PNAS Table of Contents for July 2, 2019; Vol. 116, No. 27

[PNAS] [Science of Science Comm III DE](/cgi/adclick/?ad=54012&adclick=true&url=http%3A%2F%2Fonlinedigeditions.com%2Fpublication%2F%3Fi%3D595893%23)   [July 2, 2019; Vol. 116, No. 27]( ) This Week in PNAS [In This Issue]( --------------------------------------------------------------- Opinion [Opinion: The National Institutes of Health needs to better balance funding distributions among US institutions]( Wayne P. Wahls Leading scientists discuss current issues. --------------------------------------------------------------- Retrospective [The sui generis Sydney Brenner]( Thoru Pederson --------------------------------------------------------------- Commentaries [Identifying art forgeries by radiocarbon dating microgram quantities of artists’ paints]( Gregory W. L. Hodgins [Organic interfaces enhance strontium content of marine barite]( Adam F. Wallace [MZB1 folding and unfolding the role of IgA]( Keiichiro Suzuki, Alexis Vogelzang, and Sidonia Fagarasan [Presynaptic NMDARs and astrocytes ally to control circuit-specific information flow]( Isabel Pérez-Otaño and Antonio Rodríguez-Moreno --------------------------------------------------------------- Letters [Water is not a dynamic polydisperse branched polymer]( Teresa Head-Gordon and Francesco Paesani [Mathematical models converge on PGC1α as the key metabolic integrator of SIRT1 and AMPK regulation of the circadian clock]( Alessandro Furlan, Marine Jacquier, Aurore Woller, Laurent Héliot, Hélène Duez, Bart Staels, and Marc Lefranc [Reply to Furlan et al.: The role of SIRT1 in cell autonomous clock function]( Panagiota T. Foteinou, Anand Venkataraman, Lauren J. Francey, Ron C. Anafi, John B. Hogenesch, and Francis J. Doyle III --------------------------------------------------------------- Physical Sciences Applied Mathematics [Role of cerebellar GABAergic dysfunctions in the origins of essential tremor]( Xu Zhang and Sabato Santaniello Applied Physical Sciences [Reactive school closure weakens the network of social interactions and reduces the spread of influenza]( Maria Litvinova, Quan-Hui Liu, Evgeny S. Kulikov, and Marco Ajelli [Solar thermal desalination as a nonlinear optical process]( Pratiksha D. Dongare, Alessandro Alabastri, Oara Neumann, Peter Nordlander, and Naomi J. Halas [Spotting plants’ microfilament morphologies and nanostructures]( Ana P. Almeida, João Canejo, Urban Mur, Simon Čopar, Pedro L. Almeida, Slobodan Žumer, and Maria Helena Godinho [Stability of the A15 phase in diblock copolymer melts]( Morgan W. Bates, Joshua Lequieu, Stephanie M. Barbon, Ronald M. Lewis III, Kris T. Delaney, Athina Anastasaki, Craig J. Hawker, Glenn H. Fredrickson, and Christopher M. Bates Biophysics and Computational Biology [Regulation of nuclear architecture, mechanics, and nucleocytoplasmic shuttling of epigenetic factors by cell geometric constraints]( Farid Alisafaei, Doorgesh Sharma Jokhun, G. V. Shivashankar, and Vivek B. Shenoy [Intracellular mechanisms of fungal space searching in microenvironments]( Marie Held, Ondřej Kašpar, Clive Edwards, and Dan V. Nicolau Chemistry [Uncovering modern paint forgeries by radiocarbon dating]( Laura Hendriks, Irka Hajdas, Ester S. B. Ferreira, Nadim C. Scherrer, Stefan Zumbühl, Gregory D. Smith, Caroline Welte, Lukas Wacker, Hans-Arno