PNAS Table of Contents for May 1, 2018; Vol. 115, No. 18

[PNAS] [Looking for high-impact, cutting-edge research in chemical sciences?](/cgi/adclick/?ad=52463&adclick=true&url=http%3A%2F%2Fchemistry.pnas.org%2F)   [May 1, 2018; Vol. 115, No. 18]( ) This Week in PNAS [In This Issue]( --------------------------------------------------------------- Letters (Online Only) [How the manakin got its crown: A novel trait that is unlikely to cause speciation]( Gil G. Rosenthal, Molly Schumer, and Peter Andolfatto [Reply to Rosenthal et al.: Both premating and postmating isolation likely contributed to manakin hybrid speciation]( Alfredo O. Barrera-Guzmán, Alexandre Aleixo, Matthew D. Shawkey, and Jason T. Weir [Iron status as a confounder in the gender gap in survival under extreme conditions]( Joris R. Delanghe, Marijn M. Speeckaert, and Marc L. De Buyzere [Reply to Delanghe et al.: Iron status is not likely to play a key role in the gender survival gap under extreme conditions]( Virginia Zarulli, Kaare Christensen, and James W. Vaupel --------------------------------------------------------------- Science and Culture [Science and Culture: Animal cognition research offers outreach opportunity]( John Carey How science intersects with culture. --------------------------------------------------------------- Inner Workings [Inner Workings: A new crop of landers and rovers seeks to answer key questions about Venus—and, by extension, Earth]( Sid Perkins An over-the-shoulder look at scientists at work. --------------------------------------------------------------- QnAs [QnAs with Donald Geman]( Farooq Ahmed --------------------------------------------------------------- Commentaries [LSD1: A single target to combat lineage plasticity in lethal prostate cancer]( Leigh Ellis and Massimo Loda [Sizing up a supercharged ferryl]( Kyle M. Lancaster [PDCD5 says no to NO]( Dario F. Riascos-Bernal, Nicholas E. S. Sibinga, and Richard N. Kitsis --------------------------------------------------------------- PNAS Plus Significance Statements [PNAS Plus Significance Statements]( Brief statements written by the authors about the significance of their papers. --------------------------------------------------------------- Perspective [A call for more science in forensic science]( Suzanne Bell, Sunita Sah, Thomas D. Albright, S. James Gates Jr., M. Bonner Denton, and Arturo Casadevall --------------------------------------------------------------- Physical Sciences Biophysics and Computational Biology [DRUG-NEM: Optimizing drug combinations using single-cell perturbation response to account for intratumoral heterogeneity]( Benedict Anchang, Kara L. Davis, Harris G. Fienberg, Brian D. Williamson, Sean C. Bendall, Loukia G. Karacosta, Robert Tibshirani, Garry P. Nolan, and Sylvia K. Plevritis [MinE conformational switching confers robustness on self-organized Min protein patterns]( Jonas Denk, Simon Kretschmer, Jacob Halatek, Caroline Hartl, Petra Schwille, and Erwin Frey Chemistry [Discovery of recombinases enables genome mining of cryptic biosynthetic gene clusters in Burkholderiales species]( Xue Wang, Haibo Zhou, Hanna Chen, Xiaoshu Jing, Wentao Zheng, Ruijuan Li, Tao Sun, Jiaqi Liu, Jun Fu, Liujie Huo, Yue-zhong Li, Yuemao Shen, Xiaoming Ding, Rolf Müller, Xiaoying Bian, and Youming Zhang [Shewanella oneidensis as a living electrode for controlled radical polymerization]( Gang Fan, Christopher