PNAS Table of Contents for October 23, 2018; Vol. 115, No. 43

[PNAS] [Listen to the latest PNAS Podcast.](/cgi/adclick/?ad=53154&adclick=true&url=http%3A%2F%2Fwww.pnas.org%2Fpage%2Fmedia%2Fpodcasts)   [October 23, 2018; Vol. 115, No. 43]( ) This Week in PNAS [In This Issue]( --------------------------------------------------------------- Opinion [Opinion: Advocating for science progress as a human right]( S. Porsdam Mann, Y. Donders, C. Mitchell, V. J. Bradley, M. F. Chou, M. Mann, G. Church, and H. Porsdam Leading scientists discuss current issues. --------------------------------------------------------------- Commentaries [Navigating genetic diversity by painting the bacteria red]( Claire M. Palmer and Hal S. Alper [Stress response regulation and the hemodynamic response]( Katharine Dunlop and Conor Liston --------------------------------------------------------------- PNAS Plus Significance Statements [PNAS Plus Significance Statements]( Brief statements written by the authors about the significance of their papers. --------------------------------------------------------------- Perspective [Prolonging healthy aging: Longevity vitamins and proteins]( Bruce N. Ames --------------------------------------------------------------- Trisections of Smooth Manifolds Special Feature (Free Online) Introduction [Trisections of 4-manifolds]( Robion Kirby Physical Sciences — Mathematics [A new invariant of 4-manifolds]( Robion Kirby and Abigail Thompson [Trisections of 4-manifolds with boundary]( Nickolas A. Castro, David T. Gay, and Juanita Pinzón-Caicedo [Calculating the homology and intersection form of a 4-manifold from a trisection diagram]( Peter Feller, Michael Klug, Trenton Schirmer, and Drew Zemke [Functoriality of group trisections]( Michael Klug [Bridge trisections of knotted surfaces in 4-manifolds]( Jeffrey Meier and Alexander Zupan [Characterizing Dehn surgeries on links via trisections]( Jeffrey Meier and Alexander Zupan [Simplified broken Lefschetz fibrations and trisections of 4-manifolds]( R. İnanç Baykur and Osamu Saeki [Computing trisections of 4-manifolds]( Mark Bell, Joel Hass, Joachim Hyam Rubinstein, and Stephan Tillmann [Generalized trisections in all dimensions]( J. Hyam Rubinstein and Stephan Tillmann --------------------------------------------------------------- Physical Sciences Applied Mathematics [Randomly distributed embedding making short-term high-dimensional data predictable]( Huanfei Ma, Siyang Leng, Kazuyuki Aihara, Wei Lin, and Luonan Chen Applied Physical Sciences [Verifying Larché–Cahn elasticity, a milestone of 20th-century thermodynamics]( Shan Shi, Jürgen Markmann, and Jörg Weissmüller Chemistry [Nonproteinogenic deep mutational scanning of linear and cyclic peptides]( Joseph M. Rogers, Toby Passioura, and Hiroaki Suga [Protein shape modulates crowding effects]( Alex J. Guseman, Gerardo M. Perez Goncalves, Shannon L. Speer, Gregory B. Young, and Gary J. Pielak [Native-state imaging of calcifying and noncalcifying microalgae reveals similarities in their calcium storage organelles]( Assaf Gal, Andrea Sorrentino, Keren Kahil, Eva Pereiro, Damien Faivre, and André Scheffel Earth, Atmospheric, and Planetary Sciences [Volatile loss following cooling and accretion of the Moon