PNAS Table of Contents for October 29, 2019; Vol. 116, No. 44

[PNAS] [Cozzarelli Prize Nominations](/cgi/adclick/?ad=54421&adclick=true&url=https%3A%2F%2Fwww.pnas.org%2Fpage%2Fabout%2Fcozzarelli-prize)   [October 29, 2019; Vol. 116, No. 44]( ) This Week in PNAS [In This Issue]( --------------------------------------------------------------- Science and Culture [Science and Culture: Why “seeing” some scientific phenomena entails a touch of artistry and a dash of interpretation]( Amy McDermott How science intersects with culture. --------------------------------------------------------------- Core Concepts [Core Concept: Emerging science of chronotherapy offers big opportunities to optimize drug delivery]( David Adam A brief introduction to emerging topics in science. --------------------------------------------------------------- Commentaries [Mechanosensing tensile solid stresses]( Lance L. Munn and Hadi T. Nia [Linking long noncoding RNA to drug resistance]( Michael J. Smallegan and John L. Rinn [Tar adhesives, Neandertals, and the tyranny of the discontinuous mind]( João Zilhão [T cell antigen recognition: Evolution-driven affinities]( Rémy Bosselut --------------------------------------------------------------- Letters [Sighted people’s language is not helpful for blind individuals’ acquisition of typical animal colors]( Markus Ostarek, Jeroen van Paridon, and Guillermo Montero-Melis [Reply to Ostarek et al.: Language, but not co-occurrence statistics, is useful for learning animal appearance]( Judy S. Kim, Giulia V. Elli, and Marina Bedny [Not even noninvasive cell-free DNA can rescue preimplantation genetic testing]( Norbert Gleicher and David H. Barad [Reply to Gleicher and Barad: Noninvasive preimplantation genetic testing may provide the solution to the problem of embryo mosaicism]( Lei Huang, Sijia Lu, Catherine Racowsky, and X. Sunney Xie --------------------------------------------------------------- Brief Report [Staphylococcus aureus exhibits heterogeneous siderophore production within the vertebrate host]( William J. Perry, Jeffrey M. Spraggins, Jessica R. Sheldon, Caroline M. Grunenwald, David E. Heinrichs, James E. Cassat, Eric P. Skaar, and Richard M. Caprioli --------------------------------------------------------------- Physical Sciences Applied Mathematics [Uniformly accurate machine learning-based hydrodynamic models for kinetic equations]( Jiequn Han, Chao Ma, Zheng Ma, and Weinan E Applied Physical Sciences [Carrier localization in perovskite nickelates from oxygen vacancies]( Michele Kotiuga, Zhen Zhang, Jiarui Li, Fanny Rodolakis, Hua Zhou, Ronny Sutarto, Feizhou He, Qi Wang, Yifei Sun, Ying Wang, Neda Alsadat Aghamiri, Steven Bennett Hancock, Leonid P. Rokhinson, David P. Landau, Yohannes Abate, John W. Freeland, Riccardo Comin, Shriram Ramanathan, and Karin M. Rabe [Synergistic boost of output power density and efficiency in In-Li–codoped SnTe]( Fengkai Guo, Haijun Wu, Jianbo Zhu, Honghao Yao, Yang Zhang, Bo Cui, Qian Zhang, Bo Yu, Stephen J. Pennycook, Wei Cai, Ching-Wu Chu, and Jiehe Sui Biophysics and Computational Biology [Cell mechanosensing is regulated by substrate strain energy rather than stiffness]( Valeria Panzetta, Sabato Fusco, and Paolo A. Netti [4D electron microscopy of T cell activation]( Yue Lu, Byung-Kuk Yoo, Alphonsus H. C. Ng, Jungwoo Kim, Sinchul Yeom, Jau Tang, Milo M. Lin, Ahmed H. Zewail, and James R. Heath [Discovering long noncoding RNA predictors of anticancer drug sensitivity beyond protein-coding genes]( Aritro Nath, Eunice