[PNAS] [Artificial Intelligence](/cgi/adclick/?ad=55360&adclick=true&url=https%3A%2F%2Fwww.pnas.org%2Fcontent%2Fearly%2F2020%2F10%2F13%2F2018732117%3Fcct%3D1971) Â [November 10, 2020; Vol. 117, No. 45](
) This Week in PNAS
[In This Issue]( This week's research highlights
--------------------------------------------------------------- Opinion
[Opinion: A riskâbenefit framework for human research during the COVID-19 pandemic](
Julie C. Lumeng, Tabbye M. Chavous, Anna S. Lok, Srijan Sen, Nicholas S. Wigginton, and Rebecca M. Cunningham
Leading scientists discuss current issues
--------------------------------------------------------------- Core Concepts
[Core Concept: The pandemic is prompting widespread useâand misuseâof real-world data](
Elie Dolgin
A brief introduction to emerging topics in science
--------------------------------------------------------------- Retrospective
[Zena Werb (1945â2020): Mourning the loss of a tissue microenvironment icon](
Valerie M. Weaver and Mina J. Bissell --------------------------------------------------------------- Commentaries
[p31comet and TRIP13 recycle Rev7 to regulate DNA repair](
Kevin D. Corbett
[The microbiome requires a genetically susceptible host to induce central nervous system autoimmunity](
Laura M. Cox and Howard L. Weiner --------------------------------------------------------------- Perspective
[The pandemic exposes human nature: 10 evolutionary insights](
Benjamin M. Seitz, Athena Aktipis, David M. Buss, Joe Alcock, Paul Bloom, Michele Gelfand, Sam Harris, Debra Lieberman, Barbara N. Horowitz, Steven Pinker, David Sloan Wilson, and Martie G. Haselton
[It is unclear how important CRISPR-Cas systems are for protecting natural populations of bacteria against infections by mobile genetic elements](
Edze R. Westra and Bruce R. Levin --------------------------------------------------------------- Letters
[Crystalline water in gypsum is unavailable for cyanobacteria in laboratory experiments and in natural desert endolithic habitats](
Jacek Wierzchos, Octavio Artieda, Carmen Ascaso, Fernando Nieto GarcĂa, Petr VĂtek, Armando Azua-Bustos, and Alberto G. FairĂ©n
[Reply to Wierzchos et al.: Microorganism-induced gypsum to anhydrite phase transformation](
Wei Huang, Emine Ertekin, Taifeng Wang, Luz Cruz, Micah Dailey, Jocelyne DiRuggiero, and David Kisailus
[RCP8.5 is a problematic scenario for near-term emissions](
Zeke Hausfather and Glen P. Peters
[Reply to Hausfather and Peters: RCP8.5 is neither problematic nor misleading](
Christopher R. Schwalm, Spencer Glendon, and Philip B. Duffy --------------------------------------------------------------- Physical Sciences
Applied Mathematics
[Origin of exponential growth in nonlinear reaction networks](
Wei-Hsiang Lin, Edo Kussell, Lai-Sang Young, and Christine Jacobs-Wagner
[Electoral College bias and the 2020 presidential election](
Robert S. Erikson, Karl Sigman, and Linan Yao
[High-amplitude cofluctuations in cortical activity drive functional connectivity](
Farnaz Zamani Esfahlani, Youngheun Jo, Joshua Faskowitz, Lisa Byrge, Daniel P. Kennedy, Olaf Sporns, and Richard F. Betzel Applied Physical Sciences
[A symmetry-derived mechanism for atomic resolution imaging](
Matus Krajnak and Joanne Etheridge Biophysics and Computational Biology
[Abnormal morphology biases hematocrit distribution in tumor vasculature and contributes to heterogeneity in tissue oxygenation](
