[PNAS]
[Cell & Molecular Bio](/cgi/adclick/?ad=54870&adclick=true&url=https%3A%2F%2Fwww.pnas.org%2Fcontent%2F2020-call-papers-cell-and-molecular-biology%3F)
 [April 14, 2020; Vol. 117, No. 15](
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This Week in PNAS
[In This Issue](
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News Feature
[News Feature: Avoiding pitfalls in the pursuit of a COVID-19 vaccine](
Lynne Peeples
An in-depth look at trending science issues.
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Commentaries
[Could confounding the allosteric communication of biotic machinery be an alternative path to antibiotics?](
R. Andrew Byrd
[CRISPR-based technology to silence the expression of IncRNAs](
James D. Phelan and Louis M. Staudt
[Squalene and cholesterol in the balance at the ER membrane](
James A. Nathan
[Metabolic–electrical control of coronary blood flow](
Nathan Grainger and L. Fernando Santana
[What failure to predict life outcomes can teach us](
Filiz Garip
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Perspective
[Modified nucleotides may have enhanced early RNA catalysis](
Steven K. Wolk, Wesley S. Mayfield, Amy D. Gelinas, David Astling, Jessica Guillot, Edward N. Brody, Nebojsa Janjic, and Larry Gold
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Letters
[Learning to overcome political opposition to transformative environmental law](
Jason MacLean
[Reply to MacLean: The flexibility of existing laws is an essential element of environmental governance](
Robin K. Craig, J. B. Ruhl, and Ahjond Garmestani
[Is ionic choline and geranate (CAGE) liquid caging diet-derived fat, limiting its absorption?](
Franck Peiretti, René Valéro, and Roland Govers
[Reply to Peiretti et al.: Effect of CAGE on fat uptake and food intake](
Md Nurunnabi, Kelly N. Ibsen, Eden E. L. Tanner, and Samir Mitragotri
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Archaeology, Climate, and Global Change Special Feature (Free Online)
Introduction
[Archaeology, climate, and global change in the Age of Humans](
Torben C. Rick and Daniel H. Sandweiss
Perspectives
[Archaeology, environmental justice, and climate change on islands of the Caribbean and southwestern Indian Ocean](
Kristina Douglass and Jago Cooper
[Archaeological climate proxies and the complexities of reconstructing Holocene El Niño in coastal Peru](
Daniel H. Sandweiss, C. Fred T. Andrus, Alice R. Kelley, Kirk A. Maasch, Elizabeth J. Reitz, and Paul B. Roscoe
[Coastal heritage, global climate change, public engagement, and citizen science](
Tom Dawson, Joanna Hambly, Alice Kelley, William Lees, and Sarah Miller
[Leveraging legacy archaeological collections as proxies for climate and environmental research](
Frankie St. Amand, S. Terry Childs, Elizabeth J. Reitz, Sky Heller, Bonnie Newsom, Torben C. Rick, Daniel H. Sandweiss, and Ryan Wheeler
[Expanding use of archaeology in climate change response by changing its social environment](
Marcy Rockman and Carrie Hritz
Research Article
[Human responses to climate and ecosystem change in ancient Arabia](
Michael D. Petraglia, Huw S. Groucutt, Maria Guagnin, Paul S. Breeze, and Nicole Boivin
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Brief Report
[Convergent spectral shifts to blue-green vision in mammals extends the known sensitivity of vertebrate M/LWS pigments](
Hai Chi, Yimeng Cui, Stephen J. Rossiter, and Yang Liu
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Physical Sciences
Applied Physical Sciences
[Fibration symmetries uncover the building blocks of biological networks](
