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--------------------------------------------------------------- [Circadian rhythms and mood disorders: Time to see the light](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00710-9/1/0100018cd04bd9c7-310125c8-be74-44ac-8551-30c23da08008-000000/dgjWArlq1jYtnwP1_l0ulUjIyuuT2QDw0BkBDJNMchY=334)
Dollish et al. [An evolutionary perspective on complex neuropsychiatric disease](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00842-5/1/0100018cd04bd9c7-310125c8-be74-44ac-8551-30c23da08008-000000/EYf8cuRVr59r1ihgJdPnfOzBX8f9qMht_X0M2hh4Sw4=334)
McClellan et al. [Responsive deep brain stimulation guided by ventral striatal electrophysiology of obsession durably ameliorates compulsion](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00747-X/1/0100018cd04bd9c7-310125c8-be74-44ac-8551-30c23da08008-000000/fM7U7WkWIId0_Y2kfTibEvfC5N4o5IxdwMMvvLRoPwU=334)
Nho et al. [Mapping of neuronal and glial primary cilia contactome and connectome in the human cerebral cortex](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00719-5/1/0100018cd04bd9c7-310125c8-be74-44ac-8551-30c23da08008-000000/nNGS6tmphHc3Cz0rnte0Gd_T7-4bGsOS6yHNCggjdd0=334)
Wu et al. Online now
--------------------------------------------------------------- [Restoration of a paraventricular thalamo-accumbal behavioral suppression circuit prevents reinstatement of heroin seeking](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00928-5/1/0100018cd04bd9c7-310125c8-be74-44ac-8551-30c23da08008-000000/-EvjfDd6kv9ifCOiu1w1u-n9gJjaLvQ1mb0pW6IKazY=334)
Paniccia et al. [Activity-dependent recruitment of inhibition and excitation in the awake mammalian cortex during electrical stimulation](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00927-3/1/0100018cd04bd9c7-310125c8-be74-44ac-8551-30c23da08008-000000/O0IxbUgnhDV1H5lnFHL-aWeD3BNyFxWjC9UqE0FNps4=334)
Dadarlat et al. [D1 and D2 medium spiny neurons in the nucleus accumbens core have distinct and valence-independent roles in learning](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00926-1/1/0100018cd04bd9c7-310125c8-be74-44ac-8551-30c23da08008-000000/dtS3cQxuA0ZyoGUe857UhFnGK0Yc-gNvysK_O0R1L8g=334)
Zachry et al. [Lights, fiber, action! A primer on in vivo fiber photometry](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00890-5/1/0100018cd04bd9c7-310125c8-be74-44ac-8551-30c23da08008-000000/1rJfhh1uEoxjWT7WfR2PZwwDKddCAj7fBPm2Zj0U_fY=334)
Simpson et al. Table of Contents Previews
--------------------------------------------------------------- [Alcohol withdrawal and pain: Peripheral mechanisms join central circuits](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00932-7%3Fdgcid=raven_jbs_etoc_email/1/0100018cd04bd9c7-310125c8-be74-44ac-8551-30c23da08008-000000/1iEt2bqBhFzIynfMwMSw6Au7UNarUMLrRSRs7qIrhl8=334)
Volker Neugebauer, Igor Ponomarev Negative affective aspects of alcohol withdrawal and pain involve converging brain circuits. In this issue of Neuron, Son et al. identify a peripheral mechanism of an alcohol-withdrawal-induced headache-like condition, which is centered on mast-cell-specific receptor MrgprB2 activated by corticotropin-releasing factor (CRF) in dura mater to drive nociception. [Dopamineâs reach: Unlocked by sleep loss](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00889-9%3Fdgcid=raven_jbs_etoc_email/1/0100018cd04bd9c7-310125c8-be74-44ac-8551-30c23da08008-000000/h_FZ-czrJ-Ih64NzCpI5kX_OYrB0h81fhGdpZQQD-Xw=334)
Bibi Alika Sulaman, Tyler Kudlak, Ada Eban-Rothschild In this issue of Neuron, Wu et al. employ cutting-edge techniques to provide a mechanistic understanding of how sleep deprivation induces an altered affective state. They reveal a key function for dopaminergic signaling, and the formation of cortical spines, in this process. Perspective
