[PNAS]
[PNAS 2019 Top Ten](/cgi/adclick/?ad=54578&adclick=true&url=https%3A%2F%2Fwww.pnas.org%2Fpage%2Ftopten2019)
 [December 26, 2019; Vol. 116, No. 52](
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This Week in PNAS
[In This Issue](
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Guest Editor and Reviewer Acknowledgment (Online Only)
[Acknowledgment of Guest Editors, 2019](
[Acknowledgment of Reviewers, 2019](
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Opinion
[Opinion: Why green âclimate gentrificationâ threatens poor and vulnerable populations](
Isabelle Anguelovski, James J. T. Connolly, Hamil Pearsall, Galia Shokry, Melissa Checker, Juliana Maantay, Kenneth Gould, Tammy Lewis, Andrew Maroko, and J. Timmons Roberts
Leading scientists discuss current issues.
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Profile
[Profile of Dennis L. Kasper](
Jennifer Viegas
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Commentary
[Toward treatment and cure of epidermolysis bullosa](
Jouni Uitto
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Letters
[Ca2+/CaM interaction with voltage-gated Na+ channels](
Geoffrey S. Pitt and Seok-Yong Lee
[Reply to Pitt and Lee: Occupancies of Ca2+ in complexes of calmodulin with voltage-gated sodium channels](
Filip Van Petegem and Bernd R. Gardill
[Urban heating and canopy cover need to be considered as matters of environmental justice](
Michael Drescher
[Reply to Drescher: Interdisciplinary collaboration is essential to understand and implement climate-resilient strategies in cities](
Carly D. Ziter, Eric J. Pedersen, Christopher J. Kucharik, and Monica G. Turner
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Arthur M. Sackler Colloquium ON Using Monkey Models to Understand and Develop Treatments for Human Brain Disorders (Free Online)
Introduction
[From basic brain research to treating human brain disorders](
Elizabeth A. Buffalo, J. Anthony Movshon, and Robert H. Wurtz
Colloquium Papers
BRAINS AND BEHAVIOR: MICE, MONKEYS AND HUMANS
[Cerebral cortical folding, parcellation, and connectivity in humans, nonhuman primates, and mice](
David C. Van Essen, Chad J. Donahue, Timothy S. Coalson, Henry Kennedy, Takuya Hayashi, and Matthew F. Glasser
[Translational implications of the anatomical nonequivalence of functionally equivalent cholinergic circuit motifs](
Anita A. Disney and Jason S. Robert
[Attention can be subdivided into neurobiological components corresponding to distinct behavioral effects](
Thomas Zhihao Luo and John H. R. Maunsell
[Primate optogenetics: Progress and prognosis](
Yasmine El-Shamayleh and Gregory D. Horwitz
DISORDERS OF DEVELOPMENT
[Contributions of nonhuman primate research to understanding the consequences of human brain injury during development](
Francesca Cacucci and Faraneh Vargha-Khadem
[Nonhuman primate models of hippocampal development and dysfunction](
Jocelyne Bachevalier
[Understanding the development of amblyopia using macaque monkey models](
Lynne Kiorpes
DISORDERS OF AGING
[Alzheimerâs disease: A clinical perspective and future nonhuman primate research opportunities](
Rafi U. Haque and Allan I. Levey
[Alzheimerâs-like pathology in aging rhesus macaques: Unique opportunity to study the etiology and treatment of Alzheimerâs disease](
Amy F. T. Arnsten, Dibyadeep Datta, Shannon Leslie, Sheng-Tao Yang, Min Wang, and Angus C. Nairn
[Oligomeric AÎČ in the monkey brain impacts synaptic integrity and induces accelerated cortical aging](
Danielle Beckman, Sean Ott, Kristine Donis-Cox, William G. Janssen, Eliza Bliss-Moreau, Peter H. Rudebeck, Mark G. Baxter, and John H. Morrison
[Experiments in macaque monkeys provide critical insights into age-associated changes in cognitive and sensory function](
Daniel T. Gray and Carol A. Barnes
RESTORING MOTOR AND SENSORY FUNCTION
[The neurology clinic needs monkey research](
Michael E. Goldberg
[Understanding Parkinsonâs disease and deep brain stimulation: Role of monkey models](
Jerrold L. Vitek and Luke A. Johnson
[Distributed processing of movement signaling](
Scott D. Kennedy and Andrew B. Schwartz
[From thought to action: The brainâmachine interface in posterior parietal cortex](
Richard A. Andersen, Tyson Aflalo, and Spencer Kellis
[The primate model for understanding and restoring vision](
Serge Picaud, Deniz Dalkara, Katia Marazova, Olivier Goureau, Botond Roska, and José-Alain Sahel
DISORDERS OF MOOD
[From bed to bench side: Reverse translation to optimize neuromodulation for mood disorders](
Peter H. Rudebeck, Erin L. Rich, and Helen S. Mayberg