revealed by chromium isotopes]( Paolo A. Sossi, Frédéric Moynier, and Kirsten van Zuilen [Redox-dependent niche differentiation provides evidence for multiple bacterial sources of glycerol tetraether lipids in lakes]( Yuki Weber, Jaap S. Sinninghe Damsté, Jakob Zopfi, Cindy De Jonge, Adrian Gilli, Carsten J. Schubert, Fabio Lepori, Moritz F. Lehmann, and Helge Niemann [Mountain snowpack response to different levels of warming]( Laurie S. Huning and Amir AghaKouchak Environmental Sciences [Faults and associated karst collapse suggest conduits for fluid flow that influence hydraulic fracturing-induced seismicity]( Elwyn Galloway, Tyler Hauck, Hilary Corlett, Dinu Pană, and Ryan Schultz Physics [Topological quantum computation based on chiral Majorana fermions]( Biao Lian, Xiao-Qi Sun, Abolhassan Vaezi, Xiao-Liang Qi, and Shou-Cheng Zhang [Machine learning determination of atomic dynamics at grain boundaries]( Tristan A. Sharp, Spencer L. Thomas, Ekin D. Cubuk, Samuel S. Schoenholz, David J. Srolovitz, and Andrea J. Liu [Why large icosahedral viruses need scaffolding proteins]( Siyu Li, Polly Roy, Alex Travesset, and Roya Zandi --------------------------------------------------------------- Social Sciences Anthropology [Salt and marine products in the Classic Maya economy from use-wear study of stone tools]( Heather McKillop and Kazuo Aoyama Psychological and Cognitive Sciences [Distinct facial expressions represent pain and pleasure across cultures]( Chaona Chen, Carlos Crivelli, Oliver G. B. Garrod, Philippe G. Schyns, José-Miguel Fernández-Dols, and Rachael E. Jack [Dopaminergic basis for signaling belief updates, but not surprise, and the link to paranoia]( Matthew M. Nour, Tarik Dahoun, Philipp Schwartenbeck, Rick A. Adams, Thomas H. B. FitzGerald, Christopher Coello, Matthew B. Wall, Raymond J. Dolan, and Oliver D. Howes [Empirical evidence of mental health risks posed by climate change]( Nick Obradovich, Robyn Migliorini, Martin P. Paulus, and Iyad Rahwan Sustainability Science [Empirical evidence of mental health risks posed by climate change]( Nick Obradovich, Robyn Migliorini, Martin P. Paulus, and Iyad Rahwan --------------------------------------------------------------- Biological Sciences Biochemistry [The structural basis for cancer drug interactions with the catalytic and allosteric sites of SAMHD1]( Kirsten M. Knecht, Olga Buzovetsky, Constanze Schneider, Dominique Thomas, Vishok Srikanth, Lars Kaderali, Florentina Tofoleanu, Krystle Reiss, Nerea Ferreirós, Gerd Geisslinger, Victor S. Batista, Xiaoyun Ji, Jindrich Cinatl Jr., Oliver T. Keppler, and Yong Xiong [Molecular mechanism of activation of the immunoregulatory amidase NAAA]( Alexei Gorelik, Ahmad Gebai, Katalin Illes, Daniele Piomelli, and Bhushan Nagar [Meiosis-specific recombinase Dmc1 is a potent inhibitor of the Srs2 antirecombinase]( J. Brooks Crickard, Kyle Kaniecki, Youngho Kwon, Patrick Sung, and Eric C. Greene [Cryo-EM structures of ASC and NLRC4 CARD filaments reveal a unified mechanism of nucleation and activation of caspase-1]( Yang Li, Tian-Min Fu, Alvin Lu, Kristen Witt, Jianbin Ruan, Chen Shen, and Hao Wu Biophysics and Computational Biology [Randomly distributed embedding making short-term high-dimensional data