banerjee [The antibiotic sorangicin A inhibits promoter DNA unwinding in a Mycobacterium tuberculosis rifampicin-resistant RNA polymerase]( Mirjana Lilic, James Chen, Hande Boyaci, Nathaniel Braffman, Elizabeth A. Hubin, Jennifer Herrmann, Rolf Müller, Rachel Mooney, Robert Landick, Seth A. Darst, and Elizabeth A. Campbell [Interface switch mediates signal transmission in a two-component system]( Mingxing Wang, Qiong Guo, Kongfu Zhu, Bo Fang, Yifan Yang, Maikun Teng, Xu Li, and Yuyong Tao Biophysics and Computational Biology [From particle attachment to space-filling coral skeletons]( Chang-Yu Sun, Cayla A. Stifler, Rajesh V. Chopdekar, Connor A. Schmidt, Ganesh Parida, Vanessa Schoeppler, Benjamin I. Fordyce, Jack H. Brau, Tali Mass, Sylvie Tambutté, and Pupa U. P. A. Gilbert [An S/T motif controls reversible oligomerization of the Hsp40 chaperone DNAJB6b through subtle reorganization of a β sheet backbone]( Theodoros K. Karamanos, Vitali Tugarinov, and G. Marius Clore [Biophysical analysis of the structural evolution of substrate specificity in RuBisCO]( Saroj Poudel, Douglas H. Pike, Hagai Raanan, Joshua A. Mancini, Vikas Nanda, Rosalind E. M. Rickaby, and Paul G. Falkowski [Structural basis for polarized elongation of actin filaments]( Vilmos Zsolnay, Harshwardhan H. Katkar, Steven Z. Chou, Thomas D. Pollard, and Gregory A. Voth [Single-molecule and in silico dissection of the interaction between Polycomb repressive complex 2 and chromatin]( Rachel Leicher, Eva J. Ge, Xingcheng Lin, Matthew J. Reynolds, Wenjun Xie, Thomas Walz, Bin Zhang, Tom W. Muir, and Shixin Liu Cell Biology [Modular transient nanoclustering of activated β2-adrenergic receptors revealed by single-molecule tracking of conformation-specific nanobodies]( Rachel S. Gormal, Pranesh Padmanabhan, Ravikiran Kasula, Adekunle T. Bademosi, Sean Coakley, Jean Giacomotto, Ailisa Blum, Merja Joensuu, Tristan P. Wallis, Harriet P. Lo, Srikanth Budnar, James Rae, Charles Ferguson, Michele Bastiani, Walter G. Thomas, Els Pardon, Jan Steyaert, Alpha S. Yap, Geoffrey J. Goodhill, Massimo A. Hilliard, Robert G. Parton, and Frédéric A. Meunier [FoxO1 is a crucial mediator of TGF-β/TAK1 signaling and protects against osteoarthritis by maintaining articular cartilage homeostasis]( Cuicui Wang, Jie Shen, Jun Ying, Ding Xiao, and Regis J. O’Keefe [The Cockayne syndrome group A and B proteins are part of a ubiquitin–proteasome degradation complex regulating cell division]( Elena Paccosi, Federico Costanzo, Michele Costantino, Alessio Balzerano, Laura Monteonofrio, Silvia Soddu, Giorgio Prantera, Stefano Brancorsini, Jean-Marc Egly, and Luca Proietti-De-Santis Developmental Biology [Mammalian-specific ectodermal enhancers control the expression of Hoxc genes in developing nails and hair follicles]( Marc Fernandez-Guerrero, Nayuta Yakushiji-Kaminatsui, Lucille Lopez-Delisle, Sofía Zdral, Fabrice Darbellay, Rocío Perez-Gomez, Christopher Chase Bolt, Manuel A. Sanchez-Martin, Denis Duboule, and Marian A. Ros [Rox8 promotes microRNA-dependent yki messenger RNA decay]( Xiaowei Guo, Yihao Sun, Taha Azad, H. J. Janse van Rensburg, Jingjing Luo, Shuai Yang, Peng Liu, Zhongwei Lv, Meixiao Zhan, Ligong Lu, Yingqun Zhou, Xianjue Ma, Xiaoping Zhang, Xiaolong Yang, and Lei Xue Ecology [Estimating