[Why we need nonhuman primates to study the role of ventromedial prefrontal cortex in the regulation of threat- and reward-elicited responses](
Angela C. Roberts and Hannah F. Clarke
[The contribution of nonhuman primate research to the understanding of emotion and cognition and its clinical relevance](
Silvia Bernardi and C. Daniel Salzman
[Multiple neuronal circuits for variable objectâaction choices based on short- and long-term memories](
Okihide Hikosaka, Masaharu Yasuda, Kae Nakamura, Masaki Isoda, Hyoung F. Kim, Yasuo Terao, Hidetoshi Amita, and Kazutaka Maeda
[The mindâbody problem: Circuits that link the cerebral cortex to the adrenal medulla](
Richard P. Dum, David J. Levinthal, and Peter L. Strick
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Brief Report
[Reactivation of critical period plasticity in adult auditory cortex through chemogenetic silencing of parvalbumin-positive interneurons](
J. Miguel Cisneros-Franco and Ătienne de Villers-Sidani
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Physical Sciences
Applied Mathematics
[A formula for the value of a stochastic game](
Luc Attia and Miquel Oliu-Barton
Applied Physical Sciences
[Sono-optogenetics facilitated by a circulation-delivered rechargeable light source for minimally invasive optogenetics](
Xiang Wu, Xingjun Zhu, Paul Chong, Junlang Liu, Louis N. Andre, Kyrstyn S. Ong, Kenneth Brinson Jr, Ali I. Mahdi, Jiachen Li, Lief E. Fenno, Huiliang Wang, and Guosong Hong
[Autonomous bioluminescence imaging of single mammalian cells with the bacterial bioluminescence system](
Carola Gregor, Jasmin K. Pape, Klaus C. Gwosch, Tanja Gilat, Steffen J. Sahl, and Stefan W. Hell
Biophysics and Computational Biology
[Anticipating critical transitions in epithelialâhybrid-mesenchymal cell-fate determination](
Sukanta Sarkar, Sudipta Kumar Sinha, Herbert Levine, Mohit Kumar Jolly, and Partha Sharathi Dutta
[Mechanism for antigenic peptide selection by endoplasmic reticulum aminopeptidase 1](
Petros Giastas, Anastasia Mpakali, Athanasios Papakyriakou, Aggelos Lelis, Paraskevi Kokkala, Margarete Neu, Paul Rowland, John Liddle, Dimitris Georgiadis, and Efstratios Stratikos
[Precise timing is ubiquitous, consistent, and coordinated across a comprehensive, spike-resolved flight motor program](
Joy Putney, Rachel Conn, and Simon Sponberg
Chemistry
[Steering CO2 electroreduction toward ethanol production by a surface-bound Ru polypyridyl carbene catalyst on N-doped porous carbon](
Yanming Liu, Xinfei Fan, Animesh Nayak, Ying Wang, Bing Shan, Xie Quan, and Thomas J. Meyer
[Nanoscale spectroscopic origins of photoinduced tipâsample force in the midinfrared](
Junghoon Jahng, Eric O. Potma, and Eun Seong Lee
Computer Sciences
[Individual structural features constrain the mouse functional connectome](
Francesca Melozzi, Eyal Bergmann, Julie A. Harris, Itamar Kahn, Viktor Jirsa, and Christophe Bernard
[Deep learning for inferring gene relationships from single-cell expression data](
Ye Yuan and Ziv Bar-Joseph
Earth, Atmospheric, and Planetary Sciences
[Triple junction kinematics accounts for the 2016 Mw 7.8 Kaikoura earthquake rupture complexity](
Xuhua Shi, Paul Tapponnier, Teng Wang, Shengji Wei, Yu Wang, Xin Wang, and Liqing Jiao
[Satellite observations reveal extreme methane leakage from a natural gas well blowout](
Sudhanshu Pandey, Ritesh Gautam, Sander Houweling, Hugo Denier van der Gon, Pankaj Sadavarte, Tobias Borsdorff, Otto Hasekamp, Jochen Landgraf, Paul Tol, Tim van Kempen, Ruud Hoogeveen, Richard van Hees, Steven P. Hamburg, Joannes D. Maasakkers, and Ilse Aben
[Disappearance of the last tropical glaciers in the Western Pacific Warm Pool (Papua, Indonesia) appears imminent](
Donaldi S. Permana, Lonnie G. Thompson, Ellen Mosley-Thompson, Mary E. Davis, Ping-Nan Lin, Julien P. Nicolas, John F. Bolzan, Broxton W. Bird, Vladimir N. Mikhalenko, Paolo Gabrielli, Victor Zagorodnov, Keith R. Mountain, Ulrich Schotterer, Wido Hanggoro, Muhammad N. Habibie, Yohanes Kaize, Dodo Gunawan, Gesang Setyadi, Raden D. Susanto, Alfonso FernĂĄndez, and Bryan G. Mark
[Anisotropic diffusion creep in postperovskite provides a new model for deformation at the coreâmantle boundary](
David P. Dobson, Alexander Lindsay-Scott, Simon A. Hunt, Edward Bailey, Ian G. Wood, John P. Brodholt, Lidunka Vocadlo, and John Wheeler
[Microbial chemolithotrophy mediates oxidative weathering of granitic bedrock](
Stephanie A. Napieralski, Heather L. Buss, Susan L. Brantley, Seungyeol Lee, Huifang Xu, and Eric E. Roden
Engineering
[Temperature-independent thermal radiation](