Synal, and Detlef Günther [Anomalous phonon relaxation in Au333(SR)79 nanoparticles with nascent plasmons]( Tatsuya Higaki, Meng Zhou, Guiying He, Stephen D. House, Matthew Y. Sfeir, Judith C. Yang, and Rongchao Jin Earth, Atmospheric, and Planetary Sciences [Organic–mineral interfacial chemistry drives heterogeneous nucleation of Sr-rich (Bax, Sr1−x)SO4 from undersaturated solution]( Ning Deng, Andrew G. Stack, Juliane Weber, Bo Cao, James J. De Yoreo, and Yandi Hu [Two deep-mantle sources for Paleocene doming and volcanism in the North Atlantic]( Petar Glišović and Alessandro M. Forte [Rapid mixing and exchange of deep-ocean waters in an abyssal boundary current]( Alberto C. Naveira Garabato, Eleanor E. Frajka-Williams, Carl P. Spingys, Sonya Legg, Kurt L. Polzin, Alexander Forryan, E. Povl Abrahamsen, Christian E. Buckingham, Stephen M. Griffies, Stephen D. McPhail, Keith W. Nicholls, Leif N. Thomas, and Michael P. Meredith Engineering [Buckling and twisting of advanced materials into morphable 3D mesostructures]( Hangbo Zhao, Kan Li, Mengdi Han, Feng Zhu, Abraham Vázquez-Guardado, Peijun Guo, Zhaoqian Xie, Yoonseok Park, Lin Chen, Xueju Wang, Haiwen Luan, Yiyuan Yang, Heling Wang, Cunman Liang, Yeguang Xue, Richard D. Schaller, Debashis Chanda, Yonggang Huang, Yihui Zhang, and John A. Rogers Physics [Evidence for a vestigial nematic state in the cuprate pseudogap phase]( Sourin Mukhopadhyay, Rahul Sharma, Chung Koo Kim, Stephen D. Edkins, Mohammad H. Hamidian, Hiroshi Eisaki, Shin-ichi Uchida, Eun-Ah Kim, Michael J. Lawler, Andrew P. Mackenzie, J. C. Séamus Davis, and Kazuhiro Fujita [Topology on a new facet of bismuth]( Chuang-Han Hsu, Xiaoting Zhou, Tay-Rong Chang, Qiong Ma, Nuh Gedik, Arun Bansil, Su-Yang Xu, Hsin Lin, and Liang Fu [Shaping the branched flow of light through disordered media]( Andre Brandstötter, Adrian Girschik, Philipp Ambichl, and Stefan Rotter --------------------------------------------------------------- Social Sciences Anthropology [A hypothesis linking the energy demand of the brain to obesity risk]( Christopher W. Kuzawa and Clancy Blair Economic Sciences [Social evolution leads to persistent corruption]( Joung-Hun Lee, Yoh Iwasa, Ulf Dieckmann, and Karl Sigmund Sustainability Science [Experimental evidence on promotion of electric and improved biomass cookstoves]( S. K. Pattanayak, M. Jeuland, J. J. Lewis, F. Usmani, N. Brooks, V. Bhojvaid, A. Kar, L. Lipinski, L. Morrison, O. Patange, N. Ramanathan, I. H. Rehman, R. Thadani, M. Vora, and V. Ramanathan --------------------------------------------------------------- Biological Sciences Agricultural Sciences [Direct delivery of adenoviral CRISPR/Cas9 vector into the blastoderm for generation of targeted gene knockout in quail]( Joonbum Lee, Jisi Ma, and Kichoon Lee Biochemistry [The E3 ligase HOIL-1 catalyses ester bond formation between ubiquitin and components of the Myddosome in mammalian cells]( Ian R. Kelsall, Jiazhen Zhang, Axel Knebel, J. Simon C. Arthur, and Philip Cohen [Molecular basis for enantioselective herbicide degradation imparted by aryloxyalkanoate dioxygenases in transgenic plants]( Jonathan R. Chekan, Chayanid Ongpipattanakul, Terry R. Wright, Bo Zhang, J. Martin Bollinger Jr., Lauren J. Rajakovich, Carsten Krebs, Robert M. Cicchillo, and Satish K. Nair [Compartmentalized biosynthesis of