Miguel O. Bernabeu, Jakub Köry, James A. Grogan, Bostjan Markelc, Albert Beardo, Mayeul dâAvezac, Romain Enjalbert, Jakob Kaeppler, Nicholas Daly, James Hetherington, Timm KrĂŒger, Philip K. Maini, Joe M. Pitt-Francis, Ruth J. Muschel, TomĂĄs AlarcĂłn, and Helen M. Byrne
[Laser spectroscopic technique for direct identification of a single virus I: FASTER CARS](
Volker Deckert, Tanja Deckert-Gaudig, Dana Cialla-May, JĂŒrgen Popp, Roland Zell, Stefanie Deinhard-Emmer, Alexei V. Sokolov, Zhenhuan Yi, and Marlan O. Scully
[A far-red cyanobacteriochrome lineage specific for verdins](
Marcus V. Moreno, Nathan C. Rockwell, Manuel Mora, Andrew J. Fisher, and J. Clark Lagarias
[The human CRY1 tail controls circadian timing by regulating its association with CLOCK:BMAL1](
Gian Carlo G. Parico, Ivette Perez, Jennifer L. Fribourgh, Britney N. Hernandez, Hsiau-Wei Lee, and Carrie L. Partch
[Wake-sleep cycles are severely disrupted by diseases affecting cytoplasmic homeostasis](
Stephen Beesley, Dae Wook Kim, Matthew DâAlessandro, Yuanhu Jin, Kwangjun Lee, Hyunjeong Joo, Yang Young, Robert J. Tomko Jr, John Faulkner, Joshua Gamsby, Jae Kyoung Kim, and Choogon Lee
[Improving the taxonomy of fossil pollen using convolutional neural networks and superresolution microscopy](
Ingrid C. Romero, Shu Kong, Charless C. Fowlkes, Carlos Jaramillo, Michael A. Urban, Francisca Oboh-Ikuenobe, Carlos DâApolito, and Surangi W. Punyasena Chemistry
[Insights into the composition of ancient Egyptian red and black inks on papyri achieved by synchrotron-based microanalyses](
Thomas Christiansen, Marine Cotte, Wout de Nolf, Elouan Mouro, Juan Reyes-Herrera, Steven de Meyer, Frederik Vanmeert, Nati SalvadĂł, Victor Gonzalez, Poul Erik Lindelof, Kell Mortensen, Kim Ryholt, Koen Janssens, and Sine Larsen
[Nearly free surface silanols are the critical molecular moieties that initiate the toxicity of silica particles](
Cristina Pavan, Rosangela Santalucia, Riccardo Leinardi, Marco Fabbiani, Yousof Yakoub, Francine Uwambayinema, Piero Ugliengo, Maura Tomatis, Gianmario Martra, Francesco Turci, Dominique Lison, and Bice Fubini
[A high-performance potassium metal battery using safe ionic liquid electrolyte](
Hao Sun, Peng Liang, Guanzhou Zhu, Wei Hsuan Hung, Yuan-Yao Li, Hung-Chun Tai, Cheng-Liang Huang, Jiachen Li, Yongtao Meng, Michael Angell, Chang-An Wang, and Hongjie Dai
[Anionic nanoparticle-induced perturbation to phospholipid membranes affects ion channel function](
Isabel U. Foreman-Ortiz, Dongyue Liang, Elizabeth D. Laudadio, Jorge D. Calderin, Meng Wu, Puspam Keshri, Xianzhi Zhang, Michael P. Schwartz, Robert J. Hamers, Vincent M. Rotello, Catherine J. Murphy, Qiang Cui, and Joel A. Pedersen Computer Sciences
[A spiking neural program for sensorimotor control during foraging in flying insects](
Hannes Rapp and Martin Paul Nawrot Earth, Atmospheric, and Planetary Sciences
[Anthropogenic Asian aerosols provide Fe to the North Pacific Ocean](
Paulina Pinedo-GonzĂĄlez, Nicholas J. Hawco, Randelle M. Bundy, E. Virginia Armbrust, Michael J. Follows, B. B. Cael, Angelicque E. White, Sara FerrĂłn, David M. Karl, and Seth G. John
[Evidence for massive emission of methane from a deepâwater gas field during the Pliocene](
Martino Foschi, Joseph A. Cartwright, Christopher W. MacMinn, and Giuseppe Etiope
[Causes and consequences of asymmetric lateral plume flow during South Atlantic rifting](
