Neuron: March 1, 2023 (Volume 111, Issue 5)

[Advertisement] [Cell press](%2F%2Fwww.cell.com/1/010001869e1e13df-de5ca56c-f3d2-412e-8142-33782bd03ddc-000000/JboTVHLr5mzKLhxFt_K5FVU6FnVB4kdiufM7KnyQrsI=290) [Facebook](%2F%2Ffacebook.com%2Fcellpress/1/010001869e1e13df-de5ca56c-f3d2-412e-8142-33782bd03ddc-000000/5GjQkvIm3vnv6lTVmeGjn0T3rQljghxGB2IOkfxxKfk=290) [Twitter](%2F%2Ftwitter.com%2FNeuroCellPress/1/010001869e1e13df-de5ca56c-f3d2-412e-8142-33782bd03ddc-000000/DJlCGshNBVzywp-ZM6X4cDIoRCFPsoRJ2-apIVkN7Vg=290) [Youtube](%2F%2Fwww.youtube.com%2Fuser%2Fcellvideoabstracts/1/010001869e1e13df-de5ca56c-f3d2-412e-8142-33782bd03ddc-000000/h1ooyScBP9IwRS-U6nfnSNb9GoEEK13TzhPtc8JytvI=290) [Weibo](%2F%2Fweibo.com%2FCellPress/1/010001869e1e13df-de5ca56c-f3d2-412e-8142-33782bd03ddc-000000/dXUDGh0chbymeTqisjYbjtYDObKMMp8QEhCsWh6IQ4E=290) [Issue cover](%2F%2Fwww.cell.com%2Fneuron%2Fissue%3Fpii=S0896627322X00068/1/010001869e1e13df-de5ca56c-f3d2-412e-8142-33782bd03ddc-000000/HBFbcmNGOSUHWH2rOwFpQWx6GjGcuXUGaq3IDyDnW_k=290) [Mar 01, 2023](%2F%2Fwww.cell.com%2Fneuron%2Fissue%3Fpii=S0896627322X00068/2/010001869e1e13df-de5ca56c-f3d2-412e-8142-33782bd03ddc-000000/QCBNMafffddJrzFrSAR0eVk2j-9pzffpBybYh4PuC-o=290) Vol. 111, Iss. 5 [Website](%2F%2Fwww.cell.com%2Fneuron%2Fhome%3Fdgcid=raven_jbs_etoc_email/1/010001869e1e13df-de5ca56c-f3d2-412e-8142-33782bd03ddc-000000/Mz6QwDatJTXwZO_BrX-rvUrxH344kagbEnaRxFDQC5I=290) [Table of Contents](%2F%2Fwww.cell.com%2Fneuron%2Fissue%3Fpii=S0896627322X00068%26dgcid=raven_jbs_etoc_email/1/010001869e1e13df-de5ca56c-f3d2-412e-8142-33782bd03ddc-000000/ThXGcDuUZujSqcL2X3yhx2EvGb6057Wby7MLgbz5h0M=290) [Online Now](%2F%2Fwww.cell.com%2Fneuron%2Fnewarticles%3Fdgcid=raven_jbs_etoc_email/1/010001869e1e13df-de5ca56c-f3d2-412e-8142-33782bd03ddc-000000/dKTtngebsgRFhgIT7KrQeHkOW8G38c7cwu-t0RNIXjI=290) [Archive](%2F%2Fwww.cell.com%2Fneuron%2Farchive%3Fdgcid=raven_jbs_etoc_email/1/010001869e1e13df-de5ca56c-f3d2-412e-8142-33782bd03ddc-000000/dmW3IfvpBaMR7SNIOB3XkrZbwSyZZn3Q_0v3LpW3ZmI=290) Highlights Announcements --------------------------------------------------------------- [Neuroimaging troubleshooting?](%2F%2Fstar-protocols.cell.com%2Fprotocols%2F2401/1/010001869e1e13df-de5ca56c-f3d2-412e-8142-33782bd03ddc-000000/nJ1Ax2hS8p0GPQ9MMDl2Bqr_G2S7KYuYAMpFrQTPZaA=290) Ask a question, and protocol authors within the same field will respond with troubleshooting tips. [Access Med's most downloaded papers in 2022](%2F%2Fwww.cell.com%2Fmed%2Fcollections%2Fmost-accessed-2022/1/010001869e1e13df-de5ca56c-f3d2-412e-8142-33782bd03ddc-000000/dyqI1r8ii5dy7ZjWEf34BBgPdh2Fyv9u4KRGT1odKh0=290) Read the articles. [Cell Symposia: The conceptual power of single cell biology](%2F%2Fwww.cell-symposia.com%2Fconceptual-single-cells-2023%2F/1/010001869e1e13df-de5ca56c-f3d2-412e-8142-33782bd03ddc-000000/WyKIWNvempssPKdE3iewOWhYbPN-W-ZeJoElew0mER8=290) August 28–30, 2023 | San Diego, CA, USA. [Cell Metabolism recognizes World Obesity Day](%2F%2Fwww.cell.com%2Fcell-metabolism%2Fcollections%2Fdiabetes-obesity/1/010001869e1e13df-de5ca56c-f3d2-412e-8142-33782bd03ddc-000000/UjyyiKJhcUs0V8ZjADFy1cBnIYEjMdY701nbNGAy2Eg=290) Read the obesity and diabetes collection, freely available through the end of March 2023. Featured