Flaviano Morone, Ian Leifer, and Hernán A. Makse
Biophysics and Computational Biology
[Entrainment of mammalian motile cilia in the brain with hydrodynamic forces](
Nicola Pellicciotta, Evelyn Hamilton, Jurij Kotar, Marion Faucourt, Nathalie Delgehyr, Nathalie Spassky, and Pietro Cicuta
[Connectivity and plasticity determine collagen network fracture](
Federica Burla, Simone Dussi, Cristina Martinez-Torres, Justin Tauber, Jasper van der Gucht, and Gijsje H. Koenderink
Chemistry
[The surface tension of surfactant-containing, finite volume droplets](
Bryan R. Bzdek, Jonathan P. Reid, Jussi Malila, and Nønne L. Prisle
[Securing timelines in the ancient Mediterranean using multiproxy annual tree-ring data](
Charlotte Pearson, Matthew Salzer, Lukas Wacker, Peter Brewer, Adam Sookdeo, and Peter Kuniholm
[In silico design and validation of high-affinity RNA aptamers targeting epithelial cellular adhesion molecule dimers](
David R. Bell, Jeffrey K. Weber, Wang Yin, Tien Huynh, Wei Duan, and Ruhong Zhou
Computer Sciences
[Towards formalizing the GDPR’s notion of singling out](
Aloni Cohen and Kobbi Nissim
Earth, Atmospheric, and Planetary Sciences
[Alkali magmatism on a carbonaceous chondrite planetesimal](
Jérôme Aléon, Alice Aléon-Toppani, Bernard Platevoet, Jacques-Marie Bardintzeff, Kevin D. McKeegan, and François Brisset
Engineering
[Hanging droplets from liquid surfaces](
Ganhua Xie, Joe Forth, Shipei Zhu, Brett A. Helms, Paul D. Ashby, Ho Cheung Shum, and Thomas P. Russell
[Insights into the rheology of cohesive granular media](
Sandip Mandal, Maxime Nicolas, and Olivier Pouliquen
[Accumulation of high-value bioproducts in planta can improve the economics of advanced biofuels](
Minliang Yang, Nawa Raj Baral, Blake A. Simmons, Jenny C. Mortimer, Patrick M. Shih, and Corinne D. Scown
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Social Sciences
Anthropology
[Human responses to climate and ecosystem change in ancient Arabia](
Michael D. Petraglia, Huw S. Groucutt, Maria Guagnin, Paul S. Breeze, and Nicole Boivin
[Ancient engineering of fish capture and storage in southwest Florida](
Victor D. Thompson, William H. Marquardt, Michael Savarese, Karen J. Walker, Lee A. Newsom, Isabelle Lulewicz, Nathan R. Lawres, Amanda D. Roberts Thompson, Allan R. Bacon, and Christoph A. Walser
Psychological and Cognitive Sciences
[Disentangling the origins of confidence in speeded perceptual judgments through multimodal imaging](
Michael Pereira, Nathan Faivre, Iñaki Iturrate, Marco Wirthlin, Luana Serafini, Stéphanie Martin, Arnaud Desvachez, Olaf Blanke, Dimitri Van De Ville, and José del R. Millán
[Humans incorporate trial-to-trial working memory uncertainty into rewarded decisions](
Maija Honig, Wei Ji Ma, and Daryl Fougnie
[Longitudinal changes in DLPFC activation during childhood are related to decreased aggression following social rejection](
Michelle Achterberg, Anna C. K. van Duijvenvoorde, Marinus H. van IJzendoorn, Marian J. Bakermans-Kranenburg, and Eveline A. Crone
Social Sciences
[Measuring the predictability of life outcomes with a scientific mass collaboration](
