PNAS Table of Contents for October 1, 2019; Vol. 116, No. 40

[PNAS] [Eye movements](/cgi/adclick/?ad=54360&adclick=true&url=https%3A%2F%2Fwww.pnas.org%2Fpage%2Fmedia%2Fpodcasts%23eye)   [October 1, 2019; Vol. 116, No. 40]( ) This Week in PNAS [In This Issue]( --------------------------------------------------------------- Inner Workings [Inner Workings: Dwarf galaxies pose new questions about dark matter and the early universe that models are struggling to answer]( Adam Mann An over-the-shoulder look at scientists at work. --------------------------------------------------------------- Commentaries [Understanding the industrial contribution to pollution offers opportunities to further improve air quality in the United States]( Juan Moreno-Cruz [Premotor cortex implements causal inference in multisensory own-body perception]( H. Henrik Ehrsson and Marie Chancel [Physiological signaling in the absence of amidated peptides]( Iris Lindberg and Christopher C. Glembotski --------------------------------------------------------------- Perspective [Structural basis for power stroke vs. Brownian ratchet mechanisms of motor proteins]( Wonmuk Hwang and Martin Karplus --------------------------------------------------------------- Letters [Effect of alder on soil bacteria offers an alternative explanation to the role played by alder in rock weathering]( Mayank Krishna, Saurabh Kumar Singh, Jayant K. Tripathi, Rupesh Chaturvedi, and Satish Chandra Garkoti [Reply to Krishna et al.: Resolving age-related changes in nitrogen fixation and mineral weathering by Alnus tree species]( Steven S. Perakis and Julie C. Pett-Ridge [On the origin of a pathogenic HERV-W envelope protein present in multiple sclerosis lesions]( Klemens Ruprecht and Jens Mayer [Reply to Ruprecht and Mayer: Unearthing genomic fossils in the pathogenesis of multiple sclerosis]( David Kremer, Hervé Perron, and Patrick Küry [Inside-out signaling through FAK–integrin axis may regulate circulating cancer cell metastatic adhesion]( Christina Downey-Biechler, David H. Craig, Shyam K. More, and Marc D. Basson --------------------------------------------------------------- Brief Reports [The value of thoughts and prayers]( Linda Thunström and Shiri Noy [Force-induced recruitment of cten along keratin network in epithelial cells]( Joleen S. Cheah, Kyle A. Jacobs, Volkmar Heinrich, Su Hao Lo, and Soichiro Yamada [The gut microbiome regulates host glucose homeostasis via peripheral serotonin]( Alyce M. Martin, Julian M. Yabut, Jocelyn M. Choo, Amanda J. Page, Emily W. Sun, Claire F. Jessup, Steve L. Wesselingh, Waliul I. Khan, Geraint B. Rogers, Gregory R. Steinberg, and Damien J. Keating --------------------------------------------------------------- Physical Sciences Biophysics and Computational Biology [Spatial organization of RNA polymerase and its relationship with transcription in Escherichia coli]( Xiaoli Weng, Christopher H. Bohrer, Kelsey Bettridge, Arvin Cesar Lagda, Cedric Cagliero, Ding Jun Jin, and Jie Xiao Chemistry [Genomic analysis of siderophore β-hydroxylases reveals divergent stereocontrol and expands the condensation domain family]( Zachary L. Reitz, Clifford D. Hardy, Jaewon Suk, Jean Bouvet, and Alison Butler [Relative hydrophilicities of cis and trans formamides]( Yong-Sheng Li, Luis Escobar, Yu-Jie Zhu, Yoram Cohen, Pablo Ballester, Julius Rebek Jr., and Yang Yu [Heme binding to human CLOCK affects interactions with the E-box]( Samuel L. Freeman, Hanna