Y. T. Lau, Adam M. Lee, Paul Geeleher, William C. S. Cho, and R. Stephanie Huang [Fundamental helical geometry consolidates the plant photosynthetic membrane]( Yuval Bussi, Eyal Shimoni, Allon Weiner, Ruti Kapon, Dana Charuvi, Reinat Nevo, Efi Efrati, and Ziv Reich Chemistry [Electrostatic shape control of a charged molecular membrane from ribbon to scroll]( Changrui Gao, Sumit Kewalramani, Dulce Maria Valencia, Honghao Li, Joseph M. McCourt, Monica Olvera de la Cruz, and Michael J. Bedzyk [A relatively wide-bandgap and air-stable donor polymer for fabrication of efficient semitransparent and tandem organic photovoltaics]( Mohammad Mahdi Tavakoli, Riccardo Po, Gabriele Bianchi, Alessandra Cominetti, Chiara Carbonera, Nadia Camaioni, Francesca Tinti, and Jing Kong [Computationally generated maps of surface structures and catalytic activities for alloy phase diagrams]( Liang Cao, Le Niu, and Tim Mueller Earth, Atmospheric, and Planetary Sciences [Ion exchange selectivity in clay is controlled by nanoscale chemical–mechanical coupling]( Michael L. Whittaker, Laura N. Lammers, Sergio Carrero, Benjamin Gilbert, and Jillian F. Banfield Environmental Sciences [The concurrent decline of soil lead and children’s blood lead in New Orleans]( Howard W. Mielke, Christopher R. Gonzales, Eric T. Powell, Mark A. S. Laidlaw, Kenneth J. Berry, Paul W. Mielke Jr., and Sara Perl Egendorf Physics [Rotation and propulsion in 3D active chiral droplets]( Livio Nicola Carenza, Giuseppe Gonnella, Davide Marenduzzo, and Giuseppe Negro [Efficient team structures in an open-ended cooperative creativity experiment]( Bernardo Monechi, Giulia Pullano, and Vittorio Loreto Statistics [Definitions, methods, and applications in interpretable machine learning]( W. James Murdoch, Chandan Singh, Karl Kumbier, Reza Abbasi-Asl, and Bin Yu --------------------------------------------------------------- Social Sciences Anthropology [Middle Paleolithic complex technology and a Neandertal tar-backed tool from the Dutch North Sea]( Marcel J. L. Th. Niekus, Paul R. B. Kozowyk, Geeske H. J. Langejans, Dominique Ngan-Tillard, Henk van Keulen, Johannes van der Plicht, Kim M. Cohen, Willy van Wingerden, Bertil van Os, Bjørn I. Smit, Luc W. S. W. Amkreutz, Lykke Johansen, Annemieke Verbaas, and Gerrit L. Dusseldorp Psychological and Cognitive Sciences [The concurrent decline of soil lead and children’s blood lead in New Orleans]( Howard W. Mielke, Christopher R. Gonzales, Eric T. Powell, Mark A. S. Laidlaw, Kenneth J. Berry, Paul W. Mielke Jr., and Sara Perl Egendorf Social Sciences [Efficient team structures in an open-ended cooperative creativity experiment]( Bernardo Monechi, Giulia Pullano, and Vittorio Loreto [Shorter distances between papers over time are due to more cross-field references and increased citation rate to higher-impact papers]( Attila Varga [Work time and market integration in the original affluent society]( Rahul Bhui, Maciej Chudek, and Joseph Henrich Sustainability Science [11,500 y of human–clam relationships provide long-term context for intertidal management in the Salish Sea, British Columbia]( Ginevra Toniello, Dana Lepofsky, Gavia Lertzman-Lepofsky, Anne K. Salomon, and Kirsten Rowell --------------------------------------------------------------- Biological Sciences Anthropology [11,500 y of human–clam relationships provide long-term context for intertidal management in the Salish Sea, British Columbia]( Ginevra Toniello, Dana Lepofsky, Gavia Lertzman-Lepofsky, Anne K. Salomon, and Kirsten Rowell [Evidence