Alireza Shahsafi, Patrick Roney, You Zhou, Zhen Zhang, Yuzhe Xiao, Chenghao Wan, Raymond Wambold, Jad Salman, Zhaoning Yu, Jiarui Li, Jerzy T. Sadowski, Riccardo Comin, Shriram Ramanathan, and Mikhail A. Kats
[Programmable active kirigami metasheets with more freedom of actuation](
Yichao Tang, Yanbin Li, Yaoye Hong, Shu Yang, and Jie Yin
[Deep learning predicts path-dependent plasticity](
M. Mozaffar, R. Bostanabad, W. Chen, K. Ehmann, J. Cao, and M. A. Bessa
[Performance-advantaged ether diesel bioblendstock production by a priori design](
Nabila A. Huq, Xiangchen Huo, Glenn R. Hafenstine, Stephen M. Tifft, Jim Stunkel, Earl D. Christensen, Gina M. Fioroni, Lisa Fouts, Robert L. McCormick, Patrick A. Cherry, Charles S. McEnally, Lisa D. Pfefferle, Matthew R. Wiatrowski, P. Thathiana Benavides, Mary J. Biddy, Raynella M. Connatser, Michael D. Kass, Teresa L. Alleman, Peter C. St. John, Seonah Kim, and Derek R. Vardon
Physics
[Universal Fermi-surface anisotropy renormalization for interacting Dirac fermions with long-range interactions](
Jia Ning Leaw, Ho-Kin Tang, Maxim Trushin, Fakher F. Assaad, and Shaffique Adam
Sustainability Science
[Provincial and sector-level material footprints in China](
Meng Jiang, Paul Behrens, Tao Wang, Zhipeng Tang, Yadong Yu, Dingjiang Chen, Lin Liu, Zijian Ren, Wenji Zhou, Shengjun Zhu, Canfei He, Arnold Tukker, and Bing Zhu
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Social Sciences
Economic Sciences
[A formula for the value of a stochastic game](
Luc Attia and Miquel Oliu-Barton
[Climate variability reduces employment in New England fisheries](
Kimberly L. Oremus
Environmental Sciences
[Persistent, bioaccumulative, and toxic properties of liquid crystal monomers and their detection in indoor residential dust](
Huijun Su, Shaobo Shi, Ming Zhu, Doug Crump, Robert J. Letcher, John P. Giesy, and Guanyong Su
Psychological and Cognitive Sciences
[Social media-predicted personality traits and values can help match people to their ideal jobs](
Margaret L. Kern, Paul X. McCarthy, Deepanjan Chakrabarty, and Marian-Andrei Rizoiu
[Ventral hippocampus interacts with prelimbic cortex during inhibition of threat response via learned safety in both mice and humans](
Heidi C. Meyer, Paola Odriozola, Emily M. Cohodes, Jeffrey D. Mandell, Anfei Li, Ruirong Yang, Baila S. Hall, Jason T. Haberman, Sadie J. Zacharek, Conor Liston, Francis S. Lee, and Dylan G. Gee
Sustainability Science
[A socialâecological analysis of the global agrifood system](
Elisa Oteros-Rozas, Adriana Ruiz-Almeida, Mateo Aguado, José A. Gonzålez, and Marta G. Rivera-Ferre
[Sixteen years of social and ecological dynamics reveal challenges and opportunities for adaptive management in sustaining the commons](
J. E. Cinner, J. D. Lau, A. G. Bauman, D. A. Feary, F. A. Januchowski-Hartley, C. A. Rojas, M. L. Barnes, B. J. Bergseth, E. Shum, R. Lahari, J. Ben, and N. A. J. Graham
[Provincial and sector-level material footprints in China](
Meng Jiang, Paul Behrens, Tao Wang, Zhipeng Tang, Yadong Yu, Dingjiang Chen, Lin Liu, Zijian Ren, Wenji Zhou, Shengjun Zhu, Canfei He, Arnold Tukker, and Bing Zhu
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Biological Sciences
Biochemistry
[Autonomous bioluminescence imaging of single mammalian cells with the bacterial bioluminescence system](
Carola Gregor, Jasmin K. Pape, Klaus C. Gwosch, Tanja Gilat, Steffen J. Sahl, and Stefan W. Hell
[Molybdate pumping into the molybdenum storage protein via an ATP-powered piercing mechanism](
Steffen BrĂŒnle, Martin L. Eisinger, Juliane Poppe, Deryck J. Mills, Julian D. Langer, Janet Vonck, and Ulrich Ermler
[Combining conservation and species-specific differences to determine how human telomerase binds telomeres](
Valerie M. Tesmer, Eric M. Smith, Oana Danciu, Shilpa Padmanaban, and Jayakrishnan Nandakumar
[The antimicrobial peptide ZY4 combats multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii infection](
James Mwangi, Yizhu Yin, Gan Wang, Min Yang, Ya Li, Zhiye Zhang, and Ren Lai
[Approaching infinite affinity through engineering of peptideâprotein interaction](
Anthony H. Keeble, Paula Turkki, Samuel Stokes, Irsyad N. A. Khairil Anuar, Rolle Rahikainen, Vesa P. Hytönen, and Mark Howarth
Biophysics and Computational Biology
[Anticipating critical transitions in epithelialâhybrid-mesenchymal cell-fate determination](
Sukanta Sarkar, Sudipta Kumar Sinha, Herbert Levine, Mohit Kumar Jolly, and Partha Sharathi Dutta
[Supercoiling DNA optically](
Graeme A. King, Federica Burla, Erwin J. G. Peterman, and Gijs J. L. Wuite
