Neuron: January 17, 2024 (Volume 112, Issue 2)

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Featured articles --------------------------------------------------------------- [The hardware is the software](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00878-4/1/0100018d1843bdab-345124c2-1d88-4c00-8a5b-290661294407-000000/cCI5nFnfeTNlEy02tObqOGYkqdd_KnvCCBJ3t2e7n8o=336) Laydevant et al. [Layer 1 neocortex: Gating and integrating multidimensional signals](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00754-7/1/0100018d1843bdab-345124c2-1d88-4c00-8a5b-290661294407-000000/EbBc7_GWL1HCHfEDg1T69UkarEBUcehOXt53locPcLA=336) Huang et al. [Synapse-specific burst coding sustained by local axonal translation](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00767-5/1/0100018d1843bdab-345124c2-1d88-4c00-8a5b-290661294407-000000/PEAOy8SnDn6Rb0QcYdf2nktqNVRQAttyjpF1WIljkBw=336) Wong et al. [Visuotactile integration facilitates mirror-induced self-directed behavior through activation of hippocampal neuronal ensembles in mice](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00803-6/1/0100018d1843bdab-345124c2-1d88-4c00-8a5b-290661294407-000000/EQVEGpN253BS1RkBPtE5BlABmnVQ2VdjXCM-JcUl_Ho=336) Yokose et al. Online now --------------------------------------------------------------- [Discrete prefrontal neuronal circuits determine repeated stress-induced behavioral phenotypes in male mice](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00934-0/1/0100018d1843bdab-345124c2-1d88-4c00-8a5b-290661294407-000000/ZvD6hLCK7ZLsU-S8Nq4kvJCzKR7Y3gBWPUtRNio4k-k=336) Li et al. [Dissociable neuronal substrates of visual feature attention and working memory](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00935-2/1/0100018d1843bdab-345124c2-1d88-4c00-8a5b-290661294407-000000/1vN5rEgq44rcLQAxk4p0pDLfeDjyajuySYm49PMZdDU=336) Mendoza-Halliday et al. [Developmental transformation of Ca2+ channel-vesicle nanotopography at a central GABAergic synapse](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00930-3/1/0100018d1843bdab-345124c2-1d88-4c00-8a5b-290661294407-000000/Q1hRZn5_4ZDnKByQexpio757Dv8AB-mrzdKNwOrtNLE=336) Chen et al. [Restoration of a paraventricular thalamo-accumbal behavioral suppression circuit prevents reinstatement of heroin seeking](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00928-5/1/0100018d1843bdab-345124c2-1d88-4c00-8a5b-290661294407-000000/h2LAsw6TOEJm692Hf-YR9YXUXTZIFbm20BbfvJ-W3gE=336) Paniccia et al. Table of Contents Previews --------------------------------------------------------------- [Guiding axon regeneration: Instructions from blood vessels](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00891-7%3Fdgcid=raven_jbs_etoc_email/1/0100018d1843bdab-345124c2-1d88-4c00-8a5b-290661294407-000000/1t6eq0-y_YZeIBzNaLlodIBwGaS2CP21tvAwvu6oqoU=336) Amparo Acker-Palmer In this issue of Neuron, Bhat et al. unveil the temporary reawakening of an embryonic guidance program, which facilitates the alignment of blood neovessels, creating a supportive “bridge” microenvironment for axon regrowth and tissue regeneration after peripheral nervous system (PNS) injury. [Can mirror self-recognition in mice unpack the neural underpinnings of self-awareness?](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00933-9%3Fdgcid=raven_jbs_etoc_email/1/0100018d1843bdab-345124c2-1d88-4c00-8a5b-290661294407-000000/BQXkckMiAOBW7OQc99jF6ZaO4Qk4mm8n810YiHUcvfw=336) Christian Keysers, Frédéric Michon In this issue of Neuron, Yokose et al. show that mice groom a mark on their forehead when exposed to a mirror. Comparing this behavior with hominids’ helps carve self-awareness into its component parts and explore the neural mechanisms of its shared components. NeuroView --------------------------------------------------------------- [The hardware is the software](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00878-4%3Fdgcid=raven_jbs_etoc_email/1/0100018d1843bdab-345124c2-1d88-4c00-8a5b-290661294407-000000/OYGZw9Vspesebb8x-RJRdK2hERkvvS6xu_1GxpfLuuU=336) Jérémie