PNAS Table of Contents for October 15, 2019; Vol. 116, No. 42

[PNAS] [Cozzarelli Prize Nominations](/cgi/adclick/?ad=54387&adclick=true&url=https%3A%2F%2Fwww.pnas.org%2Fpage%2Fabout%2Fcozzarelli-prize)   [October 15, 2019; Vol. 116, No. 42]( ) This Week in PNAS [In This Issue]( --------------------------------------------------------------- Core Concepts [Core Concept: Blockchain offers applications well beyond Bitcoin but faces its own limitations]( Stephen Ornes A brief introduction to emerging topics in science. --------------------------------------------------------------- Commentaries [Messenger RNA therapy as an option for treating metabolic disorders]( Randy J. Chandler [Forgetting memories through distinct actin remodeling mechanisms]( Kuan-Lin Feng and Ann-Shyn Chiang --------------------------------------------------------------- Letters [On the multibin logarithmic score used in the FluSight competitions]( Johannes Bracher [Reply to Bracher: Scoring probabilistic forecasts to maximize public health interpretability]( Nicholas G. Reich, Dave Osthus, Evan L. Ray, Teresa K. Yamana, Matthew Biggerstaff, Michael A. Johansson, Roni Rosenfeld, and Jeffrey Shaman [Reward prediction tells us less than expected about musical pleasure]( Rémi de Fleurian, Peter M. C. Harrison, Marcus T. Pearce, and David R. Quiroga-Martinez [Reply to de Fleurian et al.: Toward a fuller understanding of reward prediction errors and their role in musical pleasure]( Benjamin P. Gold, Ernest Mas-Herrero, Alain Dagher, and Robert J. Zatorre --------------------------------------------------------------- Brief Report [A triple drug combination targeting components of the nutrient-sensing network maximizes longevity]( Jorge Iván Castillo-Quan, Luke S. Tain, Kerri J. Kinghorn, Li Li, Sebastian Grönke, Yvonne Hinze, T. Keith Blackwell, Ivana Bjedov, and Linda Partridge --------------------------------------------------------------- Physical Sciences Applied Physical Sciences [Wildfire prevention through prophylactic treatment of high-risk landscapes using viscoelastic retardant fluids]( Anthony C. Yu, Hector Lopez Hernandez, Andrew H. Kim, Lyndsay M. Stapleton, Ruben J. Brand, Eric T. Mellor, Cameron P. Bauer, Gregory D. McCurdy, Albert J. Wolff III, Doreen Chan, Craig S. Criddle, Jesse D. Acosta, and Eric A. Appel [A general constitutive model for dense, fine-particle suspensions validated in many geometries]( Aaron S. Baumgarten and Ken Kamrin [Rationally engineered Staphylococcus aureus Cas9 nucleases with high genome-wide specificity]( Yuanyan Tan, Athena H. Y. Chu, Siyu Bao, Duc Anh Hoang, Firaol Tamiru Kebede, Wenjun Xiong, Mingfang Ji, Jiahai Shi, and Zongli Zheng Biophysics and Computational Biology [Structure of a C2S2M2N2-type PSII–LHCII supercomplex from the green alga Chlamydomonas reinhardtii]( Liangliang Shen, Zihui Huang, Shenghai Chang, Wenda Wang, Jingfen Wang, Tingyun Kuang, Guangye Han, Jian-Ren Shen, and Xing Zhang Chemistry [Intact carbonic acid is a viable protonating agent for biological bases]( Daniel Aminov, Dina Pines, Philip M. Kiefer, Snehasis Daschakraborty, James T. Hynes, and Ehud Pines [Waterproof molecular monolayers stabilize 2D materials]( Cong Su, Zongyou Yin, Qing-Bo Yan, Zegao Wang, Hongtao