Jason P. Morgan, Jorge M. Taramón, Mario Araujo, Jörg Hasenclever, and Marta Perez-Gussinye
[The critical role of cloudâinfrared radiation feedback in tropical cyclone development](
James H. Ruppert Jr, Allison A. Wing, Xiaodong Tang, and Erika L. Duran
[The niobium and tantalum concentration in the mantle constrains the composition of Earthâs primordial magma ocean](
Dongyang Huang, James Badro, and Julien Siebert
[Experimental evidence for silica-enriched Earthâs lower mantle with ferrous iron dominant bridgmanite](
Izumi Mashino, Motohiko Murakami, Nobuyoshi Miyajima, and Sylvain Petitgirard Engineering
[Soft, skin-interfaced microfluidic systems with integrated immunoassays, fluorometric sensors, and impedance measurement capabilities](
Sungbong Kim, Boram Lee, Jonathan T. Reeder, Seon Hee Seo, Sung-Uk Lee, Aurélie Hourlier-Fargette, Joonchul Shin, Yurina Sekine, Hyoyoung Jeong, Yong Suk Oh, Alexander J. Aranyosi, Stephen P. Lee, Jeffrey B. Model, Geumbee Lee, Min-Ho Seo, Sung Soo Kwak, Seongbin Jo, Gyungmin Park, Sunghyun Han, Inkyu Park, Hyo-Il Jung, Roozbeh Ghaffari, Jahyun Koo, Paul V. Braun, and John A. Rogers
[Reconfigurable multifunctional ferrofluid droplet robots](
Xinjian Fan, Xiaoguang Dong, Alp C. Karacakol, Hui Xie, and Metin Sitti
[Insect pectinate antennae maximize odor capture efficiency at intermediate flight speeds](
Mourad Jaffar-Bandjee, Thomas Steinmann, Gijs Krijnen, and JérÎme Casas Physics
[Two-step crystallization and solidâsolid transitions in binary colloidal mixtures](
Huang Fang, Michael F. Hagan, and W. Benjamin Rogers --------------------------------------------------------------- Social Sciences
Anthropology
[Insights into the composition of ancient Egyptian red and black inks on papyri achieved by synchrotron-based microanalyses](
Thomas Christiansen, Marine Cotte, Wout de Nolf, Elouan Mouro, Juan Reyes-Herrera, Steven de Meyer, Frederik Vanmeert, Nati SalvadĂł, Victor Gonzalez, Poul Erik Lindelof, Kell Mortensen, Kim Ryholt, Koen Janssens, and Sine Larsen
[A genomic and historical synthesis of plague in 18th century Eurasia](
Meriam Guellil, Oliver Kersten, Amine Namouchi, Stefania Luciani, Isolina Marota, Caroline A. Arcini, Elisabeth Iregren, Robert A. Lindemann, Gunnar Warfvinge, Lela Bakanidze, Lia Bitadze, Mauro Rubini, Paola Zaio, Monica Zaio, Damiano Neri, N. C. Stenseth, and Barbara Bramanti Economic Sciences
[Initial economic damage from the COVID-19 pandemic in the United States is more widespread across ages and geographies than initial mortality impacts](
Maria Polyakova, Geoffrey Kocks, Victoria Udalova, and Amy Finkelstein Environmental Sciences
[Improving rural health care reduces illegal logging and conserves carbon in a tropical forest](
Isabel J. Jones, Andrew J. MacDonald, Skylar R. Hopkins, Andrea J. Lund, Zac Yung-Chun Liu, Nurul Ihsan Fawzi, Mahardika Putra Purba, Katie Fankhauser, Andrew J. Chamberlin, Monica Nirmala, Arthur G. Blundell, Ashley Emerson, Jonathan Jennings, Lynne Gaffikin, Michele Barry, David Lopez-Carr, Kinari Webb, Giulio A. De Leo, and Susanne H. Sokolow Political Sciences
[Electoral College bias and the 2020 presidential election](
Robert S. Erikson, Karl Sigman, and Linan Yao Psychological and Cognitive Sciences
[Longitudinally adaptive assessment and instruction increase numerical skills of preschool children](
