PNAS Table of Contents for January 7, 2020; Vol. 117, No. 1

[PNAS] [Chemistry Portal](/cgi/adclick/?ad=54598&adclick=true&url=http%3A%2F%2Fchemistry.pnas.org%2F)   [January 7, 2020; Vol. 117, No. 1]( ) This Week in PNAS [In This Issue]( --------------------------------------------------------------- Editorial [On a subject no one wants to read about (about which no one wants to read?)]( May R. Berenbaum --------------------------------------------------------------- News Feature [News Feature: Cannabis and the adolescent brain]( Helen Shen An in-depth look at trending science issues. --------------------------------------------------------------- QnAs [QnAs with Max D. Cooper and Jacques F. A. P. Miller]( Brian Doctrow --------------------------------------------------------------- Retrospective [In Memoriam: Lelio Orci, 1937–2019]( Roberto Montesano, Randy Schekman, James Rothman, and Alain Perrelet --------------------------------------------------------------- Commentaries [Human bloodsucking parasite in service of materials science]( Alexander Y. Grosberg [Studying human attention on the Internet]( David Lazer [Rising inequality is not balanced by intergenerational mobility]( Jason Beckfield [Functional testing of ASD-associated genes]( Marla B. Sokolowski --------------------------------------------------------------- Perspective [Drivers of change in China’s energy-related CO2 emissions]( Xiaoqi Zheng, Yonglong Lu, Jingjing Yuan, Yvette Baninla, Sheng Zhang, Nils Chr. Stenseth, Dag O. Hessen, Hanqin Tian, Michael Obersteiner, and Deliang Chen --------------------------------------------------------------- Letters [A more comprehensive view of the Denisovan 3-rooted lower second molar from Xiahe]( G. Richard Scott, Joel D. Irish, and María Martinón-Torres [Reply to Scott et al: A closer look at the 3-rooted lower second molar of an archaic human from Xiahe]( Shara E. Bailey, Kornelius Kupczik, Jean-Jacques Hublin, and Susan C. Antón [Signaling the trustworthiness of science should not be a substitute for direct action against research misconduct]( Donald S. Kornfeld and Sandra L. Titus [Reply to Kornfeld and Titus: No distraction from misconduct]( Kathleen Hall Jamieson, Marcia McNutt, Veronique Kiermer, and Richard Sever --------------------------------------------------------------- Physical Sciences Applied Mathematics [Mechanics unlocks the morphogenetic puzzle of interlocking bivalved shells]( Derek E. Moulton, Alain Goriely, and Régis Chirat [Using machine learning to predict extreme events in complex systems]( Di Qi and Andrew J. Majda Applied Physical Sciences [Accurate and rapid background estimation in single-molecule localization microscopy using the deep neural network BGnet]( Leonhard Möckl, Anish R. Roy, Petar N. Petrov, and W. E. Moerner [Competing stripe and magnetic phases in the cuprates from first principles]( Yubo Zhang, Christopher Lane, James W. Furness, Bernardo Barbiellini, John P. Perdew, Robert S. Markiewicz, Arun Bansil, and Jianwei Sun [The intrinsic behavior of lithium fluoride in solid electrolyte interphases on lithium]( Mingfu He, Rui Guo, Gustavo M. Hobold, Haining Gao, and Betar M. Gallant [High-performance, semiconducting membrane composed of ultrathin, single-crystal organic semiconductors]( Tatsuyuki Makita, Shohei Kumagai, Akihito Kumamoto, Masato Mitani, Junto Tsurumi, Ryohei Hakamatani, Mari Sasaki, Toshihiro Okamoto, Yuichi Ikuhara, Shun Watanabe, and Jun Takeya [Elastic avalanches reveal marginal behavior in amorphous solids]( Baoshuang Shang, Pengfei Guan, and Jean-Louis Barrat Biophysics and Computational Biology [High-density chemical