Neuron: December 6, 2023 (Volume 111, Issue 23)

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[Deep-brain optical recording of neural dynamics during behavior](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00670-0/1/0100018c404e9392-e8686218-8770-4171-8c4d-cfaaa2d7fcb2-000000/GO8nNWGzhzGvMlx94FJWMUad8sak3MDAAzC_w1ReE6U=330) Zhou et al. [Synaptotagmin 1-triggered lipid signaling facilitates coupling of exo- and endocytosis](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00628-1/1/0100018c404e9392-e8686218-8770-4171-8c4d-cfaaa2d7fcb2-000000/Mewyi089tIm8imsQThbS4SOUg3FZoaYdiy55kKZcnCs=330) Bolz et al. [Molecular anatomy of adult mouse leptomeninges](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00666-9/1/0100018c404e9392-e8686218-8770-4171-8c4d-cfaaa2d7fcb2-000000/4fdZcCisgU5p5aTCZ6xXkraXDf9Yws-N6XeUOe-P4os=330) Pietilä et al. Online now --------------------------------------------------------------- [Visuotactile integration facilitates mirror-induced self-directed behavior through activation of hippocampal neuronal ensembles in mice](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00803-6/1/0100018c404e9392-e8686218-8770-4171-8c4d-cfaaa2d7fcb2-000000/fP-gIXh5w2LWnDkrbKnP-CvLPqInIpICxiRy7KQkKXw=330) Yokose et al. [An excitatory projection from the basal forebrain to the ventral tegmental area that underlies anorexia-like phenotypes](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00845-0/1/0100018c404e9392-e8686218-8770-4171-8c4d-cfaaa2d7fcb2-000000/XRh4aJqwLT7HIuyyDAFKjes9A6AyPYB-T2SEXryK4n0=330) Cai et al. [Activated Protein C Prevents Neuronal Apoptosis via Protease Activated Receptors 1 and 3](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00929-7/1/0100018c404e9392-e8686218-8770-4171-8c4d-cfaaa2d7fcb2-000000/UoLJuHEBQgBnp4n8pbDGytXfnseqJUhgyV6cr_XEGRU=330) Guo et al. [An evolutionary perspective on complex neuropsychiatric disease](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00842-5/1/0100018c404e9392-e8686218-8770-4171-8c4d-cfaaa2d7fcb2-000000/lp-UKDyanI6vlHwicZCcvvXcP4J2Z-pqeRlunD010lY=330) McClellan et al. Table of Contents Previews --------------------------------------------------------------- [It takes a village: Neurons partner with vascular pericytes to make memories](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00841-3%3Fdgcid=raven_jbs_etoc_email/1/0100018c404e9392-e8686218-8770-4171-8c4d-cfaaa2d7fcb2-000000/CYDqt7aNHux98F7eOI5SjlKigI2G_t9j74OvhxJhjBk=330) Stephen Maren Neurons have a central role in memory formation, but emerging work points to the critical role that non-neuronal cells play in this process. In this issue of Neuron, Pandey and colleagues1 show that hippocampal neurons communicate with vascular pericytes during memory consolidation. Through this dialogue, pericyte-derived growth factors support long-term memory. [Dynamic prefrontal inhibition code mediates reward devaluation](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00800-0%3Fdgcid=raven_jbs_etoc_email/1/0100018c404e9392-e8686218-8770-4171-8c4d-cfaaa2d7fcb2-000000/eeolo1TnaJen9Q8DrCvEvxTybWsZhK7aQjuEMd73P5Y=330) Yiyan Dong, Qi Qin, Yihui Cui Repeated reward intake decreases its subjective pleasantness, which is a common phenomenon called reward devaluation. In this issue of Neuron, Yuan et al. unravel that blunted inhibitory response of anterior cingulate cortex (ACC) encodes this process, whose hypersensitization leads to anhedonia. NeuroViews --------------------------------------------------------------- [Dismantling silos: The case for an integrated approach to address childhood determinants of lifelong brain health](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00667-0%3Fdgcid=raven_jbs_etoc_email/1/0100018c404e9392-e8686218-8770-4171-8c4d-cfaaa2d7fcb2-000000/ACuzEQsS_7dSYp0YKdLmq7uYeOl093H5ZAUzBd2nOfg=330) Ravikiran M. Raju, Li-Huei Tsai Early-life environments