and forecasting spatial population dynamics of apex predators using transnational genetic monitoring]( Richard Bischof, Cyril Milleret, Pierre Dupont, Joseph Chipperfield, Mahdieh Tourani, Andrés Ordiz, Perry de Valpine, Daniel Turek, J. Andrew Royle, Olivier Gimenez, Øystein Flagstad, Mikael Åkesson, Linn Svensson, Henrik Brøseth, and Jonas Kindberg [Parental benefits and offspring costs reflect parent–offspring conflict over the age of fledging among songbirds]( Todd M. Jones, Jeffrey D. Brawn, Ian J. Ausprey, Andrew C. Vitz, Amanda D. Rodewald, Douglas W. Raybuck, Than J. Boves, Cameron J. Fiss, Darin J. McNeil, Scott H. Stoleson, Jeffery L. Larkin, W. Andrew Cox, Amy C. Schwarzer, Noah P. Horsley, Evalynn M. Trumbo, and Michael P. Ward [The impact of COVID-19 nonpharmaceutical interventions on the future dynamics of endemic infections]( Rachel E. Baker, Sang Woo Park, Wenchang Yang, Gabriel A. Vecchi, C. Jessica E. Metcalf, and Bryan T. Grenfell Evolution [Genomic islands of differentiation in a rapid avian radiation have been driven by recent selective sweeps]( Hussein A. Hejase, Ayelet Salman-Minkov, Leonardo Campagna, Melissa J. Hubisz, Irby J. Lovette, Ilan Gronau, and Adam Siepel Genetics [Aneuploidy increases resistance to chemotherapeutics by antagonizing cell division]( John Michael Replogle, Wen Zhou, Adrianna E. Amaro, James M. McFarland, Mariana Villalobos-Ortiz, Jeremy Ryan, Anthony Letai, Omer Yilmaz, Jason Sheltzer, Stephen J. Lippard, Uri Ben-David, and Angelika Amon [Exo1 recruits Cdc5 polo kinase to MutLγ to ensure efficient meiotic crossover formation]( Aurore Sanchez, Céline Adam, Felix Rauh, Yann Duroc, Lepakshi Ranjha, Bérangère Lombard, Xiaojing Mu, Mélody Wintrebert, Damarys Loew, Alba Guarné, Stefano Gnan, Chun-Long Chen, Scott Keeney, Petr Cejka, Raphaël Guérois, Franz Klein, Jean-Baptiste Charbonnier, and Valérie Borde [A microbial metabolite synergizes with endogenous serotonin to trigger C. elegans reproductive behavior]( Yen-Chih Chen, Mohammad R. Seyedsayamdost, and Niels Ringstad [Incompatibility between proliferation and plant invasion is mediated by a regulator of appressorium formation in the corn smut fungus Ustilago maydis]( Antonio de la Torre, Sónia Castanheira, and José Pérez-Martín Immunology and Inflammation [Markov state modeling reveals alternative unbinding pathways for peptide–MHC complexes]( Jayvee R. Abella, Dinler Antunes, Kyle Jackson, Gregory Lizée, Cecilia Clementi, and Lydia E. Kavraki [Leukotriene B4 licenses inflammasome activation to enhance skin host defense]( Ana Carolina Guerta Salina, Stephanie L. Brandt, Nathan Klopfenstein, Amondrea Blackman, Júlia Miranda Ribeiro Bazzano, Anderson Sá-Nunes, Nicole Byers-Glosson, Claudia Brodskyn, Natalia Machado Tavares, Icaro Bonyek Santos Da Silva, Alexandra I. Medeiros, and C. Henrique Serezani [TLR signaling adapter BCAP regulates inflammatory to reparatory macrophage transition by promoting histone lactylation]( Ricardo A. Irizarry-Caro, Margaret M. McDaniel, Garrett R. Overcast, Viral G. Jain, Ty Dale Troutman, and Chandrashekhar Pasare [Aberrant expression of USF2 in refractory rheumatoid arthritis and its regulation of proinflammatory cytokines in Th17 cells]( Dan Hu, Emily C. Tjon, Karin M. Andersson, Gabriela M. Molica, Minh