[Defining the remarkable structural malleability of a bacterial surface protein Rib domain implicated in infection](
Fiona Whelan, Aleix Lafita, Samuel C. Griffiths, Rachael E. M. Cooper, Jean L. Whittingham, Johan P. Turkenburg, Iain W. Manfield, Alexander N. St. John, Emanuele Paci, Alex Bateman, and Jennifer R. Potts
[Valproic acid interactions with the NavMs voltage-gated sodium channel](
Geancarlo Zanatta, Altin Sula, Andrew J. Miles, Leo C. T. Ng, Rubben Torella, David C. Pryde, Paul G. DeCaen, and B. A. Wallace
[Increased stiffness and flow resistance of the inner wall of Schlemmâs canal in glaucomatous human eyes](
Amir Vahabikashi, Ariel Gelman, Biqin Dong, Lihua Gong, Elliott D. K. Cha, Margit Schimmel, Ernst R. Tamm, Kristin Perkumas, W. Daniel Stamer, Cheng Sun, Hao F. Zhang, Haiyan Gong, and Mark Johnson
[Microtubule binding kinetics of membrane-bound kinesin-1 predicts high motor copy numbers on intracellular cargo](
Rui Jiang, Steven Vandal, SooHyun Park, Sheereen Majd, Erkan TĂŒzel, and William O. Hancock
[On the possible origin of protein homochirality, structure, and biochemical function](
Jeffrey Skolnick, Hongyi Zhou, and Mu Gao
Cell Biology
[Pancreatic cancer organoids recapitulate disease and allow personalized drug screening](
Else Driehuis, Arne van Hoeck, Kat Moore, Sigrid Kolders, Hayley E. Francies, M. Can Gulersonmez, Edwin C. A. Stigter, Boudewijn Burgering, Veerle Geurts, Ana Gracanin, Gergana Bounova, Folkert H. Morsink, Robert Vries, Sylvia Boj, Johan van Es, G. Johan A. Offerhaus, Onno Kranenburg, Mathew J. Garnett, Lodewyk Wessels, Edwin Cuppen, Lodewijk A. A. Brosens, and Hans Clevers
[The role of translationally controlled tumor protein in proliferation of Drosophila intestinal stem cells](
Young V. Kwon, Bingqing Zhao, Chiwei Xu, Jiae Lee, Chiao-Lin Chen, Arunachalam Vinayagam, Bruce A. Edgar, and Norbert Perrimon
[Enteroendocrine and tuft cells support Lgr5 stem cells on Paneth cell depletion](
Johan H. van Es, Kay Wiebrands, Carmen LĂłpez-Iglesias, Marc van de Wetering, Laura Zeinstra, Maaike van den Born, Jeroen Korving, Nobuo Sasaki, Peter J. Peters, Alexander van Oudenaarden, and Hans Clevers
[Loss of p57KIP2 expression confers resistance to contact inhibition in human androgenetic trophoblast stem cells](
Sota Takahashi, Hiroaki Okae, Norio Kobayashi, Akane Kitamura, Kanako Kumada, Nobuo Yaegashi, and Takahiro Arima
[Reactivation of EpsteinâBarr virus by a dual-responsive fluorescent EBNA1-targeting agent with Zn2+-chelating function](
Lijun Jiang, Hong Lok Lung, Tao Huang, Rongfeng Lan, Shuai Zha, Lai Sheung Chan, Waygen Thor, Tik-Hung Tsoi, Ho-Fai Chau, Cecilia Boreström, Steven L. Cobb, Sai Wah Tsao, Zhao-Xiang Bian, Ga-Lai Law, Wing-Tak Wong, William Chi-Shing Tai, Wai Yin Chau, Yujun Du, Lucas Hao Xi Tang, Alan Kwok Shing Chiang, Jaap M. Middeldorp, Kwok-Wai Lo, Nai Ki Mak, Nicholas J. Long, and Ka-Leung Wong
[SIRT5 stabilizes mitochondrial glutaminase and supports breast cancer tumorigenesis](
Kai Su Greene, Michael J. Lukey, Xueying Wang, Bryant Blank, Joseph E. Druso, Miao-chong J. Lin, Clint A. Stalnecker, Chengliang Zhang, Yashira NegrĂłn Abril, Jon W. Erickson, Kristin F. Wilson, Hening Lin, Robert S. Weiss, and Richard A. Cerione
[Peripheral (not central) corneal epithelia contribute to the closure of an annular debridement injury](
Mijeong Park, Alexander Richardson, Elvis Pandzic, Erwin P. Lobo, J. Guy Lyons, and Nick Di Girolamo
[A cis-element within the ARF locus mediates repression of p16INK4A expression via long-range chromatin interactions](
Yang Zhang, Judith Hyle, Shaela Wright, Ying Shao, Xujie Zhao, Hui Zhang, and Chunliang Li
Ecology
[Toward a metabolic theory of life history](
Joseph Robert Burger, Chen Hou, and James H. Brown
[Modeling active sensing reveals echo detection even in large groups of bats](
Thejasvi Beleyur and Holger R. Goerlitz
[Postreproductive killer whale grandmothers improve the survival of their grandoffspring](
Stuart Nattrass, Darren P. Croft, Samuel Ellis, Michael A. Cant, Michael N. Weiss, Brianna M. Wright, Eva Stredulinsky, Thomas Doniol-Valcroze, John K. B. Ford, Kenneth C. Balcomb, and Daniel W. Franks
[Human activities have opposing effects on distributions of narrow-ranged and widespread plant species in China](
Wu-Bing Xu, Jens-Christian Svenning, Guo-Ke Chen, Ming-Gang Zhang, Ji-Hong Huang, Bin Chen, Alejandro Ordonez, and Ke-Ping Ma
[Resurgence of an apex marine predator and the decline in prey body size](
Jan Ohlberger, Daniel E. Schindler, Eric J. Ward, Timothy E. Walsworth, and Timothy E. Essington