articles --------------------------------------------------------------- [The costs and benefits of psychedelics on cognition and mood](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)01152-7/1/010001869e1e13df-de5ca56c-f3d2-412e-8142-33782bd03ddc-000000/LY_BM2CnNxWhCNG1ZZsMTNLKMqNGPlBxXqfssYL8F4M=290) Sayali et al. [The centrality of population-level factors to network computation is demonstrated by a versatile approach for training spiking networks](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)01080-7/1/010001869e1e13df-de5ca56c-f3d2-412e-8142-33782bd03ddc-000000/BTAA8TG33zM9Z15mkqbWONCrib6F_Pw4KcbUi1SnPhk=290) DePasquale et al. [mRNA transport, translation, and decay in adult mammalian central nervous system axons](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)01088-1/1/010001869e1e13df-de5ca56c-f3d2-412e-8142-33782bd03ddc-000000/qo7P4n23oeD8aIRTyxrR8tKaxGGuINz_7IvmqoCI1dA=290) Jung et al. [Microglia drive transient insult-induced brain injury by chemotactic recruitment of CD8+ T lymphocytes](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)01082-0/1/010001869e1e13df-de5ca56c-f3d2-412e-8142-33782bd03ddc-000000/_64oRKSjPKSYg1STtYx5EUU4gnKayzAbTDXlYR94CEc=290) Shi et al. Online now --------------------------------------------------------------- [Hidden behavioral fingerprints in epilepsy](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00081-8/1/010001869e1e13df-de5ca56c-f3d2-412e-8142-33782bd03ddc-000000/OHj9pkq1D5zZODUx3054k8i14eyHxPBHwkoKq_Sy3wY=290) Gschwind et al. [EndophilinA-dependent coupling between activity-induced calcium influx and synaptic autophagy is disrupted by a Parkinson-risk mutation](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00079-X/1/010001869e1e13df-de5ca56c-f3d2-412e-8142-33782bd03ddc-000000/PIW8OWgfsMVOdfmV611gZTroz5zgiR4frHIGx1_s0bg=290) Bademosi et al. [DNA-initiated epigenetic cascades driven by C9orf72 hexanucleotide repeat](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00072-7/1/010001869e1e13df-de5ca56c-f3d2-412e-8142-33782bd03ddc-000000/oVtjVtKl4pkvKoxWCluQFyukviWTQ7G8ctOx_gSEZGA=290) Liu et al. [Development of top-down cortical propagations in youth](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00038-7/1/010001869e1e13df-de5ca56c-f3d2-412e-8142-33782bd03ddc-000000/i9GtR5FVEBiOq1AoXIGZ2Q-t8NxQEO22jjQjSojkJ7g=290) Pines et al. Table of Contents Previews --------------------------------------------------------------- [Microglia as drivers of neurodegeneration: The role of innate-adaptive immune signaling](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00109-5%3Fdgcid=raven_jbs_etoc_email/1/010001869e1e13df-de5ca56c-f3d2-412e-8142-33782bd03ddc-000000/97N34CPpfUcBXjJTyrAgN93XuEwe5MbrlBMvXFBWtOk=290) Reena Kumari, John C. Gensel Microglia contribute to neurodegeneration through numerous mechanisms. In this issue of Neuron, Shi et al.1 identify a maladaptive innate-adaptive immune axis with CD8+ T cells, mediated through microglial CCL2/8 and CCR2/5, in radiation-induced brain injury and stroke. Their findings across species and injuries suggest broader implications for neurodegenerative conditions. [Serotonin has an eye for