cross-linking for modeling protein interactions]( Julian Mintseris and Steven P. Gygi [Unexpected intracellular biodegradation and recrystallization of gold nanoparticles]( Alice Balfourier, Nathalie Luciani, Guillaume Wang, Gerald Lelong, Ovidiu Ersen, Abdelali Khelfa, Damien Alloyeau, Florence Gazeau, and Florent Carn [Lessons from equilibrium statistical physics regarding the assembly of protein complexes]( Pablo Sartori and Stanislas Leibler [Equilibrium structure and deformation response of 2D kinetoplast sheets]( Alexander R. Klotz, Beatrice W. Soh, and Patrick S. Doyle [How tissue fluidity influences brain tumor progression]( Kaspar-Josche Streitberger, Ledia Lilaj, Felix Schrank, Jürgen Braun, Karl-Titus Hoffmann, Martin Reiss-Zimmermann, Josef A. Käs, and Ingolf Sack [Photoreversible interconversion of a phytochrome photosensory module in the crystalline state]( E. Sethe Burgie, Jonathan A. Clinger, Mitchell D. Miller, Aaron S. Brewster, Pierre Aller, Agata Butryn, Franklin D. Fuller, Sheraz Gul, Iris D. Young, Cindy C. Pham, In-Sik Kim, Asmit Bhowmick, Lee J. O’Riordan, Kyle D. Sutherlin, Joshua V. Heinemann, Alexander Batyuk, Roberto Alonso-Mori, Mark S. Hunter, Jason E. Koglin, Junko Yano, Vittal K. Yachandra, Nicholas K. Sauter, Aina E. Cohen, Jan Kern, Allen M. Orville, George N. Phillips Jr, and Richard D. Vierstra [Growth-rate dependent resource investment in bacterial motile behavior quantitatively follows potential benefit of chemotaxis]( Bin Ni, Remy Colin, Hannes Link, Robert G. Endres, and Victor Sourjik Chemistry [Light-driven carbon−carbon bond formation via CO2 reduction catalyzed by complexes of CdS nanorods and a 2-oxoacid oxidoreductase]( Hayden Hamby, Bin Li, Katherine E. Shinopoulos, Helena R. Keller, Sean J. Elliott, and Gordana Dukovic [Assessment of the manganese cluster’s oxidation state via photoactivation of photosystem II microcrystals]( Mun Hon Cheah, Miao Zhang, Dmitry Shevela, Fikret Mamedov, Athina Zouni, and Johannes Messinger [Photodissociation transition states characterized by chirped pulse millimeter wave spectroscopy]( Kirill Prozument, Joshua H. Baraban, P. Bryan Changala, G. Barratt Park, Rachel G. Shaver, John S. Muenter, Stephen J. Klippenstein, Vladimir Y. Chernyak, and Robert W. Field [Kinetics and mechanism of planar nanowire growth]( Amnon Rothman, Vladimir G. Dubrovskii, and Ernesto Joselevich [In situ self-assembling Au-DNA complexes for targeted cancer bioimaging and inhibition]( Maonan Wang, Yun Chen, Weijuan Cai, Huan Feng, Tianyu Du, Weiwei Liu, Hui Jiang, Alberto Pasquarelli, Yossi Weizmann, and Xuemei Wang Computer Sciences [Shaping the learning landscape in neural networks around wide flat minima]( Carlo Baldassi, Fabrizio Pittorino, and Riccardo Zecchina Earth, Atmospheric, and Planetary Sciences [Universal relation with regime transition for sediment transport in fine-grained rivers]( Hongbo Ma, Jeffrey A. Nittrouer, Baosheng Wu, Michael P. Lamb, Yuanfeng Zhang, David Mohrig, Xudong Fu, Kensuke Naito, Yuanjian Wang, Andrew J. Moodie, Guangqian Wang, Chunhong Hu, and Gary Parker [Complexity-based approach for El Niño magnitude forecasting before the spring predictability barrier]( Jun Meng, Jingfang Fan, Josef Ludescher, Ankit Agarwal, Xiaosong Chen, Armin Bunde, Jürgen Kurths, and Hans Joachim Schellnhuber [Evidence for the stability of ultrahydrous stishovite in Earth’s lower mantle]( Yanhao Lin, Qingyang Hu, Yue Meng, Michael Walter, and Ho-Kwang Mao [A low climate threshold for south Greenland Ice Sheet demise during the Late Pleistocene]( Nil Irvalı, Eirik V. Galaasen, Ulysses S. Ninnemann, Yair Rosenthal, Andreas Born, and