Neuron: August 16, 2023 (Volume 111, Issue 16)

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[Cell Press collection on neurodegenerative disease](%2F%2Fwww.cell.com%2Fcp%2Fcollections-neurodegenerative-disease/1/01000189ff1766d9-92bfb304-b9d2-45d7-a30e-98e56a44091b-000000/Cdxa6GYKJyLsEQRBdHIET46w5VNTdqu669b9NLUoGBI=314) Read the latest translational research and fundamental mechanisms of neurodegenerative disorders. [Webinar: Single-cell genomics for clinical samples](%2F%2Fwww.workcast.com%2Fregister%3Fcpak=9066443499831518%26referrer=etoc/1/01000189ff1766d9-92bfb304-b9d2-45d7-a30e-98e56a44091b-000000/9KnEnSQLF9zOhZg5J7mD2zqdPTJeJbz-8eae8bB1u0g=314) August 2, 2023, 11:00 am ET | available live & on demand [Inclusive language in scientific publishing: Sex and gender](%2F%2Fwww.cell.com%2Fvideo-do%2Finclusive-language-sex-and-gender/1/01000189ff1766d9-92bfb304-b9d2-45d7-a30e-98e56a44091b-000000/LnbujhhJKx4p1gX46rzWPO1epZo0-zn-QaFgvAq_mxQ=314) Watch this recent panel on making the language used to describe sex and gender more inclusive and accurate. Featured articles --------------------------------------------------------------- [Antisense drugs for rare and ultra-rare genetic neurological diseases](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00401-4/1/01000189ff1766d9-92bfb304-b9d2-45d7-a30e-98e56a44091b-000000/8UxQ66sTPnLzXC3SHyrqnyfoKHF3Fz8mNSxbHqWzd6Y=314) McCauley et al. [20 years of the default mode network: A review and synthesis](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00308-2/1/01000189ff1766d9-92bfb304-b9d2-45d7-a30e-98e56a44091b-000000/2hQBzOjrzyuO6zVSAYTiTuNck98HlDtrqtyRbYCrHdk=314) Vinod Menon [Causal evidence for the processing of bodily self in the anterior precuneus](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00386-0/1/01000189ff1766d9-92bfb304-b9d2-45d7-a30e-98e56a44091b-000000/xfWa7KuwHeJlcpRRoOzm_8BCKBxCvJxLx0deUrf-VA8=314) Lyu et al. [Labeling PIEZO2 activity in the peripheral nervous system](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00388-4/1/01000189ff1766d9-92bfb304-b9d2-45d7-a30e-98e56a44091b-000000/1pmEAAdNclSOPilkx8SmLPBrIXG3elfQRPV-scWrx0o=314) Villarino et al. Online now --------------------------------------------------------------- [Neural dynamics in the limbic system during male social behaviors](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00544-5/1/01000189ff1766d9-92bfb304-b9d2-45d7-a30e-98e56a44091b-000000/eGLQWTxzXO78IqQbh6HogC_J3jcJGYGeq1IGSfZiunE=314) Guo et al. [Temporally specific patterns of neural activity in interconnected corticolimbic structures during reward anticipation](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00545-7/1/01000189ff1766d9-92bfb304-b9d2-45d7-a30e-98e56a44091b-000000/8ewd5f7WLuRtLYSCfDTZp2nP3E5yP-32F7mynqaKqOU=314) Young et al. [Continuing trial responsibilities for implantable neural devices](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00541-X/1/01000189ff1766d9-92bfb304-b9d2-45d7-a30e-98e56a44091b-000000/NrMkx5mjWF4kD1UZcFjDIPKKKrlRQF8L3wCX4391ESA=314) Hendriks et al. [A novel immune modulator IM33 mediates a glia-gut-neuronal axis that controls lifespan](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00543-3/1/01000189ff1766d9-92bfb304-b9d2-45d7-a30e-98e56a44091b-000000/laRtSdF3-XHZvRfcxQB8FJTvwYJqHC09ERTBYSSbgZU=314) Xu et al. Table of Contents Previews --------------------------------------------------------------- [Spinocerebellar ataxia type 1: It’s not just about Purkinje cells](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00547-0%3Fdgcid=raven_jbs_etoc_email/1/01000189ff1766d9-92bfb304-b9d2-45d7-a30e-98e56a44091b-000000/OhqVxVC26VMvRIbE1vTAFy8gsi5g63S9MZ4IGgiK80g=314) Puneet Opal In this issue of Neuron, Pilotto et al. use state-of-the-art in vivo imaging in mice to show that excitatory/inhibitory imbalance drives SCA1 pathophysiology, with hyperexcitable molecular layer interneurons overinhibiting Purkinje cells, leading to hallmark neurodegeneration. [Fish who act on impulse must learn the consequences](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00549-4%3Fdgcid=raven_jbs_etoc_email/1/01000189ff1766d9-92bfb304-b9d2-45d7-a30e-98e56a44091b-000000/wZujJIyKAiRBhHyuxGQP6rt0xYWaRcqo7jW6lZD7SAU=314) WenXi Zhou, David M. Schneider Animals learn internal models that link specific behaviors to their anticipated sensory outcomes. In this issue of Neuron, Wallach and Sawtell discover that freely moving fish learn