Environmental Sciences
[Climate variability reduces employment in New England fisheries](
Kimberly L. Oremus
Evolution
[Receding ice drove parallel expansions in Southern Ocean penguins](
Theresa L. Cole, Ludovic Dutoit, Nicolas Dussex, Tom Hart, Alana Alexander, Jane L. Younger, Gemma V. Clucas, MarĂa JosĂ© Frugone, Yves Cherel, Richard Cuthbert, Ursula Ellenberg, Steven R. Fiddaman, Johanna Hiscock, David Houston, Pierre Jouventin, Thomas Mattern, Gary Miller, Colin Miskelly, Paul Nolan, Michael J. Polito, Petra Quillfeldt, Peter G. Ryan, Adrian Smith, Alan J. D. Tennyson, David Thompson, Barbara Wienecke, Juliana A. Vianna, and Jonathan M. Waters
Genetics
[Gene- and tissue-level interactions in normal gastrointestinal development and Hirschsprung disease](
Sumantra Chatterjee, Priyanka Nandakumar, Dallas R. Auer, Stacey B. Gabriel, and Aravinda Chakravarti
Immunology and Inflammation
[Symbionts exploit complex signaling to educate the immune system](
Deniz Erturk-Hasdemir, Sungwhan F. Oh, Nihal A. Okan, Giuseppe Stefanetti, Francesca S. Gazzaniga, Peter H. Seeberger, Scott E. Plevy, and Dennis L. Kasper
[Mechanism for antigenic peptide selection by endoplasmic reticulum aminopeptidase 1](
Petros Giastas, Anastasia Mpakali, Athanasios Papakyriakou, Aggelos Lelis, Paraskevi Kokkala, Margarete Neu, Paul Rowland, John Liddle, Dimitris Georgiadis, and Efstratios Stratikos
[Neutralization of IL-1α ameliorates Crohnâs disease-like ileitis by functional alterations of the gut microbiome](
Paola Menghini, Daniele Corridoni, Ludovica F. ButtĂł, Abdullah Osme, Sushma Shivaswamy, Minh Lam, Giorgos Bamias, Theresa T. Pizarro, Alexander Rodriguez-Palacios, Charles A. Dinarello, and Fabio Cominelli
[T cell receptor specificity drives accumulation of a reparative population of regulatory T cells within acutely injured skeletal muscle](
Jun Cho, Wilson Kuswanto, Christophe Benoist, and Diane Mathis
[Comprehensive analysis of a mouse model of spontaneous uveoretinitis using single-cell RNA sequencing](
Jacob S. Heng, Sean F. Hackett, Genevieve L. Stein-OâBrien, Briana L. Winer, John Williams, Loyal A. Goff, and Jeremy Nathans
[Affinity maturation in a human humoral response to influenza hemagglutinin](
Kevin R. McCarthy, Donald D. Raymond, Khoi T. Do, Aaron G. Schmidt, and Stephen C. Harrison
[Intermittent rolling is a defect of the extravasation cascade caused by Myosin1e-deficiency in neutrophils](
Eduardo Vadillo, Sandra ChĂĄnez-Paredes, Hilda Vargas-Robles, Idaira MarĂa Guerrero-Fonseca, RamĂłn Castellanos-MartĂnez, Alexander GarcĂa-Ponce, Porfirio Nava, Daniel Alberto GirĂłn-PĂ©rez, Leopoldo Santos-Argumedo, and Michael Schnoor
[Evolutionary transition from degenerate to nonredundant cytokine signaling networks supporting intrathymic T cell development](
Divine-Fondzenyuy Lawir, Isabell Hess, Katarzyna Sikora, Norimasa Iwanami, Iliana Siamishi, Michael Schorpp, and Thomas Boehm
[Ly49R activation receptor drives self-MHCâeducated NK cell immunity against cytomegalovirus infection](
Awndre Gamache, John M. Cronk, William T. Nash, Patryk Puchalski, Alyssa Gillespie, Hairong Wei, Laurie Gray, Marie-Louise Hammarskjold, Wenhao Xu, and Michael G. Brown
[Parent-of-origin differences in DNA methylation of X chromosome genes in T lymphocytes](
Lisa C. Golden, Yuichiro Itoh, Noriko Itoh, Sonia Iyengar, Patrick Coit, Youstina Salama, Arthur P. Arnold, Amr H. Sawalha, and Rhonda R. Voskuhl
[Activation-induced cell death of self-reactive regulatory T cells drives autoimmunity](
Ester Badami, Olivier N. F. Cexus, and Sonia Quaratino
Medical Sciences
[Characterization of splice-altering mutations in inherited predisposition to cancer](
Silvia Casadei, Suleyman Gulsuner, Brian H. Shirts, Jessica B. Mandell, Hannah M. Kortbawi, Barbara S. Norquist, Elizabeth M. Swisher, Ming K. Lee, Yael Goldberg, Robert OâConnor, Zheng Tan, Colin C. Pritchard, Mary-Claire King, and Tom Walsh
[Oxytocin regulates body composition](
Li Sun, Daria Lizneva, Yaoting Ji, Graziana Colaianni, Elina Hadelia, Anisa Gumerova, Kseniia Ievleva, Tan-Chun Kuo, Funda Korkmaz, Vitaly Ryu, Alina Rahimova, Sakshi Gera, Charit Taneja, Ayesha Khan, Naseer Ahmad, Roberto Tamma, Zhuan Bian, Alberta Zallone, Se-Min Kim, Maria I. New, Jameel Iqbal, Tony Yuen, and Mone Zaidi
[IgGs from patients with amyotrophic lateral sclerosis and diabetes target CaVα2Ύ1 subunits impairing islet cell function and survival](
Yue Shi, Kyoung Sun Park, Seung Hyun Kim, Jia Yu, Kaixuan Zhao, Lina Yu, Ki Wook Oh, Kayoung Lee, Jaeyoon Kim, Kanchan Chaggar, Yuxin Li, Annette C. Dolphin, William A. Catterall, Sung Ho Ryu, Shao-Nian Yang, and Per-Olof Berggren