Helga (Kikki) F. Kleiven Engineering [Disclinations and disconnections in minerals and metals]( John P. Hirth, Greg Hirth, and Jian Wang [Multiscale porous elastomer substrates for multifunctional on-skin electronics with passive-cooling capabilities]( Yadong Xu, Bohan Sun, Yun Ling, Qihui Fei, Zanyu Chen, Xiaopeng Li, Peijun Guo, Nari Jeon, Shivam Goswami, Yixuan Liao, Shinghua Ding, Qingsong Yu, Jian Lin, Guoliang Huang, and Zheng Yan [Biodegradable nanofiber-based piezoelectric transducer]( Eli J. Curry, Thinh T. Le, Ritopa Das, Kai Ke, Elise M. Santorella, Debayon Paul, Meysam T. Chorsi, Khanh T. M. Tran, Jeffrey Baroody, Emily R. Borges, Brian Ko, Asiyeh Golabchi, Xiaonan Xin, David Rowe, Lixia Yue, Jianlin Feng, M. Daniela Morales-Acosta, Qian Wu, I-Ping Chen, X. Tracy Cui, Joel Pachter, and Thanh D. Nguyen Physics [Studies on the origin of the interfacial superconductivity of Sb2Te3/Fe1+yTe heterostructures]( Jing Liang, Yu Jun Zhang, Xiong Yao, Hui Li, Zi-Xiang Li, Jiannong Wang, Yuanzhen Chen, and Iam Keong Sou [Quantitative determination of atomic buckling of silicene by atomic force microscopy]( Rémy Pawlak, Carl Drechsel, Philipp D’Astolfo, Marcin Kisiel, Ernst Meyer, and Jorge Iribas Cerda [Spectroscopic fingerprint of chiral Majorana modes at the edge of a quantum anomalous Hall insulator/superconductor heterostructure]( Junying Shen, Jian Lyu, Jason Z. Gao, Ying-Ming Xie, Chui-Zhen Chen, Chang-woo Cho, Omargeldi Atanov, Zhijie Chen, Kai Liu, Yajian J. Hu, King Yau Yip, Swee K. Goh, Qing Lin He, Lei Pan, Kang L. Wang, Kam Tuen Law, and Rolf Lortz --------------------------------------------------------------- Social Sciences Political Sciences [Assessing the Russian Internet Research Agency’s impact on the political attitudes and behaviors of American Twitter users in late 2017]( Christopher A. Bail, Brian Guay, Emily Maloney, Aidan Combs, D. Sunshine Hillygus, Friedolin Merhout, Deen Freelon, and Alexander Volfovsky Psychological and Cognitive Sciences [Early childhood deprivation is associated with alterations in adult brain structure despite subsequent environmental enrichment]( Nuria K. Mackes, Dennis Golm, Sagari Sarkar, Robert Kumsta, Michael Rutter, Graeme Fairchild, Mitul A. Mehta, Edmund J. S. Sonuga-Barke, and on behalf of the ERA Young Adult Follow-up team Social Sciences [Long-term decline in intergenerational mobility in the United States since the 1850s]( Xi Song, Catherine G. Massey, Karen A. Rolf, Joseph P. Ferrie, Jonathan L. Rothbaum, and Yu Xie Sustainability Science [Smallholder farmers and contract farming in developing countries]( Eva-Marie Meemken and Marc F. Bellemare [Mangroves protect coastal economic activity from hurricanes]( Alejandro del Valle, Mathilda Eriksson, Oscar A. Ishizawa, and Juan Jose Miranda [Long-term effects of cultural filtering on megafauna species distributions across China]( Shuqing N. Teng, Chi Xu, Licheng Teng, and Jens-Christian Svenning --------------------------------------------------------------- Biological Sciences Agricultural Sciences [Smallholder farmers and contract farming in developing countries]( Eva-Marie Meemken and Marc F. Bellemare [An R2R3 MYB transcription factor confers brown planthopper resistance by regulating the phenylalanine ammonia-lyase pathway in rice]( Jun He, Yuqiang Liu, Dingyang Yuan, Meijuan Duan, Yanling Liu, Zijie Shen, Chunyan Yang, Zeyu Qiu, Daoming Liu, Peizheng Wen, Jie Huang, Dejia Fan, Shizhuo Xiao, Yeyun Xin, Xianian Chen, Ling Jiang, Haiyang Wang, Longping Yuan, and Jianmin Wan Anthropology [Insights into the lower torso in late Miocene hominoid Oreopithecus bambolii]( Ashley