Stephen W. Raudenbush, Marc Hernandez, Susan Goldin-Meadow, Cristina Carrazza, Alana Foley, Debbie Leslie, Janet E. Sorkin, and Susan C. Levine Social Sciences
[Fine-scale spatial clustering of measles nonvaccination that increases outbreak potential is obscured by aggregated reporting data](
Nina B. Masters, Marisa C. Eisenberg, Paul L. Delamater, Matthew Kay, Matthew L. Boulton, and Jon Zelner Sustainability Science
[A global network of marine protected areas for food](
Reniel B. Cabral, Darcy Bradley, Juan Mayorga, Whitney Goodell, Alan M. Friedlander, Enric Sala, Christopher Costello, and Steven D. Gaines --------------------------------------------------------------- Biological Sciences
Applied Biological Sciences
[Elucidating aromatic acid tolerance at low pH in Saccharomyces cerevisiae using adaptive laboratory evolution](
Rui Pereira, Elsayed T. Mohamed, Mohammad S. Radi, Markus J. HerrgÄrd, Adam M. Feist, Jens Nielsen, and Yun Chen Biochemistry
[A far-red cyanobacteriochrome lineage specific for verdins](
Marcus V. Moreno, Nathan C. Rockwell, Manuel Mora, Andrew J. Fisher, and J. Clark Lagarias
[The human CRY1 tail controls circadian timing by regulating its association with CLOCK:BMAL1](
Gian Carlo G. Parico, Ivette Perez, Jennifer L. Fribourgh, Britney N. Hernandez, Hsiau-Wei Lee, and Carrie L. Partch
[Mcl-1 and Bok transmembrane domains: Unexpected players in the modulation of apoptosis](
EstefanĂa Lucendo, MĂłnica Sancho, Fabio Lolicato, Matti Javanainen, Waldemar Kulig, Diego Leiva, Gerard Duart, Vicente Andreu-FernĂĄndez, Ismael Mingarro, and Mar OrzĂĄez
[Reversible autoinhibitory regulation of Escherichia coli metallopeptidase BepA for selective ÎČ-barrel protein degradation](
Yasushi Daimon, Shin-ichiro Narita, Ryoji Miyazaki, Yohei Hizukuri, Hiroyuki Mori, Yoshiki Tanaka, Tomoya Tsukazaki, and Yoshinori Akiyama
[Amyloid formation of fish ÎČ-parvalbumin involves primary nucleation triggered by disulfide-bridged protein dimers](
Tony E. R. Werner, David Bernson, Elin K. Esbjörner, Sandra Rocha, and Pernilla Wittung-Stafshede
[Multistep substrate binding and engagement by the AAA+ ClpXP protease](
Reuben A. Saunders, Benjamin M. Stinson, Tania A. Baker, and Robert T. Sauer Biophysics and Computational Biology
[Origin of exponential growth in nonlinear reaction networks](
Wei-Hsiang Lin, Edo Kussell, Lai-Sang Young, and Christine Jacobs-Wagner
[Multistep substrate binding and engagement by the AAA+ ClpXP protease](
Reuben A. Saunders, Benjamin M. Stinson, Tania A. Baker, and Robert T. Sauer
[Visualization of the HIV-1 Env glycan shield across scales](
Zachary T. Berndsen, Srirupa Chakraborty, Xiaoning Wang, Christopher A. Cottrell, Jonathan L. Torres, Jolene K. Diedrich, Cesar A. LĂłpez, John R. Yates III, Marit J. van Gils, James C. Paulson, Sandrasegaram Gnanakaran, and Andrew B. Ward
[SurA is a cryptically grooved chaperone that expands unfolded outer membrane proteins](
Dagan C. Marx, Ashlee M. Plummer, Anneliese M. Faustino, Taylor Devlin, Michaela A. Roskopf, Mathis J. Leblanc, Henry J. Lessen, Barbara T. Amann, Patrick J. Fleming, Susan Krueger, Stephen D. Fried, and Karen G. Fleming
[The role of Ca2+ and protein scaffolding in the formation of natureâs water oxidizing complex](
Anton P. Avramov, Hong J. Hwang, and Robert L. Burnap
[Engineered ACE2 receptor traps potently neutralize SARS-CoV-2](