have an immense influence on long-term health outcomes. We have started to elucidate the mechanisms underlying this association but have made little progress in reducing the disease burden of environmentally mediated neurological and psychiatric illness. Here, we highlight barriers to innovation and how they may be overcome. [Benefits of sharing neurophysiology data from the BRAIN Initiative Research Opportunities in Humans Consortium](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00717-1%3Fdgcid=raven_jbs_etoc_email/1/0100018c404e9392-e8686218-8770-4171-8c4d-cfaaa2d7fcb2-000000/avctCSFF6kYroABph4mV6y0I7x8SWXh6RgVrCXBYUhA=330) Vasiliki Rahimzadeh, Kathryn Maxson Jones, Mary A. Majumder, Michael J. Kahana, Ueli Rutishauser, Ziv M. Williams, Sydney S. Cash, Angelique C. Paulk, Jie Zheng, Michael S. Beauchamp, Jennifer L. Collinger, Nader Pouratian, Amy L. McGuire, Sameer A. Sheth NIH Research Opportunities in Humans (ROH) Consortium Sharing human brain data can yield scientific benefits, but because of various disincentives only a fraction of these data is currently shared. Rahimzadeh et al. profile three successful data-sharing experiences from the NIH BRAIN Initiative Research Opportunities in Humans (ROH) Consortium and demonstrate benefits to data producers and to users. Primer --------------------------------------------------------------- [Deep-brain optical recording of neural dynamics during behavior](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00670-0%3Fdgcid=raven_jbs_etoc_email/1/0100018c404e9392-e8686218-8770-4171-8c4d-cfaaa2d7fcb2-000000/LBJuRbkk4HFc4MuV5XK2dbUSFSkJ0OD2VW3hED2887E=330) Zhe Charles Zhou, Adam Gordon-Fennell, Sean C. Piantadosi, Na Ji, Spencer LaVere Smith, Michael R. Bruchas, Garret D. Stuber In this Neuron primer, Zhou et al. provide a comprehensive guide for in vivo deep-brain fluorescence optical recordings in awake, behaving rodent models, detailing major steps from project planning to data analysis for fluorescence recording techniques in hard-to-reach brain nuclei. Letters --------------------------------------------------------------- [Challenges of profiling motor neuron transcriptomes from human spinal cord](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00840-1%3Fdgcid=raven_jbs_etoc_email/1/0100018c404e9392-e8686218-8770-4171-8c4d-cfaaa2d7fcb2-000000/RpkMmuE1gEhuz-vCCNkoQUIH24dkOM6ZtlVfc2-5U7U=330) Olivia Gautier, Jacob A. Blum, James Maksymetz, Derek Chen, Christoph Schweingruber, Irene Mei, Anita Hermann, David H. Hackos, Eva Hedlund, John Ravits, Aaron D. Gitler [A reproducible signature of cytoskeletal and ALS-related genes in human motoneurons](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00839-5%3Fdgcid=raven_jbs_etoc_email/1/0100018c404e9392-e8686218-8770-4171-8c4d-cfaaa2d7fcb2-000000/TvTv7pWrGitFLwnosTnc2pMOAutWI7UPXHJmy1i_XQQ=330) Archana Yadav, Kaya J.E. Matson, Dylan Lee, Mor R. Alkaslasi, R. Brian Roome, Michael E. Ward, Hemali Phatnani, Claire E. Le Pichon, Vilas Menon, Ariel J. Levine NeuroResource --------------------------------------------------------------- [Molecular anatomy of adult mouse leptomeninges](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00666-9%3Fdgcid=raven_jbs_etoc_email/1/0100018c404e9392-e8686218-8770-4171-8c4d-cfaaa2d7fcb2-000000/asnLoII9qOaIxsQ6QQCjOaBz46uBfRj7lG_3IbIjw9c=330) Riikka Pietilä, Francesca Del Gaudio, Liqun He, Elisa Vázquez-Liébanas, Michael Vanlandewijck, Lars Muhl, Giuseppe Mocci, Katrine D. Bjørnholm, Caroline Lindblad, Alexander Fletcher-Sandersjöö, Mikael Svensson, Eric P. Thelin, Jianping Liu, A. Jantine van Voorden, Monica Torres, Salli Antila, Li Xin, Helena Karlström, Jon Storm-Mathisen, Linda Hildegard Bergersen, Aldo Moggio, Emil M. Hansson, Maria H. Ulvmar, Per Nilsson, Taija Mäkinen, Maarja Andaloussi Mäe, Kari Alitalo, Steven T. Proulx, Britta Engelhardt, Donald M. McDonald, Urban