mycophenolic acid]( Wei Zhang, Lei Du, Zepeng Qu, Xingwang Zhang, Fengwei Li, Zhong Li, Feifei Qi, Xiao Wang, Yuanyuan Jiang, Ping Men, Jingran Sun, Shaona Cao, Ce Geng, Fengxia Qi, Xiaobo Wan, Changning Liu, and Shengying Li [Pak2 kinase promotes cellular senescence and organismal aging]( Jong-Sun Lee, Yan Mo, Haiyun Gan, Rebecca J. Burgess, Darren J. Baker, Jan M. van Deursen, and Zhiguo Zhang [Small-molecule allosteric activators of PDE4 long form cyclic AMP phosphodiesterases]( Faisa Omar, Jane E. Findlay, Gemma Carfray, Robert W. Allcock, Zhong Jiang, Caitlin Moore, Amy L. Muir, Morgane Lannoy, Bracy A. Fertig, Deborah Mai, Jonathan P. Day, Graeme Bolger, George S. Baillie, Erik Schwiebert, Enno Klussmann, Nigel J. Pyne, Albert C. M. Ong, Keith Bowers, Julia M. Adam, David R. Adams, Miles D. Houslay, and David J. P. Henderson [SHOC2 complex-driven RAF dimerization selectively contributes to ERK pathway dynamics]( Isabel Boned del Río, Lucy C. Young, Sibel Sari, Greg G. Jones, Benjamin Ringham-Terry, Nicole Hartig, Ewa Rejnowicz, Winnie Lei, Amandeep Bhamra, Silvia Surinova, and Pablo Rodriguez-Viciana Biophysics and Computational Biology [How the avidity of polymerase binding to the –35/–10 promoter sites affects gene expression]( Tal Einav and Rob Phillips [Nanoparticle-based local translation reveals mRNA as a translation-coupled scaffold with anchoring function]( Shunnichi Kashida, Dan Ohtan Wang, Hirohide Saito, and Zoher Gueroui [Membrane perforation by the pore-forming toxin pneumolysin]( Martin Vögele, Ramachandra M. Bhaskara, Estefania Mulvihill, Katharina van Pee, Özkan Yildiz, Werner Kühlbrandt, Daniel J. Müller, and Gerhard Hummer [Gating modules of the AMPA receptor pore domain revealed by unnatural amino acid mutagenesis]( Mette H. Poulsen, Anahita Poshtiban, Viktoria Klippenstein, Valentina Ghisi, and Andrew J. R. Plested Cell Biology [Regulation of nuclear architecture, mechanics, and nucleocytoplasmic shuttling of epigenetic factors by cell geometric constraints]( Farid Alisafaei, Doorgesh Sharma Jokhun, G. V. Shivashankar, and Vivek B. Shenoy [Predominant localization of phosphatidylserine at the cytoplasmic leaflet of the ER, and its TMEM16K-dependent redistribution]( Takuma Tsuji, Jinglei Cheng, Tsuyako Tatematsu, Aoi Ebata, Hiroki Kamikawa, Akikazu Fujita, Sayuri Gyobu, Katsumori Segawa, Hiroyuki Arai, Tomohiko Taguchi, Shigekazu Nagata, and Toyoshi Fujimoto [An ATR and CHK1 kinase signaling mechanism that limits origin firing during unperturbed DNA replication]( Tatiana N. Moiseeva, Yandong Yin, Michael J. Calderon, Chenao Qian, Sandra Schamus-Haynes, Norie Sugitani, Hatice U. Osmanbeyoglu, Eli Rothenberg, Simon C. Watkins, and Christopher J. Bakkenist [Genome-wide CRISPR screen identifies suppressors of endoplasmic reticulum stress-induced apoptosis]( Ronald A. Panganiban, Hae-Ryung Park, Maoyun Sun, Maya Shumyatcher, Blanca E. Himes, and Quan Lu [PFKFB3-mediated endothelial glycolysis promotes pulmonary hypertension]( Yapeng Cao, Xiaoyu Zhang, Lina Wang, Qiuhua Yang, Qian Ma, Jiean Xu, Jingjing Wang, Laszlo Kovacs, Ramon J. Ayon, Zhiping Liu, Min Zhang, Yaqi Zhou, Xianqiu Zeng, Yiming Xu, Yong Wang, David J. Fulton, Neal L. Weintraub, Rudolf Lucas, Zheng Dong, Jason X.