Anum Glasgow, Jeff Glasgow, Daniel Limonta, Paige Solomon, Irene Lui, Yang Zhang, Matthew A. Nix, Nicholas J. Rettko, Shoshana Zha, Rachel Yamin, Kevin Kao, Oren S. Rosenberg, Jeffrey V. Ravetch, Arun P. Wiita, Kevin K. Leung, Shion A. Lim, Xin X. Zhou, Tom C. Hobman, Tanja Kortemme, and James A. Wells Cell Biology
[PtdIns(3,4,5)P3-dependent Rac exchanger 1 (P-Rex1) promotes mammary tumor initiation and metastasis](
Nuthasuda Srijakotre, Heng-Jia Liu, Max Nobis, Joey Man, Hon Yan Kelvin Yip, Antonella Papa, Helen E. Abud, Kurt I. Anderson, Heidi C. E. Welch, Tony Tiganis, Paul Timpson, Catriona A. McLean, Lisa M. Ooms, and Christina A. Mitchell
[Targeted CRISPR screening identifies PRMT5 as synthetic lethality combinatorial target with gemcitabine in pancreatic cancer cells](
Xiaolong Wei, Jiekun Yang, Sara J. Adair, Harun Ozturk, Cem Kuscu, Kyung Yong Lee, William J. Kane, Patrick E. OâHara, Denis Liu, Yusuf Mert Demirlenk, Alaa Hamdi Habieb, Ebru Yilmaz, Anindya Dutta, Todd W. Bauer, and Mazhar Adli
[Identification of a degradation signal at the carboxy terminus of SREBP2: A new role for this domain in cholesterol homeostasis](
Daniel L. Kober, Shimeng Xu, Shili Li, Bilkish Bajaj, Guosheng Liang, Daniel M. Rosenbaum, and Arun Radhakrishnan
[RNA-binding protein DDX3 mediates posttranscriptional regulation of androgen receptor: A mechanism of castration resistance](
Jordan E. Vellky, Sean T. McSweeney, Emily A. Ricke, and William A. Ricke
[Myelination of peripheral nerves is controlled by PI4KB through regulation of Schwann cell Golgi function](
Takashi Baba, Alejandro Alvarez-Prats, Yeun Ju Kim, Daniel Abebe, Steve Wilson, Zane Aldworth, Mark A. Stopfer, John Heuser, and Tamas Balla
[USP7 regulates ALS-associated proteotoxicity and quality control through the NEDD4LâSMAD pathway](
Tao Zhang, Goran Periz, Yu-Ning Lu, and Jiou Wang Ecology
[Insect pectinate antennae maximize odor capture efficiency at intermediate flight speeds](
Mourad Jaffar-Bandjee, Thomas Steinmann, Gijs Krijnen, and JérÎme Casas
[A global network of marine protected areas for food](
Reniel B. Cabral, Darcy Bradley, Juan Mayorga, Whitney Goodell, Alan M. Friedlander, Enric Sala, Christopher Costello, and Steven D. Gaines
[Land-use intensity alters networks between biodiversity, ecosystem functions, and services](
MarĂa R. Felipe-Lucia, Santiago Soliveres, Caterina Penone, Markus Fischer, Christian Ammer, Steffen Boch, Runa S. Boeddinghaus, Michael Bonkowski, François Buscot, Anna Maria Fiore-Donno, Kevin Frank, Kezia Goldmann, Martin M. Gossner, Norbert Hölzel, Malte Jochum, Ellen Kandeler, Valentin H. Klaus, Till Kleinebecker, Sophia Leimer, Peter Manning, Yvonne Oelmann, Hugo Saiz, Peter Schall, Michael Schloter, Ingo Schöning, Marion Schrumpf, Emily F. Solly, Barbara Stempfhuber, Wolfgang W. Weisser, Wolfgang Wilcke, Tesfaye Wubet, and Eric Allan
[Ancient genomes reveal tropical bovid species in the Tibetan Plateau contributed to the prevalence of hunting game until the late Neolithic](
Ningbo Chen, Lele Ren, Linyao Du, Jiawen Hou, Victoria E. Mullin, Duo Wu, Xueye Zhao, Chunmei Li, Jiahui Huang, Xuebin Qi, Marco Rosario Capodiferro, Alessandro Achilli, Chuzhao Lei, Fahu Chen, Bing Su, Guanghui Dong, and Xiaoming Zhang
[Climate drives the geography of marine consumption by changing predator communities](
