Neuron: October 18, 2023 (Volume 111, Issue 20)

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Featured articles --------------------------------------------------------------- [Next frontiers in consciousness research](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00755-9/1/0100018b43797131-28f71561-455e-4acb-9a87-e0aeb46085e0-000000/WoMGb61k_Z3iM752WTQoVKd1RzI7u95E8LG7k35zn0o=323) Biyu J. He [Continuing trial responsibilities for implantable neural devices](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00541-X/1/0100018b43797131-28f71561-455e-4acb-9a87-e0aeb46085e0-000000/maQ1sVQFtPR3BrTYO7UdpmJ_Nj3-TCxrZOd7KI1gT44=323) Hendriks et al. [Neuronal γ-secretase regulates lipid metabolism, linking cholesterol to synaptic dysfunction in Alzheimer's disease](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00513-5/1/0100018b43797131-28f71561-455e-4acb-9a87-e0aeb46085e0-000000/bCZrYXPc0PwtdCqs91LBioB7BC7GvuxuHQPBMc9FWjo=323) Essayan-Perez et al. [A common thalamic hub for general and defensive arousal control](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00540-8/1/0100018b43797131-28f71561-455e-4acb-9a87-e0aeb46085e0-000000/f4g41-yQLroRZAIGSXhPrQTt3DQC4xgz_YdJpaeHrtM=323) Wang et al. Online now --------------------------------------------------------------- [In vivo photopharmacology with light-activated opioid drugs](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00704-3/1/0100018b43797131-28f71561-455e-4acb-9a87-e0aeb46085e0-000000/N1CgyICkLAwIKztgMvFBOqEzTWlr8_ZJ5eL0WSsFDTc=323) McClain et al. [Deep scRNA sequencing reveals a broadly applicable Regeneration Classifier and implicates antioxidant response in corticospinal axon regeneration](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00707-9/1/0100018b43797131-28f71561-455e-4acb-9a87-e0aeb46085e0-000000/usbhcRJ76f2KTata2QLE9_rX6P0I0GZWVr3n_8XNVOc=323) Kim et al. [Species-specific FMRP regulation of RACK1 is critical for prenatal cortical development](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00702-X/1/0100018b43797131-28f71561-455e-4acb-9a87-e0aeb46085e0-000000/31xaftqYXzZuhwva1b3nzqO7HfHJDHXjOui5xeEvwxs=323) Shen et al. [Adult-born granule cells facilitate remapping of spatial and non-spatial representations in the dentate gyrus](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00703-1/1/0100018b43797131-28f71561-455e-4acb-9a87-e0aeb46085e0-000000/PLNW28g_GNMWxLpRwSRPXVqic9H2e3Leq9rn2I6GWpo=323) Tuncdemir et al. Table of Contents Previews --------------------------------------------------------------- [Neuronal γ-secretase regulates synaptic functions via cholesterol homeostasis](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00708-0%3Fdgcid=raven_jbs_etoc_email/1/0100018b43797131-28f71561-455e-4acb-9a87-e0aeb46085e0-000000/d82Z5qFX80tx-wX_zTVwIwGyGtLPUZ7VlSWed1X2bKE=323) Wing-Yu Fu, Amy K.Y. Fu, Nancy Y. Ip In this issue of Neuron, Essayan-Perez and Südhof1 demonstrate roles for γ-secretase in the regulation of synaptic functions in human neurons. Chronic attenuation of γ-secretase activity increases synapse formation but decreases neurotransmission (i.e., the probability of presynaptic release), likely due to impairment of cholesterol metabolism. [Force opens a monomeric channel pore](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00663-3%3Fdgcid=raven_jbs_etoc_email/1/0100018b43797131-28f71561-455e-4acb-9a87-e0aeb46085e0-000000/G3flto0Uao3u8TPwR25eJQZ9qw8dLqwDIWCka_8SFuE=323) Wenjun Guo, Lei Chen In this issue of Neuron, Zheng et al.1 report the monomeric architecture of mechanosensitive ion channels TMEM63A and TMEM63B. They show that these high-threshold channels function as monomers on the plasma membrane. [Engineering mechanoreceptor feature