detail](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00080-6%3Fdgcid=raven_jbs_etoc_email/1/010001869e1e13df-de5ca56c-f3d2-412e-8142-33782bd03ddc-000000/fSOhjLThdsaUhjytaQEs9jw_tkqNUJQ5p1UOdgFWJ5E=290) Anton Sumser, Laura Busse In this issue of Neuron, Reggiani et al.1 show that serotonin and arousal suppress retinal inputs to the thalamus with opposing feature sensitivity, providing an elegant means for neuromodulation to selectively filter early visual processing. [New revelations from the zone of uncertainty](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00078-8%3Fdgcid=raven_jbs_etoc_email/1/010001869e1e13df-de5ca56c-f3d2-412e-8142-33782bd03ddc-000000/l_ScBtXuDJzOncTg741Z34B844fbxRdwNEVKs_0pRUk=290) Meenakshi M. Asokan, Daniel B. Polley In this issue of Neuron, Schroeder et al.1 provide the first functional account of inhibitory signaling from the zona incerta to neocortex in behaving animals. Incertocortical afferents exhibit bidirectional plasticity during threat learning, highlighting a distinct top-down signaling regime. Letters --------------------------------------------------------------- [A response to claims of emergent intelligence and sentience in a dish](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00113-7%3Fdgcid=raven_jbs_etoc_email/1/010001869e1e13df-de5ca56c-f3d2-412e-8142-33782bd03ddc-000000/xYq7hmeX8hIw-4Id6AvjEJylfYqpL-QVaB7w0tTPK40=290) Fuat Balci, Suliann Ben Hamed, Thomas Boraud, Sébastien Bouret, Thomas Brochier, Cédric Brun, Jeremiah Y. Cohen, Etienne Coutureau, Marc Deffains, Valérie Doyère, Georgia G. Gregoriou, J. Alexander Heimel, Bjørg Elisabeth Kilavik, Daeyeol Lee, Eric C. Leuthardt, Zachary F. Mainen, Mackenzie Mathis, Ilya E. Monosov, Jérémie Naudé, Amy L. Orsborn, Camillo Padoa-Schioppa, Emmanuel Procyk, Bernardo Sabatini, Jérôme Sallet, Carmen Sandi, Jeffrey D. Schall, Alireza Soltani, Karel Svoboda, Charles R.E. Wilson, Jan Zimmermann [Scientific communication and the semantics of sentience](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00112-5%3Fdgcid=raven_jbs_etoc_email/1/010001869e1e13df-de5ca56c-f3d2-412e-8142-33782bd03ddc-000000/Hs_nIGWEgtxlI1lhXhZZo7MErW760-3T_129dprKr-4=290) Brett J. Kagan, Adeel Razi, Anjali Bhat, Andy C. Kitchen, Nhi T. Tran, Forough Habibollahi, Moein Khajehnejad, Bradyn J. Parker, Ben Rollo, Karl J. Friston [Conceptual conundrums for neuroscience](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00120-4%3Fdgcid=raven_jbs_etoc_email/1/010001869e1e13df-de5ca56c-f3d2-412e-8142-33782bd03ddc-000000/oS52_XpzXIFskZ34tUWEF3S3z8m47vXo4DyZ033pCkc=290) Karen S. Rommelfanger, Khara M. Ramos, Arleen Salles [Elevated L1 expression in ataxia telangiectasia likely explained by an RNA-seq batch effect](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00111-3%3Fdgcid=raven_jbs_etoc_email/1/010001869e1e13df-de5ca56c-f3d2-412e-8142-33782bd03ddc-000000/KYZSRzZixo5x1fc7UkOIizJPnjWx5EGi3wqQvs36aUk=290) Geoffrey J. Faulkner [Response to: Elevated L1 expression in ataxia telangiectasia likely explained by an RNA-seq batch effect](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00110-1%3Fdgcid=raven_jbs_etoc_email/1/010001869e1e13df-de5ca56c-f3d2-412e-8142-33782bd03ddc-000000/W_LiGImfIbZ_azek7vzL8Bl4pBLalhk8BPTZ9q5qiq8=290) Takehiro Takahashi, Milan