C. Pham, Brian Healy, Gopal Murugaiyan, Nathalie Pochet, Vijay K. Kuchroo, Maria I. Bokarewa, and Howard L. Weiner [Thymus-derived B cell clones persist in the circulation after thymectomy in myasthenia gravis]( Ruoyi Jiang, Kenneth B. Hoehn, Casey S. Lee, Minh C. Pham, Robert J. Homer, Frank C. Detterbeck, Inmaculada Aban, Leslie Jacobson, Angela Vincent, Richard J. Nowak, Henry J. Kaminski, Steven H. Kleinstein, and Kevin C. O’Connor Medical Sciences [Label-free adaptive optics imaging of human retinal macrophage distribution and dynamics]( Daniel X. Hammer, Anant Agrawal, Ricardo Villanueva, Osamah Saeedi, and Zhuolin Liu [Unbiased in vivo preclinical evaluation of anticancer drugs identifies effective therapy for the treatment of pancreatic adenocarcinoma]( Olivera Grbovic-Huezo, Kenneth L. Pitter, Nicolas Lecomte, Joseph Saglimbeni, Gokce Askan, Matilda Holm, Jerry P. Melchor, Rohit Chandwani, Suhasini Joshi, Caj Haglund, Christine A. Iacobuzio-Donahue, Gabriela Chiosis, Tuomas Tammela, and Steven D. Leach Microbiology [Analysis of genomic distributions of SARS-CoV-2 reveals a dominant strain type with strong allelic associations]( Hsin-Chou Yang, Chun-houh Chen, Jen-Hung Wang, Hsiao-Chi Liao, Chih-Ting Yang, Chia-Wei Chen, Yin-Chun Lin, Chiun-How Kao, Mei-Yeh Jade Lu, and James C. Liao [The SKI complex is a broad-spectrum, host-directed antiviral drug target for coronaviruses, influenza, and filoviruses]( Stuart Weston, Lauren Baracco, Chloe Keller, Krystal Matthews, Marisa E. McGrath, James Logue, Janie Liang, Julie Dyall, Michael R. Holbrook, Lisa E. Hensley, Peter B. Jahrling, Wenbo Yu, Alexander D. MacKerell Jr, and Matthew B. Frieman [Transcriptome-based design of antisense inhibitors potentiates carbapenem efficacy in CRE Escherichia coli]( Thomas R. Aunins, Keesha E. Erickson, and Anushree Chatterjee Neuroscience [The unreasonable effectiveness of deep learning in artificial intelligence]( Terrence J. Sejnowski [mGreenLantern: a bright monomeric fluorescent protein with rapid expression and cell filling properties for neuronal imaging]( Benjamin C. Campbell, Elisa M. Nabel, Mitchell H. Murdock, Cristina Lao-Peregrin, Pantelis Tsoulfas, Murray G. Blackmore, Francis S. Lee, Conor Liston, Hirofumi Morishita, and Gregory A. Petsko [Fast recovery of disrupted tip links induced by mechanical displacement of hair bundles]( R. G. Alonso, M. Tobin, P. Martin, and A. J. Hudspeth [Evidence accumulation for value computation in the prefrontal cortex during decision making]( Zhongqiao Lin, Chechang Nie, Yuanfeng Zhang, Yang Chen, and Tianming Yang [Maternally inherited peptides as strain-specific chemosignals]( Hideto Kaba, Hiroko Fujita, Takeshi Agatsuma, and Hiroaki Matsunami [Thirst recruits phasic dopamine signaling through subfornical organ neurons]( Ted M. Hsu, Paula Bazzino, Samantha J. Hurh, Vaibhav R. Konanur, Jamie D. Roitman, and Mitchell F. Roitman Pharmacology [An inactive receptor-G protein complex maintains the dynamic range of agonist-induced signaling]( Wonjo Jang, C. Elizabeth Adams, Heng Liu, Cheng Zhang, Finn Olav Levy, Kjetil Wessel Andressen, and Nevin A. Lambert Physiology [Dirac cones and chiral selection of elastic waves in a soft strip]( Maxime Lanoy, Fabrice Lemoult, Antonin Eddi, and Claire Prada [Lack of