Neuron: February 7, 2024 (Volume 112, Issue 3)

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Featured articles --------------------------------------------------------------- [Mechanics in the nervous system: From development to disease](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00759-6/1/0100018d848b84fc-c6696fd6-92f2-471d-9b48-7f285d131366-000000/iXVCmwtArklrpVWUabirKb6zytwvAZlY_J6S9I1-4MQ=339) Pillai et al. [Daniel Kronauer](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00035-7/1/0100018d848b84fc-c6696fd6-92f2-471d-9b48-7f285d131366-000000/xDomEjckVaj2ItOhsn2AJklEfhqheaCqXV8f6gxTu6Y=339) Daniel J.C. Kronauer [Absence of paresthesia during high-rate spinal cord stimulation reveals importance of synchrony for sensations evoked by electrical stimulation](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00802-4/1/0100018d848b84fc-c6696fd6-92f2-471d-9b48-7f285d131366-000000/MAQtWEPrMdwYlzP982NmQSwOKb9Pc6SCcs0_i_opsd0=339) Sagalajev et al. [An excitatory projection from the basal forebrain to the ventral tegmental area that underlies anorexia-like phenotypes](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00845-0/1/0100018d848b84fc-c6696fd6-92f2-471d-9b48-7f285d131366-000000/mO0hqx7CryMHxI8oTIUl8phQMgXjU6tuzWnYGTOeL0A=339) Cai et al. Online now --------------------------------------------------------------- [A role for the cerebellum in motor-triggered alleviation of anxiety](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00007-2/1/0100018d848b84fc-c6696fd6-92f2-471d-9b48-7f285d131366-000000/0FTyv2v7Fs3UOcToE_d-xyB2eT00OUbhaG6RsuK9t6s=339) Zhang et al. [APOE loss-of-function variants: Compatible with longevity and associated with resistance to Alzheimer's disease pathology](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00008-4/1/0100018d848b84fc-c6696fd6-92f2-471d-9b48-7f285d131366-000000/eNF19kQV_O3akjR2cHG_4A2DkBxrnuJSijbBHR1irsc=339) Chemparathy et al. [Clearance of β-amyloid and synapses by the optogenetic depolarization of microglia is complement selective](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00931-5/1/0100018d848b84fc-c6696fd6-92f2-471d-9b48-7f285d131366-000000/HDBsKbZzUtOul_BKmXz_4PL9RnDO0-6ZIIr95eA_P70=339) Lv et al. [The Calmodulin-interacting peptide Pcp4a regulates feeding state-dependent behavioral choice in zebrafish](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00001-1/1/0100018d848b84fc-c6696fd6-92f2-471d-9b48-7f285d131366-000000/EPY6vOQCREl3EXzhLG55AKBobOlipZ8nt9tcx-tplXs=339) Zaupa et al. Table of Contents Previews --------------------------------------------------------------- [Does high-frequency stimulation of sensory axons break the causal link between pain relief and paresthesia?](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00041-2%3Fdgcid=raven_jbs_etoc_email/1/0100018d848b84fc-c6696fd6-92f2-471d-9b48-7f285d131366-000000/ZAbVO7p5WRrBP7goKA7MredDM3UWuLwpwZodYv_RQsQ=339) Evan R. Rogers, Scott F. Lempka, Marco Capogrosso Neurostimulation produces unnatural cutaneous sensations with potent analgesic effects in pain syndromes. In this issue of Neuron, Sagalajev et al. demonstrate that these sensations are an epiphenomenon and explain how high-frequency stimulation can provide analgesia without these unnecessary sensations. [The brain’s go-getter circuit: Anterior cingulate cortex to nucleus accumbens and its disruption by stress](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00009-6%3Fdgcid=raven_jbs_etoc_email/1/0100018d848b84fc-c6696fd6-92f2-471d-9b48-7f285d131366-000000/188h5F0e-beuQDenzfPwfHAFgAuUGmDlcfKpUK_BBAE=339) Simone Astori, Carmen Sandi In this issue of Neuron, Fetcho, Parekh, et al.1 