Kwon, Nicola Portolano, Gary Parkin, Umakhanth Venkatraman Girija, Jaswir Basran, Alistair J. Fielding, Louise Fairall, Dimitri A. Svistunenko, Peter C. E. Moody, John W. R. Schwabe, Charalambos P. Kyriacou, and Emma L. Raven Earth, Atmospheric, and Planetary Sciences [Quantifying stochastic uncertainty in detection time of human-caused climate signals]( Benjamin D. Santer, John C. Fyfe, Susan Solomon, Jeffrey F. Painter, Céline Bonfils, Giuliana Pallotta, and Mark D. Zelinka Engineering [Mechanical fatigue of human red blood cells]( Yuhao Qiang, Jia Liu, Ming Dao, Subra Suresh, and E. Du [T cell activation and immune synapse organization respond to the microscale mechanics of structured surfaces]( Weiyang Jin, Fella Tamzalit, Parthiv Kant Chaudhuri, Charles T. Black, Morgan Huse, and Lance C. Kam [Neuromuscular actuation of biohybrid motile bots]( Onur Aydin, Xiaotian Zhang, Sittinon Nuethong, Gelson J. Pagan-Diaz, Rashid Bashir, Mattia Gazzola, and M. Taher A. Saif [High-resolution limited-angle phase tomography of dense layered objects using deep neural networks]( Alexandre Goy, Girish Rughoobur, Shuai Li, Kwabena Arthur, Akintunde I. Akinwande, and George Barbastathis Environmental Sciences [Fine particulate matter damages and value added in the US economy]( Peter Tschofen, Inês L. Azevedo, and Nicholas Z. Muller Physics [Interfacial charge-transfer Mott state in iridate–nickelate superlattices]( Xiaoran Liu, Michele Kotiuga, Heung-Sik Kim, Alpha T. N’Diaye, Yongseong Choi, Qinghua Zhang, Yanwei Cao, Mikhail Kareev, Fangdi Wen, Banabir Pal, John W. Freeland, Lin Gu, Daniel Haskel, Padraic Shafer, Elke Arenholz, Kristjan Haule, David Vanderbilt, Karin M. Rabe, and Jak Chakhalian [Thermalization and possible signatures of quantum chaos in complex crystalline materials]( Jiecheng Zhang, Erik D. Kountz, Kamran Behnia, and Aharon Kapitulnik [Photoenhanced metastable c-axis electrodynamics in stripe-ordered cuprate La1.885Ba0.115CuO4]( Kevin A. Cremin, Jingdi Zhang, Christopher C. Homes, G. D. Gu, Zhiyuan Sun, Michael M. Fogler, Andrew J. Millis, D. N. Basov, and Richard D. Averitt [Optical deformation of single aerosol particles]( Aidan Rafferty, Kyle Gorkowski, Andreas Zuend, and Thomas C. Preston Statistics [Building more accurate decision trees with the additive tree]( José Marcio Luna, Efstathios D. Gennatas, Lyle H. Ungar, Eric Eaton, Eric S. Diffenderfer, Shane T. Jensen, Charles B. Simone II, Jerome H. Friedman, Timothy D. Solberg, and Gilmer Valdes --------------------------------------------------------------- Social Sciences Economic Sciences [Fine particulate matter damages and value added in the US economy]( Peter Tschofen, Inês L. Azevedo, and Nicholas Z. Muller Social Sciences [A field experiment on community policing and police legitimacy]( Kyle Peyton, Michael Sierra-Arévalo, and David G. Rand Sustainability Science [Untapped capacity for resilience in environmental law]( Ahjond Garmestani, J. B. Ruhl, Brian C. Chaffin, Robin K. Craig, Helena F. M. W. van Rijswick, David G. Angeler, Carl Folke, Lance Gunderson, Dirac Twidwell, and Craig R. Allen --------------------------------------------------------------- Biological Sciences Anthropology [Selection of endurance capabilities and the trade-off between pressure and volume in the evolution of the human heart]( Robert E. Shave, Daniel E. Lieberman, Aimee L. Drane, Marcel G. Brown, Alan M. Batterham, Steven Worthington, Rebeca Atencia, Yedra