S. Hammond, Lorenzo Rook, Alisha D. Anaya, Elisabetta Cioppi, Loïc Costeur, Salvador Moyà-Solà, and Sergio Almécija Applied Biological Sciences [High-density chemical cross-linking for modeling protein interactions]( Julian Mintseris and Steven P. Gygi [Ultrasmall silica nanoparticles directly ligate the T cell receptor complex]( Bradley Vis, Rachel E. Hewitt, Tom P. Monie, Camilla Fairbairn, Suzanne D. Turner, Stephen D. Kinrade, and Jonathan J. Powell [Kappa-on-Heavy (KoH) bodies are a distinct class of fully-human antibody-like therapeutic agents with antigen-binding properties]( Lynn E. Macdonald, Karoline A. Meagher, Matthew C. Franklin, Natasha Levenkova, Johanna Hansen, Ashok T. Badithe, Maggie Zhong, Pamela Krueger, Ashique Rafique, Naxin Tu, James Shevchuk, Saurabh Wadhwa, George Ehrlich, Joannie Bautista, Craig Grant, Lakeisha Esau, William T. Poueymirou, Wojtek Auerbach, Lori Morton, Robert Babb, Gang Chen, Tammy Huang, Douglas MacDonald, Kenneth Graham, Cagan Gurer, Vera A. Voronina, John R. McWhirter, Chunguang Guo, George D. Yancopoulos, and Andrew J. Murphy Biochemistry [Light-driven carbon−carbon bond formation via CO2 reduction catalyzed by complexes of CdS nanorods and a 2-oxoacid oxidoreductase]( Hayden Hamby, Bin Li, Katherine E. Shinopoulos, Helena R. Keller, Sean J. Elliott, and Gordana Dukovic [Photoreversible interconversion of a phytochrome photosensory module in the crystalline state]( E. Sethe Burgie, Jonathan A. Clinger, Mitchell D. Miller, Aaron S. Brewster, Pierre Aller, Agata Butryn, Franklin D. Fuller, Sheraz Gul, Iris D. Young, Cindy C. Pham, In-Sik Kim, Asmit Bhowmick, Lee J. O’Riordan, Kyle D. Sutherlin, Joshua V. Heinemann, Alexander Batyuk, Roberto Alonso-Mori, Mark S. Hunter, Jason E. Koglin, Junko Yano, Vittal K. Yachandra, Nicholas K. Sauter, Aina E. Cohen, Jan Kern, Allen M. Orville, George N. Phillips Jr, and Richard D. Vierstra [In situ self-assembling Au-DNA complexes for targeted cancer bioimaging and inhibition]( Maonan Wang, Yun Chen, Weijuan Cai, Huan Feng, Tianyu Du, Weiwei Liu, Hui Jiang, Alberto Pasquarelli, Yossi Weizmann, and Xuemei Wang [Molecular mechanism of leukocidin GH–integrin CD11b/CD18 recognition and species specificity]( Nikolina Trstenjak, Dalibor Milić, Melissa A. Graewert, Harald Rouha, Dmitri Svergun, Kristina Djinović-Carugo, Eszter Nagy, and Adriana Badarau [Reversible phosphorylation of Rpn1 regulates 26S proteasome assembly and function]( Xiaoyan Liu, Weidi Xiao, Yanan Zhang, Sandra E. Wiley, Tao Zuo, Yingying Zheng, Natalie Chen, Lu Chen, Xiaorong Wang, Yawen Zheng, Lan Huang, Shixian Lin, Anne N. Murphy, Jack E. Dixon, Ping Xu, and Xing Guo [Structure, function, and evolution of Gga-AvBD11, the archetype of the structural avian-double-β-defensin family]( Nicolas Guyot, Hervé Meudal, Sascha Trapp, Sophie Iochmann, Anne Silvestre, Guillaume Jousset, Valérie Labas, Pascale Reverdiau, Karine Loth, Virginie Hervé, Vincent Aucagne, Agnès F. Delmas, Sophie Rehault-Godbert, and Céline Landon [Analysis of allosteric communication in a multienzyme complex by ancestral sequence reconstruction]( Michael Schupfner, Kristina Straub, Florian Busch, Rainer Merkl, and Reinhard Sterner [Uncovering the functional residues of Arabidopsis isoprenoid biosynthesis enzyme HDS]( Jin-Zheng Wang, Yongxing Lei, Yanmei Xiao, Xiang He, Jiubo Liang, Jishan Jiang, Shangzhi Dong, Haiyan Ke, Patricia Leon, Philipp Zerbe, Youli Xiao, and Katayoon Dehesh [An inhibitor of complement C5 provides structural insights into activation]( Martin P. Reichhardt, Steven Johnson, Terence Tang, Thomas Morgan, Nchimunya Tebeka, Niko Popitsch, Justin C. Deme, Matthijs