[FOXA1 upregulation promotes enhancer and transcriptional reprogramming in endocrine-resistant breast cancer](
Xiaoyong Fu, Resel Pereira, Carmine De Angelis, Jamunarani Veeraraghavan, Sarmistha Nanda, Lanfang Qin, Maria L. Cataldo, Vidyalakshmi Sethunath, Sepideh Mehravaran, Carolina Gutierrez, Gary C. Chamness, Qin Feng, Bert W. OâMalley, Pier Selenica, Britta Weigelt, Jorge S. Reis-Filho, Ofir Cohen, Nikhil Wagle, Agostina Nardone, Rinath Jeselsohn, Myles Brown, Mothaffar F. Rimawi, C. Kent Osborne, and Rachel Schiff
[Epithelial to mesenchymal plasticity and differential response to therapies in pancreatic ductal adenocarcinoma](
Rebecca L. Porter, Neelima K. C. Magnus, Vishal Thapar, Robert Morris, Annamaria Szabolcs, Azfar Neyaz, Anupriya S. Kulkarni, Eric Tai, Abhijit Chougule, Alessandra Hillis, Gabriel Golczer, Hongshan Guo, Teppei Yamada, Tomohiro Kurokawa, Chittampalli Yashaswini, Matteo Ligorio, Kevin D. Vo, Linda Nieman, Andrew S. Liss, Vikram Deshpande, Michael S. Lawrence, Shyamala Maheswaran, Carlos Fernandez-Del Castillo, Theodore S. Hong, David P. Ryan, Peter J. OâDwyer, Jeffrey A. Drebin, Cristina R. Ferrone, Daniel A. Haber, and David T. Ting
[CRISPR/Cas9-based targeted genome editing for correction of recessive dystrophic epidermolysis bullosa using iPS cells](
Joanna JackĂłw, Zongyou Guo, Corey Hansen, Hasan E. Abaci, Yanne S. Doucet, Jung U Shin, Ryota Hayashi, Dominick DeLorenzo, Yudai Kabata, Satoru Shinkuma, Julio C. Salas-Alanis, and Angela M. Christiano
[The emergence of classical BSE from atypical/Nor98 scrapie](
Alvina Huor, Juan Carlos Espinosa, Enric Vidal, HervĂ© Cassard, Jean-Yves Douet, SĂ©verine Lugan, Naima Aron, Alba MarĂn-Moreno, Patricia Lorenzo, Patricia Aguilar-Calvo, Juan Badiola, Rosa Bolea, MartĂ Pumarola, Sylvie L. Benestad, Leonore Orge, Alana M. Thackray, Raymond Bujdoso, Juan-Maria Torres, and Olivier Andreoletti
[Extensive subclonal mutational diversity in human colorectal cancer and its significance](
Lawrence A. Loeb, Brendan F. Kohrn, Kaitlyn J. Loubet-Senear, Yasmin J. Dunn, Eun Hyun Ahn, Jacintha N. OâSullivan, Jesse J. Salk, Mary P. Bronner, and Robert A. Beckman
[A tumorigenic index for quantitative analysis of liver cancer initiation and progression](
Gaowei Wang, Xiaolin Luo, Yan Liang, Kota Kaneko, Hairi Li, Xiang-Dong Fu, and Gen-Sheng Feng
Microbiology
[Evolution of resistance in vitro reveals mechanisms of artemisinin activity in Toxoplasma gondii](
Alex Rosenberg, Madeline R. Luth, Elizabeth A. Winzeler, Michael Behnke, and L. David Sibley
[Extracellular electron transfer powers flavinylated extracellular reductases in Gram-positive bacteria](
Samuel H. Light, RaphaĂ«l MĂ©heust, Jessica L. Ferrell, Jooyoung Cho, David Deng, Marco Agostoni, Anthony T. Iavarone, Jillian F. Banfield, Sarah E. F. DâOrazio, and Daniel A. Portnoy
[Cross-genotype protection of live-attenuated vaccine candidate for severe fever with thrombocytopenia syndrome virus in a ferret model](
Kwang-Min Yu, Su-Jin Park, Min-Ah Yu, Young-Il Kim, Younho Choi, Jae U. Jung, Benjamin Brennan, and Young Ki Choi
[Antitumor astins originate from the fungal endophyte Cyanodermella asteris living within the medicinal plant Aster tataricus](
Thomas Schafhauser, Linda Jahn, Norbert Kirchner, Andreas Kulik, Liane Flor, Alexander Lang, Thibault Caradec, David P. Fewer, Kaarina Sivonen, Willem J. H. van Berkel, Philippe Jacques, Tilmann Weber, Harald Gross, Karl-Heinz van PĂ©e, Wolfgang Wohlleben, and Jutta Ludwig-MĂŒller
[A population shift between two heritable cell types of the pathogen Candida albicans is based both on switching and selective proliferation](
Chiraj K. Dalal, Ignacio A. Zuleta, Matthew B. Lohse, Rebecca E. Zordan, Hana El-Samad, and Alexander D. Johnson
[Antimicrobial sensing coupled with cell membrane remodeling mediates antibiotic resistance and virulence in Enterococcus faecalis](
Ayesha Khan, Milya Davlieva, Diana Panesso, Sandra Rincon, William R. Miller, Lorena Diaz, Jinnethe Reyes, Melissa R. Cruz, Orville Pemberton, April H. Nguyen, Sara D. Siegel, Paul J. Planet, Apurva Narechania, Mauricio Latorre, Rafael Rios, Kavindra V. Singh, Hung Ton-That, Danielle A. Garsin, Truc T. Tran, Yousif Shamoo, and Cesar A. Arias
[Viral neutralization by antibody-imposed physical disruption](
Qingbing Zheng, Jie Jiang, Maozhou He, Zizheng Zheng, Hai Yu, Tingting Li, Wenhui Xue, Zimin Tang, Dong Ying, Zekai Li, Shuo Song, Xinlin Liu, Kaihang Wang, Zhiqing Zhang, Daning Wang, Yingbin Wang, Xiaodong Yan, Qinjian Zhao, Jun Zhang, Ying Gu, Shaowei Li, and Ningshao Xia