Feltrer, Jennifer Neary, Rory B. Weiner, Meagan M. Wasfy, and Aaron L. Baggish Biochemistry [Genomic analysis of siderophore β-hydroxylases reveals divergent stereocontrol and expands the condensation domain family]( Zachary L. Reitz, Clifford D. Hardy, Jaewon Suk, Jean Bouvet, and Alison Butler [Heme binding to human CLOCK affects interactions with the E-box]( Samuel L. Freeman, Hanna Kwon, Nicola Portolano, Gary Parkin, Umakhanth Venkatraman Girija, Jaswir Basran, Alistair J. Fielding, Louise Fairall, Dimitri A. Svistunenko, Peter C. E. Moody, John W. R. Schwabe, Charalambos P. Kyriacou, and Emma L. Raven [A higher-order configuration of the heterodimeric DOT1L–AF10 coiled-coil domains potentiates their leukemogenenic activity]( Xiaosheng Song, Liuliu Yang, Mingzhu Wang, Yue Gu, Buqing Ye, Zusen Fan, Rui-Ming Xu, and Na Yang Biophysics and Computational Biology [Redox-dependent gating of VDAC by mitoNEET]( Colin H. Lipper, Jason T. Stofleth, Fang Bai, Yang-Sung Sohn, Susmita Roy, Ron Mittler, Rachel Nechushtai, José N. Onuchic, and Patricia A. Jennings [Tubulin lattice in cilia is in a stressed form regulated by microtubule inner proteins]( Muneyoshi Ichikawa, Ahmad Abdelzaher Zaki Khalifa, Shintaroh Kubo, Daniel Dai, Kaustuv Basu, Mohammad Amin Faghfor Maghrebi, Javier Vargas, and Khanh Huy Bui [Organization of fast and slow chromatin revealed by single-nucleosome dynamics]( S. S. Ashwin, Tadasu Nozaki, Kazuhiro Maeshima, and Masaki Sasai [Monomeric structure of an active form of bovine cytochrome c oxidase]( Kyoko Shinzawa-Itoh, Takashi Sugimura, Tomonori Misaki, Yoshiki Tadehara, Shogo Yamamoto, Makoto Hanada, Naomine Yano, Tetsuya Nakagawa, Shigefumi Uene, Takara Yamada, Hiroshi Aoyama, Eiki Yamashita, Tomitake Tsukihara, Shinya Yoshikawa, and Kazumasa Muramoto [A network of phosphatidylinositol 4,5-bisphosphate binding sites regulates gating of the Ca2+-activated Cl− channel ANO1 (TMEM16A)]( Kuai Yu, Tao Jiang, YuanYuan Cui, Emad Tajkhorshid, and H. Criss Hartzell [Conformational equilibrium defines the variable induction of the multidrug-binding transcriptional repressor QacR]( Koh Takeuchi, Misaki Imai, and Ichio Shimada [Structural basis of molecular logic OR in a dual-sensor histidine kinase]( Heewhan Shin, Zhong Ren, Xiaoli Zeng, Sepalika Bandara, and Xiaojing Yang Cell Biology [Mechanical fatigue of human red blood cells]( Yuhao Qiang, Jia Liu, Ming Dao, Subra Suresh, and E. Du [Atp6ap2 deletion causes extensive vacuolation that consumes the insulin content of pancreatic β cells]( Katrina J. Binger, Martin Neukam, Sudhir Gopal Tattikota, Fatimunnisa Qadri, Dmytro Puchkov, Diana M. Willmes, Sabrina Wurmsee, Sabrina Geisberger, Ralf Dechend, Klemens Raile, Thomas Kurth, Genevieve Nguyen, Matthew N. Poy, Michele Solimena, Dominik N. Muller, and Andreas L. Birkenfeld Ecology [Climate drives loss of phylogenetic diversity in a grassland community]( Daijiang Li, Jesse E. D. Miller, and Susan Harrison [Fishing down then up the food web of an invaded lake]( Erin S. Dunlop, Daisuke Goto, and Donald A. Jackson Evolution [Elevated mutation and selection in wild emmer wheat in response to 28 years of global warming]( Yong-Bi Fu, Gregory W. Peterson, Carolee Horbach, David J. Konkin, Avigdor Beiles, and Eviatar Nevo [Pervasive convergent evolution and extreme phenotypes define chaperone requirements of protein homeostasis]( Yasmine Draceni and Sebastian Pechmann [Global invasion history of the agricultural pest butterfly