Lendahl, Johanna Andrae, Christer Betsholtz Open Access This study establishes the molecular and anatomical landscape of mouse brain fibroblasts using single-cell transcriptomics and in situ RNA-, protein-, and reporter-labeling, specifically focusing on the leptomeninges. The data pave the way for further studies of brain fibroblasts and their role in CNS barrier functions in health and disease. Report --------------------------------------------------------------- [Synaptotagmin 1-triggered lipid signaling facilitates coupling of exo- and endocytosis](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00628-1%3Fdgcid=raven_jbs_etoc_email/1/0100018c404e9392-e8686218-8770-4171-8c4d-cfaaa2d7fcb2-000000/_WaHEZ0oUDXOUqCAfHBFrQKhT0A4AQBJA4xcGD1CZAY=330) Svenja Bolz, Natalie Kaempf, Dmytro Puchkov, Michael Krauss, Giulia Russo, Tolga Soykan, Christopher Schmied, Martin Lehmann, Rainer Müller, Carsten Schultz, David Perrais, Tanja Maritzen, Volker Haucke Synaptic exocytosis and endocytosis are of prime importance for brain function. How a neuronal synapse “knows” how many synaptic vesicles have fused is essentially unknown. Bolz et al. identify here a lipid-based mechanism for the coupling of exocytic vesicle fusion to synaptic vesicle endocytosis via Synaptotagmin 1. Articles --------------------------------------------------------------- [Parkinson’s disease-linked parkin mutation disrupts recycling of synaptic vesicles in human dopaminergic neurons](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00629-3%3Fdgcid=raven_jbs_etoc_email/1/0100018c404e9392-e8686218-8770-4171-8c4d-cfaaa2d7fcb2-000000/CBBL7gcf64VuAJhYhyfqt05j4VUH5tUnZsB7FPEZcHI=330) Pingping Song, Wesley Peng, Veronique Sauve, Rayan Fakih, Zhong Xie, Daniel Ysselstein, Talia Krainc, Yvette C. Wong, Niccolò E. Mencacci, Jeffrey N. Savas, D. James Surmeier, Kalle Gehring, Dimitri Krainc In brief, Song et al. found that neuronal activity triggers CaMK2-mediated activation of parkin and its recruitment to synaptic vesicles where parkin promotes binding of synaptojanin-1 to endophilin A1 and facilitates vesicle endocytosis. Mutant parkin leads to defective recycling of vesicles and accumulation of toxic oxidized dopamine in PD neurons. [Stress relief as a natural resilience mechanism against depression-like behaviors](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00668-2%3Fdgcid=raven_jbs_etoc_email/1/0100018c404e9392-e8686218-8770-4171-8c4d-cfaaa2d7fcb2-000000/32zddKSqoycdKtkvfzxnK3DkiDHrYt1bJysHp25K6Wg=330) Yiyan Dong, Yifei Li, Xinkuan Xiang, Zhuo-Cheng Xiao, Ji Hu, Yulong Li, Haohong Li, Hailan Hu Open Access Dong et al. identify stress relief as a natural resilience mechanism against depression-like behaviors, delineate underlying dissociable mesoaccumbal dopamine circuits for preventing despair or anhedonia, and introduce a non-invasive behavioral strategy for promoting resilience. [Evolutionary conservation of hippocampal mossy fiber synapse properties](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00669-4%3Fdgcid=raven_jbs_etoc_email/1/0100018c404e9392-e8686218-8770-4171-8c4d-cfaaa2d7fcb2-000000/4opBvy-eVCtJFWp55qRadEL5Bb56_lB42tCBGBFWAsU=330) Kenneth A. Pelkey, Geoffrey A. Vargish, Leonardo V. Pellegrini, Daniela Calvigioni, Julio Chapeton, Xiaoqing Yuan, Steven Hunt, Alex C. Cummins, Mark A.G. Eldridge, James Pickel, Ramesh Chittajallu, Bruno B. Averbeck, Katalin Tóth, Kareem Zaghloul, Chris J. McBain Although investigated to exquisite detail in model organisms, human synapses have undergone limited functional interrogation, leaving the translational relevance of unique subtype-specific synapse features unknown. Through combined electrophysiological/ultrastructural interrogation, Pelkey et al. demonstrate remarkable evolutionary conservation from rodents to humans in the core structural/functional features defining hippocampal mossy fiber