Lin, Lei Sun, Wenshuo Xu, Tetsuya Yamada, Xiang Ji, Nobuyuki Zettsu, Katsuya Teshima, Jamie H. Warner, Mircea Dincă, Juejun Hu, Mingdong Dong, Gang Su, Jing Kong, and Ju Li [The binuclear cluster of [FeFe] hydrogenase is formed with sulfur donated by cysteine of an [Fe(Cys)(CO)2(CN)] organometallic precursor]( Guodong Rao, Scott A. Pattenaude, Katherine Alwan, Ninian J. Blackburn, R. David Britt, and Thomas B. Rauchfuss [Theory and simulations for RNA folding in mixtures of monovalent and divalent cations]( Hung T. Nguyen, Naoto Hori, and D. Thirumalai [Photopotentiation of the GABAA receptor with caged diazepam]( Lorenzo Sansalone, Joshua Bratsch-Prince, Sicheng Tang, Burjor Captain, David D. Mott, and Françisco M. Raymo Engineering [Shape-shifting structured lattices via multimaterial 4D printing]( J. William Boley, Wim M. van Rees, Charles Lissandrello, Mark N. Horenstein, Ryan L. Truby, Arda Kotikian, Jennifer A. Lewis, and L. Mahadevan [Multibioinspired slippery surfaces with wettable bump arrays for droplets pumping]( Xiaoxuan Zhang, Lingyu Sun, Yu Wang, Feika Bian, Yuetong Wang, and Yuanjin Zhao Environmental Sciences [Rapid increase in Asian bottles in the South Atlantic Ocean indicates major debris inputs from ships]( Peter G. Ryan, Ben J. Dilley, Robert A. Ronconi, and Maëlle Connan Physics [Intrinsically undamped plasmon modes in narrow electron bands]( Cyprian Lewandowski and Leonid Levitov [Dynamics of wrinkling in ultrathin elastic sheets]( Finn Box, Doireann O’Kiely, Ousmane Kodio, Maxime Inizan, Alfonso A. Castrejón-Pita, and Dominic Vella Statistics [Sampling can be faster than optimization]( Yi-An Ma, Yuansi Chen, Chi Jin, Nicolas Flammarion, and Michael I. Jordan --------------------------------------------------------------- Social Sciences Economic Sciences [Declining CO2 price paths]( Kent D. Daniel, Robert B. Litterman, and Gernot Wagner Environmental Sciences [Rapid increase in Asian bottles in the South Atlantic Ocean indicates major debris inputs from ships]( Peter G. Ryan, Ben J. Dilley, Robert A. Ronconi, and Maëlle Connan Political Sciences [Local alliances and rivalries shape near-repeat terror activity of al-Qaeda, ISIS, and insurgents]( Yao-Li Chuang, Noam Ben-Asher, and Maria R. D’Orsogna Psychological and Cognitive Sciences [Great apes use self-experience to anticipate an agent’s action in a false-belief test]( Fumihiro Kano, Christopher Krupenye, Satoshi Hirata, Masaki Tomonaga, and Josep Call [Laminar specific fMRI reveals directed interactions in distributed networks during language processing]( Daniel Sharoh, Tim van Mourik, Lauren J. Bains, Katrien Segaert, Kirsten Weber, Peter Hagoort, and David G. Norris [Distinct representations of spatial and categorical relationships across human scene-selective cortex]( Andrew S. Persichetti and Daniel D. Dilks Social Sciences [Postdocs’ lab engagement predicts trajectories of PhD students’ skill development]( David F. Feldon, Kaylee Litson, Soojeong Jeong, Jennifer M. Blaney, Jina Kang, Candace Miller, Kimberly Griffin, and Josipa Roksa Sustainability Science [Detecting community response to water quality violations using bottled water sales]( Maura Allaire, Taylor Mackay, Shuyan Zheng, and Upmanu Lall [Impact of