for independent brain and neurocranial reorganization during hominin evolution]( José Luis Alatorre Warren, Marcia S. Ponce de León, William D. Hopkins, and Christoph P. E. Zollikofer Applied Biological Sciences [KRAS G13D sensitivity to neurofibromin-mediated GTP hydrolysis]( Dana Rabara, Timothy H. Tran, Srisathiyanarayanan Dharmaiah, Robert M. Stephens, Frank McCormick, Dhirendra K. Simanshu, and Matthew Holderfield [Cytosolic delivery of inhibitory antibodies with cationic lipids]( Hejia Henry Wang and Andrew Tsourkas Biochemistry [AFF1 acetylation by p300 temporally inhibits transcription during genotoxic stress response]( Nidhi Kumari, M. Abul Hassan, Xiangdong Lu, Robert G. Roeder, and Debabrata Biswas [PRC2 engages a bivalent H3K27M-H3K27me3 dinucleosome inhibitor]( Katharine L. Diehl, Eva J. Ge, Daniel N. Weinberg, Krupa S. Jani, C. David Allis, and Tom W. Muir [The deaminase APOBEC3B triggers the death of cells lacking uracil DNA glycosylase]( Artur A. Serebrenik, Gabriel J. Starrett, Sterre Leenen, Matthew C. Jarvis, Nadine M. Shaban, Daniel J. Salamango, Hilde Nilsen, William L. Brown, and Reuben S. Harris [A mesophilic cysteine-less split intein for protein trans-splicing applications under oxidizing conditions]( Maniraj Bhagawati, Tobias M. E. Terhorst, Friederike Füsser, Simon Hoffmann, Tim Pasch, Shmuel Pietrokovski, and Henning D. Mootz Biophysics and Computational Biology [Proteostasis collapse is a driver of cell aging and death]( Mantu Santra, Ken A. Dill, and Adam M. R. de Graff [Quantitative structural assessment of graded receptor agonism]( Jinsai Shang, Richard Brust, Patrick R. Griffin, Theodore M. Kamenecka, and Douglas J. Kojetin Cell Biology [Cell mechanosensing is regulated by substrate strain energy rather than stiffness]( Valeria Panzetta, Sabato Fusco, and Paolo A. Netti [Wnt activator FOXB2 drives the neuroendocrine differentiation of prostate cancer]( Lavanya Moparthi, Giulia Pizzolato, and Stefan Koch [Optimized filopodia formation requires myosin tail domain cooperation]( Ashley L. Arthur, Livia D. Songster, Helena Sirkia, Akash Bhattacharya, Carlos Kikuti, Fernanda Pires Borrega, Anne Houdusse, and Margaret A. Titus Developmental Biology [Cellular defects resulting from disease-related myosin II mutations in Drosophila]( Karen E. Kasza, Sara Supriyatno, and Jennifer A. Zallen Ecology [Amazon deforestation drives malaria transmission, and malaria burden reduces forest clearing]( Andrew J. MacDonald and Erin A. Mordecai Evolution [Middle Paleolithic complex technology and a Neandertal tar-backed tool from the Dutch North Sea]( Marcel J. L. Th. Niekus, Paul R. B. Kozowyk, Geeske H. J. Langejans, Dominique Ngan-Tillard, Henk van Keulen, Johannes van der Plicht, Kim M. Cohen, Willy van Wingerden, Bertil van Os, Bjørn I. Smit, Luc W. S. W. Amkreutz, Lykke Johansen, Annemieke Verbaas, and Gerrit L. Dusseldorp [Multilayered horizontal operon transfers from bacteria reconstruct a thiamine salvage pathway in yeasts]( Carla Gonçalves and Paula Gonçalves Genetics [Tissue-specific FAH deficiency alters sleep–wake patterns and results in chronic tyrosinemia in mice]( Shuzhang Yang, Sandra M. Siepka, Kimberly H. Cox, Vivek Kumar, Marleen de Groot, Yogarany Chelliah, Jun Chen, Benjamin Tu, and Joseph S. Takahashi [Gastrointestinal dysfunction in autism displayed by altered motility and achalasia in Foxp1+/− mice]( Henning Fröhlich, Marie Luise Kollmeyer, Valerie Catherine Linz, Manuel Stuhlinger, Dieter Groneberg, Amelie Reigl, Eugen Zizer, Andreas Friebe, Beate