M. Dundas, Austin J. Graham, Nathaniel A. Lynd, and Benjamin K. Keitz [Structural characterization of a non-heme iron active site in zeolites that hydroxylates methane]( Benjamin E. R. Snyder, Lars H. Böttger, Max L. Bols, James J. Yan, Hannah M. Rhoda, Ariel B. Jacobs, Michael Y. Hu, Jiyong Zhao, E. Ercan Alp, Britt Hedman, Keith O. Hodgson, Robert A. Schoonheydt, Bert F. Sels, and Edward I. Solomon [Vibrations of a molecule in an external force field]( Norio Okabayashi, Angelo Peronio, Magnus Paulsson, Toyoko Arai, and Franz J. Giessibl Computer Sciences [An explainable deep machine vision framework for plant stress phenotyping]( Sambuddha Ghosal, David Blystone, Asheesh K. Singh, Baskar Ganapathysubramanian, Arti Singh, and Soumik Sarkar Earth, Atmospheric, and Planetary Sciences [GoAmazon2014/5 campaign points to deep-inflow approach to deep convection across scales]( Kathleen A. Schiro, Fiaz Ahmed, Scott E. Giangrande, and J. David Neelin Engineering [Mechanisms of sampling interstitial fluid from skin using a microneedle patch]( Pradnya P. Samant and Mark R. Prausnitz [Thermally stable, highly efficient, ultraflexible organic photovoltaics]( Xiaomin Xu, Kenjiro Fukuda, Akchheta Karki, Sungjun Park, Hiroki Kimura, Hiroaki Jinno, Nobuhiro Watanabe, Shuhei Yamamoto, Satoru Shimomura, Daisuke Kitazawa, Tomoyuki Yokota, Shinjiro Umezu, Thuc-Quyen Nguyen, and Takao Someya Physics [Interaction instability of localization in quasiperiodic systems]( Marko Žnidarič and Marko Ljubotina Statistics [Digitizing omics profiles by divergence from a baseline]( Wikum Dinalankara, Qian Ke, Yiran Xu, Lanlan Ji, Nicole Pagane, Anching Lien, Tejasvi Matam, Elana J. Fertig, Nathan D. Price, Laurent Younes, Luigi Marchionni, and Donald Geman --------------------------------------------------------------- Social Sciences Anthropology [Hominin skeletal part abundances and claims of deliberate disposal of corpses in the Middle Pleistocene]( Charles P. Egeland, Manuel Domínguez-Rodrigo, Travis Rayne Pickering, Colin G. Menter, and Jason L. Heaton Psychological and Cognitive Sciences [Individuals, institutions, and innovation in the debates of the French Revolution]( Alexander T. J. Barron, Jenny Huang, Rebecca L. Spang, and Simon DeDeo --------------------------------------------------------------- Biological Sciences Agricultural Sciences [Draft genome sequence of Camellia sinensis var. sinensis provides insights into the evolution of the tea genome and tea quality]( Chaoling Wei, Hua Yang, Songbo Wang, Jian Zhao, Chun Liu, Liping Gao, Enhua Xia, Ying Lu, Yuling Tai, Guangbiao She, Jun Sun, Haisheng Cao, Wei Tong, Qiang Gao, Yeyun Li, Weiwei Deng, Xiaolan Jiang, Wenzhao Wang, Qi Chen, Shihua Zhang, Haijing Li, Junlan Wu, Ping Wang, Penghui Li, Chengying Shi, Fengya Zheng, Jianbo Jian, Bei Huang, Dai Shan, Mingming Shi, Congbing Fang, Yi Yue, Fangdong Li, Daxiang Li, Shu Wei, Bin Han, Changjun Jiang, Ye Yin, Tao Xia, Zhengzhu Zhang, Jeffrey L. Bennetzen, Shancen Zhao, and Xiaochun Wan [An explainable deep machine vision framework for plant stress phenotyping]( Sambuddha Ghosal, David Blystone, Asheesh K. Singh, Baskar Ganapathysubramanian, Arti Singh, and Soumik Sarkar Applied Biological Sciences [Rapid selection of a pyrethroid metabolic enzyme CYP9K1 by operational malaria control activities]( John Vontas, Linda Grigoraki, John Morgan, Dimitra Tsakireli, Godwin Fuseini, Luis Segura, Julie Niemczura