--------------------------------------------------------------- [An evolutionary perspective on complex neuropsychiatric disease](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00842-5%3Fdgcid=raven_jbs_etoc_email/1/0100018cd04bd9c7-310125c8-be74-44ac-8551-30c23da08008-000000/-UkCWQ9maW1RU-HcfYjpFHE4KNFhG4sXRRUkPrXVp2o=334)
Jon M. McClellan, Anthony W. Zoghbi, Joseph D. Buxbaum, Carolina Cappi, James J. Crowley, Jonathan Flint, Dorothy E. Grice, Suleyman Gulsuner, Conrad Iyegbe, Sanjeev Jain, Po-Hsiu Kuo, Maria Claudia Lattig, Maria Rita Passos-Bueno, Meera Purushottam, Dan J. Stein, Anna B. Sunshine, Ezra S. Susser, Christopher A. Walsh, Olivia Wootton, Mary-Claire King Members of the NIMH Network for Studies of Mental Disorders in Ancestrally Diverse Populations illuminate the genetic architecture of complex neuropsychiatric illnesses in the context of forces of evolution: mutation, selection, migration, and genetic drift/population structure. Review
--------------------------------------------------------------- [Circadian rhythms and mood disorders: Time to see the light](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00710-9%3Fdgcid=raven_jbs_etoc_email/1/0100018cd04bd9c7-310125c8-be74-44ac-8551-30c23da08008-000000/5MWGJIe0pQe3flDtkZF9GckHB_9wwQEHkBVQxDmRTtI=334)
Hannah K. Dollish, Mariya Tsyglakova, Colleen A. McClung In Dollish et al., they review the clinical literature and provide mechanistic insights into how circadian rhythms contribute to mood disorders. They also describe chronotherapeutic treatments and provide hypotheses for testing in future studies of both mechanism and novel treatments. NeuroResources
--------------------------------------------------------------- [Mapping of neuronal and glial primary cilia contactome and connectome in the human cerebral cortex](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00719-5%3Fdgcid=raven_jbs_etoc_email/1/0100018cd04bd9c7-310125c8-be74-44ac-8551-30c23da08008-000000/D_D8NFDQTFaNogM_jCOgcmnEeUC7pnkA2WA06xawy7I=334)
Jun Yao Wu, Su-Ji Cho, Katherine Descant, Peter H. Li, Alexander Shapson-Coe, Michal Januszewski, Daniel R. Berger, Cailyn Meyer, Cristine Casingal, Ariba Huda, Jiaqi Liu, Tina Ghashghaei, Mikayla Brenman, Michelle Jiang, Joseph Scarborough, Art Pope, Viren Jain, Jason L. Stein, Jiami Guo, Ryohei Yasuda, Jeff W. Lichtman, E.S. Anton The unique pattern of primary cilia contacts with the surrounding cortical circuitry may enable cilia signaling to serve as a mechanism through which local environmental signals can shape and refine neuronal circuits. Disruptions in the primary cilia connectome may thus contribute to circuit dysfunction in ciliopathies and other human brain disorders. [Viral vector-mediated transgene delivery with novel recombinase systems for targeting neuronal populations defined by multiple features](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00751-1%3Fdgcid=raven_jbs_etoc_email/1/0100018cd04bd9c7-310125c8-be74-44ac-8551-30c23da08008-000000/97NhLdBFYXrXzcqpJeO6-iM63_w5DWO0wCic93TnmS8=334)
Minju Jeong, Jun-Hyeok Choi, Hyeonseok Jang, Dong Hyun Sohn, Qingdi Wang, Joann Lee, Li Yao, Eun Ji Lee, Jiachen Fan, Marta Pratelli, Eric H. Wang, Christen N. Snyder, Xiao-yun Wang, Sora Shin, Aryn H. Gittis, Tsung-Chang Sung, Nicholas C. Spitzer, Byung Kook Lim
Open Access Jeong et al. created a new viral technique, ΦC31/pSIO vector, to target specific neuronal cell types without cross-reactivity with Cre and Flp recombinases. These easy-to-use viral tools for robust and effective intersectional expression of numerous transgenes in neurons with multiple characteristics will help in the functional understanding of diverse brain circuitry. Case study