predictable]( Huanfei Ma, Siyang Leng, Kazuyuki Aihara, Wei Lin, and Luonan Chen [Entropic contribution to enhanced thermal stability in the thermostable P450 CYP119]( Zhuo Liu, Sara Lemmonds, Juan Huang, Madhusudan Tyagi, Liang Hong, and Nitin Jain [Swi5–Sfr1 stimulates Rad51 recombinase filament assembly by modulating Rad51 dissociation]( Chih-Hao Lu, Hsin-Yi Yeh, Guan-Chin Su, Kentaro Ito, Yumiko Kurokawa, Hiroshi Iwasaki, Peter Chi, and Hung-Wen Li [Nonproteinogenic deep mutational scanning of linear and cyclic peptides]( Joseph M. Rogers, Toby Passioura, and Hiroaki Suga [Protein shape modulates crowding effects]( Alex J. Guseman, Gerardo M. Perez Goncalves, Shannon L. Speer, Gregory B. Young, and Gary J. Pielak [Why large icosahedral viruses need scaffolding proteins]( Siyu Li, Polly Roy, Alex Travesset, and Roya Zandi Cell Biology [mTOR inhibitors lower an intrinsic barrier to virus infection mediated by IFITM3]( Guoli Shi, Stosh Ozog, Bruce E. Torbett, and Alex A. Compton [Mitosis-specific MRN complex promotes a mitotic signaling cascade to regulate spindle dynamics and chromosome segregation]( Ran Xu, Yixi Xu, Wei Huo, Zhicong Lv, Jingsong Yuan, Shaokai Ning, Qingsong Wang, Mei Hou, Ge Gao, Jianguo Ji, Junjie Chen, Rong Guo, and Dongyi Xu [XBP1s activation can globally remodel N-glycan structure distribution patterns]( Madeline Y. Wong, Kenny Chen, Aristotelis Antonopoulos, Brian T. Kasper, Mahender B. Dewal, Rebecca J. Taylor, Charles A. Whittaker, Pyae P. Hein, Anne Dell, Joseph C. Genereux, Stuart M. Haslam, Lara K. Mahal, and Matthew D. Shoulders [Noncanonical autophagy at ER exit sites regulates procollagen turnover]( Shakib Omari, Elena Makareeva, Anna Roberts-Pilgrim, Lynn Mirigian, Michal Jarnik, Carolyn Ott, Jennifer Lippincott-Schwartz, and Sergey Leikin [Cryo-ET reveals the macromolecular reorganization of S. pombe mitotic chromosomes in vivo]( Shujun Cai, Chen Chen, Zhi Yang Tan, Yinyi Huang, Jian Shi, and Lu Gan [SUMO protease SENP1 deSUMOylates and stabilizes c-Myc]( Xiao-Xin Sun, Yingxiao Chen, Yulong Su, Xiaoyan Wang, Krishna Mohan Chauhan, Juan Liang, Colin J. Daniel, Rosalie C. Sears, and Mu-Shui Dai Ecology [Changes in temperature alter the relationship between biodiversity and ecosystem functioning]( Francisca C. García, Elvire Bestion, Ruth Warfield, and Gabriel Yvon-Durocher [Magnetic map in nonanadromous Atlantic salmon]( Michelle M. Scanlan, Nathan F. Putman, Amanda M. Pollock, and David L. G. Noakes Environmental Sciences [Native-state imaging of calcifying and noncalcifying microalgae reveals similarities in their calcium storage organelles]( Assaf Gal, Andrea Sorrentino, Keren Kahil, Eva Pereiro, Damien Faivre, and André Scheffel Evolution [Selection and gene flow shape genomic islands that control floral guides]( Hugo Tavares, Annabel Whibley, David L. Field, Desmond Bradley, Matthew Couchman, Lucy Copsey, Joane Elleouet, Monique Burrus, Christophe Andalo, Miaomiao Li, Qun Li, Yongbiao Xue, Alexandra B. Rebocho, Nicolas H. Barton, and Enrico Coen [Whole-genome comparison of endogenous retrovirus segregation across wild and domestic host species populations]( Salvador Daniel Rivas-Carrillo, Mats E. Pettersson, Carl-Johan Rubin, and Patric Jern Genetics [Human leukemia