M. Jore, and Susan M. Lea [DeepRiPP integrates multiomics data to automate discovery of novel ribosomally synthesized natural products]( Nishanth J. Merwin, Walaa K. Mousa, Chris A. Dejong, Michael A. Skinnider, Michael J. Cannon, Haoxin Li, Keshav Dial, Mathusan Gunabalasingam, Chad Johnston, and Nathan A. Magarvey [Insights into the mechanism and regulation of the CbbQO-type Rubisco activase, a MoxR AAA+ ATPase]( Yi-Chin Candace Tsai, Fuzhou Ye, Lynette Liew, Di Liu, Shashi Bhushan, Yong-Gui Gao, and Oliver Mueller-Cajar Biophysics and Computational Biology [Accurate and rapid background estimation in single-molecule localization microscopy using the deep neural network BGnet]( Leonhard Möckl, Anish R. Roy, Petar N. Petrov, and W. E. Moerner [Assessment of the manganese cluster’s oxidation state via photoactivation of photosystem II microcrystals]( Mun Hon Cheah, Miao Zhang, Dmitry Shevela, Fikret Mamedov, Athina Zouni, and Johannes Messinger [A bacterial surface layer protein exploits multistep crystallization for rapid self-assembly]( Jonathan Herrmann, Po-Nan Li, Fatemeh Jabbarpour, Anson C. K. Chan, Ivan Rajkovic, Tsutomu Matsui, Lucy Shapiro, John Smit, Thomas M. Weiss, Michael E. P. Murphy, and Soichi Wakatsuki [Two closed ATP- and ADP-dependent conformations in yeast Hsp90 chaperone detected by Mn(II) EPR spectroscopic techniques]( Angeliki Giannoulis, Akiva Feintuch, Yoav Barak, Hisham Mazal, Shira Albeck, Tamar Unger, Feng Yang, Xun-Cheng Su, and Daniella Goldfarb [Microsecond-timescale simulations suggest 5-HT–mediated preactivation of the 5-HT3A serotonin receptor]( Nicholas B. Guros, Arvind Balijepalli, and Jeffery B. Klauda Cell Biology [B2 and ALU retrotransposons are self-cleaving ribozymes whose activity is enhanced by EZH2]( Alfredo J. Hernandez, Athanasios Zovoilis, Catherine Cifuentes-Rojas, Lu Han, Bojan Bujisic, and Jeannie T. Lee [Immunity against cancer cells may promote their proliferation and metastasis]( Chih-Wei Lin, Jia Xie, Ding Zhang, Kyung Ho Han, Geramie Grande, Nicholas C. Wu, Zhuo Yang, Kyungmoo Yea, and Richard A. Lerner [Actin protrusions push at apical junctions to maintain E-cadherin adhesion]( John Xiao He Li, Vivian W. Tang, and William M. Brieher [Regulation of INF2-mediated actin polymerization through site-specific lysine acetylation of actin itself]( Mu A, Tak Shun Fung, Lisa M. Francomacaro, Thao Huynh, Tommi Kotila, Zdenek Svindrych, and Henry N. Higgs [Enhanced expression of β cell CaV3.1 channels impairs insulin release and glucose homeostasis]( Jia Yu, Yue Shi, Kaixuan Zhao, Guang Yang, Lina Yu, Yuxin Li, Eva-Marie Andersson, Carina Ämmälä, Shao-Nian Yang, and Per-Olof Berggren [Identification of Pparγ-modulated miRNA hubs that target the fibrotic tumor microenvironment]( Ivana Winkler, Catrin Bitter, Sebastian Winkler, Dieter Weichenhan, Abhishek Thavamani, Jan G. Hengstler, Erawan Borkham-Kamphorst, Oliver Kohlbacher, Christoph Plass, Robert Geffers, Ralf Weiskirchen, and Alfred Nordheim Developmental Biology [An in vivo RNAi screen uncovers the role of AdoR signaling and adenosine deaminase in controlling intestinal stem cell activity]( Chiwei Xu, Brian Franklin, Hong-Wen Tang, Yannik Regimbald-Dumas, Yanhui Hu, Justine Ramos, Justin A. Bosch, Christians Villalta, Xi He, and Norbert Perrimon Ecology [Predator-informed looming stimulus experiments reveal how large filter feeding whales capture highly maneuverable forage fish]( David E. Cade, Nicholas Carey, Paolo Domenici, Jean Potvin, and Jeremy A. Goldbogen [Hidden similarities in the dynamics of a weakly synchronous marine metapopulation]( Tanya L. Rogers and Stephan B. Munch