Matthew J. Salganik, Ian Lundberg, Alexander T. Kindel, Caitlin E. Ahearn, Khaled Al-Ghoneim, Abdullah Almaatouq, Drew M. Altschul, Jennie E. Brand, Nicole Bohme Carnegie, Ryan James Compton, Debanjan Datta, Thomas Davidson, Anna Filippova, Connor Gilroy, Brian J. Goode, Eaman Jahani, Ridhi Kashyap, Antje Kirchner, Stephen McKay, Allison C. Morgan, Alex Pentland, Kivan Polimis, Louis Raes, Daniel E. Rigobon, Claudia V. Roberts, Diana M. Stanescu, Yoshihiko Suhara, Adaner Usmani, Erik H. Wang, Muna Adem, Abdulla Alhajri, Bedoor AlShebli, Redwane Amin, Ryan B. Amos, Lisa P. Argyle, Livia Baer-Bositis, Moritz Büchi, Bo-Ryehn Chung, William Eggert, Gregory Faletto, Zhilin Fan, Jeremy Freese, Tejomay Gadgil, Josh Gagné, Yue Gao, Andrew Halpern-Manners, Sonia P. Hashim, Sonia Hausen, Guanhua He, Kimberly Higuera, Bernie Hogan, Ilana M. Horwitz, Lisa M. Hummel, Naman Jain, Kun Jin, David Jurgens, Patrick Kaminsk i, Areg Karapetyan, E. H. Kim, Ben Leizman, Naijia Liu, Malte Möser, Andrew E. Mack, Mayank Mahajan, Noah Mandell, Helge Marahrens, Diana Mercado-Garcia, Viola Mocz, Katariina Mueller-Gastell, Ahmed Musse, Qiankun Niu, William Nowak, Hamidreza Omidvar, Andrew Or, Karen Ouyang, Katy M. Pinto, Ethan Porter, Kristin E. Porter, Crystal Qian, Tamkinat Rauf, Anahit Sargsyan, Thomas Schaffner, Landon Schnabel, Bryan Schonfeld, Ben Sender, Jonathan D. Tang, Emma Tsurkov, Austin van Loon, Onur Varol, Xiafei Wang, Zhi Wang, Julia Wang, Flora Wang, Samantha Weissman, Kirstie Whitaker, Maria K. Wolters, Wei Lee Woon, James Wu, Catherine Wu, Kengran Yang, Jingwen Yin, Bingyu Zhao, Chenyun Zhu, Jeanne Brooks-Gunn, Barbara E. Engelhardt, Moritz Hardt, Dean Knox, Karen Levy, Arvind Narayanan, Brandon M. Stewart, Duncan J. Watts, and Sara McLanahan
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Biological Sciences
Agricultural Sciences
[The miR-9b microRNA mediates dimorphism and development of wing in aphids](
Feng Shang, Jinzhi Niu, Bi-Yue Ding, Wei Zhang, Dan-Dan Wei, Dong Wei, Hong-Bo Jiang, and Jin-Jun Wang
Anthropology
[Securing timelines in the ancient Mediterranean using multiproxy annual tree-ring data](
Charlotte Pearson, Matthew Salzer, Lukas Wacker, Peter Brewer, Adam Sookdeo, and Peter Kuniholm
[Evidence for habitual climbing in a Pleistocene hominin in South Africa](
Leoni Georgiou, Christopher J. Dunmore, Ameline Bardo, Laura T. Buck, Jean-Jacques Hublin, Dieter H. Pahr, Dominic Stratford, Alexander Synek, Tracy L. Kivell, and Matthew M. Skinner
[Wild chimpanzees exhibit humanlike aging of glucocorticoid regulation](
Melissa Emery Thompson, Stephanie A. Fox, Andreas Berghänel, Kris H. Sabbi, Sarah Phillips-Garcia, Drew K. Enigk, Emily Otali, Zarin P. Machanda, Richard W. Wrangham, and Martin N. Muller
Applied Biological Sciences
[Hanging droplets from liquid surfaces](
Ganhua Xie, Joe Forth, Shipei Zhu, Brett A. Helms, Paul D. Ashby, Ho Cheung Shum, and Thomas P. Russell
[Soluble epoxide hydrolase is an endogenous regulator of obesity-induced intestinal barrier dysfunction and bacterial translocation](
Yuxin Wang, Jun Yang, Weicang Wang, Katherine Z. Sanidad, Maris A. Cinelli, Debin Wan, Sung Hee Hwang, Daeyoung Kim, Kin Sing Stephen Lee, Hang Xiao, Bruce D. Hammock, and Guodong Zhang
[Synthetic molecular evolution of host cell-compatible, antimicrobial peptides effective against drug-resistant, biofilm-forming bacteria](
Charles G. Starr, Jenisha Ghimire, Shantanu Guha, Joseph P. Hoffmann, Yihui Wang, Leisheng Sun, Brooke N. Landreneau, Zachary D. Kolansky, Isabella M. Kilanowski-Doroh, Mimi C. Sammarco, Lisa A. Morici, and William C. Wimley
Biochemistry
[Unraveling the iterative type I polyketide synthases hidden in Streptomyces](
Bin Wang, Fang Guo, Chunshuai Huang, and Huimin Zhao
[Crystal structures of cyanobacterial light-dependent protochlorophyllide oxidoreductase](
Chen-Song Dong, Wei-Lun Zhang, Qiao Wang, Yu-Shuai Li, Xiao Wang, Min Zhang, and Lin Liu
[Ribosome reactivates transcription by physically pushing RNA polymerase out of transcription arrest](