show that neurons in the anterior cingulate cortex (ACC) projecting to the nucleus accumbens (NAc) are essential for integrating reward and effort evaluation in mice, and that this circuit is sensitive to exposure to stress hormones. Q&A --------------------------------------------------------------- [Daniel Kronauer](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00035-7%3Fdgcid=raven_jbs_etoc_email/1/0100018d848b84fc-c6696fd6-92f2-471d-9b48-7f285d131366-000000/1fyuBqij4Wa2tP7_W7t0EVEH5eeGP6Cn7YFo3K-7kTo=339) Daniel J.C. Kronauer Daniel Kronauer explores the behavioral genetics and neurobiology of ants, tracing their evolution from solitary ancestors to supremely social insects. In this interview with Neuron, he discusses his lab’s efforts to develop a new ant model species and describes how his passion for natural history inspires his research. NeuroView --------------------------------------------------------------- [Tranceformation: Digital dissemination of hypnosis](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00969-8%3Fdgcid=raven_jbs_etoc_email/1/0100018d848b84fc-c6696fd6-92f2-471d-9b48-7f285d131366-000000/SYuXkDDKP8QorsXhuHxSLAQmZEU83RRsOHfADqTcDuA=339) David Spiegel Hypnosis is an underutilized tool despite evidence of efficacy from randomized clinical trials. In this NeuroView, Spiegel discusses potential mechanisms in the context of brain networks and proposes the use of app-based instruction in self-hypnosis. Review --------------------------------------------------------------- [Mechanics in the nervous system: From development to disease](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00759-6%3Fdgcid=raven_jbs_etoc_email/1/0100018d848b84fc-c6696fd6-92f2-471d-9b48-7f285d131366-000000/apKClZjRVESymufqu8H6sXI4mAulvNf0vHCnJsgy-68=339) Eva K. Pillai, Kristian Franze Open Access Pillai and Franze provide a comprehensive overview of recent advancements in our understanding of how mechanical cues, e.g., tissue stiffness and cellular forces, contribute to nervous system development, homeostasis, and disorder. They illuminate experimental approaches, mechanotransduction pathways, and open questions. Articles --------------------------------------------------------------- [Longitudinal single-cell transcriptional dynamics throughout neurodegeneration in SCA1](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00844-9%3Fdgcid=raven_jbs_etoc_email/1/0100018d848b84fc-c6696fd6-92f2-471d-9b48-7f285d131366-000000/u1IvRiuea95vnXKKKg2SL1yNHCusmkaRuHxhGNBx_3Y=339) Leon Tejwani, Neal G. Ravindra, Changwoo Lee, Yubao Cheng, Billy Nguyen, Kimberly Luttik, Luhan Ni, Shupei Zhang, Logan M. Morrison, John Gionco, Yangfei Xiang, Jennifer Yoon, Hannah Ro, Fatema Haidery, Rosalie M. Grijalva, Eunwoo Bae, Kristen Kim, Regina T. Martuscello, Harry T. Orr, Huda Y. Zoghbi, Hayley S. McLoughlin, Laura P.W. Ranum, Vikram G. Shakkottai, Phyllis L. Faust, Siyuan Wang, David van Dijk, Janghoo Lim Open Access In neurodegeneration, vulnerable neuronal populations are highly influenced by concomitant changes in surrounding cells, including glia. Here, Tejwani et al. performed longitudinal single-nucleus profiling of the mouse and human SCA1 cerebellum, which elucidated the progressive dysregulation of Purkinje cells and revealed early transcriptional changes in oligodendroglia and unipolar brush cells. [Amelioration of Tau and ApoE4-linked glial lipid accumulation and neurodegeneration with an LXR agonist](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00804-8%3Fdgcid=raven_jbs_etoc_email/1/0100018d848b84fc-c6696fd6-92f2-471d-9b48-7f285d131366-000000/dzowSuw1YxNrQnKUtEAy8t6GVzIxWZ9ZC_4mdQAsrvs=339) Alexandra