increasing vegetarian availability on meal selection and sales in cafeterias]( Emma E. Garnett, Andrew Balmford, Chris Sandbrook, Mark A. Pilling, and Theresa M. Marteau --------------------------------------------------------------- Biological Sciences Agricultural Sciences [Reviving rare chicken breeds using genetically engineered sterility in surrogate host birds]( Mark E. Woodcock, Almas A. Gheyas, Andrew S. Mason, Sunil Nandi, Lorna Taylor, Adrian Sherman, Jacqueline Smith, Dave W. Burt, Rachel Hawken, and Michael J. McGrew [Xanthomonas translucens commandeers the host rate-limiting step in ABA biosynthesis for disease susceptibility]( Zhao Peng, Ying Hu, Junli Zhang, Jose C. Huguet-Tapia, Anna K. Block, Sunghun Park, Suraj Sapkota, Zhaohui Liu, Sanzhen Liu, and Frank F. White Applied Biological Sciences [Engineering the stereoisomeric structure of seed oil to mimic human milk fat]( Harrie van Erp, Fiona M. Bryant, Jose Martin-Moreno, Louise V. Michaelson, Govindprasad Bhutada, and Peter J. Eastmond [A large-scale study reveals 24-h operational rhythms in hospital treatment]( Marc D. Ruben, Lauren J. Francey, Yuping Guo, Gang Wu, Edward B. Cooper, Amy S. Shah, John B. Hogenesch, and David F. Smith [Francisella novicida Cas9 interrogates genomic DNA with very high specificity and can be used for mammalian genome editing]( Sundaram Acharya, Arpit Mishra, Deepanjan Paul, Asgar Hussain Ansari, Mohd. Azhar, Manoj Kumar, Riya Rauthan, Namrata Sharma, Meghali Aich, Dipanjali Sinha, Saumya Sharma, Shivani Jain, Arjun Ray, Suman Jain, Sivaprakash Ramalingam, Souvik Maiti, and Debojyoti Chakraborty Biochemistry [Rationally engineered Staphylococcus aureus Cas9 nucleases with high genome-wide specificity]( Yuanyan Tan, Athena H. Y. Chu, Siyu Bao, Duc Anh Hoang, Firaol Tamiru Kebede, Wenjun Xiong, Mingfang Ji, Jiahai Shi, and Zongli Zheng [Rotational symmetry of the structured Chip/LDB-SSDP core module of the Wnt enhanceosome]( Miha Renko, Marc Fiedler, Trevor J. Rutherford, Jonas V. Schaefer, Andreas Plückthun, and Mariann Bienz [Structural basis of light-induced redox regulation in the Calvin–Benson cycle in cyanobacteria]( Ciaran R. McFarlane, Nita R. Shah, Burak V. Kabasakal, Blanca Echeverria, Charles A. R. Cotton, Doryen Bubeck, and James W. Murray [A CTG repeat-selective chemical screen identifies microtubule inhibitors as selective modulators of toxic CUG RNA levels]( Kaalak Reddy, Jana R. Jenquin, Ona L. McConnell, John D. Cleary, Jared I. Richardson, Belinda S. Pinto, Maja C. Haerle, Elizabeth Delgado, Lori Planco, Masayuki Nakamori, Eric T. Wang, and J. Andrew Berglund [Mapping low-affinity/high-specificity peptide–protein interactions using ligand-footprinting mass spectrometry]( Benjamin W. Parker, Edward J. Goncz, David T. Krist, Alexander V. Statsyuk, Alexey I. Nesvizhskii, and Eric L. Weiss [Overcoming insecticide resistance through computational inhibitor design]( Galen J. Correy, Daniel Zaidman, Alon Harmelin, Silvia Carvalho, Peter D. Mabbitt, Viviane Calaora, Peter J. James, Andrew C. Kotze, Colin J. Jackson, and Nir London Biophysics and Computational Biology [Theory and simulations for RNA folding in mixtures of monovalent and divalent cations]( Hung T. Nguyen, Naoto Hori, and D. Thirumalai [How internal cavities destabilize a protein]( Mengjun Xue, Takuro Wakamoto, Camilla Kejlberg, Yuichi Yoshimura, Tania Aaquist Nielsen, Michael Wulff Risør, Kristian Wejse Sanggaard, Ryo Kitahara, and Frans A. A. Mulder [Capsid expansion of bacteriophage T5 revealed by high resolution cryoelectron microscopy]( Alexis Huet, Robert L. Duda, Pascale Boulanger, and James F. Conway Developmental Biology [Paternal knockout of Slc38a4/SNAT4 causes placental hypoplasia associated with intrauterine growth restriction in mice]( Shogo Matoba, Shoko Nakamuta, Kento Miura, Michiko Hirose, Hirosuke Shiura, Takashi Kohda, Nobuaki Nakamuta, and Atsuo Ogura [β-Catenin is required for radial cell patterning and identity in the developing mouse cochlea]( Lina Jansson, Michael Ebeid, Jessica W. Shen, Tara E. Mokhtari, Lee A. Quiruz, David M. Ornitz, Sung-Ho Huh, and Alan G. Cheng Ecology [The conflict between adaptation and dispersal for maintaining biodiversity in changing environments]( Patrick L. Thompson and Emanuel A. Fronhofer Evolution [On the feasibility of saltational evolution]( Mikhail I. Katsnelson, Yuri I. Wolf, and Eugene V. Koonin [Multiple modes of convergent adaptation in the spread of glyphosate-resistant Amaranthus tuberculatus]( Julia M. Kreiner, Darci Ann Giacomini, Felix Bemm, Bridgit Waithaka, Julian Regalado, Christa Lanz, Julia Hildebrandt, Peter H. Sikkema, Patrick J. Tranel, Detlef Weigel, John R. Stinchcombe, and Stephen I. Wright [Empirical measures of mutational effects define neutral models of regulatory evolution in Saccharomyces cerevisiae]( Andrea Hodgins-Davis, Fabien Duveau, Elizabeth A. Walker, and Patricia J. Wittkopp [A functional enrichment test for molecular convergent evolution finds a clear protein-coding signal in echolocating bats and whales]( Amir Marcovitz, Yatish Turakhia, Heidi I. Chen, Michael Gloudemans, Benjamin A. Braun, Haoqing Wang, and Gill Bejerano [Allele-specific nonstationarity in evolution of influenza A virus surface proteins]( Anfisa V. Popova, Ksenia R. Safina, Vasily V. Ptushenko, Anastasia V. Stolyarova, Alexander V. Favorov, Alexey D. Neverov, and Georgii A. Bazykin Immunology and Inflammation [Cowpox virus encodes a protein that binds B7.1 and B7.2 and subverts T cell costimulation]( Xiaoli Wang, Sytse J. Piersma, Jabari I. Elliott, John M. Errico, Maria D. Gainey, Liping Yang, Christopher A. Nelson, Wayne M. Yokoyama, and Daved H. Fremont [IL-2 receptors preassemble and signal in the ER/Golgi causing resistance to antiproliferative anti–IL-2Rα therapies]( Julianna Volkó, Ádám Kenesei, Meili Zhang, Péter Várnai, Gábor Mocsár, Michael N. Petrus, Károly Jambrovics, Zoltán Balajthy, Gabriele Müller, Andrea Bodnár, Katalin Tóth, Thomas A. Waldmann, and György Vámosi [Extrapituitary prolactin promotes generation of Eomes-positive helper T cells mediating neuroinflammation]( Chenyang Zhang, Ben J. E. Raveney, Hirohiko Hohjoh, Chiharu Tomi, Shinji Oki, and Takashi Yamamura [RORα is crucial for attenuated inflammatory response to maintain intestinal homeostasis]( Se Kyu Oh, Dongha Kim, Kyeongkyu Kim, Kyungjin Boo, Young Suk Yu, Ik Soo Kim, Yoon Jeon, Sun-Kyoung Im, Su-Hyung Lee, Ji Min Lee, Younhee Ko, Ho Lee, Daechan Park, Sungsoon Fang, and Sung Hee Baek