Neuron: December 7, 2022 (Volume 110, Issue 23)

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[Cell Symposia: Structural biology from the nanoscale to cellular mesoscale](%2F%2Fwww.cell-symposia.com%2Fstructuralbiology-2023%2Fdefault.asp/1/01000184eda4999b-211d9129-8f5c-4987-9bd1-62f6d0c01468-000000/ZGC3JtnAXNWB3dKvp5HpHvMywk6i9_yu8VKGoXVrABk=278) In partnership with the Biophysical Society of China November 3–5, 2023 | Huangshan, China. Featured articles --------------------------------------------------------------- [Challenges for machine learning in clinical translation of big data imaging studies](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00817-0/1/01000184eda4999b-211d9129-8f5c-4987-9bd1-62f6d0c01468-000000/CDNOuinomkAOOuxyMjX9HNFuJSIZ-wUDsuEkaEcy850=278) Dinsdale et al. [Myeloid cell interferon secretion restricts Zika flavivirus infection of developing and malignant human neural progenitor cells](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00807-8/1/01000184eda4999b-211d9129-8f5c-4987-9bd1-62f6d0c01468-000000/p6vyTVKBGdBCVwFV_R01Omd9m-UPptmyNFVy2dXaRMw=278) Bulstrode et al. [Anatomical barriers against SARS-CoV-2 neuroinvasion at vulnerable interfaces visualized in deceased COVID-19 patients](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)01028-5/1/01000184eda4999b-211d9129-8f5c-4987-9bd1-62f6d0c01468-000000/pzktKZCLjsG0EYunywe4WkqxbL0Ov4hCPlNnVIVzp70=278) Khan et al. [Joint coding of visual input and eye/head position in V1 of freely moving mice](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00804-2/1/01000184eda4999b-211d9129-8f5c-4987-9bd1-62f6d0c01468-000000/wrrv5-R2X07Aeu6R1C2HGFope9q8qumzEn6AhGhxR00=278) Parker et al. Online now --------------------------------------------------------------- [Hypothalamic warm-sensitive neurons require TRPC4 channel for detecting internal warmth and regulating body temperature in mice](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)01029-7/1/01000184eda4999b-211d9129-8f5c-4987-9bd1-62f6d0c01468-000000/-nLB_YzhgMCtc-zGJ829xJq2p99TQV6tB378lzL0nCY=278) Zhou et al. [Flexible sensory-motor mapping rules manifest in correlated variability of stimulus and action codes across the brain](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)01032-7/1/01000184eda4999b-211d9129-8f5c-4987-9bd1-62f6d0c01468-000000/juIlFXXKzThejD-rIeOdSPnOVl1OcrVBwAu0bZp5dhI=278) van den Brink et al. [Frontal and temporal coding dynamics in successive steps of complex behavior](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)01003-0/1/01000184eda4999b-211d9129-8f5c-4987-9bd1-62f6d0c01468-000000/XuCt15p8-VIZE7sPYU3uaj7qdGz64X_tgmwFmhmfxeY=278) Kadohisa et al. [Hemispherically lateralized rhythmic oscillations in the cingulate-amygdala circuit drive affective empathy in mice](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)01000-5/1/01000184eda4999b-211d9129-8f5c-4987-9bd1-62f6d0c01468-000000/tAVOfsx46U488zq41XtKxjJzb3TmftJPrnJ1bOFQx0Y=278) Kim et al. Table of Contents Previews --------------------------------------------------------------- [Interfer(on)ing with Zika virus](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00960-6%3Fdgcid=raven_jbs_etoc_email/1/01000184eda4999b-211d9129-8f5c-4987-9bd1-62f6d0c01468-000000/sbIT_tU4j7dMpkRaezrSWp-6ziztjGr2zALUf0aHkFo=278) Alvaro G. Alvarado, Harley I. Kornblum In this issue of Neuron, Bulstrode et al.1 demonstrate that glioblastoma slice cultures, unlike neural progenitors, are refractory to Zika virus infection. The anti-infective mechanism is myeloid-lineage cell-secreted interferon beta. These studies