Flint Stevenson-Jones, Jason Woodgate, Daniel Castro-Roa, and Nikolay Zenkin
[Identification of MLKL membrane translocation as a checkpoint in necroptotic cell death using Monobodies](
Emma J. Petrie, Richard W. Birkinshaw, Akiko Koide, Eric Denbaum, Joanne M. Hildebrand, Sarah E. Garnish, Katherine A. Davies, Jarrod J. Sandow, Andre L. Samson, Xavier Gavin, Cheree Fitzgibbon, Samuel N. Young, Patrick J. Hennessy, Phoebe P. C. Smith, Andrew I. Webb, Peter E. Czabotar, Shohei Koide, and James M. Murphy
[Mechanistic basis for microhomology identification and genome scarring by polymerase theta](
Juan Carvajal-Garcia, Jang-Eun Cho, Pablo Carvajal-Garcia, Wanjuan Feng, Richard D. Wood, Jeff Sekelsky, Gaorav P. Gupta, Steven A. Roberts, and Dale A. Ramsden
Biophysics and Computational Biology
[Connectivity and plasticity determine collagen network fracture](
Federica Burla, Simone Dussi, Cristina Martinez-Torres, Justin Tauber, Jasper van der Gucht, and Gijsje H. Koenderink
[In silico design and validation of high-affinity RNA aptamers targeting epithelial cellular adhesion molecule dimers](
David R. Bell, Jeffrey K. Weber, Wang Yin, Tien Huynh, Wei Duan, and Ruhong Zhou
[Model-based integration of genomics and metabolomics reveals SNP functionality in Mycobacterium tuberculosis](
Ove Øyås, Sonia Borrell, Andrej Trauner, Michael Zimmermann, Julia Feldmann, Thomas Liphardt, Sebastien Gagneux, Jörg Stelling, Uwe Sauer, and Mattia Zampieri
[Nonclassical nuclear localization signals mediate nuclear import of CIRBP](
Benjamin Bourgeois, Saskia Hutten, Benjamin Gottschalk, Mario Hofweber, Gesa Richter, Julia Sternat, Claudia Abou-Ajram, Christoph Göbl, Gerd Leitinger, Wolfgang F. Graier, Dorothee Dormann, and Tobias Madl
Cell Biology
[Cancer epithelia-derived mitochondrial DNA is a targetable initiator of a paracrine signaling loop that confers taxane resistance](
Subhash Haldar, Rajeev Mishra, Sandrine Billet, Manish Thiruvalluvan, Veronica R. Placencio-Hickok, Anisha Madhav, Frank Duong, Bryan Angara, Priyanka Agarwal, Mourad Tighiouart, Edwin M. Posadas, and Neil A. Bhowmick
Ecology
[Bioluminescent backlighting illuminates the complex visual signals of a social squid in the deep sea](
Benjamin P. Burford and Bruce H. Robison
[Trait velocities reveal that mortality has driven widespread coordinated shifts in forest hydraulic trait composition](
Anna T. Trugman, Leander D. L. Anderegg, John D. Shaw, and William R. L. Anderegg
[DNA metabarcoding reveals metacommunity dynamics in a threatened boreal wetland wilderness](
Alex Bush, Wendy A. Monk, Zacchaeus G. Compson, Daniel L. Peters, Teresita M. Porter, Shadi Shokralla, Michael T. G. Wright, Mehrdad Hajibabaei, and Donald J. Baird
Evolution
[Sex differences in adult lifespan and aging rates of mortality across wild mammals](
Jean-François Lemaître, Victor Ronget, Morgane Tidière, Dominique Allainé, Vérane Berger, Aurélie Cohas, Fernando Colchero, Dalia A. Conde, Michael Garratt, András Liker, Gabriel A. B. Marais, Alexander Scheuerlein, Tamás Székely, and Jean-Michel Gaillard
[Evolution of hyperossification expands skull diversity in frogs](
Daniel J. Paluh, Edward L. Stanley, and David C. Blackburn
Immunology and Inflammation
[Genetic and structural studies of RABL3 reveal an essential role in lymphoid development and function](
Xue Zhong, Lijing Su, Yi Yang, Evan Nair-Gill, Miao Tang, Priscilla Anderton, Xiaohong Li, Jianhui Wang, Xiaoming Zhan, Diana R. Tomchick, Chad A. Brautigam, Eva Marie Y. Moresco, Jin Huk Choi, and Bruce Beutler