Medical Sciences [Lipid nanoparticle-targeted mRNA therapy as a treatment for the inherited metabolic liver disorder arginase deficiency]( Brian Truong, Gabriella Allegri, Xiao-Bo Liu, Kristine E. Burke, Xuling Zhu, Stephen D. Cederbaum, Johannes Häberle, Paolo G. V. Martini, and Gerald S. Lipshutz Microbiology [Genetic ablation of purine salvage in Cryptosporidium parvum reveals nucleotide uptake from the host cell]( Mattie C. Pawlowic, Mastanbabu Somepalli, Adam Sateriale, Gillian T. Herbert, Alexis R. Gibson, Gregory D. Cuny, Lizbeth Hedstrom, and Boris Striepen [The cbb3-type cytochrome oxidase assembly factor CcoG is a widely distributed cupric reductase]( Dorian Marckmann, Petru-Iulian Trasnea, Johannes Schimpf, Christine Winterstein, Andreea Andrei, Stefan Schmollinger, Crysten E. Blaby-Haas, Thorsten Friedrich, Fevzi Daldal, and Hans-Georg Koch Neuroscience [Photopotentiation of the GABAA receptor with caged diazepam]( Lorenzo Sansalone, Joshua Bratsch-Prince, Sicheng Tang, Burjor Captain, David D. Mott, and Françisco M. Raymo [Laminar specific fMRI reveals directed interactions in distributed networks during language processing]( Daniel Sharoh, Tim van Mourik, Lauren J. Bains, Katrien Segaert, Kirsten Weber, Peter Hagoort, and David G. Norris [Genetic dissection of active forgetting in labile and consolidated memories in Drosophila]( Yang Gao, Yichun Shuai, Xuchen Zhang, Yuwei Peng, Lianzhang Wang, Jing He, Yi Zhong, and Qian Li [Amyloid-beta impairs TOM1-mediated IL-1R1 signaling]( Alessandra Cadete Martini, Angela Gomez-Arboledas, Stefania Forner, Carlos J. Rodriguez-Ortiz, Amanda McQuade, Emma Danhash, Jimmy Phan, Dominic Javonillo, Jordan-Vu Ha, Melanie Tram, Laura Trujillo-Estrada, Celia da Cunha, Rahasson R. Ager, Jose C. Davila, Masashi Kitazawa, Mathew Blurton-Jones, Antonia Gutierrez, David Baglietto-Vargas, Rodrigo Medeiros, and Frank M. LaFerla [N-terminal alternative splicing of GluN1 regulates the maturation of excitatory synapses and seizure susceptibility]( Hong Liu, Hao Wang, Matthew Peterson, Wen Zhang, Guoqiang Hou, and Zhong-wei Zhang [Gray Matter Age Prediction as a Biomarker for Risk of Dementia]( Johnny Wang, Maria J. Knol, Aleksei Tiulpin, Florian Dubost, Marleen de Bruijne, Meike W. Vernooij, Hieab H. H. Adams, M. Arfan Ikram, Wiro J. Niessen, and Gennady V. Roshchupkin [Gradients of structure–function tethering across neocortex]( Bertha Vázquez-Rodríguez, Laura E. Suárez, Ross D. Markello, Golia Shafiei, Casey Paquola, Patric Hagmann, Martijn P. van den Heuvel, Boris C. Bernhardt, R. Nathan Spreng, and Bratislav Misic [Muscle acetylcholine receptor conversion into chloride conductance at positive potentials by a single mutation]( Hakan Cetin, Max Epstein, Wei W. Liu, Susan Maxwell, Pedro M. Rodriguez Cruz, Judith Cossins, Angela Vincent, Richard Webster, Philip C. Biggin, and David Beeson Pharmacology [KCNQ5 activation is a unifying molecular mechanism shared by genetically and culturally diverse botanical hypotensive folk medicines]( Rían W. Manville, Jennifer van der Horst, Kaitlyn E. Redford, Benjamin B. Katz, Thomas A. Jepps, and Geoffrey W. Abbott Plant Biology [Structure of a C2S2M2N2-type PSII–LHCII supercomplex from the green alga Chlamydomonas reinhardtii]( Liangliang