Matthew A. Whalen, Ross D. B. Whippo, John J. Stachowicz, Paul H. York, Erin Aiello, Teresa Alcoverro, Andrew H. Altieri, Lisandro Benedetti-Cecchi, Camilla Bertolini, Midoli Bresch, Fabio Bulleri, Paul E. Carnell, StĂ©phanie Cimon, Rod M. Connolly, Mathieu Cusson, Meredith S. Diskin, Elrika DâSouza, Augusto A. V. Flores, F. Joel Fodrie, Aaron W. E. Galloway, Leo C. Gaskins, Olivia J. Graham, Torrance C. Hanley, Christopher J. Henderson, Clara M. Hereu, Margot Hessing-Lewis, Kevin A. Hovel, Brent B. Hughes, A. Randall Hughes, Kristin M. Hultgren, Holger JĂ€nes, Dean S. Janiak, Lane N. Johnston, Pablo Jorgensen, Brendan P. Kelaher, Claudia Kruschel, Brendan S. Lanham, Kun-Seop Lee, Jonathan S. Lefcheck, Enrique Lozano-Ălvarez, Peter I. Macreadie, Zachary L. Monteith, Nessa E. OâConnor, Andrew D. Olds, Jennifer K. OâLeary, Christopher J. Patrick, Oscar Pino, Alistair G. B. Poore, Michae l A. Rasheed, Wendel W. Raymond, Katrin Reiss, O. Kennedy Rhoades, Max T. Robinson, Paige G. Ross, Francesca Rossi, Thomas A. Schlacher, Janina Seemann, Brian R. Silliman, Delbert L. Smee, Martin Thiel, Richard K. F. Unsworth, Brigitta I. van Tussenbroek, Adriana VergĂ©s, Mallarie E. Yeager, Bree K. Yednock, Shelby L. Ziegler, and J. Emmett Duffy
[Modular genetic control of social status in a cichlid fish](
Beau A. Alward, Vibhav A. Laud, Christopher J. Skalnik, Ryan A. York, Scott A. Juntti, and Russell D. Fernald Environmental Sciences
[Outsized nutrient contributions from small tributaries to a Great Lake](
Robert J. Mooney, Emily H. Stanley, William C. Rosenthal, Peter C. Esselman, Anthony D. Kendall, and Peter B. McIntyre
[Floristic evidence for alternative biome states in tropical Africa](
J. C. Aleman, A. Fayolle, C. Favier, A. C. Staver, K. G. Dexter, C. M. Ryan, A. F. Azihou, D. Bauman, M. te Beest, E. N. Chidumayo, J. A. Comiskey, J. P. G. M. Cromsigt, H. Dessard, J.-L. Doucet, M. Finckh, J.-F. Gillet, S. Gourlet-Fleury, G. P. Hempson, R. M. Holdo, B. Kirunda, F. N. Kouame, G. Mahy, F. Maiato P. Gonçalves, I. McNicol, P. Nieto Quintano, A. J. Plumptre, R. C. Pritchard, R. Revermann, C. B. Schmitt, A. M. Swemmer, H. Talila, E. Woollen, and M. D. Swaine Genetics
[Genome-wide mapping of spontaneous genetic alterations in diploid yeast cells](
Yang Sui, Lei Qi, Jian-Kun Wu, Xue-Ping Wen, Xing-Xing Tang, Zhong-Jun Ma, Xue-Chang Wu, Ke Zhang, Robert J. Kokoska, Dao-Qiong Zheng, and Thomas D. Petes
[Comprehensive characterization of amino acid positions in protein structures reveals molecular effect of missense variants](
Sumaiya Iqbal, Eduardo Pérez-Palma, Jakob B. Jespersen, Patrick May, David Hoksza, Henrike O. Heyne, Shehab S. Ahmed, Zaara T. Rifat, M. Sohel Rahman, Kasper Lage, Aarno Palotie, Jeffrey R. Cottrell, Florence F. Wagner, Mark J. Daly, Arthur J. Campbell, and Dennis Lal
[A mosaic analysis system with Cre or Tomato expression in the mouse](
Qun Wang, Yen-Yu Lin, Baojun Zhang, Jianxuan Wu, Sumedha Roy, Jeremy J. Ratiu, Yanping Xu, Meifang Dai, Laura P. Hale, Yue Xiong, Qi-Jing Li, and Yuan Zhuang
[Characterization of systemic genomic instability in budding yeast](
Nadia M. V. Sampaio, V. P. Ajith, Ruth A. Watson, Lydia R. Heasley, Parijat Chakraborty, Aline Rodrigues-Prause, Ewa P. Malc, Piotr A. Mieczkowski, Koodali T. Nishant, and Juan Lucas Argueso Immunology and Inflammation
[Nearly free surface silanols are the critical molecular moieties that initiate the toxicity of silica particles](
Cristina Pavan, Rosangela Santalucia, Riccardo Leinardi, Marco Fabbiani, Yousof Yakoub, Francine Uwambayinema, Piero Ugliengo, Maura Tomatis, Gianmario Martra, Francesco Turci, Dominique Lison, and Bice Fubini