de Carvalho, Raul Nguema, David Weetman, Michel A. Slotman, and Janet Hemingway [Developmentally inspired programming of adult human mesenchymal stromal cells toward stable chondrogenesis]( Paola Occhetta, Sebastien Pigeot, Marco Rasponi, Boris Dasen, Arne Mehrkens, Thomas Ullrich, Ina Kramer, Sabine Guth-Gundel, Andrea Barbero, and Ivan Martin [Biomaterial surface energy-driven ligand assembly strongly regulates stem cell mechanosensitivity and fate on very soft substrates]( Tojo Razafiarison, Claude N. Holenstein, Tino Stauber, Milan Jovic, Edward Vertudes, Marko Loparic, Maciej Kawecki, Laetitia Bernard, Unai Silvan, and Jess G. Snedeker Biochemistry [eIF1 Loop 2 interactions with Met-tRNAi control the accuracy of start codon selection by the scanning preinitiation complex]( Anil Thakur and Alan G. Hinnebusch [Human N-acetylglucosaminyltransferase II substrate recognition uses a modular architecture that includes a convergent exosite]( Renuka Kadirvelraj, Jeong-Yeh Yang, Justin H. Sanders, Lin Liu, Annapoorani Ramiah, Pradeep Kumar Prabhakar, Geert-Jan Boons, Zachary A. Wood, and Kelley W. Moremen [Disparate binding kinetics by an intrinsically disordered domain enables temporal regulation of transcriptional complex formation]( Neil O. Robertson, Ngaio C. Smith, Athina Manakas, Mahiar Mahjoub, Gordon McDonald, Ann H. Kwan, and Jacqueline M. Matthews [Complementary charge-based interaction between the ribosomal-stalk protein L7/12 and IF2 is the key to rapid subunit association]( Xueliang Ge, Chandra Sekhar Mandava, Christoffer Lind, Johan Åqvist, and Suparna Sanyal Biophysics and Computational Biology [Study of protein folding under native conditions by rapidly switching the hydrostatic pressure inside an NMR sample cell]( Cyril Charlier, T. Reid Alderson, Joseph M. Courtney, Jinfa Ying, Philip Anfinrud, and Adriaan Bax [Digitizing omics profiles by divergence from a baseline]( Wikum Dinalankara, Qian Ke, Yiran Xu, Lanlan Ji, Nicole Pagane, Anching Lien, Tejasvi Matam, Elana J. Fertig, Nathan D. Price, Laurent Younes, Luigi Marchionni, and Donald Geman [MinE conformational switching confers robustness on self-organized Min protein patterns]( Jonas Denk, Simon Kretschmer, Jacob Halatek, Caroline Hartl, Petra Schwille, and Erwin Frey [Dynamic activation and regulation of the mitogen-activated protein kinase p38]( Ganesan Senthil Kumar, Michael W. Clarkson, Micha B. A. Kunze, Daniele Granata, A. Joshua Wand, Kresten Lindorff-Larsen, Rebecca Page, and Wolfgang Peti [Large SOD1 aggregates, unlike trimeric SOD1, do not impact cell viability in a model of amyotrophic lateral sclerosis]( Cheng Zhu, Matthew V. Beck, Jack D. Griffith, Mohanish Deshmukh, and Nikolay V. Dokholyan [A folding nucleus and minimal ATP binding domain of Hsp70 identified by single-molecule force spectroscopy]( Daniela Bauer, Sarah Meinhold, Roman P. Jakob, Johannes Stigler, Ulrich Merkel, Timm Maier, Matthias Rief, and Gabriel Žoldák Cell Biology [LSD1 activates a lethal prostate cancer gene network independently of its demethylase function]( Archana Sehrawat, Lina Gao, Yuliang Wang, Armand Bankhead III, Shannon K. McWeeney, Carly J. King, Jacob Schwartzman, Joshua Urrutia, William H. Bisson, Daniel J. Coleman, Sunil K. Joshi, Dae-Hwan Kim, David A. Sampson, Sheila Weinmann, Bhaskar V. S. Kallakury, Deborah L. Berry, Reina Haque, Stephen K. Van Den Eeden, Sunil Sharma, Jared Bearss, Tomasz M. Beer, George