Stoiljkovic, Eric Song, Xiao-Bing Gao, Yuki Yasumoto, Eriko Kudo, Fernando Carvalho, Yong Kong, Annsea Park, Marya Shanabrough, Klara Szigeti-Buck, Zhong-Wu Liu, Ashley Kristant, Yalan Zhang, Parker Sulkowski, Peter M. Glazer, Leonard K. Kaczmarek, Tamas L. Horvath, Akiko Iwasaki Review --------------------------------------------------------------- [The costs and benefits of psychedelics on cognition and mood](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)01152-7%3Fdgcid=raven_jbs_etoc_email/1/010001869e1e13df-de5ca56c-f3d2-412e-8142-33782bd03ddc-000000/hvU_sgQtBp5-OH_KIP5-0igTxUzVCmn7385KPog7iwM=290) Ceyda Sayalı, Frederick S. Barrett The acute effects of psychedelics on creativity are explored from the lens of a cognitive control framework. While there is growing evidence that psychedelics may bias cognitive control processes in favor of cognitive flexibility at the cost of cognitive stability, the literature on the effects of psychedelics on cognition is mixed. The mixed results may be due to the task dependence of the cognitive processes that are being measured as well as the dose and baseline dependence of psychoactive drug effects. Finally, the value of cognitive control strategies that are learned during acute psychedelic experiences is proposed to contribute to long-term therapeutic outcomes. Viewpoint --------------------------------------------------------------- [The centrality of population-level factors to network computation is demonstrated by a versatile approach for training spiking networks](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)01080-7%3Fdgcid=raven_jbs_etoc_email/1/010001869e1e13df-de5ca56c-f3d2-412e-8142-33782bd03ddc-000000/_DmmmG8r1BW1IrSy_ahqd_Ey7I25JyFWKmWKwdmpIY8=290) Brian DePasquale, David Sussillo, L.F. Abbott, Mark M. Churchland DePasquale et al. introduce a method for building artificial spiking neural networks using latent factors, a powerful concept in data analysis not yet grounded in neurophysiological terms. Factors are computationally central, enabling robust, flexible learning. Networks clarify that “factor” and firing rate are concretely defined and crucial to understanding computation. NeuroResource --------------------------------------------------------------- [mRNA transport, translation, and decay in adult mammalian central nervous system axons](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)01088-1%3Fdgcid=raven_jbs_etoc_email/1/010001869e1e13df-de5ca56c-f3d2-412e-8142-33782bd03ddc-000000/4T3yco_ffe_JNCrONA5fYQ7Axr8Z8FBhRuZjiRvlyPE=290) Jane Jung, Jiyeon Ohk, Hyeyoung Kim, Christine E. Holt, Hyun Jung Park, Hosung Jung Neurons make proteins on site by local translation, but how transcript-selective axonal transport and translation are regulated is unclear. Jung et al. report techniques to isolate mRNAs present or translated in axon terminals of retinal ganglion cells in mouse, which allow a genome-wide analysis of axonal mRNA transport, translation, and decay. Report --------------------------------------------------------------- [Spinal VGLUT3 lineage neurons drive visceral mechanical allodynia but not sensitized visceromotor