Pieris rapae revealed with genomics and citizen science]( Sean F. Ryan, Eric Lombaert, Anne Espeset, Roger Vila, Gerard Talavera, Vlad Dincă, Meredith M. Doellman, Mark A. Renshaw, Matthew W. Eng, Emily A. Hornett, Yiyuan Li, Michael E. Pfrender, and DeWayne Shoemaker [Microbiome composition shapes rapid genomic adaptation of Drosophila melanogaster]( Seth M. Rudman, Sharon Greenblum, Rachel C. Hughes, Subhash Rajpurohit, Ozan Kiratli, Dallin B. Lowder, Skyler G. Lemmon, Dmitri A. Petrov, John M. Chaston, and Paul Schmidt Genetics [Identification of C2CD4A as a human diabetes susceptibility gene with a role in β cell insulin secretion]( Taiyi Kuo, Michael J. Kraakman, Manashree Damle, Richard Gill, Mitchell A. Lazar, and Domenico Accili [Monitoring of switches in heterochromatin-induced silencing shows incomplete establishment and developmental instabilities]( Farah Bughio, Gary R. Huckell, and Keith A. Maggert Immunology and Inflammation [T cell activation and immune synapse organization respond to the microscale mechanics of structured surfaces]( Weiyang Jin, Fella Tamzalit, Parthiv Kant Chaudhuri, Charles T. Black, Morgan Huse, and Lance C. Kam [Differential requirements for FcγR engagement by protective antibodies against Ebola virus]( Stylianos Bournazos, David J. DiLillo, Arthur J. Goff, Pamela J. Glass, and Jeffrey V. Ravetch [PTPN1/2-mediated dephosphorylation of MITA/STING promotes its 20S proteasomal degradation and attenuates innate antiviral response]( Tian Xia, Xue-Mei Yi, Xin Wu, Jun Shang, and Hong-Bing Shu [Proliferation-competent Tcf1+ CD8 T cells in dysfunctional populations are CD4 T cell help independent]( Kristiyan Kanev, Ming Wu, Antar Drews, Patrick Roelli, Christine Wurmser, Madlaina von Hösslin, and Dietmar Zehn [The circadian clock of CD8 T cells modulates their early response to vaccination and the rhythmicity of related signaling pathways]( Chloé C. Nobis, Geneviève Dubeau Laramée, Laura Kervezee, Dave Maurice De Sousa, Nathalie Labrecque, and Nicolas Cermakian [Genetic variation of DNA methyltransferase-3A contributes to protection against persistent MRSA bacteremia in patients]( Felix Mba Medie, Batu K. Sharma-Kuinkel, Felicia Ruffin, Liana C. Chan, Maura Rossetti, Yu-Ling Chang, Lawrence P. Park, Arnold S. Bayer, Scott G. Filler, Richard Ahn, Elaine F. Reed, David Gjertson, Michael R. Yeaman, Vance G. Fowler Jr., and the MRSA Systems Immunobiology Group Medical Sciences [Genetic ablation of acid ceramidase in Krabbe disease confirms the psychosine hypothesis and identifies a new therapeutic target]( Yedda Li, Yue Xu, Bruno A. Benitez, Murtaza S. Nagree, Joshua T. Dearborn, Xuntian Jiang, Miguel A. Guzman, Josh C. Woloszynek, Alex Giaramita, Bryan K. Yip, Joseph Elsbernd, Michael C. Babcock, Melanie Lo, Stephen C. Fowler, David F. Wozniak, Carole A. Vogler, Jeffrey A. Medin, Brett E. Crawford, and Mark S. Sands [Conversion of Sox2-dependent Merkel cell carcinoma to a differentiated neuron-like phenotype by T antigen inhibition]( Alexis Harold, Yutaka Amako, Junichi Hachisuka, Yulong Bai, Meng Yen Li, Linda Kubat, Jan Gravemeyer, Jonathan Franks, Julia R. Gibbs, Hyun Jung Park, Elena Ezhkova, Jürgen C. Becker, and Masahiro Shuda Microbiology [Spatial organization of RNA polymerase and its relationship with transcription in Escherichia coli]( Xiaoli Weng, Christopher H. Bohrer, Kelsey Bettridge, Arvin Cesar Lagda, Cedric Cagliero, Ding Jun Jin, and Jie Xiao [Structural insights into