V. Thomas, Laura M. Heiser, and Joshi J. Alumkal [DNA methylation and transcriptome aberrations mediated by ERα in mouse seminal vesicles following developmental DES exposure]( Yin Li, Katherine J. Hamilton, Tianyuan Wang, Laurel A. Coons, Wendy N. Jefferson, Ruifang Li, Yu Wang, Sara A. Grimm, J. Tyler Ramsey, Liwen Liu, Kevin E. Gerrish, Carmen J. Williams, Paul A. Wade, and Kenneth S. Korach [Nuclear export of ubiquitinated proteins via the UBIN-POST system]( Shoshiro Hirayama, Munechika Sugihara, Daisuke Morito, Shun-ichiro Iemura, Tohru Natsume, Shigeo Murata, and Kazuhiro Nagata [Programmed cell death 5 suppresses AKT-mediated cytoprotection of endothelium]( Seung-Hyun Lee, Jaesung Seo, Soo-Yeon Park, Mi-Hyeon Jeong, Hyo-Kyoung Choi, Chan Joo Lee, Mi Jeong Kim, Garam Guk, SooYeon Lee, Hyewon Park, Jae-Wook Jeong, Chang Hoon Ha, Sungha Park, and Ho-Geun Yoon [Deubiquitylation and stabilization of p21 by USP11 is critical for cell-cycle progression and DNA damage responses]( Tanggang Deng, Guobei Yan, Xin Song, Lin Xie, Yu Zhou, Jianglin Li, Xiaoxiao Hu, Zhen Li, Jun Hu, Yibin Zhang, Hui Zhang, Yang Sun, Peifu Feng, Dong Wei, Bin Hu, Jing Liu, Weihong Tan, and Mao Ye [Control of vacuole membrane homeostasis by a resident PI-3,5-kinase inhibitor]( PC Malia, Johannes Numrich, Taki Nishimura, Ayelén González Montoro, Christopher J. Stefan, and Christian Ungermann Developmental Biology [Formate rescues neural tube defects caused by mutations in Slc25a32]( Jimi Kim, Yunping Lei, Jin Guo, Sung-Eun Kim, Bogdan J. Wlodarczyk, Robert M. Cabrera, Ying Linda Lin, Torbjorn K. Nilsson, Ting Zhang, Aiguo Ren, Linlin Wang, Zhengwei Yuan, Yu-Fang Zheng, Hong-Yan Wang, and Richard H. Finnell [Muscularis macrophage development in the absence of an enteric nervous system]( Marina Avetisyan, Julia E. Rood, Silvia Huerta Lopez, Rajarshi Sengupta, Elizabeth Wright-Jin, Joseph D. Dougherty, Edward M. Behrens, and Robert O. Heuckeroth Ecology [Plasmodium-associated changes in human odor attract mosquitoes]( Ailie Robinson, Annette O. Busula, Mirjam A. Voets, Khalid B. Beshir, John C. Caulfield, Stephen J. Powers, Niels O. Verhulst, Peter Winskill, Julian Muwanguzi, Michael A. Birkett, Renate C. Smallegange, Daniel K. Masiga, W. Richard Mukabana, Robert W. Sauerwein, Colin J. Sutherland, Teun Bousema, John A. Pickett, Willem Takken, James G. Logan, and Jetske G. de Boer [Temperature accelerates the rate fields become forests]( Jason D. Fridley and Justin P. Wright Environmental Sciences [Integrating effects of species composition and soil properties to predict shifts in montane forest carbon–water relations]( Toby M. Maxwell, Lucas C. R. Silva, and William R. Horwath [Urbanization prolongs hantavirus epidemics in cities]( Huaiyu Tian, Shixiong Hu, Bernard Cazelles, Gerardo Chowell, Lidong Gao, Marko Laine, Yapin Li, Huisuo Yang, Yidan Li, Qiqi Yang, Xin Tong, Ru Huang, Ottar N. Bjornstad, Hong Xiao, and Nils Chr. Stenseth Evolution [Horizontal transfer of retrotransposons between bivalves and other aquatic species of multiple phyla]( Michael J. Metzger, Ashley N. Paynter, Mark E. Siddall, and Stephen P. Goff [Multiple large-scale gene and genome duplications during the evolution of hexapods]( Zheng Li, George P. Tiley, Sally R. Galuska, Chris R. Reardon, Thomas I. Kidder, Rebecca J. Rundell, and Michael S. Barker Genetics [Next-generation CRISPR/Cas9 transcriptional activation in