selectivity](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00746-8%3Fdgcid=raven_jbs_etoc_email/1/0100018b43797131-28f71561-455e-4acb-9a87-e0aeb46085e0-000000/6aa-bEOfOHjN30tqXLRk-RUysqFnzHnhr9PCv82PSs0=323) Joriene C. de Nooij Touch and proprioception rely on the discriminative abilities of distinct classes of mechanosensory neurons. In this issue of Neuron, two studies provide evidence that biomechanical mechanisms and ultrastructural cellular specializations are key contributors in defining mechanoreceptor stimulus threshold and selectivity. [Several ways to wake you up by the thalamus](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00705-5%3Fdgcid=raven_jbs_etoc_email/1/0100018b43797131-28f71561-455e-4acb-9a87-e0aeb46085e0-000000/Qlu6nej8l3B1zG0EhG0qv9yHzyeJgerWjHUz8ppzMKU=323) László Acsády, Ferenc Mátyás An organism can be aroused in many different manners. Here, Wang el al.1 demonstrate that a multisensory thalamic region can mediate spontaneous, sensory, and defensive arousal via its widespread projection, which indicates a non-canonical function of this area. NeuroView --------------------------------------------------------------- [Continuing trial responsibilities for implantable neural devices](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00541-X%3Fdgcid=raven_jbs_etoc_email/1/0100018b43797131-28f71561-455e-4acb-9a87-e0aeb46085e0-000000/g2ZmOa6UiSRbdT74Bk-A3_6UfVRgbD6V6TySspHC_uY=323) Saskia Hendriks, Nina Hsu, Andrea C. Beckel-Mitchener, John Ngai, Christine Grady Participants of neural implant studies have research-related posttrial care needs (e.g., hardware replacements). Gaps in plans for posttrial care are currently common, which can have major consequences for patients. Professionals and organizations involved should address important unmet posttrial needs. Meeting report --------------------------------------------------------------- [Next frontiers in consciousness research](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00755-9%3Fdgcid=raven_jbs_etoc_email/1/0100018b43797131-28f71561-455e-4acb-9a87-e0aeb46085e0-000000/Jhwcu6roW_3Ord-b4h9RsEXOoHDyxwo5zHGQiPQ405g=323) Biyu J. He Consciousness science has matured over the past three decades and is currently on the cusp of explosive growth, with the potential to transform medicine and technology. The global community recently met to synthesize the current state of knowledge and define the most exciting approaches to advance the field. Review --------------------------------------------------------------- [Hippocampal GABAergic interneurons and memory](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00475-0%3Fdgcid=raven_jbs_etoc_email/1/0100018b43797131-28f71561-455e-4acb-9a87-e0aeb46085e0-000000/YT8ozrnAWq8cMuBJm-7lipchLyqGqj7nZOi6Gp0Xenw=323) Alexandra Tzilivaki, John J. Tukker, Nikolaus Maier, Panayiota Poirazi, Rosanna P. Sammons, Dietmar Schmitz Open Access In this review, Tzilivaki et al. summarize current information on hippocampal GABAergic interneurons with an emphasis on their connectivity patterns, mechanisms of plasticity induction, and regulation of oscillatory rhythms during memory processing. Articles --------------------------------------------------------------- [Neuronal γ-secretase regulates lipid metabolism, linking cholesterol to synaptic dysfunction in Alzheimer’s disease](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00513-5%3Fdgcid=raven_jbs_etoc_email/1/0100018b43797131-28f71561-455e-4acb-9a87-e0aeb46085e0-000000/rJDUTRW07K0GSPKdNzEwKCjArihvkGDhmUQdIkm9eSM=323) Sofia Essayan-Perez, Thomas C. Südhof Open Access Essayan-Perez and Südhof chronically suppressed γ-secretase in human-induced neurons to record their synaptic activity and image their synapses. They show that γ-secretase regulates the probability of neurotransmitter release and synapse number and identify that the mechanism underlying changes