synapses. [Neuronal activity drives IGF2 expression from pericytes to form long-term memory](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00664-5%3Fdgcid=raven_jbs_etoc_email/1/0100018c404e9392-e8686218-8770-4171-8c4d-cfaaa2d7fcb2-000000/l22kCxKRctzb19RvoSjjlizXcrI3DH2KthdzdAsQ0xY=330) Kiran Pandey, Benjamin Bessières, Susan L. Sheng, Julian Taranda, Pavel Osten, Ionel Sandovici, Miguel Constancia, Cristina M. Alberini Pandey, Bessières, et al. report that Igf2 expression in hippocampal pericytes, but not neurons, astrocytes, microglia, endothelial cells, or fibroblasts, is increased by learning and required for long-term memory. Pericytic Igf2 expression is driven by neuronal activity and controls neuronal mechanisms. Thus, pericyte-neuron cooperation plays a key role in memory. [A corticoamygdalar pathway controls reward devaluation and depression using dynamic inhibition code](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00633-5%3Fdgcid=raven_jbs_etoc_email/1/0100018c404e9392-e8686218-8770-4171-8c4d-cfaaa2d7fcb2-000000/XTf2sxKAgi14bOmrC709GPcjjrMoHP-hTxrDWmraivg=330) Zhengwei Yuan, Zhongyang Qi, Ruiyu Wang, Yuting Cui, Sile An, Guoli Wu, Qiru Feng, Rui Lin, Ruicheng Dai, Anan Li, Hui Gong, Qingming Luo, Ling Fu, Minmin Luo Yuan et al. show that the neural pathway from the anterior cingulate cortex (ACC) to the basolateral amygdala (BLA) employs a dynamic inhibition code to control reward devaluation and depression. Silencing ACC desensitizes reward devaluation and enhances reward intake, suggesting a viable therapeutic approach for treating depression. [Functional architecture of dopamine neurons driving fear extinction learning](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00636-0%3Fdgcid=raven_jbs_etoc_email/1/0100018c404e9392-e8686218-8770-4171-8c4d-cfaaa2d7fcb2-000000/sZKxaSlRATqJbDH4XpiFZvBjQf99vIAq9XZCRZWjgDU=330) Ximena I. Salinas-Hernández, Daphne Zafiri, Torfi Sigurdsson, Sevil Duvarci Open Access Dopamine (DA) neurons encode an extinction prediction error signal that drives fear extinction learning, but the neural circuitry of this signal has remained elusive. Salinas-Hernández et al. show that this DA prediction error signal is sent to the anteromedial NAc and depends on inputs from VTA-projecting DR neurons in mice. [A view-based decision mechanism for rewards in the primate amygdala](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00635-9%3Fdgcid=raven_jbs_etoc_email/1/0100018c404e9392-e8686218-8770-4171-8c4d-cfaaa2d7fcb2-000000/OeyeQ1b7gMWMV0mjkOVIvXA-4XjsYCAt5bmmzCY3KCY=330) Fabian Grabenhorst, Adrián Ponce-Alvarez, Alexandra Battaglia-Mayer, Gustavo Deco, Wolfram Schultz Open Access The amygdala is important for assigning value to objects. Grabenhorst et al. find that primate amygdala neurons translate object values into behavioral choices by implementing a decision mechanism. The amygdala’s decision mechanism uses abstract representations defined by the monkey’s current view rather than by specific object or reward properties. [Goal-seeking compresses neural codes for space in the human hippocampus and orbitofrontal cortex](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00632-3%3Fdgcid=raven_jbs_etoc_email/1/0100018c404e9392-e8686218-8770-4171-8c4d-cfaaa2d7fcb2-000000/8dahp6WmZQiPfJM9NvegVnzEP72ZjR4zzOzbVQteFQE=330) Paul S. Muhle-Karbe, Hannah Sheahan, Giovanni Pezzulo, Hugo J. Spiers, Samson Chien, Nicolas W. Schuck, Christopher Summerfield Open Access How do goals affect the representation of space? Muhle-Karbe et al. show that spatial maps in the hippocampus and orbitofrontal cortex are “compressed” during goal-directed navigation with goals that share a prospective pathway clustering together in representational space, as if participants were simultaneously imagining themselves at current and goal locations. 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