how the sensory outcome of a single behavior changes with local context. NeuroView --------------------------------------------------------------- [Antisense drugs for rare and ultra-rare genetic neurological diseases](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00401-4%3Fdgcid=raven_jbs_etoc_email/1/01000189ff1766d9-92bfb304-b9d2-45d7-a30e-98e56a44091b-000000/cqNej9CVb8CoCQE5Xc9U0cUdwUQ7tCP0654KulX2660=314) Madelyn E. McCauley, C. Frank Bennett The regulatory approvals of nusinersen and tofersen, plus the large body of clinical and preclinical data from other drugs, have significantly de-risked antisense technology for neurological diseases. The platform learnings over the last 2 decades can be applied to subsequent drugs to improve the efficiency of discovering effective neuro-therapeutics. Perspective --------------------------------------------------------------- [20 years of the default mode network: A review and synthesis](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00308-2%3Fdgcid=raven_jbs_etoc_email/1/01000189ff1766d9-92bfb304-b9d2-45d7-a30e-98e56a44091b-000000/F5e_6FCb-nRJh8HU3kcVf3K5dDh6MEqu7OcgOXOwf9k=314) Vinod Menon The author reviews the role of the default mode network (DMN) in human cognition, proposing that the DMN integrates and broadcasts memory, language, and semantic representations to create an internal narrative crucial for introspection, social engagement, and consciousness. NeuroResource --------------------------------------------------------------- [Labeling PIEZO2 activity in the peripheral nervous system](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00388-4%3Fdgcid=raven_jbs_etoc_email/1/01000189ff1766d9-92bfb304-b9d2-45d7-a30e-98e56a44091b-000000/qdFuGvD6K9gxjQogiaYzubCTRS3js66bnMtEwkR7Vxs=314) Nicholas W. Villarino, Yasmeen M.F. Hamed, Britya Ghosh, Adrienne E. Dubin, Amanda H. Lewis, Max A. Odem, Meaghan C. Loud, Yu Wang, M. Rocio Servin-Vences, Ardem Patapoutian, Kara L. Marshall Open Access Mechanosensory processes are critical for the function of many organ systems. Villarino et al. find that the fluorescent dye FM 1-43 specifically labels the activity of the mechanosensitive ion channel PIEZO2 in mouse sensory neurons in vivo. This tool enables characterization of neuronal processes that rely on this important mechanosensor. Case study --------------------------------------------------------------- [Causal evidence for the processing of bodily self in the anterior precuneus](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00386-0%3Fdgcid=raven_jbs_etoc_email/1/01000189ff1766d9-92bfb304-b9d2-45d7-a30e-98e56a44091b-000000/zDcTgm1qY5AxPmaNSYGrSG2Sg2e_6g61hlWkW4DhH_4=314) Dian Lyu, James Robert Stieger, Cindy Xin, Eileen Ma, Zoe Lusk, Mariel Kalkach Aparicio, Katherine Werbaneth, Claire Megan Perry, Karl Deisseroth, Vivek Buch, Josef Parvizi Lyu et al. studied the human posteromedial cortex using a combination of fMRI, intracranial EEG, and direct cortical stimulations. They argue that the anterior PMC is important for the sense of physical self, the distortion of which causes self-dissociation. Report --------------------------------------------------------------- [Dissociation of vicarious and experienced rewards by coupling frequency within the same neural pathway](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00393-8%3Fdgcid=raven_jbs_etoc_email/1/01000189ff1766d9-92bfb304-b9d2-45d7-a30e-98e56a44091b-000000/w56VK198y6jnYi6h6Vluo5prto3GnV6kWQwPkjg5MOk=314) Philip T. Putnam, Cheng-Chi J. Chu, Nicholas A. Fagan, Olga Dal Monte, Steve W.C. Chang Putnam et al. investigated specific interareal coordination between the anterior cingulate cortex and the amygdala underlying vicarious and experienced rewards arising from making social decisions. Vicarious and experienced reward outcomes were communicated using distinct frequency channels within the same shared pathway in the primate brain. Articles --------------------------------------------------------------- [Early molecular layer interneuron hyperactivity triggers Purkinje neuron degeneration in SCA1](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00389-6%3Fdgcid=raven_jbs_etoc_email/1/01000189ff1766d9-92bfb304-b9d2-45d7-a30e-98e56a44091b-000000/ZWwchxMNxwO1DAhdEcp-wOdbyf-1eHYNCOJaV9k6ygE=314) Federica Pilotto, Christopher Douthwaite, Rim Diab, XiaoQian Ye, Zahraa Al qassab, Christoph Tietje, Meriem Mounassir, Adolfo Odriozola, Aishwarya Thapa, Ronald