Litvinchuk, Jung H. Suh, Jing L. Guo, Karin Lin, Sonnet S. Davis, Nga Bien-Ly, Eric Tycksen, G. Travis Tabor, Javier Remolina Serrano, Melissa Manis, Xin Bao, Choonghee Lee, Megan Bosch, Enmanuel J. Perez, Carla M. Yuede, Anil G. Cashikar, Jason D. Ulrich, Gilbert Di Paolo, David M. Holtzman Using lipidomics coupled with immunostaining, Litvinchuk et al. demonstrate that ApoE promotes changes in cholesterol metabolism and lipid accumulation in glia of 9.5-month-old P301S mice. LXR agonist GW3965 diet and Abca1 overexpression markedly decrease tauopathy, neurodegeneration, synapse loss and behavioral deficits, neuroinflammation, and glial lipid accumulation in 9.5-month-old P301S/ApoE4 mice. [Absence of paresthesia during high-rate spinal cord stimulation reveals importance of synchrony for sensations evoked by electrical stimulation](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00802-4%3Fdgcid=raven_jbs_etoc_email/1/0100018d848b84fc-c6696fd6-92f2-471d-9b48-7f285d131366-000000/5oLrhrjAdrt-dxbpyWhHZMTQGAiIRF8G7AdD8zf6ULw=339) Boriss Sagalajev, Tianhe Zhang, Nooshin Abdollahi, Noosha Yousefpour, Laura Medlock, Dhekra Al-Basha, Alfredo Ribeiro-da-Silva, Rosana Esteller, Stéphanie Ratté, Steven A. Prescott Electrically stimulating somatosensory afferents at high frequency does not evoke paresthesia. Sagalajev et al. show that spikes desynchronize when axons are stimulated faster than their refractory period. Spikes engage inhibition regardless of their synchrony, but asynchronous spikes are preferentially blocked by inhibition and thus fail to activate cortex and cause paresthesia. [Reorganization of adolescent prefrontal cortex circuitry is required for mouse cognitive maturation](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00805-X%3Fdgcid=raven_jbs_etoc_email/1/0100018d848b84fc-c6696fd6-92f2-471d-9b48-7f285d131366-000000/HET3-YZ2AdPqs9KDfo8rNOdw2fo9Ptxq1YAecekTtfE=339) Jastyn A. Pöpplau, Timo Schwarze, Mariia Dorofeikova, Irina Pochinok, Anne Günther, Annette Marquardt, Ileana L. Hanganu-Opatz Open Access Pöpplau et al. uncover a non-linear trajectory of prefrontal development in mice with a major reorganization of activity and structure during adolescence. Interfering with these non-linear dynamics via microglia manipulation results in a long-lasting disruption of adult network function and mPFC-dependent cognitive abilities. [CB1R dysfunction of inhibitory synapses in the ACC drives chronic social isolation stress-induced social impairments in male mice](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00808-5%3Fdgcid=raven_jbs_etoc_email/1/0100018d848b84fc-c6696fd6-92f2-471d-9b48-7f285d131366-000000/HUwd5NmoeEBSiU7Byi5Mrn1hcY94cfzxx2dhwQjM3UA=339) Baolin Guo, Kaiwen Xi, Honghui Mao, Keke Ren, Haoxiang Xiao, Nolan D. Hartley, Yangming Zhang, Junjun Kang, Yingying Liu, Yuqiao Xie, Yongsheng Zhou, Yuanyuan Zhu, Xia Zhang, Zhanyan Fu, Jiang-Fan Chen, Hailan Hu, Wenting Wang, Shengxi Wu Guo et al. uncover cell-specific mechanisms in the anterior cingulate cortex that underlie the social impairments resulting from chronic social isolation and reveal a potential therapeutic strategy targeting the cannabinoid type-1 receptors (CB1Rs) to correct social avoidance. [An excitatory projection from the basal forebrain to the ventral tegmental area that underlies anorexia-like phenotypes](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00845-0%3Fdgcid=raven_jbs_etoc_email/1/0100018d848b84fc-c6696fd6-92f2-471d-9b48-7f285d131366-000000/gje0tTxea1Q-Ud8NYO9S4PP-B5LFAHwKC8A94_YD8v4=339) Jing Cai, Yanyan Jiang, Yuanzhong Xu, Zhiying Jiang, Claire Young, Hongli Li, Joshua Ortiz-Guzman, Yizhou