--------------------------------------------------------------- [Responsive deep brain stimulation guided by ventral striatal electrophysiology of obsession durably ameliorates compulsion](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00747-X%3Fdgcid=raven_jbs_etoc_email/1/0100018cd04bd9c7-310125c8-be74-44ac-8551-30c23da08008-000000/iQTVHhYht1BY5QmTp8MJeDsXYNcZ9qmjIYZisq9NMIU=334)
Young-Hoon Nho, Camarin E. Rolle, Uros Topalovic, Rajat S. Shivacharan, Tricia N. Cunningham, Sonja Hiller, Daniel Batista, Austin Feng, Flint M. Espil, Ian H. Kratter, Mahendra T. Bhati, Marissa Kellogg, Ahmed M. Raslan, Nolan R. Williams, John Garnett, Bijan Pesaran, Desmond J. Oathes, Nanthia Suthana, Daniel A.N. Barbosa, Casey H. Halpern
Open Access We report on a first-in-human application of responsive deep brain stimulation (rDBS) of the ventral striatum for treatment-refractory OCD. rDBS detected the time-domain area-based feature from invasive electroencephalography low-frequency oscillatory power fluctuations that triggered bursts of stimulation to ameliorate OCD symptoms in a closed-loop fashion. Report
--------------------------------------------------------------- [A frontopolar-temporal circuit determines the impact of social information in macaque decision making](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00748-1%3Fdgcid=raven_jbs_etoc_email/1/0100018cd04bd9c7-310125c8-be74-44ac-8551-30c23da08008-000000/kynyoF1EoMWaNb80AtyZnJ50alAR8vhLhHiLrJzmqX0=334)
Ali Mahmoodi, Caroline Harbison, Alessandro Bongioanni, Andrew Emberton, Lea Roumazeilles, Jerome Sallet, Nima Khalighinejad, Matthew F.S. Rushworth
Open Access Mahmoodi et al. identify a neural circuit in macaques that comprises dorsomedial frontopolar cortex (dmFPC) and mid-superior temporal sulcus (mSTS) for regulating the impact of social information according to its reliability. Disruption of dmFPC and mSTS produces distinct changes in social information use. Articles
--------------------------------------------------------------- [Astrocyte growth is driven by the Tre1/S1pr1 phospholipid-binding G protein-coupled receptor](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00882-6%3Fdgcid=raven_jbs_etoc_email/1/0100018cd04bd9c7-310125c8-be74-44ac-8551-30c23da08008-000000/U2CSeeQ8CA1maWKjjJA_OVa8UC_t4tzc0myv-Db07xY=334)
Jiakun Chen, Tobias Stork, Yunsik Kang, Katherine A.M. Nardone, Franziska Auer, Ryan J. Farrell, Taylor R. Jay, Dongeun Heo, Amy Sheehan, Cameron Paton, Katherine I. Nagel, David Schoppik, Kelly R. Monk, Marc R. Freeman Chen et al. show that the lipid-binding GPCR Tre1/S1pr1 promotes astrocyte morphological growth in Drosophila and zebrafish. Astrocytes compete for local phospholipids, which are processed by the LPPs Wun/Wun2 to promote process outgrowth via Tre1, thereby enabling astrocyte control of behavior. [Mast-cell-specific receptor mediates alcohol-withdrawal-associated headache in male mice](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00752-3%3Fdgcid=raven_jbs_etoc_email/1/0100018cd04bd9c7-310125c8-be74-44ac-8551-30c23da08008-000000/0hef8ivapr6vTShswZO5mu-MYSGzrfPJIascdJ-zLqM=334)
Hyeonwi Son, Yan Zhang, John Shannonhouse, Hirotake Ishida, Ruben Gomez, Yu Shin Kim Son et al. show that activation of the mast-cell-specific receptor MrgprB2 in the dura mater of male mice causes mast cell degranulation and sensitization of sensory neurons, resulting in headache after alcohol withdrawal. [Localized APP expression results in progressive network dysfunction by disorganizing spike timing](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00757-2%3Fdgcid=raven_jbs_etoc_email/1/0100018cd04bd9c7-310125c8-be74-44ac-8551-30c23da08008-000000/tnqMY88LJmhHm0O3wIh-PPa5oWSablCScc3Cz2eG-K0=334)