mutations corrupt but do not abrogate GATA-2 function]( Koichi R. Katsumura, Charu Mehta, Kyle J. Hewitt, Alexandra A. Soukup, Isabela Fraga de Andrade, Erik A. Ranheim, Kirby D. Johnson, and Emery H. Bresnick [Genetic variation in the SIM1 locus is associated with erectile dysfunction]( Eric Jorgenson, Navneet Matharu, Melody R. Palmer, Jie Yin, Jun Shan, Thomas J. Hoffmann, Khanh K. Thai, Xujia Zhou, James M. Hotaling, Gail P. Jarvik, Nadav Ahituv, Hunter Wessells, and Stephen K. Van Den Eeden [Human mitochondrial degradosome prevents harmful mitochondrial R loops and mitochondrial genome instability]( Sonia Silva, Lola P. Camino, and Andrés Aguilera [Functional and evolutionary characterization of a secondary metabolite gene cluster in budding yeasts]( David J. Krause, Jacek Kominek, Dana A. Opulente, Xing-Xing Shen, Xiaofan Zhou, Quinn K. Langdon, Jeremy DeVirgilio, Amanda Beth Hulfachor, Cletus P. Kurtzman, Antonis Rokas, and Chris Todd Hittinger Immunology and Inflammation [Regnase-1 controls colon epithelial regeneration via regulation of mTOR and purine metabolism]( Yasuharu Nagahama, Mayuko Shimoda, Guoliang Mao, Shailendra Kumar Singh, Yuuki Kozakai, Xin Sun, Daisuke Motooka, Shota Nakamura, Hiroki Tanaka, Takashi Satoh, Kazuhiko Maeda, and Shizuo Akira [Glucose metabolism mediates disease tolerance in cerebral malaria]( Andrew Wang, Sarah C. Huen, Harding H. Luan, Kelly Baker, Henry Rinder, Carmen J. Booth, and Ruslan Medzhitov [Toxicity of an Fc-engineered anti-CD40 antibody is abrogated by intratumoral injection and results in durable antitumor immunity]( David A. Knorr, Rony Dahan, and Jeffrey V. Ravetch [C-type lectin receptor LSECtin-mediated apoptotic cell clearance by macrophages directs intestinal repair in experimental colitis]( Zaopeng Yang, Qian Li, Xin Wang, Xuepei Jiang, Dianyuan Zhao, Xin Lin, Fuchu He, and Li Tang Medical Sciences [Differential regulation of PD-L1 expression by immune and tumor cells in NSCLC and the response to treatment with atezolizumab (anti–PD-L1)]( Marcin Kowanetz, Wei Zou, Scott N. Gettinger, Hartmut Koeppen, Mark Kockx, Peter Schmid, Edward E. Kadel III, Ignacio Wistuba, Jamie Chaft, Naiyer A. Rizvi, David R. Spigel, Alexander Spira, Fred R. Hirsch, Victor Cohen, Dustin Smith, Zach Boyd, Natasha Miley, Susan Flynn, Vincent Leveque, David S. Shames, Marcus Ballinger, Simonetta Mocci, Geetha Shankar, Roel Funke, Garret Hampton, Alan Sandler, Lukas Amler, Ira Mellman, Daniel S. Chen, and Priti S. Hegde [iNOS promotes CD24+CD133+ liver cancer stem cell phenotype through a TACE/ADAM17-dependent Notch signaling pathway]( Ronghua Wang, Yawen Li, Allan Tsung, Hai Huang, Qiang Du, Muqing Yang, Meihong Deng, Si Xiong, Xiju Wang, Liyong Zhang, David A. Geller, Bin Cheng, and Timothy R. Billiar [Histone methylation regulator PTIP is required to maintain normal and leukemic bone marrow niches]( Prosun Das, Kylee J. Veazey, Hieu T. Van, Saakshi Kaushik, Kevin Lin, Yue Lu, Masaru Ishii, Junichi Kikuta, Kai Ge, Andre Nussenzweig, and Margarida A. Santos [Metastatic growth instructed by neutrophil-derived transferrin]( Wei Liang, Qin Li, and Napoleone Ferrara [Reducing dynamin 2 (DNM2) rescues DNM2-related dominant centronuclear myopathy]( Suzie Buono, Jacob A. Ross, Hichem