A.M. Buijsen, Sophie Lagache, Anne-Christine Uldry, Manfred Heller, Stefan Müller, Willeke M.C. van Roon-Mom, Benoît Zuber, Sabine Liebscher, Smita Saxena Open Access Pilotto et al. identify early hyperexcitability of molecular layer interneurons (MLINs) in SCA1 driving circuit dysfunction and motor deficits. Inhibition of MLINs in SCA1 mice induced lasting improvements of circuit pathology and behavior. MLIN proteomics revealed a signature accounting for hyperexcitability, conserved in patient-derived GABAergic neurons. [A Noelin-organized extracellular network of proteins required for constitutive and context-dependent anchoring of AMPA-receptors](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00546-9%3Fdgcid=raven_jbs_etoc_email/1/01000189ff1766d9-92bfb304-b9d2-45d7-a30e-98e56a44091b-000000/CIMCVkYS-gj81jApF8hZHxRh7T6rsw6_EaxMgkBlboM=314) Sami Boudkkazi, Jochen Schwenk, Naoki Nakaya, Aline Brechet, Astrid Kollewe, Harumi Harada, Wolfgang Bildl, Akos Kulik, Lijin Dong, Afia Sultana, Gerd Zolles, Uwe Schulte, Stanislav Tomarev, Bernd Fakler Open Access Processing and storage of information in the mammalian brain critically rely on AMPA-receptors (AMPARs) and their context-dependent dynamics. Boudkkazi et al. show that distribution and dynamics of AMPARs in the surface membrane are controlled by Noelins, highly conserved secreted proteins that are abundantly expressed throughout the brain in a cell-type-specific manner. [Direct and indirect neurogenesis generate a mosaic of distinct glutamatergic projection neuron types in cerebral cortex](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00394-X%3Fdgcid=raven_jbs_etoc_email/1/01000189ff1766d9-92bfb304-b9d2-45d7-a30e-98e56a44091b-000000/R-Iknsf5DsRwG0Y18Kl8ULqPcs9kNfrhmLzjkGLRL4U=314) Dhananjay Huilgol, Jesse M. Levine, William Galbavy, Bor-Shuen Wang, Miao He, Shreyas M. Suryanarayana, Z. Josh Huang Cortical projection neurons (PNs) are born through direct (dNG) and indirect neurogenesis (iNG). Huilgol et al. establish a genetic strategy to visualize dNG and iNG simultaneously and show their differential contribution to cortical structures. In the neocortex, dNG generates all PN classes; iNG differentially amplifies and diversifies PNs within each class. [An internal model for canceling self-generated sensory input in freely behaving electric fish](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00392-6%3Fdgcid=raven_jbs_etoc_email/1/01000189ff1766d9-92bfb304-b9d2-45d7-a30e-98e56a44091b-000000/mQku_y622F95BaYEySS_GFtoiUZdkojSe4gH7O6hI0I=314) Avner Wallach, Nathaniel B. Sawtell Wallach and Sawtell use recordings from a cerebellum-like circuit in freely swimming electric fish to examine how the nervous system distinguishes self-generated from externally generated sensory input under naturalistic conditions. They show that motor signals and electrosensory feedback are combined to generate environmental-state-dependent predictions of the sensory consequences of self-motion. [Critical role of lateral habenula circuits in the control of stress-induced palatable food consumption](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00383-5%3Fdgcid=raven_jbs_etoc_email/1/01000189ff1766d9-92bfb304-b9d2-45d7-a30e-98e56a44091b-000000/4oDInZOLmOCW9g11JgUFyiyRxksmkDumF-7Bz5h4npo=314) Chi Kin Ip, Jemma Rezitis, Yue Qi, Nikita Bajaj, Julia Koller, Aitak Farzi, Yan-Chuan Shi, Ramon Tasan, Lei Zhang, Herbert Herzog Neuropeptide Y is a major regulator of feeding and also protects from adverse effects caused by stress, but how this is altered under chronic stress is unclear. Here, Ip et al. discovered a lateral habenular, Npy1r-neuron-specific pathway that drives palatable food intake in mice in an attempt to overcome the negative valence of chronic stress. [A neural mechanism for terminating decisions](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00400-2%3Fdgcid=raven_jbs_etoc_email/1/01000189ff1766d9-92bfb304-b9d2-45d7-a30e-98e56a44091b-000000/09FQXW-TWxpWCHvgabWONbBYFe-Bq8UFihbQb_RIHmY=314) Gabriel M. Stine, Eric M. Trautmann, Danique Jeurissen, Michael N. Shadlen Open Access LIP and SC are interconnected areas important for perceptual decision making. Stine et al. show that these areas play distinct roles during decisions. LIP represents the accumulation of evidence, whereas SC is critical for terminating this process and enacting the relevant motor plan. 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