in synaptic transmission occurs via the regulation of cholesterol levels by γ-secretase. [TMEM63 proteins function as monomeric high-threshold mechanosensitive ion channels](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00512-3%3Fdgcid=raven_jbs_etoc_email/1/0100018b43797131-28f71561-455e-4acb-9a87-e0aeb46085e0-000000/PnHnKcSwFfNUAA1QtJOCqMwd0sAxciRGyxgTaG7Ofeo=323) Wang Zheng, Shaun Rawson, Zhangfei Shen, Elakkiya Tamilselvan, Harper E. Smith, Julia Halford, Chen Shen, Swetha E. Murthy, Maximilian H. Ulbrich, Marcos Sotomayor, Tian-Min Fu, Jeffrey R. Holt Zheng et al. reveal that mammalian TMEM63 proteins form uniquely monomeric mechanosensitive ion channels, in contrast to dimeric OSCA channels in plants. The monomeric configurations of TMEM63s induce less favorable conformations of mechano-sensing domain IL2 and gating helix TM6 for channel activation, endowing high-threshold mechanosensitivties. [Three-dimensional reconstructions of mechanosensory end organs suggest a unifying mechanism underlying dynamic, light touch](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00634-7%3Fdgcid=raven_jbs_etoc_email/1/0100018b43797131-28f71561-455e-4acb-9a87-e0aeb46085e0-000000/hej6dOl9bmY9vL0BpkTVVIVt4ZxMJTKu5F2qlzp7mSw=323) Annie Handler, Qiyu Zhang, Song Pang, Tri M. Nguyen, Michael Iskols, Michael Nolan-Tamariz, Stuart Cattel, Rebecca Plumb, Brianna Sanchez, Karyl Ashjian, Aria Shotland, Bartianna Brown, Madiha Kabeer, Josef Turecek, Michelle M. DeLisle, Genelle Rankin, Wangchu Xiang, Elisa C. Pavarino, Nusrat Africawala, Celine Santiago, Wei-Chung Allen Lee, C. Shan Xu, David D. Ginty Open Access Handler, Zhang, et al. show restricted subcellular localization and function of Piezo2 to the sensory axons of mechanosensory end organs, and through high-resolution enhanced FIB-SEM, they reveal a conserved ultrastructural anchoring motif shared by end organs involved in dynamic, light touch. These findings suggest a unified model of mechanotransduction. [Biomechanical origins of proprioceptor feature selectivity and topographic maps in the Drosophila leg](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00542-1%3Fdgcid=raven_jbs_etoc_email/1/0100018b43797131-28f71561-455e-4acb-9a87-e0aeb46085e0-000000/J0QYinY34Okp8EW6Xxfd3y-BBTS043E4wZpacnDEGwU=323) Akira Mamiya, Anne Sustar, Igor Siwanowicz, Yanyan Qi, Tzu-Chiao Lu, Pralaksha Gurung, Chenghao Chen, Jasper S. Phelps, Aaron T. Kuan, Alexandra Pacureanu, Wei-Chung Allen Lee, Hongjie Li, Natasha Mhatre, John C. Tuthill The sense of self relies on proprioceptors, sensory neurons that detect mechanical forces within the body. Mamiya and colleagues investigate how proprioceptors detect specific mechanical features, such as joint position and movement. They show how feature selectivity arises from the biomechanics of the proprioceptive organ and discover topographic neural maps of leg joint angle and vibration frequency. [A novel immune modulator IM33 mediates a glia-gut-neuronal axis that controls lifespan](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00543-3%3Fdgcid=raven_jbs_etoc_email/1/0100018b43797131-28f71561-455e-4acb-9a87-e0aeb46085e0-000000/b9wcA6UzEaLKVIb3C3MLvzncpOlHa07El1zr4xScDuM=323) Wangchao Xu, Justin Rustenhoven, Christopher A. Nelson, Taitea Dykstra, Aura Ferreiro, Zachary Papadopoulos, Carey-Ann D. Burnham, Gautam Dantas, Daved H. Fremont, Jonathan Kipnis Xu et al. used Drosophila to identify a novel immune modulator that mediates a brain-gut-brain axis, connecting four aspects of aging: neuroinflammation, dysbiosis, oxidative stress, and sleep decline. [Input-specific synaptic depression shapes temporal integration in mouse visual cortex](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00510-X%3Fdgcid=raven_jbs_etoc_email/1/0100018b43797131-28f71561-455e-4acb-9a87-e0aeb46085e0-000000/ejUjirulQFvcdkB5hF_lzEXUNnSgra0FaweaDKTnBCY=323) Jennifer