diverse modes of ICAM-1 binding by Plasmodium falciparum-infected erythrocytes]( Frank Lennartz, Cameron Smith, Alister G. Craig, and Matthew K. Higgins [Unstable chromosome rearrangements in Staphylococcus aureus cause phenotype switching associated with persistent infections]( Romain Guérillot, Xenia Kostoulias, Liam Donovan, Lucy Li, Glen P. Carter, Abderrahman Hachani, Koen Vandelannoote, Stefano Giulieri, Ian R. Monk, Mayu Kunimoto, Lora Starrs, Gaétan Burgio, Torsten Seemann, Anton Y. Peleg, Timothy P. Stinear, and Benjamin P. Howden [αvβ3-integrin regulates PD-L1 expression and is involved in cancer immune evasion]( Andrea Vannini, Valerio Leoni, Catia Barboni, Mara Sanapo, Anna Zaghini, Paolo Malatesta, Gabriella Campadelli-Fiume, and Tatiana Gianni Neuroscience [Statistical inference of body representation in the macaque brain]( Wen Fang, Junru Li, Guangyao Qi, Shenghao Li, Mariano Sigman, and Liping Wang [Molecular control limiting sensitivity of sweet taste neurons in Drosophila]( Hsueh-Ling Chen, Ulrich Stern, and Chung-Hui Yang [Identifying roles for peptidergic signaling in mice]( Kathryn G. Powers, Xin-Ming Ma, Betty A. Eipper, and Richard E. Mains [Cell class-specific modulation of attentional signals by acetylcholine in macaque frontal eye field]( Miguel Dasilva, Christian Brandt, Sascha Gotthardt, Marc Alwin Gieselmann, Claudia Distler, and Alexander Thiele [Maternal viral infection causes global alterations in porcine fetal microglia]( Adrienne M. Antonson, Marcus A. Lawson, Megan P. Caputo, Stephanie M. Matt, Brian J. Leyshon, and Rodney W. Johnson [Ca2+-independent but voltage-dependent quantal catecholamine secretion (CiVDS) in the mammalian sympathetic nervous system]( Rong Huang, Yuan Wang, Jie Li, Xiaohan Jiang, Yinglin Li, Bing Liu, Xi Wu, Xingyu Du, Yuqi Hang, Mu Jin, Feipeng Zhu, Changhe Wang, Zuying Chai, and Zhuan Zhou Pharmacology [Discordance between eNOS phosphorylation and activation revealed by multispectral imaging and chemogenetic methods]( Emrah Eroglu, Seyed Soheil Saeedi Saravi, Andrea Sorrentino, Benjamin Steinhorn, and Thomas Michel Plant Biology [Arabidopsis PP6 phosphatases dephosphorylate PIF proteins to repress photomorphogenesis]( Xiaodan Yu, Jie Dong, Zhaoguo Deng, Yaping Jiang, Chong Wu, Xiaofang Qin, William Terzaghi, Haodong Chen, Mingqiu Dai, and Xing Wang Deng [Arabidopsis H+-ATPase AHA1 controls slow wave potential duration and wound-response jasmonate pathway activation]( Archana Kumari, Aurore Chételat, Chi Tam Nguyen, and Edward E. Farmer [Auronidins are a previously unreported class of flavonoid pigments that challenges when anthocyanin biosynthesis evolved in plants]( Helge Berland, Nick W. Albert, Anne Stavland, Monica Jordheim, Tony K. McGhie, Yanfei Zhou, Huaibi Zhang, Simon C. Deroles, Kathy E. Schwinn, Brian R. Jordan, Kevin M. Davies, and Øyvind M. Andersen --------------------------------------------------------------- Corrections [Correction for Lister and Garcia, Reply to Willig et al.: Long-term population trends in the Luquillo Rainforest]( [Correction for Branch and Wulfmeyer, Deliberate enhancement of rainfall using desert plantations]( [Cover] --------------------------------------------------------------- This message was sent to {EMAIL}. [Unsubscribe]( from or [edit]( your subscription for this service. Or by mail: Customer Service * 973 University Avenue * Los Gatos, CA 95032 * U.S.A. Copyright © 2019 by the National Academy of Sciences