Drosophila using flySAM]( Yu Jia, Rong-Gang Xu, Xingjie Ren, Ben Ewen-Campen, Rajendhran Rajakumar, Jonathan Zirin, Donghui Yang-Zhou, Ruibao Zhu, Fang Wang, Decai Mao, Ping Peng, Huan-Huan Qiao, Xia Wang, Lu-Ping Liu, Bowen Xu, Jun-Yuan Ji, Qingfei Liu, Jin Sun, Norbert Perrimon, and Jian-Quan Ni [Synthetically engineered Medea gene drive system in the worldwide crop pest Drosophila suzukii]( Anna Buchman, John M. Marshall, Dennis Ostrovski, Ting Yang, and Omar S. Akbari [O6-methylguanine–induced transcriptional mutagenesis reduces p53 tumor-suppressor function]( Monika Ezerskyte, João A. Paredes, Stefano Malvezzi, John A. Burns, Geoffrey P. Margison, Magnus Olsson, David A. Scicchitano, and Kristian Dreij [Ribosomal DNA copy loss and repeat instability in ATRX-mutated cancers]( Maheshi Udugama, Elaine Sanij, Hsiao P. J. Voon, Jinbae Son, Linda Hii, Jeremy D. Henson, F. Lyn Chan, Fiona T. M. Chang, Yumei Liu, Richard B. Pearson, Paul Kalitsis, Jeffrey R. Mann, Philippe Collas, Ross D. Hannan, and Lee H. Wong Immunology and Inflammation [MK2 contributes to tumor progression by promoting M2 macrophage polarization and tumor angiogenesis]( Lucia Suarez-Lopez, Ganapathy Sriram, Yi Wen Kong, Sandra Morandell, Karl A. Merrick, Yuliana Hernandez, Kevin M. Haigis, and Michael B. Yaffe [Anti–HIV-1 B cell responses are dependent on B cell precursor frequency and antigen-binding affinity]( Pia Dosenovic, Ervin E. Kara, Anna-Klara Pettersson, Andrew T. McGuire, Matthew Gray, Harald Hartweger, Eddy S. Thientosapol, Leonidas Stamatatos, and Michel C. Nussenzweig [Role of PD-1 during effector CD8 T cell differentiation]( Eunseon Ahn, Koichi Araki, Masao Hashimoto, Weiyan Li, James L. Riley, Jeanne Cheung, Arlene H. Sharpe, Gordon J. Freeman, Bryan A. Irving, and Rafi Ahmed [Shared epitope–aryl hydrocarbon receptor crosstalk underlies the mechanism of gene–environment interaction in autoimmune arthritis]( Jiaqi Fu, Sarah V. Nogueira, Vincent van Drongelen, Patrick Coit, Song Ling, Edward F. Rosloniec, Amr H. Sawalha, and Joseph Holoshitz Medical Sciences [Endoplasmic reticulum stress activates SRC, relocating chaperones to the cell surface where GRP78/CD109 blocks TGF-β signaling]( Yuan-Li Tsai, Dat P. Ha, He Zhao, Anthony J. Carlos, Shan Wei, Tsam Kiu Pun, Kaijin Wu, Ebrahim Zandi, Kevin Kelly, and Amy S. Lee [Mechanisms of sampling interstitial fluid from skin using a microneedle patch]( Pradnya P. Samant and Mark R. Prausnitz [Tunable cytotoxic aptamer–drug conjugates for the treatment of prostate cancer]( Bethany Powell Gray, Linsley Kelly, Douglas P. Ahrens, Ashley P. Barry, Christina Kratschmer, Matthew Levy, and Bruce A. Sullenger [Mutations in the pancreatic secretory enzymes CPA1 and CPB1 are associated with pancreatic cancer]( Koji Tamura, Jun Yu, Tatsuo Hata, Masaya Suenaga, Koji Shindo, Toshiya Abe, Anne MacGregor-Das, Michael Borges, Christopher L. Wolfgang, Matthew J. Weiss, Jin He, Marcia Irene Canto, Gloria M. Petersen, Steven Gallinger, Sapna Syngal, Randall E. Brand, Anil Rustgi, Sara H. Olson, Elena Stoffel, Michele L. Cote, George Zogopoulos, James B. Potash, Fernando S. Goes, Richard W. McCombie, Peter P. Zandi, Mehdi Pirooznia, Melissa Kramer, Jennifer Parla, James R. Eshleman, Nicholas J. Roberts, Ralph H. Hruban, Alison Patricia Klein, and Michael Goggins Microbiology [Discovery of recombinases enables genome mining of cryptic biosynthetic gene clusters in Burkholderiales