Y. Li, Lindsey L. Glickfeld Sensory adaptation filters stimulus information by reducing responses to redundant inputs. Using a combination of in vivo and in vitro electrophysiological approaches, Li and Glickfeld find that short-term depression generates stimulus-specific adaptation in superficial layers of mouse primary visual cortex and shapes temporal integration at a seconds-long timescale. [A common thalamic hub for general and defensive arousal control](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00540-8%3Fdgcid=raven_jbs_etoc_email/1/0100018b43797131-28f71561-455e-4acb-9a87-e0aeb46085e0-000000/G52HQDMz56Tfq7bj7Jur81R2jUxGuJjRqHjYwmyEh0c=323) Yiwei Wang, Ling You, KaMun Tan, Meijie Li, Jingshan Zou, Zhifeng Zhao, Wenxin Hu, Tianyu Li, Fenghua Xie, Caiqin Li, Ruizhi Yuan, Kai Ding, Lingwei Cao, Fengyuan Xin, Congping Shang, Miaomiao Liu, Yixiao Gao, Liqiang Wei, Zhiwei You, Xiaorong Gao, Wei Xiong, Peng Cao, Minmin Luo, Feng Chen, Kun Li, Jiamin Wu, Bo Hong, Kexin Yuan Wang et al. show that the medial sector of the auditory thalamus, a multimodal association thalamic nucleus, in mice is implicated in the control of both general and defensive arousal. This finding may shed light on the comorbidity of sleep disturbances and abnormal sensory sensitivity in specific brain disorders. [Neural dynamics in the limbic system during male social behaviors](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00544-5%3Fdgcid=raven_jbs_etoc_email/1/0100018b43797131-28f71561-455e-4acb-9a87-e0aeb46085e0-000000/uY57oTOCZp-a9nxnujlGFCL8EmGWysMkgQM1_CXMiYA=323) Zhichao Guo, Luping Yin, Veronica Diaz, Bing Dai, Takuya Osakada, Julieta E. Lischinsky, Jonathan Chien, Takashi Yamaguchi, Ashley Urtecho, Xiaoyu Tong, Zhe S. Chen, Dayu Lin Guo et al. use multi-fiber photometry to simultaneously record Ca2+ activity from 13 brain regions in the expanded social behavior network during mating and fighting in male mice. The recordings reveal widespread activities in the network that evolve in distinct ways throughout male-male and male-female social interactions. [Single basolateral amygdala neurons in macaques exhibit distinct connectional motifs with frontal cortex](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00711-0%3Fdgcid=raven_jbs_etoc_email/1/0100018b43797131-28f71561-455e-4acb-9a87-e0aeb46085e0-000000/D2xXYOUzYgHWGqfExcJ9nSbpjxx2xnOsvLnti6dERH8=323) Zachary R. Zeisler, Liza London, William G. Janssen, J. Megan Fredericks, Catherine Elorette, Atsushi Fujimoto, Huiqing Zhan, Brian E. Russ, Roger L. Clem, Patrick R. Hof, Frederic M. Stoll, Peter H. Rudebeck Zeisler et al. utilize multiplexed analysis of projections by sequencing (MAPseq) to profile the anatomical connections of single neurons in primate basolateral amygdala. Analyzing the connections of more than 3,000 single neurons, they identify highly structured and repeating single-neuron projection motifs that are indicative of separable BLA-centered networks. [Top-down control of exogenous attentional selection is mediated by beta coherence in prefrontal cortex](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00506-8%3Fdgcid=raven_jbs_etoc_email/1/0100018b43797131-28f71561-455e-4acb-9a87-e0aeb46085e0-000000/d2_jYO44ne2_vtQcjj6tJ9lUD0SzbB3xT47mahvwrPA=323) Agrita Dubey, David A. Markowitz, Bijan Pesaran Dubey et al. demonstrate inhibitory network mechanisms of top-down control of attentional selection in the prefrontal cortex. A specific neuronal-response class—visual-movement neurons—encodes exogenous and endogenous selection. Coherent beta activity selectively suppresses sensory information flow in these neurons to favor endogenous selection during conflict. 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