[Inhibition of ULK1 and Beclin1 by an α-herpesvirus Akt-like Ser/Thr kinase limits autophagy to stimulate virus replication](
Rosa M. Rubio and Ian Mohr
Neuroscience
[Cerebral cortical folding, parcellation, and connectivity in humans, nonhuman primates, and mice](
David C. Van Essen, Chad J. Donahue, Timothy S. Coalson, Henry Kennedy, Takuya Hayashi, and Matthew F. Glasser
[Translational implications of the anatomical nonequivalence of functionally equivalent cholinergic circuit motifs](
Anita A. Disney and Jason S. Robert
[Attention can be subdivided into neurobiological components corresponding to distinct behavioral effects](
Thomas Zhihao Luo and John H. R. Maunsell
[Primate optogenetics: Progress and prognosis](
Yasmine El-Shamayleh and Gregory D. Horwitz
[Nonhuman primate models of hippocampal development and dysfunction](
Jocelyne Bachevalier
[Understanding the development of amblyopia using macaque monkey models](
Lynne Kiorpes
[Alzheimerâs-like pathology in aging rhesus macaques: Unique opportunity to study the etiology and treatment of Alzheimerâs disease](
Amy F. T. Arnsten, Dibyadeep Datta, Shannon Leslie, Sheng-Tao Yang, Min Wang, and Angus C. Nairn
[Oligomeric AÎČ in the monkey brain impacts synaptic integrity and induces accelerated cortical aging](
Danielle Beckman, Sean Ott, Kristine Donis-Cox, William G. Janssen, Eliza Bliss-Moreau, Peter H. Rudebeck, Mark G. Baxter, and John H. Morrison
[Experiments in macaque monkeys provide critical insights into age-associated changes in cognitive and sensory function](
Daniel T. Gray and Carol A. Barnes
[Understanding Parkinsonâs disease and deep brain stimulation: Role of monkey models](
Jerrold L. Vitek and Luke A. Johnson
[Distributed processing of movement signaling](
Scott D. Kennedy and Andrew B. Schwartz
[From thought to action: The brainâmachine interface in posterior parietal cortex](
Richard A. Andersen, Tyson Aflalo, and Spencer Kellis
[The primate model for understanding and restoring vision](
Serge Picaud, Deniz Dalkara, Katia Marazova, Olivier Goureau, Botond Roska, and José-Alain Sahel
[Why we need nonhuman primates to study the role of ventromedial prefrontal cortex in the regulation of threat- and reward-elicited responses](
Angela C. Roberts and Hannah F. Clarke
[The contribution of nonhuman primate research to the understanding of emotion and cognition and its clinical relevance](
Silvia Bernardi and C. Daniel Salzman
[Multiple neuronal circuits for variable objectâaction choices based on short- and long-term memories](
Okihide Hikosaka, Masaharu Yasuda, Kae Nakamura, Masaki Isoda, Hyoung F. Kim, Yasuo Terao, Hidetoshi Amita, and Kazutaka Maeda
[The mindâbody problem: Circuits that link the cerebral cortex to the adrenal medulla](
Richard P. Dum, David J. Levinthal, and Peter L. Strick
[Precise timing is ubiquitous, consistent, and coordinated across a comprehensive, spike-resolved flight motor program](
Joy Putney, Rachel Conn, and Simon Sponberg
[Individual structural features constrain the mouse functional connectome](
Francesca Melozzi, Eyal Bergmann, Julie A. Harris, Itamar Kahn, Viktor Jirsa, and Christophe Bernard
[Ventral hippocampus interacts with prelimbic cortex during inhibition of threat response via learned safety in both mice and humans](
Heidi C. Meyer, Paola Odriozola, Emily M. Cohodes, Jeffrey D. Mandell, Anfei Li, Ruirong Yang, Baila S. Hall, Jason T. Haberman, Sadie J. Zacharek, Conor Liston, Francis S. Lee, and Dylan G. Gee
[Molecular profiling of single neurons of known identity in two ganglia from the crab Cancer borealis](
Adam J. Northcutt, Daniel R. Kick, Adriane G. Otopalik, Benjamin M. Goetz, Rayna M. Harris, Joseph M. Santin, Hans A. Hofmann, Eve Marder, and David J. Schulz
[The network architecture of rat intrinsic interbrain (diencephalic) macroconnections](
Larry W. Swanson, Olaf Sporns, and Joel D. Hahn
[Sources of off-target expression from recombinase-dependent AAV vectors and mitigation with cross-over insensitive ATG-out vectors](
Kyle B. Fischer, Hannah K. Collins, and Edward M. Callaway
[Synaptic control of spinal GRPR+ neurons by local and long-range inhibitory inputs](
Ming-Zhe Liu, Xiao-Jun Chen, Tong-Yu Liang, Qing Li, Meng Wang, Xin-Yan Zhang, Yu-Zhuo Li, Qiang Sun, and Yan-Gang Sun
[Second-order cues to figure motion enable object detection during prey capture by praying mantises](
Vivek Nityananda, James OâKeeffe, Diana Umeton, Adam Simmons, and Jenny C. A. Read