Zhuo, Yulong Li, Yong Xu, Benjamin R. Arenkiel, Qingchun Tong Through combined circuit tracing, in vivo fiber photometry recording, and mouse genetics and behavioral studies, Cai et al. identified a glutamatergic circuit from the basal forebrain to VTA glutamatergic neurons, activation of which led to anorexia-like phenotypes. They observed that the hypophagia phenotype was accompanied by reduced dopamine release. [A stress-sensitive frontostriatal circuit supporting effortful reward-seeking behavior](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00801-2%3Fdgcid=raven_jbs_etoc_email/1/0100018d848b84fc-c6696fd6-92f2-471d-9b48-7f285d131366-000000/945Z9goCdTVN_q42NRGm-EzRdl3BMPoogCpzlLCgG44=339) Robert N. Fetcho, Puja K. Parekh, Jolin Chou, Margaux Kenwood, Laura Chalençon, David J. Estrin, Megan Johnson, Conor Liston Fetcho, Parekh et al. show how anterior cingulate-to-nucleus accumbens-projecting neurons integrate reward and effort information to support future effortful choices. They show that motivational anhedonia following chronic stress may be driven in part by a disruption in the effort-sensitive reward activity of this circuit. [Mesoaccumbal glutamate neurons drive reward via glutamate release but aversion via dopamine co-release](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00846-2%3Fdgcid=raven_jbs_etoc_email/1/0100018d848b84fc-c6696fd6-92f2-471d-9b48-7f285d131366-000000/6zFOOBz2XfOGZ9mrIxSK_orqtay6pqnbmBoVl8oJHCg=339) Shelley M. Warlow, Sarthak M. Singhal, Nick G. Hollon, Lauren Faget, Dina S. Dowlat, Vivien Zell, Avery C. Hunker, Larry S. Zweifel, Thomas S. Hnasko VTA glutamate neurons co-release glutamate and dopamine in the nucleus accumbens, and their activation is associated with both positive reinforcement and aversion. Warlow et al. demonstrate that disrupting glutamate release from VTA glutamate neurons selectively abolishes positive reinforcement, whereas disrupting their ability to co-release dopamine selectively abolishes place aversion. [Striatal dopamine integrates cost, benefit, and motivation](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00843-7%3Fdgcid=raven_jbs_etoc_email/1/0100018d848b84fc-c6696fd6-92f2-471d-9b48-7f285d131366-000000/bvofdk7GzY7Tc3y_D13rVJXhYyIgIJ7nuwSWmM0j3_4=339) Neir Eshel, Gavin C. Touponse, Allan R. Wang, Amber K. Osterman, Amei N. Shank, Alexandra M. Groome, Lara Taniguchi, Daniel F. Cardozo Pinto, Jason Tucciarone, Brandon S. Bentzley, Robert C. Malenka Eshel et al. combine economic analyses with dopamine recordings and manipulations to find that dopamine release in the striatum encodes both the magnitude of a reward and how much the mouse has worked for it. Furthermore, the higher the mouse’s motivational level, the lower the reward-evoked dopamine release. Corrections --------------------------------------------------------------- [Alternative Splicing of Presynaptic Neurexins Differentially Controls Postsynaptic NMDA and AMPA Receptor Responses](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00038-2%3Fdgcid=raven_jbs_etoc_email/1/0100018d848b84fc-c6696fd6-92f2-471d-9b48-7f285d131366-000000/6IPh-RNXwd4dxZ6P-8upd2ke2n73W4t1fBySTIQtvms=339) Jinye Dai, Jason Aoto, Thomas C. Südhof [Brain-derived autophagosome profiling reveals the engulfment of nucleoid-enriched mitochondrial fragments by basal autophagy in neurons](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00037-0%3Fdgcid=raven_jbs_etoc_email/1/0100018d848b84fc-c6696fd6-92f2-471d-9b48-7f285d131366-000000/d7QhGh60Gu9iNIYGwd36UQaaetTV4yWkNmLUfEF-dvw=339) Juliet Goldsmith, Alban Ordureau, J. Wade Harper, Erika L.F. 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