adipocyte purinergic P2Y6 receptor greatly improves whole body glucose homeostasis]( Shanu Jain, Sai P. Pydi, Kiran S. Toti, Bernard Robaye, Marco Idzko, Oksana Gavrilova, Jürgen Wess, and Kenneth A. Jacobson [The intracellular Ca2+ release channel TRPML1 regulates lower urinary tract smooth muscle contractility]( Caoimhin S. Griffin, Michael G. Alvarado, Evan Yamasaki, Bernard T. Drumm, Vivek Krishnan, Sher Ali, Eleanor M. Nagle, Kenton M. Sanders, and Scott Earley [Allosteric modulation of alternatively spliced Ca2+-activated Cl− channels TMEM16A by PI(4,5)P2 and CaMKII]( Woori Ko, Seung-Ryoung Jung, Kwon-Woo Kim, Jun-Hee Yeon, Cheon-Gyu Park, Joo Hyun Nam, Bertil Hille, and Byung-Chang Suh Plant Biology [Broad noncoding transcription suggests genome surveillance by RNA polymerase V]( Masayuki Tsuzuki, Shriya Sethuraman, Adriana N. Coke, M. Hafiz Rothi, Alan P. Boyle, and Andrzej T. Wierzbicki [HOS15 is a transcriptional corepressor of NPR1-mediated gene activation of plant immunity]( Mingzhe Shen, Chae Jin Lim, Junghoon Park, Jeong Eun Kim, Dongwon Baek, Jaesung Nam, Sang Yeol Lee, Jose M. Pardo, Woe-Yeon Kim, David Mackey, and Dae-Jin Yun [Dissection of the general two-step di-C-glycosylation pathway for the biosynthesis of (iso)schaftosides in higher plants]( Zi-Long Wang, Hao-Meng Gao, Shuang Wang, Meng Zhang, Kuan Chen, Ya-Qun Zhang, Hai-Dong Wang, Bo-Yun Han, Lu-Lu Xu, Tian-Qiao Song, Cai-Hong Yun, Xue Qiao, and Min Ye Population Biology [Network interventions for managing the COVID-19 pandemic and sustaining economy]( Akihiro Nishi, George Dewey, Akira Endo, Sophia Neman, Sage K. Iwamoto, Michael Y. Ni, Yusuke Tsugawa, Georgios Iosifidis, Justin D. Smith, and Sean D. Young [Global associations between macronutrient supply and age-specific mortality]( Alistair M. Senior, Shinichi Nakagawa, David Raubenheimer, and Stephen J. Simpson Psychological and Cognitive Sciences [A source for awareness-dependent figure–ground segregation in human prefrontal cortex]( Ling Huang, Lijuan Wang, Wangming Shen, Mengsha Li, Shiyu Wang, Xiaotong Wang, Leslie G. Ungerleider, and Xilin Zhang Systems Biology [Mutation bias within oncogene families is related to proliferation-specific codon usage]( Hannah Benisty, Marc Weber, Xavier Hernandez-Alias, Martin H. Schaefer, and Luis Serrano --------------------------------------------------------------- Corrections [Correction for Li et al., Multiorbital charge-density wave excitations and concomitant phonon anomalies in Bi2Sr2LaCuO6+δ]( [Correction for Ahmad et al., Potent competitive inhibition of human ribonucleotide reductase by a nonnucleoside small molecule]( [Correction for Yaron et al., Forelimb force direction and magnitude independently controlled by spinal modules in the macaque]( --------------------------------------------------------------- SI Correction [Correction to Supporting Information for Morales-Castilla et al., Diversity buffers winegrowing regions from climate change losses]( [Cover] --------------------------------------------------------------- This message was sent to {EMAIL}. [Unsubscribe]( from or [edit]( your subscription for this service. Or by mail: Customer Service * 15575-A Los Gatos Blvd * Los Gatos, CA 95032 * U.S.A. 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