[HLA tapasin independence: broader peptide repertoire and HIV control](
Arman A. Bashirova, Mathias Viard, Vivek Naranbhai, Alba Grifoni, Wilfredo Garcia-Beltran, Marjan Akdag, Yuko Yuki, Xiaojiang Gao, Colm OâhUigin, Malini Raghavan, Steven Wolinsky, Jay H. Bream, Priya Duggal, Jeremy Martinson, Nelson L. Michael, Gregory D. Kirk, Susan P. Buchbinder, David Haas, James J. Goedert, Steven G. Deeks, Jacques Fellay, Bruce Walker, Philip Goulder, Peter Cresswell, Tim Elliott, Alessandro Sette, Jonathan Carlson, and Mary Carrington
[KLHL22 maintains PD-1 homeostasis and prevents excessive T cell suppression](
Xiao Albert Zhou, Jiadong Zhou, Long Zhao, Guihui Yu, Jun Zhan, Chanyi Shi, Ruoshi Yuan, Yan Wang, Changfeng Chen, Wenjia Zhang, Donghao Xu, Yingjiang Ye, Weibin Wang, Zhanlong Shen, Wei Wang, and Jiadong Wang
[Phosphatidylinositol-4-kinase IIα licenses phagosomes for TLR4 signaling and MHC-II presentation in dendritic cells](
Cynthia LĂłpez-Haber, Roni Levin-Konigsberg, Yueyao Zhu, Jing Bi-Karchin, Tamas Balla, Sergio Grinstein, Michael S. Marks, and Adriana R. Mantegazza
[Stimulation of soluble guanylate cyclase exerts antiinflammatory actions in the liver through a VASP/NF-ÎșB/NLRP3 inflammasome circuit](
Roger Flores-Costa, Marta Duran-GĂŒell, Mireia Casulleras, Cristina LĂłpez-Vicario, JosĂ© Alcaraz-Quiles, Alba Diaz, Juan J. Lozano, Esther Titos, Katherine Hall, Renee Sarno, Jaime L. Masferrer, and Joan ClĂ ria Medical Sciences
[Abnormal morphology biases hematocrit distribution in tumor vasculature and contributes to heterogeneity in tissue oxygenation](
Miguel O. Bernabeu, Jakub Köry, James A. Grogan, Bostjan Markelc, Albert Beardo, Mayeul dâAvezac, Romain Enjalbert, Jakob Kaeppler, Nicholas Daly, James Hetherington, Timm KrĂŒger, Philip K. Maini, Joe M. Pitt-Francis, Ruth J. Muschel, TomĂĄs AlarcĂłn, and Helen M. Byrne
[GPR56/ADGRG1 is a platelet collagen-responsive GPCR and hemostatic sensor of shear force](
Jennifer Yeung, Reheman Adili, Emily N. Stringham, Rong Luo, Alexander Vizurraga, Luciana K. Rosselli-Murai, Hannah M. Stoveken, Maiya Yu, Xianhua Piao, Michael Holinstat, and Gregory G. Tall
[FOXM1 drives HPV+ HNSCC sensitivity to WEE1 inhibition](
Ahmed Diab, Hakan Gem, Jherek Swanger, Hee Yeon Kim, Kaleb Smith, Grace Zou, Sharat Raju, Michael Kao, Matthew Fitzgibbon, Keith R. Loeb, Cristina P. Rodriguez, Eduardo Méndez, Denise A. Galloway, Julia M. Sidorova, and Bruce E. Clurman
[An allosteric peptide inhibitor of HIF-1α regulates hypoxia-induced retinal neovascularization](
Ayumi Usui-Ouchi, Edith Aguilar, Salome Murinello, Mitchell Prins, Marin L. Gantner, Peter E. Wright, Rebecca B. Berlow, and Martin Friedlander
[The adaptor protein APPL2 controls glucose-stimulated insulin secretion via F-actin remodeling in pancreatic ÎČ-cells](
Baile Wang, Huige Lin, Xiaomu Li, Wenqi Lu, Jae Bum Kim, Aimin Xu, and Kenneth K. Y. Cheng
[Harnessing 64Cu/67Cu for a theranostic approach to pretargeted radioimmunotherapy](
Outi KeinÀnen, Kimberly Fung, James M. Brennan, Nicholas Zia, Matt Harris, Ellen van Dam, Colin Biggin, Amos Hedt, Jon Stoner, Paul S. Donnelly, Jason S. Lewis, and Brian M. Zeglis Microbiology
[A genomic and historical synthesis of plague in 18th century Eurasia](