Niesler, and Gudrun Rappold Immunology and Inflammation [4D electron microscopy of T cell activation]( Yue Lu, Byung-Kuk Yoo, Alphonsus H. C. Ng, Jungwoo Kim, Sinchul Yeom, Jau Tang, Milo M. Lin, Ahmed H. Zewail, and James R. Heath [Autoimmune antibodies correlate with immune checkpoint therapy-induced toxicities]( Salahaldin A. Tahir, Jianjun Gao, Yuji Miura, Jorge Blando, Rebecca S. S. Tidwell, Hao Zhao, Sumit K. Subudhi, Hussein Tawbi, Emily Keung, Jennifer Wargo, James P. Allison, and Padmanee Sharma [Inherent reactivity of unselected TCR repertoires to peptide-MHC molecules]( S. Harsha Krovi, John W. Kappler, Philippa Marrack, and Laurent Gapin [Myeloid cells activate iNKT cells to produce IL-4 in the thymic medulla]( Haiguang Wang, Elise R. Breed, You Jeong Lee, Lily J. Qian, Stephen C. Jameson, and Kristin A. Hogquist Medical Sciences [Exquisite sensitivity of adrenocortical carcinomas to induction of ferroptosis]( Alexia Belavgeni, Stefan R. Bornstein, Anne von Mässenhausen, Wulf Tonnus, Julian Stumpf, Claudia Meyer, Evelyn Othmar, Markus Latk, Waldemar Kanczkowski, Matthias Kroiss, Constanze Hantel, Christian Hugo, Martin Fassnacht, Christian G. Ziegler, Andrew V. Schally, Nils P. Krone, and Andreas Linkermann [Structure of Pseudomonas aeruginosa ribosomes from an aminoglycoside-resistant clinical isolate]( Yehuda Halfon, Alicia Jimenez-Fernandez, Ruggero La Rosa, Rocio Espinosa Portero, Helle Krogh Johansen, Donna Matzov, Zohar Eyal, Anat Bashan, Ella Zimmerman, Matthew Belousoff, Søren Molin, and Ada Yonath [CaM kinase II regulates cardiac hemoglobin expression through histone phosphorylation upon sympathetic activation]( Ali Reza Saadatmand, Viviana Sramek, Silvio Weber, Daniel Finke, Matthias Dewenter, Carsten Sticht, Norbert Gretz, Till Wüstemann, Marco Hagenmueller, Stephan R. Kuenzel, Stefanie Meyer-Roxlau, Martin Kramer, Samuel Sossalla, Lorenz H. Lehmann, Susanne Kämmerer, Johannes Backs, and Ali El-Armouche [Loss of p53 function at late stages of tumorigenesis confers ARF-dependent vulnerability to p53 reactivation therapy]( Boris Klimovich, Samet Mutlu, Jean Schneikert, Sabrina Elmshäuser, Maria Klimovich, Andrea Nist, Marco Mernberger, Oleg Timofeev, and Thorsten Stiewe [Alternative pathway androgen biosynthesis and human fetal female virilization]( Nicole Reisch, Angela E. Taylor, Edson F. Nogueira, Daniel J. Asby, Vivek Dhir, Andrew Berry, Nils Krone, Richard J. Auchus, Cedric H. L. Shackleton, Neil A. Hanley, and Wiebke Arlt [Differential development of large-cell neuroendocrine or small-cell lung carcinoma upon inactivation of 4 tumor suppressor genes]( Sara Lázaro, Miriam Pérez-Crespo, Corina Lorz, Alejandra Bernardini, Marta Oteo, Ana Belén Enguita, Eduardo Romero, Pilar Hernández, Laura Tomás, Miguel Ángel Morcillo, Jesús M. Paramio, and Mirentxu Santos Microbiology [Aggregatibacter actinomycetemcomitans colonization and persistence in a primate model]( Senthil Kumar Velusamy, Vandana Sampathkumar, Narayanan Ramasubbu, Bruce J. Paster, and Daniel H. Fine [A Wolbachia nuclease and its binding partner provide a distinct mechanism for cytoplasmic incompatibility]( Hongli Chen, Judith A. Ronau, John F. Beckmann, and Mark Hochstrasser [Redirection of SKN-1 abates the negative metabolic outcomes of a perceived pathogen infection]( James D. Nhan, Christian D. Turner, Sarah M. Anderson, Chia-An Yen, Hans M. Dalton, Hilary K. Cheesman, Dana L. Ruter, Nandhitha Uma Naresh, Cole M. Haynes, Alexander A. Soukas, Read Pukkila-Worley, and Sean P. Curran [Agrobacteria reprogram