[Dicer up-regulation by inhibition of specific proteolysis in differentiating monocytic cells](
Devaraj Basavarajappa, Stella Uebbing, Marius Kreiss, Ana Lukic, Beatrix Suess, Dieter Steinhilber, Bengt Samuelsson, and Olof RÃ¥dmark
Medical Sciences
[Modulation of androgen receptor DNA binding activity through direct interaction with the ETS transcription factor ERG](
Elizabeth V. Wasmuth, Elizabeth A. Hoover, Albert Antar, Sebastian Klinge, Yu Chen, and Charles L. Sawyers
Microbiology
[Influenza A and B viruses with reduced baloxavir susceptibility display attenuated in vitro fitness but retain ferret transmissibility](
Jeremy C. Jones, Philippe Noriel Q. Pascua, Thomas P. Fabrizio, Bindumadhav M. Marathe, Patrick Seiler, Subrata Barman, Richard J. Webby, Robert G. Webster, and Elena A. Govorkova
Neuroscience
[Disentangling the origins of confidence in speeded perceptual judgments through multimodal imaging](
Michael Pereira, Nathan Faivre, Iñaki Iturrate, Marco Wirthlin, Luana Serafini, Stéphanie Martin, Arnaud Desvachez, Olaf Blanke, Dimitri Van De Ville, and José del R. Millán
[Longitudinal changes in DLPFC activation during childhood are related to decreased aggression following social rejection](
Michelle Achterberg, Anna C. K. van Duijvenvoorde, Marinus H. van IJzendoorn, Marian J. Bakermans-Kranenburg, and Eveline A. Crone
[Control of food approach and eating by a GABAergic projection from lateral hypothalamus to dorsal pons](
Rosa Anna M. Marino, Ross A. McDevitt, Stephanie C. Gantz, Hui Shen, Marco Pignatelli, Wendy Xin, Roy A. Wise, and Antonello Bonci
[Nasally delivered VEGFD mimetics mitigate stroke-induced dendrite loss and brain damage](
Daniela Mauceri, Bettina Buchthal, Thekla J. Hemstedt, Ursula Weiss, Christian D. Klein, and Hilmar Bading
[Nocturnal swallowing augments arousal intensity and arousal tachycardia](
P. G. R. Burke, S. G. Carter, F. Knapman, J. Patti, M. Butlin, S. C. Gandevia, J. E. Butler, D. J. Eckert, and L. E. Bilston
Physiology
[Entrainment of mammalian motile cilia in the brain with hydrodynamic forces](
Nicola Pellicciotta, Evelyn Hamilton, Jurij Kotar, Marion Faucourt, Nathalie Delgehyr, Nathalie Spassky, and Pietro Cicuta
[A paradigm of thermal adaptation in penguins and elephants by tuning cold activation in TRPM8](
Shilong Yang, Xiancui Lu, Yunfei Wang, Lizhen Xu, Xiaoying Chen, Fan Yang, and Ren Lai
Plant Biology
[Accumulation of high-value bioproducts in planta can improve the economics of advanced biofuels](
Minliang Yang, Nawa Raj Baral, Blake A. Simmons, Jenny C. Mortimer, Patrick M. Shih, and Corinne D. Scown
[Water lily (Nymphaea thermarum) genome reveals variable genomic signatures of ancient vascular cambium losses](
Rebecca A. Povilus, Jeffrey M. DaCosta, Christopher Grassa, Prasad R. V. Satyaki, Morgan Moeglein, Johan Jaenisch, Zhenxiang Xi, Sarah Mathews, Mary Gehring, Charles C. Davis, and William E. Friedman
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Corrections
[Correction for Glaser et al., The histone demethylase JMJD2B regulates endothelial-to-mesenchymal transition](
[Correction for Srinivasan et al., MiR223-3p promotes synthetic lethality in BRCA1-deficient cancers](
[Correction for Huang et al., Salicylic acid-mediated plasmodesmal closure via Remorin-dependent lipid organization](
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Retraction
[Retraction for Li et al., Impaired lipid metabolism by age-dependent DNA methylation alterations accelerates aging](
[Cover]
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