Meriam Guellil, Oliver Kersten, Amine Namouchi, Stefania Luciani, Isolina Marota, Caroline A. Arcini, Elisabeth Iregren, Robert A. Lindemann, Gunnar Warfvinge, Lela Bakanidze, Lia Bitadze, Mauro Rubini, Paola Zaio, Monica Zaio, Damiano Neri, N. C. Stenseth, and Barbara Bramanti
[Transcriptional and proteomic insights into the host response in fatal COVID-19 cases](
Meng Wu, Yaobing Chen, Han Xia, Changli Wang, Chin Yee Tan, Xunhui Cai, Yufeng Liu, Fenghu Ji, Peng Xiong, Ran Liu, Yuanlin Guan, Yaqi Duan, Dong Kuang, Sanpeng Xu, Hanghang Cai, Qin Xia, Dehua Yang, Ming-Wei Wang, Isaac M. Chiu, Chao Cheng, Philip P. Ahern, Liang Liu, Guoping Wang, Neeraj K. Surana, Tian Xia, and Dennis L. Kasper
[SARS-CoV-2 Orf6 hijacks Nup98 to block STAT nuclear import and antagonize interferon signaling](
Lisa Miorin, Thomas Kehrer, Maria Teresa Sanchez-Aparicio, Ke Zhang, Phillip Cohen, Roosheel S. Patel, Anastasija Cupic, Tadashi Makio, Menghan Mei, Elena Moreno, Oded Danziger, Kris M. White, Raveen Rathnasinghe, Melissa Uccellini, Shengyan Gao, Teresa Aydillo, Ignacio Mena, Xin Yin, Laura Martin-Sancho, Nevan J. Krogan, Sumit K. Chanda, Michael Schotsaert, Richard W. Wozniak, Yi Ren, Brad R. Rosenberg, Beatriz M. A. Fontoura, and Adolfo GarcĂa-Sastre
[Insights into bacterial cell division from a structure of EnvC bound to the FtsX periplasmic domain](
Jonathan Cook, Tyler C. Baverstock, Martin B. L. McAndrew, Phillip J. Stansfeld, David I. Roper, and Allister Crow
[The polar Ras-like GTPase MglA activates type IV pilus via SgmX to enable twitching motility in Myxococcus xanthus](
Romain Mercier, Sarah Bautista, Maëlle Delannoy, Margaux Gibert, Annick Guiseppi, Julien Herrou, Emilia M. F. Mauriello, and Tùm Mignot
[The shrimp nephrocomplex serves as a major portal of pathogen entry and is involved in the molting process](
Gaëtan M. A. De Gryse, Thuong Van Khuong, Benedicte Descamps, Wim Van Den Broeck, Christian Vanhove, Pieter Cornillie, Patrick Sorgeloos, Peter Bossier, and Hans J. Nauwynck
[A CRISPR-Cas9 screen identifies mitochondrial translation as an essential process in latent KSHV infection of human endothelial cells](
Daniel L. Holmes, Daniel T. Vogt, and Michael Lagunoff Neuroscience
[High-amplitude cofluctuations in cortical activity drive functional connectivity](
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Isabel J. Jones, Andrew J. MacDonald, Skylar R. Hopkins, Andrea J. Lund, Zac Yung-Chun Liu, Nurul Ihsan Fawzi, Mahardika Putra Purba, Katie Fankhauser, Andrew J. Chamberlin, Monica Nirmala, Arthur G. Blundell, Ashley Emerson, Jonathan Jennings, Lynne Gaffikin, Michele Barry, David Lopez-Carr, Kinari Webb, Giulio A. De Leo, and Susanne H. Sokolow --------------------------------------------------------------- Corrections
[Correction for Wu et al., Isolation of exosomes from whole blood by integrating acoustics and microfluidicss]( [Correction for Rao et al., Inositol pyrophosphates promote tumor growth and metastasis by antagonizing liver kinase B1]( [Correction for Bao et al., BACE1 SUMOylation increases its stability and escalates the protease activity in Alzheimerâs disease]( [Correction for Bos et al., Phytophthora infestans effector AVR3a is essential for virulence and manipulates plant immunity by stabilizing host E3 ligase CMPG1]( [Cover] --------------------------------------------------------------- This message was sent to {EMAIL}. [Unsubscribe]( from or [edit]( your subscription for this service.
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