-J. Yuan, Jennifer C. Sullivan, Louise Meadows, Scott A. Barman, Chaodong Wu, Junmin Quan, Mei Hong, Yunchao Su, and Yuqing Huo [SIP/CacyBP promotes autophagy by regulating levels of BRUCE/Apollon, which stimulates LC3-I degradation]( Tian-Xia Jiang, Jiang-Bo Zou, Qian-Qian Zhu, Cui Hua Liu, Guang-Fei Wang, Ting-Ting Du, Zi-Yu Luo, Fang Guo, Lu-Ming Zhou, Juan-Juan Liu, Wensheng Zhang, You-Sheng Shu, Li Yu, Peng Li, Ze’ev A. Ronai, Shu-ichi Matsuzawa, Alfred L. Goldberg, and Xiao-Bo Qiu Developmental Biology [HIF-1α is required for development of the sympathetic nervous system]( Romana Bohuslavova, Radka Cerychova, Frantisek Papousek, Veronika Olejnickova, Martin Bartos, Agnes Görlach, Frantisek Kolar, David Sedmera, Gregg L. Semenza, and Gabriela Pavlinkova [The constrained architecture of mammalian Hox gene clusters]( Fabrice Darbellay, Célia Bochaton, Lucille Lopez-Delisle, Bénédicte Mascrez, Patrick Tschopp, Saskia Delpretti, Jozsef Zakany, and Denis Duboule Ecology [Drainage network position and historical connectivity explain global patterns in freshwater fishes’ range size]( Juan Carvajal-Quintero, Fabricio Villalobos, Thierry Oberdorff, Gaël Grenouillet, Sébastien Brosse, Bernard Hugueny, Céline Jézéquel, and Pablo A. Tedesco Environmental Sciences [Organic–mineral interfacial chemistry drives heterogeneous nucleation of Sr-rich (Bax, Sr1−x)SO4 from undersaturated solution]( Ning Deng, Andrew G. Stack, Juliane Weber, Bo Cao, James J. De Yoreo, and Yandi Hu Evolution [Rapid experimental evolution of reproductive isolation from a single natural population]( Scott M. Villa, Juan C. Altuna, James S. Ruff, Andrew B. Beach, Lane I. Mulvey, Erik J. Poole, Heidi E. Campbell, Kevin P. Johnson, Michael D. Shapiro, Sarah E. Bush, and Dale H. Clayton [Polar bear evolution is marked by rapid changes in gene copy number in response to dietary shift]( David C. Rinker, Natalya K. Specian, Shu Zhao, and John G. Gibbons [Plastic responses to novel environments are biased towards phenotype dimensions with high additive genetic variation]( Daniel W. A. Noble, Reinder Radersma, and Tobias Uller Genetics [Complete reconstitution of bypass and blocking functions in a minimal artificial Fab-7 insulator from Drosophila bithorax complex]( Olga Kyrchanova, Marat Sabirov, Vladic Mogila, Amina Kurbidaeva, Nikolay Postika, Oksana Maksimenko, Paul Schedl, and Pavel Georgiev Immunology and Inflammation [A symmetric geometry of transmembrane domains inside the B cell antigen receptor complex]( Cornelia Gottwick, Xiaocui He, Andreas Hofmann, Niklas Vesper, Michael Reth, and Jianying Yang [Outflanking immunodominance to target subdominant broadly neutralizing epitopes]( Davide Angeletti, Ivan Kosik, Jefferson J. S. Santos, William T. Yewdell, Carolyn M. Boudreau, Vamsee V. A. Mallajosyula, Madeleine C. Mankowski, Michael Chambers, Madhu Prabhakaran, Heather D. Hickman, Adrian B. McDermott, Galit Alter, Jayanta Chaudhuri, and Jonathan W. Yewdell [MZB1 promotes the secretion of J-chain–containing dimeric IgA and is critical for the suppression of gut inflammation]( Ermeng Xiong, Yingqian Li, Qing Min, Chaoqun Cui, Jun Liu, Rongjian Hong, Nannan Lai, Ying Wang, Jiping Sun, Ryohtaroh Matsumoto, Daisuke Takahashi, Koji Hase, Reiko Shinkura, Takeshi Tsubata, and Ji-Yang Wang [Immunofibroblasts are pivotal drivers of tertiary lymphoid structure formation and local pathology]( Saba Nayar, Joana Campos, Charlotte