species]( Xue Wang, Haibo Zhou, Hanna Chen, Xiaoshu Jing, Wentao Zheng, Ruijuan Li, Tao Sun, Jiaqi Liu, Jun Fu, Liujie Huo, Yue-zhong Li, Yuemao Shen, Xiaoming Ding, Rolf Müller, Xiaoying Bian, and Youming Zhang [Polysialic acid is a cellular receptor for human adenovirus 52]( Annasara Lenman, A. Manuel Liaci, Yan Liu, Lars Frängsmyr, Martin Frank, Bärbel S. Blaum, Wengang Chai, Iva I. Podgorski, Balázs Harrach, Mária Benkő, Ten Feizi, Thilo Stehle, and Niklas Arnberg [Shewanella oneidensis as a living electrode for controlled radical polymerization]( Gang Fan, Christopher M. Dundas, Austin J. Graham, Nathaniel A. Lynd, and Benjamin K. Keitz [Origin, antigenicity, and function of a secreted form of ORF2 in hepatitis E virus infection]( Xin Yin, Dong Ying, Sébastien Lhomme, Zimin Tang, Christopher M. Walker, Ningshao Xia, Zizheng Zheng, and Zongdi Feng [Spatial determinants of quorum signaling in a Pseudomonas aeruginosa infection model]( Sophie E. Darch, Olja Simoska, Mignon Fitzpatrick, Juan P. Barraza, Keith J. Stevenson, Roger T. Bonnecaze, Jason B. Shear, and Marvin Whiteley Neuroscience [Desynchronization of slow oscillations in the basal ganglia during natural sleep]( Aviv D. Mizrahi-Kliger, Alexander Kaplan, Zvi Israel, and Hagai Bergman [Spatial and temporal heterogeneity of neural responses in human posteromedial cortex]( Amy L. Daitch and Josef Parvizi Plant Biology [Drought delays development of the sorghum root microbiome and enriches for monoderm bacteria]( Ling Xu, Dan Naylor, Zhaobin Dong, Tuesday Simmons, Grady Pierroz, Kim K. Hixson, Young-Mo Kim, Erika M. Zink, Kristin M. Engbrecht, Yi Wang, Cheng Gao, Stephanie DeGraaf, Mary A. Madera, Julie A. Sievert, Joy Hollingsworth, Devon Birdseye, Henrik V. Scheller, Robert Hutmacher, Jeffery Dahlberg, Christer Jansson, John W. Taylor, Peggy G. Lemaux, and Devin Coleman-Derr [Reduced vacuolar β-1,3-glucan synthesis affects carbohydrate metabolism as well as plastid homeostasis and structure in Phaeodactylum tricornutum]( Weichao Huang, Ilka Haferkamp, Bernard Lepetit, Mariia Molchanova, Shengwei Hou, Wolfgang Jeblick, Carolina Río Bártulos, and Peter G. Kroth Psychological and Cognitive Sciences [Individuals, institutions, and innovation in the debates of the French Revolution]( Alexander T. J. Barron, Jenny Huang, Rebecca L. Spang, and Simon DeDeo Systems Biology [DRUG-NEM: Optimizing drug combinations using single-cell perturbation response to account for intratumoral heterogeneity]( Benedict Anchang, Kara L. Davis, Harris G. Fienberg, Brian D. Williamson, Sean C. Bendall, Loukia G. Karacosta, Robert Tibshirani, Garry P. Nolan, and Sylvia K. Plevritis [Deep learning improves prediction of drug–drug and drug–food interactions]( Jae Yong Ryu, Hyun Uk Kim, and Sang Yup Lee --------------------------------------------------------------- Corrections (Online Only) [Correction for Alder et al., Diagnostic utility of telomere length testing in a hospital-based setting]( [Correction for Haj-Dahman et al,. Fatty-acid–binding protein 5 controls retrograde endocannabinoid signaling at central glutamate synapses]( [Cover] --------------------------------------------------------------- This message was sent to {EMAIL}. [Unsubscribe]( from or [edit]( your subscription for this service. Or by mail: Customer Service * 973 University Avenue * Los Gatos, CA 95032 * U.S.A. Copyright © 2018 by the National Academy of Sciences