reflexes](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)01076-5%3Fdgcid=raven_jbs_etoc_email/1/010001869e1e13df-de5ca56c-f3d2-412e-8142-33782bd03ddc-000000/xbPwfG1KDTj4XukjQ_Bg0BMosenLdL2ePxOYoxCzPxM=290) Lu Qi, Shing-Hong Lin, Qiufu Ma Qi et al. uncover a spinal substrate that is required to drive aversion evoked by low-intensity colorectal distension in mice with gastrointestinal inflammation, but which is dispensable for visceromotor responses, thereby calling for a revisit on how to measure the affective component of visceral pain. Articles --------------------------------------------------------------- [Glioma epileptiform activity and progression are driven by IGSF3-mediated potassium dysregulation](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00037-5%3Fdgcid=raven_jbs_etoc_email/1/010001869e1e13df-de5ca56c-f3d2-412e-8142-33782bd03ddc-000000/y4h_cHDMw6Nftk1URu8Dcu0_ViXwK2dHZxrnkA8iyGM=290) Rachel Naomi Curry, Isamu Aiba, Jochen Meyer, Brittney Lozzi, Yeunjung Ko, Malcolm Ford McDonald, Anna Rosenbaum, Alexis Cervantes, Emmet Huang-Hobbs, Carolina Cocito, Jeffrey Peter Greenfield, Ali Jalali, Jay Gavvala, Carrie Mohila, Akdes Serin Harmanci, Jeffrey Noebels, Ganesh Rao, Benjamin Deneen Seizures are a pathophysiological feature of malignant glioma and contribute to tumor progression. Employing a human-to-mouse in vivo functionalization pipeline, we identify IGSF3 as a regulator of glioma progression and brain network hyperactivity. Associated potassium dysregulation contributes to network hyperactivity, which in vivo imaging maps to the tumor leading edge. [Microglia drive transient insult-induced brain injury by chemotactic recruitment of CD8+ T lymphocytes](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)01082-0%3Fdgcid=raven_jbs_etoc_email/1/010001869e1e13df-de5ca56c-f3d2-412e-8142-33782bd03ddc-000000/_v_ZqtN8n03xj9UQikkIxrjEInFOD5DiAm7l8mynl7w=290) Zhongshan Shi, Pei Yu, Wei-Jye Lin, Sitai Chen, Xia Hu, Siqi Chen, Jinping Cheng, Qiang Liu, Yuhua Yang, Shaojian Li, Zhan Zhang, Jiatian Xie, Jingru Jiang, Baixuan He, Yi Li, Honghong Li, Yongteng Xu, Junbo Zeng, Jialin Huang, Jinghong Mei, Jinhua Cai, Jiongxue Chen, Long-Jun Wu, Ho Ko, Yamei Tang Using single-cell transcriptomic and immune repertoire sequencing, Shi et al. identify a chemotactic action mediated by microglia-derived CCL2/CCL8 chemokines in recruiting CD8+ T cells. These cause brain injuries in radiation-induced brain injury and ischemic stroke models, providing mechanistic insight and a potential therapeutic strategy for non-infectious brain diseases. [Brainstem serotonin neurons selectively gate retinal information flow to thalamus](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)01079-0%3Fdgcid=raven_jbs_etoc_email/1/010001869e1e13df-de5ca56c-f3d2-412e-8142-33782bd03ddc-000000/d9RwXVAbwjzX2OB9zZuW3_8RdsaBz4TAuu8AUKu9k-0=290) Jasmine D.S. Reggiani, Qiufen Jiang, Melanie Barbini, Andrew Lutas, Liang Liang, Jesseba Fernando, Fei Deng, Jinxia Wan, Yulong Li, Chinfei Chen, Mark L. Andermann Reggiani et al. find that, in awake mouse primary thalamus, serotonin from brainstem inputs suppresses retinal axon bouton presynaptic calcium signals and glutamate release. Different retinal axon classes were more strongly suppressed by serotonin versus by pupil-linked arousal, indicating