Environmental Sciences [Long-term effects of cultural filtering on megafauna species distributions across China]( Shuqing N. Teng, Chi Xu, Licheng Teng, and Jens-Christian Svenning Evolution [Mechanics unlocks the morphogenetic puzzle of interlocking bivalved shells]( Derek E. Moulton, Alain Goriely, and Régis Chirat [Genetically barcoded SIV reveals the emergence of escape mutations in multiple viral lineages during immune escape]( Taina T. Immonen, Celine Camus, Carolyn Reid, Christine M. Fennessey, Gregory Q. Del Prete, Miles P. Davenport, Jeffrey D. Lifson, and Brandon F. Keele [Dorsoventral decoupling of Hox gene expression underpins the diversification of molluscs]( Pin Huan, Qian Wang, Sujian Tan, and Baozhong Liu Genetics [CRISPR-mediated modeling and functional validation of candidate tumor suppressor genes in small cell lung cancer]( Sheng Rong Ng, William M. Rideout III, Elliot H. Akama-Garren, Arjun Bhutkar, Kim L. Mercer, Jason M. Schenkel, Roderick T. Bronson, and Tyler Jacks Immunology and Inflammation [Trans-endocytosis of intact IL-15Rα–IL-15 complex from presenting cells into NK cells favors signaling for proliferation]( Olga M. Anton, Mary E. Peterson, Michael J. Hollander, David W. Dorward, Gunjan Arora, Javier Traba, Sumati Rajagopalan, Erik L. Snapp, K. Christopher Garcia, Thomas A. Waldmann, and Eric O. Long [Determinants governing T cell receptor α/β-chain pairing in repertoire formation of identical twins]( Hidetaka Tanno, Timothy M. Gould, Jonathan R. McDaniel, Wenqiang Cao, Yuri Tanno, Russell E. Durrett, Daechan Park, Steven J. Cate, William H. Hildebrand, Cornelia L. Dekker, Lu Tian, Cornelia M. Weyand, George Georgiou, and Jörg J. Goronzy [Optimized antiangiogenic reprogramming of the tumor microenvironment potentiates CD40 immunotherapy]( Abhishek S. Kashyap, Martina Schmittnaegel, Nicolò Rigamonti, Daniela Pais-Ferreira, Philipp Mueller, Melanie Buchi, Chia-Huey Ooi, Matthias Kreuzaler, Petra Hirschmann, Alan Guichard, Natascha Rieder, Ruben Bill, Frank Herting, Yvonne Kienast, Stefan Dirnhofer, Christian Klein, Sabine Hoves, Carola H. Ries, Emily Corse, Michele De Palma, and Alfred Zippelius Medical Sciences [Unexpected intracellular biodegradation and recrystallization of gold nanoparticles]( Alice Balfourier, Nathalie Luciani, Guillaume Wang, Gerald Lelong, Ovidiu Ersen, Abdelali Khelfa, Damien Alloyeau, Florence Gazeau, and Florent Carn [HLA and autoantibodies define scleroderma subtypes and risk in African and European Americans and suggest a role for molecular mimicry]( Pravitt Gourh, Sarah A. Safran, Theresa Alexander, Steven E. Boyden, Nadia D. Morgan, Ami A. Shah, Maureen D. Mayes, Ayo Doumatey, Amy R. Bentley, Daniel Shriner, Robyn T. Domsic, Thomas A. Medsger Jr, Paula S. Ramos, Richard M. Silver, Virginia D. Steen, John Varga, Vivien Hsu, Lesley Ann Saketkoo, Elena Schiopu, Dinesh Khanna, Jessica K. Gordon, Brynn Kron, Lindsey A. Criswell, Heather Gladue, Chris T. Derk, Elana J. Bernstein, S. Louis Bridges Jr, Victoria K. Shanmugam, Kathleen D. Kolstad, Lorinda Chung, Suzanne Kafaja, Reem Jan, Marcin Trojanowski, Avram Goldberg, Benjamin D. Korman, Peter J. Steinbach, Settara C. Chandrasekharappa, James C. Mullikin, Adebowale Adeyemo, Charles Rotimi, Fredrick M. Wigley, Daniel L. Kastner, Francesco Boin, and Elaine F. Remmers [A genetically defined disease model reveals that urothelial cells can initiate divergent bladder cancer phenotypes]( Liang Wang, Bryan A. Smith, Nikolas G. Balanis, Brandon L. Tsai, Kim Nguyen, Michael W. Cheng, Matthew B. Obusan, Favour N. Esedebe, Saahil J. Patel, Hanwei Zhang, Peter M. Clark, Anthony E. Sisk, Jonathan