Laydevant, Logan G. Wright, Tianyu Wang, Peter L. McMahon Human brains and bodies are not hardware running software: the hardware is the software. Laydevan et al. reason that because the physics of artificial intelligence hardware and of human biological “hardware” is distinct, neuromorphic engineers need to be selective in the inspiration they take from neuroscience. Review --------------------------------------------------------------- [Layer 1 neocortex: Gating and integrating multidimensional signals](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00754-7%3Fdgcid=raven_jbs_etoc_email/1/0100018d1843bdab-345124c2-1d88-4c00-8a5b-290661294407-000000/8u3Y0mrLglguDMIAgvBegk7cgh-FgvSOp1J83gq8JKs=336) Shuhan Huang, Sherry Jingjing Wu, Giulia Sansone, Leena Ali Ibrahim, Gord Fishell Huang et al. present a review of the structure, connectivity, and function of neocortex’s layer 1, highlighting its critical role in gating and integrating diverse signals. Report --------------------------------------------------------------- [Activated somatostatin interneurons orchestrate memory microcircuits](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00769-9%3Fdgcid=raven_jbs_etoc_email/1/0100018d1843bdab-345124c2-1d88-4c00-8a5b-290661294407-000000/XgDpENb1eE7JHnxh_BbIPDCiQ7Il7sPaPvZ6iGuM4Oc=336) TaeHyun Kim, Dong Il Choi, Ja Eun Choi, Hoonwon Lee, Hyunsu Jung, Jooyoung Kim, Yongmin Sung, HyoJin Park, Min Jung Kim, Dae Hee Han, Seung-Hee Lee, Bong-Kiun Kaang Engram refers to the physical form of memory stored in the brain. Researchers have identified the engram cells, but it is less known how these engram cells are controlled. Using a novel synapse-labeling method, Kim et al. identified a new population of inhibitory neurons that is involved in fear memory formation and expression of fear-related behaviors in mice. Articles --------------------------------------------------------------- [Structured wound angiogenesis instructs mesenchymal barrier compartments in the regenerating nerve](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00806-1%3Fdgcid=raven_jbs_etoc_email/1/0100018d1843bdab-345124c2-1d88-4c00-8a5b-290661294407-000000/UCqYhGqZ0OzutCM5fDjDz3SMWU4tljp2fO5vrxP6uGE=336) Ganesh Parameshwar Bhat, Aurora Maurizio, Alessia Motta, Paola Podini, Santo Diprima, Chiara Malpighi, Ilaria Brambilla, Luis Martins, Aurora Badaloni, Daniela Boselli, Francesca Bianchi, Marta Pellegatta, Marco Genua, Renato Ostuni, Ubaldo Del Carro, Carla Taveggia, Stefano de Pretis, Angelo Quattrini, Dario Bonanomi Injured peripheral nerves heal without permanent scarring. Bhat et al. demonstrate that guided blood vessel growth in the wound transforms the initial scar into protective stromal tubes, creating highly patterned corridors for axon regeneration and safeguarding newly formed nerve fibers. [Multipotent progenitors instruct ontogeny of the superior colliculus](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00883-8%3Fdgcid=raven_jbs_etoc_email/1/0100018d1843bdab-345124c2-1d88-4c00-8a5b-290661294407-000000/53k9MqaarAi3x2VdQ7OVQjvtedtACCo13_h2eSkifLY=336) Giselle Cheung, Florian M. Pauler, Peter Koppensteiner, Thomas Krausgruber, Carmen Streicher, Martin Schrammel, Natalie Gutmann-Özgen, Alexis E. Ivec, Christoph Bock, Ryuichi Shigemoto, Simon Hippenmeyer Open Access Cheung et al. combine MADM-based lineage tracing with single-cell RNA sequencing to uncover the ontogenetic framework of the mouse superior colliculus. Individual progenitors show an exceptional capacity to produce all known excitatory and inhibitory neuron types and thus overall neuronal cell-type diversity in superior colliculus in a PTEN-dependent manner. [The bone transcription factor Osterix controls extracellular matrix- and node of Ranvier-related gene expression in oligodendrocytes](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00764-X%3Fdgcid=raven_jbs_etoc_email/1/0100018d1843bdab-345124c2-1d88-4c00-8a5b-290661294407-000000/Iraoled6V6UmNsYciPPUTWmvUeXBM4dVD6FHadZK9xI=336) Benayahu