G. Smith, Valentina Iannizzotto, David H. Gardner, Frédéric Mourcin, David Roulois, Jason Turner, Marvin Sylvestre, Saba Asam, Bridget Glaysher, Simon J. Bowman, Douglas T. Fearon, Andrew Filer, Karin Tarte, Sanjiv A. Luther, Benjamin A. Fisher, Christopher D. Buckley, Mark C. Coles, and Francesca Barone [Borrelia burgdorferi peptidoglycan is a persistent antigen in patients with Lyme arthritis]( Brandon L. Jutras, Robert B. Lochhead, Zachary A. Kloos, Jacob Biboy, Klemen Strle, Carmen J. Booth, Sander K. Govers, Joe Gray, Peter Schumann, Waldemar Vollmer, Linda K. Bockenstedt, Allen C. Steere, and Christine Jacobs-Wagner [Treg-mediated prolonged survival of skin allografts without immunosuppression]( Nina Pilat, Mario Wiletel, Anna M. Weijler, Romy Steiner, Benedikt Mahr, Joanna Warren, Theresa M. Corpuz, Thomas Wekerle, Kylie E. Webster, and Jonathan Sprent Medical Sciences [Low cationicity is important for systemic in vivo efficacy of database-derived peptides against drug-resistant Gram-positive pathogens]( Biswajit Mishra, Jayaram Lakshmaiah Narayana, Tamara Lushnikova, Xiuqing Wang, and Guangshun Wang [Morphine tolerance is attenuated in germfree mice and reversed by probiotics, implicating the role of gut microbiome]( Li Zhang, Jingjing Meng, Yuguang Ban, Richa Jalodia, Irina Chupikova, Irina Fernandez, Nivis Brito, Umakant Sharma, Maria T. Abreu, Sundaram Ramakrishnan, and Sabita Roy [Up-regulation of FOXO1 and reduced inflammation by β-hydroxybutyric acid are essential diet restriction benefits against liver injury]( Tomoyuki Miyauchi, Yoichiro Uchida, Kentaro Kadono, Hirofumi Hirao, Junya Kawasoe, Takeshi Watanabe, Shugo Ueda, Hideaki Okajima, Hiroaki Terajima, and Shinji Uemoto Microbiology [Intracellular mechanisms of fungal space searching in microenvironments]( Marie Held, Ondřej Kašpar, Clive Edwards, and Dan V. Nicolau [Pulcherrimin formation controls growth arrest of the Bacillus subtilis biofilm]( Sofia Arnaouteli, D. A. Matoz-Fernandez, Michael Porter, Margarita Kalamara, James Abbott, Cait E. MacPhee, Fordyce A. Davidson, and Nicola R. Stanley-Wall [The purine biosynthesis regulator PurR moonlights as a virulence regulator in Staphylococcus aureus]( William E. Sause, Divya Balasubramanian, Irnov Irnov, Richard Copin, Mitchell J. Sullivan, Alexis Sommerfield, Rita Chan, Avantika Dhabaria, Manor Askenazi, Beatrix Ueberheide, Bo Shopsin, Harm van Bakel, and Victor J. Torres [CarD contributes to diverse gene expression outcomes throughout the genome of Mycobacterium tuberculosis]( Dennis X. Zhu, Ashley L. Garner, Eric A. Galburt, and Christina L. Stallings [Shigella promotes major alteration of gut epithelial physiology and tissue invasion by shutting off host intracellular transport]( Mariana L. Ferrari, Valérie Malardé, Alexandre Grassart, Laura Salavessa, Giulia Nigro, Stéphane Descorps-Declere, John R. Rohde, Pamela Schnupf, Vanessa Masson, Guillaume Arras, Damarys Loew, Philippe J. Sansonetti, and Nathalie Sauvonnet Neuroscience [Role of cerebellar GABAergic dysfunctions in the origins of essential tremor]( Xu Zhang and Sabato Santaniello [Circuit-specific control of the medial entorhinal inputs to the dentate gyrus by atypical presynaptic NMDARs activated by astrocytes]( Iaroslav Savtchouk, Maria Amalia Di Castro, Rugina Ali, Hiltrud Stubbe, Rafael Luján, and