Tasfaout, Yotam Levy, Christine Kretz, Leighla Tayefeh, John Matson, Shuling Guo, Pascal Kessler, Brett P. Monia, Marc Bitoun, Julien Ochala, Jocelyn Laporte, and Belinda S. Cowling Microbiology [MmpL8MAB controls Mycobacterium abscessus virulence and production of a previously unknown glycolipid family]( Violaine Dubois, Albertus Viljoen, Laura Laencina, Vincent Le Moigne, Audrey Bernut, Faustine Dubar, Mickaël Blaise, Jean-Louis Gaillard, Yann Guérardel, Laurent Kremer, Jean-Louis Herrmann, and Fabienne Girard-Misguich [Interplay between coronavirus, a cytoplasmic RNA virus, and nonsense-mediated mRNA decay pathway]( Masami Wada, Kumari G. Lokugamage, Keisuke Nakagawa, Krishna Narayanan, and Shinji Makino [Elongation factor P is required to maintain proteome homeostasis at high growth rate]( Rodney Tollerson II, Anne Witzky, and Michael Ibba Neuroscience [Dopaminergic basis for signaling belief updates, but not surprise, and the link to paranoia]( Matthew M. Nour, Tarik Dahoun, Philipp Schwartenbeck, Rick A. Adams, Thomas H. B. FitzGerald, Christopher Coello, Matthew B. Wall, Raymond J. Dolan, and Oliver D. Howes [Activity-dependent bulk endocytosis proteome reveals a key presynaptic role for the monomeric GTPase Rab11]( A. C. Kokotos, J. Peltier, E. C. Davenport, M. Trost, and M. A. Cousin [Chronic social stress-induced hyperglycemia in mice couples individual stress susceptibility to impaired spatial memory]( Michael A. van der Kooij, Tanja Jene, Giulia Treccani, Isabelle Miederer, Annika Hasch, Nadine Voelxen, Stefan Walenta, and Marianne B. Müller [Long noncoding RNA GM12371 acts as a transcriptional regulator of synapse function]( Bindu L. Raveendra, Supriya Swarnkar, Yosef Avchalumov, Xin-An Liu, Eddie Grinman, Kerriann Badal, Adrian Reich, Bruce D. Pascal, and Sathyanarayanan V. Puthanveettil [The brain’s hemodynamic response function rapidly changes under acute psychosocial stress in association with genetic and endocrine stress response markers]( Immanuel G. Elbau, Benedikt Brücklmeier, Manfred Uhr, Janine Arloth, Darina Czamara, Victor I. Spoormaker, Michael Czisch, Klaas Enno Stephan, Elisabeth B. Binder, and Philipp G. Sämann [DSCAM promotes self-avoidance in the developing mouse retina by masking the functions of cadherin superfamily members]( Andrew M. Garrett, Andre Khalil, David O. Walton, and Robert W. Burgess [MRI-based assessment of function and dysfunction in myelinated axons]( William M. Spees, Tsen-Hsuan Lin, Peng Sun, Chunyu Song, Ajit George, Sam E. Gary, Hsin-Chieh Yang, and Sheng-Kwei Song [Cbln2 and Cbln4 are expressed in distinct medial habenula-interpeduncular projections and contribute to different behavioral outputs]( Erica Seigneur, Jai S. Polepalli, and Thomas C. Südhof [Yin-and-yang bifurcation of opioidergic circuits for descending analgesia at the midbrain of the mouse]( Jong-Hyun Kim, Gireesh Gangadharan, Junweon Byun, Eui-Ju Choi, C. Justin Lee, and Hee-Sup Shin Pharmacology [p38α MAPK signaling drives pharmacologically reversible brain and gastrointestinal phenotypes in the SERT Ala56 mouse]( Matthew J. Robson, Meagan A. Quinlan, Kara Gross Margolis, Paula A. Gajewski-Kurdziel, Jeremy Veenstra-VanderWeele, Michael D. Gershon, D. Martin Watterson, and Randy D. Blakely [Translating biased signaling in the ghrelin receptor system into differential in vivo functions]( Franziska Mende, Cecilie Hundahl, Bianca Plouffe, Louise Julie Skov, Bjørn Sivertsen, Andreas Nygaard Madsen, Michael Lückmann, Thi Ai Diep, Stefan Offermanns, Thomas Michael Frimurer, Michel Bouvier, and Birgitte Holst Plant Biology [Quantitative and functional posttranslational modification proteomics reveals that TREPH1 plays a role in plant touch-delayed bolting]( Kai Wang, Zhu Yang, Dongjin Qing, Feng Ren, Shichang Liu, Qingsong Zheng, Jun Liu, Weiping Zhang, Chen Dai, Madeline Wu, E. Wassim Chehab, Janet Braam, and Ning Li Psychological and Cognitive Sciences [Neural reactivation in parietal cortex enhances memory for episodically linked information]( Tanya R. Jonker, Halle Dimsdale-Zucker, Maureen Ritchey, Alex Clarke, and Charan Ranganath [Humans incorporate attention-dependent uncertainty into perceptual decisions and confidence]( Rachel N. Denison, William T. Adler, Marisa Carrasco, and Wei Ji Ma Sustainability Science [Bottom trawl fishing footprints on the world’s continental shelves]( Ricardo O. Amoroso, C. Roland Pitcher, Adriaan D. Rijnsdorp, Robert A. McConnaughey, Ana M. Parma, Petri Suuronen, Ole R. Eigaard, Francois Bastardie, Niels T. Hintzen, Franziska Althaus, Susan Jane Baird, Jenny Black, Lene Buhl-Mortensen, Alexander B. Campbell, Rui Catarino, Jeremy Collie, James H. Cowan Jr., Deon Durholtz, Nadia Engstrom, Tracey P. Fairweather, Heino O. Fock, Richard Ford, Patricio A. Gálvez, Hans Gerritsen, María Eva Góngora, Jessica A. González, Jan G. Hiddink, Kathryn M. Hughes, Steven S. Intelmann, Chris Jenkins, Patrik Jonsson, Paulus Kainge, Mervi Kangas, Johannes N. Kathena, Stefanos Kavadas, Rob W. Leslie, Steve G. Lewis, Mathieu Lundy, David Makin, Julie Martin, Tessa Mazor, Genoveva Gonzalez-Mirelis, Stephen J. Newman, Nadia Papadopoulou, Paulette E. Posen, Wayne Rochester, Tommaso Russo, Antonello Sala, Jayson M. Semmens, Cristina Silva, Angelo Tsolos, Bart Vanelsla nder, Corey B. Wakefield, Brent A. Wood, Ray Hilborn, Michel J. Kaiser, and Simon Jennings Systems Biology [Characterizing posttranslational modifications in prokaryotic metabolism using a multiscale workflow]( Elizabeth Brunk, Roger L. Chang, Jing Xia, Hooman Hefzi, James T. Yurkovich, Donghyuk Kim, Evan Buckmiller, Harris H. Wang, Byung-Kwan Cho, Chen Yang, Bernhard O. Palsson, George M. Church, and Nathan E. Lewis --------------------------------------------------------------- Corrections (Online Only) [Correction for Kneller, Franck–Condon picture of incoherent neutron scattering]( [Correction for Liao et al., Metal–insulator-transition engineering by modulation tilt-control in perovskite nickelates for room temperature optical switching]( [Correction for {NAME} and Mussweiler, The culture of social comparison]( [Correction for Li et al., Mutually inhibitory Ras-PI(3,4)P2 feedback loops mediate cell migration]( [Cover] --------------------------------------------------------------- This message was sent to {EMAIL}. [Unsubscribe]( from or [edit]( your subscription for this service. Or by mail: Customer Service * 973 University Avenue * Los Gatos, CA 95032 * U.S.A. Copyright © 2018 by the National Academy of Sciences