Shen, Zihui Huang, Shenghai Chang, Wenda Wang, Jingfen Wang, Tingyun Kuang, Guangye Han, Jian-Ren Shen, and Xing Zhang [Mining for protein S-sulfenylation in Arabidopsis uncovers redox-sensitive sites]( Jingjing Huang, Patrick Willems, Bo Wei, Caiping Tian, Renan B. Ferreira, Nandita Bodra, Santiago Agustín Martínez Gache, Khadija Wahni, Keke Liu, Didier Vertommen, Kris Gevaert, Kate S. Carroll, Marc Van Montagu, Jing Yang, Frank Van Breusegem, and Joris Messens [GWAS with principal component analysis identifies a gene comprehensively controlling rice architecture]( Kenji Yano, Yoichi Morinaka, Fanmiao Wang, Peng Huang, Sayaka Takehara, Takaaki Hirai, Aya Ito, Eriko Koketsu, Mayuko Kawamura, Kunihiko Kotake, Shinya Yoshida, Masaki Endo, Gen Tamiya, Hidemi Kitano, Miyako Ueguchi-Tanaka, Ko Hirano, and Makoto Matsuoka [Light-inducible expression of translation factor EF-Tu during acclimation to strong light enhances the repair of photosystem II]( Haruhiko Jimbo, Taichi Izuhara, Yukako Hihara, Toru Hisabori, and Yoshitaka Nishiyama [Salicylic acid-mediated plasmodesmal closure via Remorin-dependent lipid organization]( Dingquan Huang, Yanbiao Sun, Zhiming Ma, Meiyu Ke, Yong Cui, Zichen Chen, Chaofan Chen, Changyang Ji, Tuan Minh Tran, Liang Yang, Sin Man Lam, Yanhong Han, Guanghou Shu, Jiří Friml, Yansong Miao, Liwen Jiang, and Xu Chen [Noncanonical auxin signaling regulates cell division pattern during lateral root development]( Rongfeng Huang, Rui Zheng, Jun He, Zimin Zhou, Jiacheng Wang, Yan Xiong, and Tongda Xu [Interaction between VPS35 and RABG3f is necessary as a checkpoint to control fusion of late compartments with the vacuole]( Cecilia Rodriguez-Furlan, David Domozych, Weixing Qian, Per-Anders Enquist, Xiaohui Li, Chunhua Zhang, Rolf Schenk, Holly Saulsbery Winbigler, William Jackson, Natasha V. Raikhel, and Glenn R. Hicks Population Biology [Contemporary evolution of maize landraces and their wild relatives influenced by gene flow with modern maize varieties]( Idalia C. Rojas-Barrera, Ana Wegier, José de Jesús Sánchez González, Gregory L. Owens, Loren H. Rieseberg, and Daniel Piñero Psychological and Cognitive Sciences [Distinct representations of spatial and categorical relationships across human scene-selective cortex]( Andrew S. Persichetti and Daniel D. Dilks [Neural dynamics of semantic composition]( Bingjiang Lyu, Hun S. Choi, William D. Marslen-Wilson, Alex Clarke, Billi Randall, and Lorraine K. Tyler --------------------------------------------------------------- Corrections [Correction for Manca et al., SNARE machinery is optimized for ultrafast fusion]( [Correction for Sotoudeh et al., Effects of the peer metagenomic environment on smoking behavior]( [Correction for Ishii et al., MPE-seq, a new method for the genome-wide analysis of chromatin structure]( [Correction for Font-Muñoz et al., Collective sinking promotes selective cell pairing in planktonic pennate diatoms]( [Cover] --------------------------------------------------------------- This message was sent to {EMAIL}. [Unsubscribe]( from or [edit]( your subscription for this service. Or by mail: Customer Service * 973 University Avenue * Los Gatos, CA 95032 * U.S.A. Copyright © 2019 by the National Academy of Sciences