W. Said, Jiaoti Huang, Thomas G. Graeber, Owen N. Witte, Arnold I. Chin, and Jung Wook Park [Ultraviolet A light induces DNA damage and estrogen-DNA adducts in Fuchs endothelial corneal dystrophy causing females to be more affected]( Cailing Liu, Taiga Miyajima, Geetha Melangath, Takashi Miyai, Shivakumar Vasanth, Neha Deshpande, Varun Kumar, Stephan Ong Tone, Reena Gupta, Shan Zhu, Dijana Vojnovic, Yuming Chen, Eleanor G. Rogan, Bodhiswatta Mondal, Muhammad Zahid, and Ula V. Jurkunas [FBXW7-mediated stability regulation of signal transducer and activator of transcription 2 in melanoma formation]( Cheol-Jung Lee, Hyun-Jung An, Seung-Min Kim, Sun-Mi Yoo, Juhee Park, Ga-Eun Lee, Woo-Young Kim, Dae Joon Kim, Han Chang Kang, Joo Young Lee, Hye Suk Lee, Sung-Jun Cho, and Yong-Yeon Cho Microbiology [Growth-rate dependent resource investment in bacterial motile behavior quantitatively follows potential benefit of chemotaxis]( Bin Ni, Remy Colin, Hannes Link, Robert G. Endres, and Victor Sourjik [Regulating vitamin B12 biosynthesis via the cbiMCbl riboswitch in Propionibacterium strain UF1]( Jing Li, Yong Ge, Mojgan Zadeh, Roy Curtiss III, and Mansour Mohamadzadeh [Retroviruses drive the rapid evolution of mammalian APOBEC3 genes]( Jumpei Ito, Robert J. Gifford, and Kei Sato [Divergent evolutionary trajectories of influenza B viruses underlie their contemporaneous epidemic activity]( Ramandeep K. Virk, Jayanthi Jayakumar, Ian H. Mendenhall, Mahesh Moorthy, Pauline Lam, Martin Linster, Julia Lim, Cui Lin, Lynette L. E. Oon, Hong Kai Lee, Evelyn S. C. Koay, Dhanasekaran Vijaykrishna, Gavin J. D. Smith, and Yvonne C. F. Su [Mycobacterial HflX is a ribosome splitting factor that mediates antibiotic resistance]( Paulami Rudra, Kelley R. Hurst-Hess, Katherine L. Cotten, Andrea Partida-Miranda, and Pallavi Ghosh [Abortive herpes simplex virus infection of nonneuronal cells results in quiescent viral genomes that can reactivate]( Efrat M. Cohen, Nir Avital, Meir Shamay, and Oren Kobiler Neuroscience [Early childhood deprivation is associated with alterations in adult brain structure despite subsequent environmental enrichment]( Nuria K. Mackes, Dennis Golm, Sagari Sarkar, Robert Kumsta, Michael Rutter, Graeme Fairchild, Mitul A. Mehta, Edmund J. S. Sonuga-Barke, and on behalf of the ERA Young Adult Follow-up team [Stress-induced modulation of endocannabinoid signaling leads to delayed strengthening of synaptic connectivity in the amygdala]( Farhana Yasmin, Roberto Colangeli, Maria Morena, Sarah Filipski, Mario van der Stelt, Quentin J. Pittman, Cecilia J. Hillard, G. Campbell Teskey, Bruce S. McEwen, Matthew N. Hill, and Sumantra Chattarji [Systematic phenomics analysis of autism-associated genes reveals parallel networks underlying reversible impairments in habituation]( Troy A. McDiarmid, Manuel Belmadani, Joseph Liang, Fabian Meili, Eleanor A. Mathews, Gregory P. Mullen, Ardalan Hendi, Wan-Rong Wong, James B. Rand, Kota Mizumoto, Kurt Haas, Paul Pavlidis, and Catharine H. Rankin [Imaging the effect of the circadian light–dark cycle on the glymphatic system in awake rats]( Xuezhu Cai, Ju Qiao, Praveen Kulkarni, Ian C. Harding, Eno Ebong, and Craig F. Ferris [Chorea-related mutations in PDE10A result in aberrant compartmentalization and functionality of the enzyme]( Gonzalo S. Tejeda, Ellanor L. Whiteley, Tarek Z. Deeb, Roland W. Bürli, Stephen J. Moss, Eamonn Sheridan, Nicholas J. Brandon, and George S. Baillie [Distinct effects of reward and navigation history on hippocampal forward and reverse replays]( Baburam Bhattarai, Jong Won Lee, and Min Whan Jung [A dual role for peripheral GDNF signaling in