Elbaz, Alaa Darwish, Maia Vardy, Sara Isaac, Haley Margaret Tokars, Yulia Dzhashiashvili, Kirill Korshunov, Murali Prakriya, Amir Eden, Brian Popko Elbaz et al. show that Sp7 mediates the expression of genes required for node of Ranvier and brain ECM formation in mature oligodendrocytes. Moreover, Elbaz et al. show that Sp7 regulates ECM gene expression in a similar manner in oligodendrocytes and osteoblasts. [Synapse-specific burst coding sustained by local axonal translation](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00767-5%3Fdgcid=raven_jbs_etoc_email/1/0100018d1843bdab-345124c2-1d88-4c00-8a5b-290661294407-000000/wkWmLDtyftfbt5L5sOwOQufsRtssSKcaZqmlZYTsykc=336) Hovy Ho-Wai Wong, Alanna J. Watt, P. Jesper Sjöström Open Access Axons extend far from neuronal cell bodies yet need stable protein supply. Although many proteins are locally synthesized in mature axons, their functional roles are unclear. Wong et al. reveal how proteins made near axon terminals boost high-frequency neurotransmission, which is important for information transfer and memory formation. [A neural substrate for short-term taste memories](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00765-1%3Fdgcid=raven_jbs_etoc_email/1/0100018d1843bdab-345124c2-1d88-4c00-8a5b-290661294407-000000/M1sJyg1Lp2dnyKjNeJs_iEPvz9shBUWouHb8aDCwR4U=336) Zhang Juen, Miguel Villavicencio, Charles S. Zuker Open Access Sensory cortices have long been proposed to play a role in working memory. Juen et al. demonstrate that persistent activity in gustatory cortex functions as a memory trace of a recent taste experience. They show that by manipulating the duration of persistent activity, they abolish or enhance short-term taste memories. [Internal-state-dependent control of feeding behavior via hippocampal ghrelin signaling](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00797-3%3Fdgcid=raven_jbs_etoc_email/1/0100018d1843bdab-345124c2-1d88-4c00-8a5b-290661294407-000000/3V-5TW_OlOtc5V-rcWxRnobSHL9n6ZzVsm7sSKq92kI=336) Ryan W.S. Wee, Karyna Mishchanchuk, Rawan AlSubaie, Timothy W. Church, Matthew G. Gold, Andrew F. MacAskill Open Access Wee et al. show that ventral hippocampal neurons that project to nucleus accumbens are active around investigation of food, and this activity inhibits the initiation of eating. Increases in the level of the peripheral hunger hormone ghrelin reduce this activity and promote eating via ghrelin-receptor-dependent increases in postsynaptic inhibition. [Visuotactile integration facilitates mirror-induced self-directed behavior through activation of hippocampal neuronal ensembles in mice](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00803-6%3Fdgcid=raven_jbs_etoc_email/1/0100018d1843bdab-345124c2-1d88-4c00-8a5b-290661294407-000000/bLe946ZM-VP-xwKC8I6ePz0tsFuiP6saD6PEeiGNHfc=336) Jun Yokose, William D. Marks, Takashi Kitamura Yokose et al. demonstrate that visual-tactile coupling stimuli facilitate a mirror-induced self-directed behavior in mice. The study suggests that visual self-image may be developed and stored in a subset of ventral hippocampal CA1 neurons through social experience and mirror habituation. [Hippocampal-cortical interactions during event boundaries support retention of complex narrative events](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00766-3%3Fdgcid=raven_jbs_etoc_email/1/0100018d1843bdab-345124c2-1d88-4c00-8a5b-290661294407-000000/Ai8OV0qMw3beGT_e8r6GpVHJutSkQCmUrSoeuaMJECs=336) Alexander J. Barnett, Mitchell Nguyen, James Spargo, Reesha Yadav, Brendan I. Cohn-Sheehy, Charan Ranganath Barnett et al. explored functional connectivity of the hippocampus during the encoding of naturalistic events. Counter to many previous memory theories, communication between the hippocampus and neocortex was particularly important at the offset of events. 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