[5-HT2A receptor activation normalizes stress-induced dysregulation of GABAergic signaling in the ventral tegmental area](
Blake A. Kimmey, Alexey Ostroumov, and John A. Dani
[Positionâtheta-phase model of hippocampal place cell activity applied to quantification of running speed modulation of firing rate](
Kathryn McClain, David Tingley, David J. Heeger, and György Buzsåki
[Photoreceptor disc membranes are formed through an Arp2/3-dependent lamellipodium-like mechanism](
William J. Spencer, Tylor R. Lewis, Sebastien Phan, Martha A. Cady, Ekaterina O. Serebrovskaya, Nicholas F. Schneider, Keun-Young Kim, Lisa A. Cameron, Nikolai P. Skiba, Mark H. Ellisman, and Vadim Y. Arshavsky
[A systematic capsid evolution approach performed in vivo for the design of AAV vectors with tailored properties and tropism](
Marcus Davidsson, Gang Wang, Patrick Aldrin-Kirk, Tiago Cardoso, Sara Nolbrant, Morgan Hartnor, Janitha Mudannayake, Malin Parmar, and Tomas Björklund
[Perineuronal nets protect long-term memory by limiting activity-dependent inhibition from parvalbumin interneurons](
Wei Shi, Xiangbo Wei, Xiaofei Wang, Shuwen Du, Weixuan Liu, Jian Song, and Yun Wang
[Evoked potentials as a biomarker of remyelination](
Moones Heidari, Abigail B. Radcliff, Gillian J. McLellan, James N. Ver Hoeve, Kore Chan, Julie A. Kiland, Nicholas S. Keuler, Benjamin K. August, Dylan Sebo, Aaron S. Field, and Ian D. Duncan
[Descending projections from the substantia nigra pars reticulata differentially control seizures](
Evan Wicker, Veronica C. Beck, Colin Kulick-Soper, Catherine V. Kulick-Soper, Safwan K. Hyder, Carolina Campos-Rodriguez, Tahiyana Khan, Prosper NâGouemo, and Patrick A. Forcelli
Physiology
[SUMO1 modification of PKD2 channels regulates arterial contractility](
Raquibul Hasan, M. Dennis Leo, Padmapriya Muralidharan, Alejandro Mata-Daboin, Wen Yin, Simon Bulley, Carlos Fernandez-Peña, Charles E. MacKay, and Jonathan H. Jaggar
Plant Biology
[A noncanonical vacuolar sugar transferase required for biosynthesis of antimicrobial defense compounds in oat](
Anastasia Orme, Thomas Louveau, Michael J. Stephenson, Ingo Appelhagen, Rachel Melton, Jitender Cheema, Yan Li, Qiang Zhao, Lei Zhang, Danlin Fan, Qilin Tian, Robert J. Vickerstaff, Tim Langdon, Bin Han, and Anne Osbourn
[The Îł-tubulin complex protein GCP6 is crucial for spindle morphogenesis but not essential for microtubule reorganization in Arabidopsis](
Huiying Miao, Rongfang Guo, Junlin Chen, Qiaomei Wang, Yuh-Ru Julie Lee, and Bo Liu
[Transcriptomic analysis of field-droughted sorghum from seedling to maturity reveals biotic and metabolic responses](
Nelle Varoquaux, Benjamin Cole, Cheng Gao, Grady Pierroz, Christopher R. Baker, Dhruv Patel, Mary Madera, Tim Jeffers, Joy Hollingsworth, Julie Sievert, Yuko Yoshinaga, Judith A. Owiti, Vasanth R. Singan, Stephanie DeGraaf, Ling Xu, Matthew J. Blow, Maria J. Harrison, Axel Visel, Christer Jansson, Krishna K. Niyogi, Robert Hutmacher, Devin Coleman-Derr, Ronan C. OâMalley, John W. Taylor, Jeffery Dahlberg, John P. Vogel, Peggy G. Lemaux, and Elizabeth Purdom
[Cryptochrome 2 competes with COP1 substrates to repress COP1 ubiquitin ligase activity during Arabidopsis photomorphogenesis](
Jathish Ponnu, Tabea Riedel, Eva Penner, Andrea Schrader, and Ute Hoecker
Population Biology
[Virusâvirus interactions impact the population dynamics of influenza and the common cold](
Sema Nickbakhsh, Colette Mair, Louise Matthews, Richard Reeve, Paul C. D. Johnson, Fiona Thorburn, Beatrix von Wissmann, Arlene Reynolds, James McMenamin, Rory N. Gunson, and Pablo R. Murcia
Sustainability Science
[Sixteen years of social and ecological dynamics reveal challenges and opportunities for adaptive management in sustaining the commons](
J. E. Cinner, J. D. Lau, A. G. Bauman, D. A. Feary, F. A. Januchowski-Hartley, C. A. Rojas, M. L. Barnes, B. J. Bergseth, E. Shum, R. Lahari, J. Ben, and N. A. J. Graham
Systems Biology
[Deep learning for inferring gene relationships from single-cell expression data](
Ye Yuan and Ziv Bar-Joseph
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Corrections
[Correction for Kumra et al., Fibulin-4 exerts a dual role in LTBP-4Lâmediated matrix assembly and function](
[Correction for Fan et al., Abscisic acid regulation of guard-cell K+ and anion channels in GÎČ- and RGS-deficient Arabidopsis lines](
[Correction for de la Cuesta et al., Oil and aid revenue produce equal demands for accountability as taxes in Ghana and Uganda](
[Correction for Duckworth et al., Cognitive and noncognitive predictors of success](
[Cover]
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