nociception and cardiovascular reflexes in the mouse]( Luis F. Queme, Alex A. Weyler, Elysia R. Cohen, Renita C. Hudgins, and Michael P. Jankowski [The olfactory basis of orchid pollination by mosquitoes]( Chloé Lahondère, Clément Vinauger, Ryo P. Okubo, Gabriella H. Wolff, Jeremy K. Chan, Omar S. Akbari, and Jeffrey A. Riffell Physiology [Shear force sensing of epithelial Na+ channel (ENaC) relies on N-glycosylated asparagines in the palm and knuckle domains of αENaC]( Fenja Knoepp, Zoe Ashley, Daniel Barth, Jan-Peter Baldin, Michael Jennings, Marina Kazantseva, Eng Leng Saw, Rajesh Katare, Diego Alvarez de la Rosa, Norbert Weissmann, and Martin Fronius Plant Biology [OsmiR528 regulates rice-pollen intine formation by targeting an uclacyanin to influence flavonoid metabolism]( Yu-Chan Zhang, Rui-Rui He, Jian-Ping Lian, Yan-Fei Zhou, Fan Zhang, Quan-Feng Li, Yang Yu, Yan-Zhao Feng, Yu-Wei Yang, Meng-Qi Lei, Huang He, Zhi Zhang, and Yue-Qin Chen [Evolution of vascular plants through redeployment of ancient developmental regulators]( Kuan-Ju Lu, Nicole van ’t Wout Hofland, Eliana Mor, Sumanth Mutte, Paul Abrahams, Hirotaka Kato, Klaas Vandepoele, Dolf Weijers, and Bert De Rybel [Redox-mediated kick-start of mitochondrial energy metabolism drives resource-efficient seed germination]( Thomas Nietzel, Jörg Mostertz, Cristina Ruberti, Guillaume Née, Philippe Fuchs, Stephan Wagner, Anna Moseler, Stefanie J. Müller-Schüssele, Abdelilah Benamar, Gernot Poschet, Michael Büttner, Ian Max Møller, Christopher H. Lillig, David Macherel, Markus Wirtz, Rüdiger Hell, Iris Finkemeier, Andreas J. Meyer, Falko Hochgräfe, and Markus Schwarzländer [The structural bases for agonist diversity in an Arabidopsis thaliana glutamate receptor-like channel]( Andrea Alfieri, Fabrizio G. Doccula, Riccardo Pederzoli, Matteo Grenzi, Maria Cristina Bonza, Laura Luoni, Alessia Candeo, Neli Romano Armada, Alberto Barbiroli, Gianluca Valentini, Thomas R. Schneider, Andrea Bassi, Martino Bolognesi, Marco Nardini, and Alex Costa [An ortholog of the Vasa intronic gene is required for small RNA-mediated translation repression in Chlamydomonas reinhardtii]( Xinrong Ma, Fadia Ibrahim, Eun-Jeong Kim, Scott Shaver, James Becker, Fareha Razvi, Ronald L. Cerny, and Heriberto Cerutti Psychological and Cognitive Sciences [Development of structure–function coupling in human brain networks during youth]( Graham L. Baum, Zaixu Cui, David R. Roalf, Rastko Ciric, Richard F. Betzel, Bart Larsen, Matthew Cieslak, Philip A. Cook, Cedric H. Xia, Tyler M. Moore, Kosha Ruparel, Desmond J. Oathes, Aaron F. Alexander-Bloch, Russell T. Shinohara, Armin Raznahan, Raquel E. Gur, Ruben C. Gur, Danielle S. Bassett, and Theodore D. Satterthwaite Systems Biology [Hypoxia induces a time- and tissue-specific response that elicits intertissue circadian clock misalignment]( Gal Manella, Rona Aviram, Nityanand Bolshette, Sapir Muvkadi, Marina Golik, David F. Smith, and Gad Asher --------------------------------------------------------------- Corrections [Correction for Battersby, Core Concept: What are the chances of a hazardous solar superflare?]( [Correction for Wu et al., Machine learning-assisted directed protein evolution with combinatorial libraries]( [Correction for Davidsohn et al., A single combination gene therapy treats multiple age-related diseases]( [Cover] --------------------------------------------------------------- This message was sent to {EMAIL}. [Unsubscribe]( from or [edit]( your subscription for this service. Or by mail: Customer Service * 973 University Avenue * Los Gatos, CA 95032 * U.S.A. Copyright © 2020 by the National Academy of Sciences