virulence gene expression by controlled release of host-conjugated signals]( Chao Wang, Fuzhou Ye, Changqing Chang, Xiaoling Liu, Jianhe Wang, Jinpei Wang, Xin-Fu Yan, Qinqin Fu, Jianuan Zhou, Shaohua Chen, Yong-Gui Gao, and Lian-Hui Zhang Neuroscience [Population-based neuroimaging reveals traces of childbirth in the maternal brain]( Ann-Marie G. de Lange, Tobias Kaufmann, Dennis van der Meer, Luigi A. Maglanoc, Dag Alnæs, Torgeir Moberget, Gwenaëlle Douaud, Ole A. Andreassen, and Lars T. Westlye [Myelin sheath structure and regeneration in peripheral nerve injury repair]( Bin Liu, Wang Xin, Jian-Rong Tan, Rui-Ping Zhu, Ting Li, Dan Wang, Sha-Sha Kan, Ding-Kui Xiong, Huan-Huan Li, Meng-Meng Zhang, Huan-Huan Sun, William Wagstaff, Chan Zhou, Zhi-Jian Wang, Yao-Guang Zhang, and Tong-Chuan He Pharmacology [Discovering long noncoding RNA predictors of anticancer drug sensitivity beyond protein-coding genes]( Aritro Nath, Eunice Y. T. Lau, Adam M. Lee, Paul Geeleher, William C. S. Cho, and R. Stephanie Huang [A tetrapeptide class of biased analgesics from an Australian fungus targets the µ-opioid receptor]( Zoltan Dekan, Setareh Sianati, Arsalan Yousuf, Katy J. Sutcliffe, Alexander Gillis, Christophe Mallet, Paramjit Singh, Aihua H. Jin, Anna M. Wang, Sarasa A. Mohammadi, Michael Stewart, Ranjala Ratnayake, Frank Fontaine, Ernest Lacey, Andrew M. Piggott, Yan P. Du, Meritxell Canals, Richard B. Sessions, Eamonn Kelly, Robert J. Capon, Paul F. Alewood, and MacDonald J. Christie Physiology [Mother-to-embryo vitellogenin transport in a viviparous teleost Xenotoca eiseni]( Atsuo Iida, Hiroyuki N. Arai, Yumiko Someya, Mayu Inokuchi, Takeshi A. Onuma, Hayato Yokoi, Tohru Suzuki, Eiichi Hondo, and Kaori Sano Plant Biology [Fundamental helical geometry consolidates the plant photosynthetic membrane]( Yuval Bussi, Eyal Shimoni, Allon Weiner, Ruti Kapon, Dana Charuvi, Reinat Nevo, Efi Efrati, and Ziv Reich [Highly ABA-Induced 1 (HAI1)-Interacting protein HIN1 and drought acclimation-enhanced splicing efficiency at intron retention sites]( Geeng Loo Chong, Mung Hsia Foo, Wen-Dar Lin, Min May Wong, and Paul E. Verslues Population Biology [The contribution of host cell-directed vs. parasite-directed immunity to the disease and dynamics of malaria infections]( Nina Wale, Matthew J. Jones, Derek G. Sim, Andrew F. Read, and Aaron A. King Sustainability Science [TROPOMI reveals dry-season increase of solar-induced chlorophyll fluorescence in the Amazon forest]( Russell Doughty, Philipp Köhler, Christian Frankenberg, Troy S. Magney, Xiangming Xiao, Yuanwei Qin, Xiaocui Wu, and Berrien Moore III Systems Biology [Heterogeneity of Myc expression in breast cancer exposes pharmacological vulnerabilities revealed through executable mechanistic modeling]( Peter Kreuzaler, Matthew A. Clarke, Elizabeth J. Brown, Catherine H. Wilson, Roderik M. Kortlever, Nir Piterman, Trevor Littlewood, Gerard I. Evan, and Jasmin Fisher --------------------------------------------------------------- Correction [Correction for Sah et al., Future epidemiological and economic impacts of universal influenza vaccines]( --------------------------------------------------------------- SI Correction [Correction to Supporting Information for Pearce et al., Variation in the β-endorphin, oxytocin, and dopamine receptor genes is associated with different dimensions of human sociality]( [Cover] --------------------------------------------------------------- This message was sent to {EMAIL}. 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