Silvia Viana da Silva, Matthias G. Haberl, Kshitij Gaur, Rina Patel, Gautam Narayan, Max Ledakis, Maylin L. Fu, Miguel de Castro Vieira, Edward H. Koo, Jill K. Leutgeb, Stefan Leutgeb
Open Access Viana da Silva et al. show that cognitive decline in Alzheimerâs disease is not only caused by spreading pathology but also that local pathology is sufficient to result in memory dysfunction and aberrant rhythmic firing patterns in brain regions that receive projections from cells that express mutant human amyloid precursor protein. [Dopamine pathways mediating affective state transitions after sleep loss](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00758-4%3Fdgcid=raven_jbs_etoc_email/1/0100018cd04bd9c7-310125c8-be74-44ac-8551-30c23da08008-000000/queXCgUcJUyN-ITCSLVPxYAaweQvp1Onk9340o_tnXo=334)
Mingzheng Wu, Xin Zhang, Sihan Feng, Sara N. Freda, Pushpa Kumari, Vasin Dumrongprechachan, Yevgenia Kozorovitskiy Sleep perturbations are known to alter mood. Wu et al. show that specific dopaminergic pathways regulate distinct behavioral changes induced by brief sleep deprivation. Optically mediated disassembly of enhanced neuroplasticity revealed a dopamine-dependent mechanism that maintains the antidepressant effects of acute sleep loss. [Spatial memory requires hypocretins to elevate medial entorhinal gamma oscillations](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00768-7%3Fdgcid=raven_jbs_etoc_email/1/0100018cd04bd9c7-310125c8-be74-44ac-8551-30c23da08008-000000/iU9nHikP5pFqcaI4oJ3odijLoPnutWeg0KY7nkaac9U=334)
Yixiang Liao, Ruyi Wen, Shengwei Fu, Xiaofang Cheng, Shuancheng Ren, Minmin Lu, Ling Qian, Fenlan Luo, Yaling Wang, Qin Xiao, Xiao Wang, Hengying Ye, Xiaolong Zhang, Chenggang Jiang, Xin Li, Shiyin Li, Ruozhi Dang, Yingying Liu, Junjun Kang, Zhongxiang Yao, Jie Yan, Jiaxiang Xiong, Yanjiang Wang, Shengxi Wu, Xiaowei Chen, Yulong Li, Jianxia Xia, Zhian Hu, Chao He Liao et al. identify a pathway from the hypothalamic hypocretin neurons to the medial entorhinal cortex. They find that hypocretins act on the presynaptic glutamatergic terminals to excite parvalbumin-positive neurons in the medial entorhinal cortex and contribute to object-place memory encoding by enhancing gamma oscillations. [Update Your Profile](%2F%2Fwww.cell.com%2Faction%2FshowPreferences%3FmenuTab=Alerts%26code=cell-site/1/0100018cd04bd9c7-310125c8-be74-44ac-8551-30c23da08008-000000/gePboWvof27PmAShsL4V4DUxP1Kgnx9TDba9A3mYCFA=334) [Terms and Conditions](%2F%2Fwww.elsevier.com%2Flegal%2Felsevier-website-terms-and-conditions/1/0100018cd04bd9c7-310125c8-be74-44ac-8551-30c23da08008-000000/GS01HjOHgoQc2UL-dfRK4wTsC13Vu5OuWCx9GWYfMN4=334) [Privacy Policy](%2F%2Fwww.elsevier.com%2Flegal%2Fprivacy-policy/1/0100018cd04bd9c7-310125c8-be74-44ac-8551-30c23da08008-000000/zxgV3yXH2IBL9Bj2dku5C7Jir55ilBXXMb8eDhiGX90=334) [Follow this link to unsubscribe.](%2F%2Fwww.cell.com%2Falerts%2Funsubscribe%3FsubscriptionID=c1bedb93-d933-486c-b094-8eaf812d893b%26hash=eeca2f294f987df4d4ae56abbd699bf6e686193b/1/0100018cd04bd9c7-310125c8-be74-44ac-8551-30c23da08008-000000/tqqNqgTPdPZuXs5rkeNq_GfRcRqBhlV-R5G2n1BChKM=334) This email has been sent from Cell Press, a division of Elsevier Inc., 50 Hampshire Street, 5th Floor, Cambridge, MA 02139, USA. You are receiving this email because you signed up for email alerts for new issues of this journal. For all inquiries, problems or suggestions regarding this service, please contact [our support group.](%2F%2Fservice.elsevier.com%2Fapp%2Foverview%2Fcell-press%2F/1/0100018cd04bd9c7-310125c8-be74-44ac-8551-30c23da08008-000000/kL1cmzUMTX_QfedpjbK1MghfD6cw0PLbrRo4kFZlgBc=334)
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