Andrea Volterra [Synaptic crosstalk conferred by a zone of differentially regulated Ca2+ signaling in the dendritic shaft adjoining a potentiated spine]( Philip J. Dittmer, Mark L. Dell’Acqua, and William A. Sather [Region-specific and activity-dependent regulation of SVZ neurogenesis and recovery after stroke]( Huixuan Liang, Handi Zhao, Amy Gleichman, Michal Machnicki, Sagar Telang, Sydney Tang, Mary Rshtouni, Jack Ruddell, and S. Thomas Carmichael [Asymmetries between achromatic and chromatic extraction of 3D motion signals]( Milena Kaestner, Ryan T. Maloney, Kirstie H. Wailes-Newson, Marina Bloj, Julie M. Harris, Antony B. Morland, and Alex R. Wade [Pattern of dopamine signaling during aversive events predicts active avoidance learning]( Claire E. Stelly, Graham C. Haug, Kaitlyn M. Fonzi, Miriam A. Garcia, Sean C. Tritley, Alexa P. Magnon, Maria Alicia P. Ramos, and Matthew J. Wanat [α2-Chimaerin is essential for neural stem cell homeostasis in mouse adult neurogenesis]( Yi-Ting Su, Shun-Fat Lau, Jacque P. K. Ip, Kit Cheung, Tom H. T. Cheung, Amy K. Y. Fu, and Nancy Y. Ip [The network organization of rat intrathalamic macroconnections and a comparison with other forebrain divisions]( Larry W. Swanson, Olaf Sporns, and Joel D. Hahn [Leptin’s hunger-suppressing effects are mediated by the hypothalamic–pituitary–adrenocortical axis in rodents]( Rachel J. Perry, Jon M. Resch, Amelia M. Douglass, Joseph C. Madara, Aviva Rabin-Court, Hakan Kucukdereli, Chen Wu, Joongyu D. Song, Bradford B. Lowell, and Gerald I. Shulman Pharmacology [Reversible silencing of endogenous receptors in intact brain tissue using 2-photon pharmacology]( Silvia Pittolo, Hyojung Lee, Anna Lladó, Sébastien Tosi, Miquel Bosch, Lídia Bardia, Xavier Gómez-Santacana, Amadeu Llebaria, Eduardo Soriano, Julien Colombelli, Kira E. Poskanzer, Gertrudis Perea, and Pau Gorostiza Plant Biology [A comprehensive genomic scan reveals gene dosage balance impacts on quantitative traits in Populus trees]( Héloïse Bastiaanse, Matthew Zinkgraf, Courtney Canning, Helen Tsai, Meric Lieberman, Luca Comai, Isabelle Henry, and Andrew Groover Population Biology [Reactive school closure weakens the network of social interactions and reduces the spread of influenza]( Maria Litvinova, Quan-Hui Liu, Evgeny S. Kulikov, and Marco Ajelli Psychological and Cognitive Sciences [A hypothesis linking the energy demand of the brain to obesity risk]( Christopher W. Kuzawa and Clancy Blair --------------------------------------------------------------- Corrections [Correction for Chao et al., Systematic assessment of the sex ratio at birth for all countries and estimation of national imbalances and regional reference levels]( [Correction for Dvir et al., Deciphering the rules by which 5′-UTR sequences affect protein expression in yeast]( [Correction for Davis et al., In vivo evidence for dysregulation of mGluR5 as a biomarker of suicidal ideation]( [Correction for Derrien et al., Degradation of the antiviral component ARGONAUTE1 by the autophagy pathway]( [Cover] --------------------------------------------------------------- This message was sent to {EMAIL}. [Unsubscribe]( from or [edit]( your subscription for this service. Or by mail: Customer Service * 973 University Avenue * Los Gatos, CA 95032 * U.S.A. Copyright © 2019 by the National Academy of Sciences