diverse gating of visual information streams before they activate thalamocortical neurons. [Inhibitory top-down projections from zona incerta mediate neocortical memory](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)01083-2%3Fdgcid=raven_jbs_etoc_email/1/010001869e1e13df-de5ca56c-f3d2-412e-8142-33782bd03ddc-000000/N5rKDMmFfXmO_DiAfH9l6RPW5LHpg6hGMLhzLxZEbu0=290) Anna Schroeder, M. Belén Pardi, Joram Keijser, Tamas Dalmay, Ayelén I. Groisman, Erin M. Schuman, Henning Sprekeler, Johannes J. Letzkus Open Access Schroeder et al. identify a key pathway that flexibly tunes neocortical computations according to the individual’s experience. These long-range inhibitory afferents derive from the subthalamic zona incerta, preferentially target neocortical interneurons, and encode the learned top-down relevance of sensory information in a bidirectional and balanced fashion to enable memory. [Parametric control of flexible timing through low-dimensional neural manifolds](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)01089-3%3Fdgcid=raven_jbs_etoc_email/1/010001869e1e13df-de5ca56c-f3d2-412e-8142-33782bd03ddc-000000/KGdQtjP2e-pzXZp-rMbWP42Qa8EHXbIjzNTHu4jwl9k=290) Manuel Beiran, Nicolas Meirhaeghe, Hansem Sohn, Mehrdad Jazayeri, Srdjan Ostojic Beiran et al. investigate how neuronal networks adapt to novel stimuli and changing environments in flexible timing tasks. By reverse-engineering trained RNNs, they show that combining low-dimensional activity and tonic control signals enables generalization and fast adaptation. They further identify signatures of this mechanism in the frontal cortex of monkeys. [Update Your Profile](%2F%2Fwww.cell.com%2Faction%2FshowPreferences%3FmenuTab=Alerts%26code=cell-site/1/010001869e1e13df-de5ca56c-f3d2-412e-8142-33782bd03ddc-000000/pvfvb1Q7dBoiHdIppTkHO_Qj_b9BEL5GaRo8woJJEt4=290) [Terms and Conditions](%2F%2Fwww.elsevier.com%2Flegal%2Felsevier-website-terms-and-conditions/1/010001869e1e13df-de5ca56c-f3d2-412e-8142-33782bd03ddc-000000/hmxd_pR142uA6mLGGT_ceDMX7ppRI8tLogquG7ANltw=290) [Privacy Policy](%2F%2Fwww.elsevier.com%2Flegal%2Fprivacy-policy/1/010001869e1e13df-de5ca56c-f3d2-412e-8142-33782bd03ddc-000000/QbCkhvpuJ9aqaZYyuJrfyM6FuZyc3YjM8cPX0Eenw8A=290) [Follow this link to unsubscribe.](%2F%2Fwww.cell.com%2Falerts%2Funsubscribe%3FsubscriptionID=c1bedb93-d933-486c-b094-8eaf812d893b%26hash=eeca2f294f987df4d4ae56abbd699bf6e686193b/1/010001869e1e13df-de5ca56c-f3d2-412e-8142-33782bd03ddc-000000/IxdRkfoFVX03VfBkXrEr2HNDR9HT2YPyf_HaTZU5HcM=290) This email has been sent from Cell Press, a division of Elsevier Inc., 50 Hampshire Street, 5th Floor, Cambridge, MA 02139, USA. You are receiving this email because you signed up for email alerts for new issues of this journal. For all inquiries, problems or suggestions regarding this service, please contact [our support group.](%2F%2Fservice.elsevier.com%2Fapp%2Foverview%2Fcell-press%2F/1/010001869e1e13df-de5ca56c-f3d2-412e-8142-33782bd03ddc-000000/hid2UFNK3oKZStXlBFf8JOdoS_v2aUJXPdzAcxHSPE4=290) Copyright © 2023 Elsevier Inc. All rights reserved. Subscription ID: c1bedb93-d933-486c-b094-8eaf812d893b Webuser ID: a55d53f7ab892786bd7dece67e5041dc06f264ea Results Event ID: aaf37995-5c6c-456b-bca1-56c21c39e193