have implications for therapeutics in both glioblastoma and Zika virus infections. [Neuronal cultures playing Pong: First steps toward advanced screening and biological computing](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)01033-9%3Fdgcid=raven_jbs_etoc_email/1/01000184eda4999b-211d9129-8f5c-4987-9bd1-62f6d0c01468-000000/jNUHAcF2pdrrYgTsCCJfk44t6t3cY41r0g1wzAIH8AA=278) Lena Smirnova, Thomas Hartung In this issue of Neuron, Kagan et al. implement learning-in-a-dish as an important step toward organoid intelligence. These systems may complement the study of molecular and cellular mechanisms of cognition and allow innovations in pharmacological and toxicological studies of neurodevelopmental or neurodegenerative disorders as well as advances in biological computing. [“Goodnight” from the heart: A cardiovascular circuit that promotes sleep](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)01004-2%3Fdgcid=raven_jbs_etoc_email/1/01000184eda4999b-211d9129-8f5c-4987-9bd1-62f6d0c01468-000000/kuvLm7Drz2P8gUMXnmVplqH_wvernNKS-u344zK93ZA=278) Chuyue D. Yu, Rui B. Chang The baroreflex is essential for blood pressure homeostasis. In this issue of Neuron, Yao et al. uncover a novel role of brainstem barosensitive neurons in promoting non-REM (NREM) sleep, providing a direct link between the cardiovascular system and sleep-wake states. [How do different parts of brain white matter develop after birth in humans?](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)01034-0%3Fdgcid=raven_jbs_etoc_email/1/01000184eda4999b-211d9129-8f5c-4987-9bd1-62f6d0c01468-000000/l297aaxkY6Vm-t_tAMY6KSqyPUkNzxer5DZQ1QIzmi8=278) Sarah Genon, Stephanie J. Forkel Understanding human white matter development is vital to characterize typical brain organization and developmental neurocognitive disorders. In this issue of Neuron, Nazeri and colleagues identify different parts of white matter in the neonatal brain and show their maturational trajectories in line with microstructural feature development. Obituary --------------------------------------------------------------- [Philippe Ascher (1936–2022)](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00998-9%3Fdgcid=raven_jbs_etoc_email/1/01000184eda4999b-211d9129-8f5c-4987-9bd1-62f6d0c01468-000000/2O7Ma87Ywdj_tsO527Cw6KTwPc_4sEYf7tR5JGzT6H4=278) Pierre Paoletti, Alain Trautmann, Alain Marty Review --------------------------------------------------------------- [Challenges for machine learning in clinical translation of big data imaging studies](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00817-0%3Fdgcid=raven_jbs_etoc_email/1/01000184eda4999b-211d9129-8f5c-4987-9bd1-62f6d0c01468-000000/YN6KG_bgzl9SXP0y7SiwPPVdZcprT764Gd2_IcVuen4=278) Nicola K. Dinsdale, Emma Bluemke, Vaanathi Sundaresan, Mark Jenkinson, Stephen M. Smith, Ana I.L. Namburete Large-scale neuroimaging datasets allow deep learning methods to be practical for medical imaging research. However, their success is limited to specific tasks and data domains. Dinsdale et al. explore the challenges of data availability, interpretability and trust, evaluation, and logistics. NeuroResource --------------------------------------------------------------- [In situ cell-type-specific cell-surface proteomic profiling in mice](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00864-9%3Fdgcid=raven_jbs_etoc_email/1/01000184eda4999b-211d9129-8f5c-4987-9bd1-62f6d0c01468-000000/GNRcRkaQLu1-pUii73KnCda5WlKf3FT72XZTsQhih3E=278) S. Andrew Shuster, Jiefu Li, URee Chon, Miley C. Sinantha-Hu, David J. Luginbuhl, Namrata D. Udeshi, Dominique Kiki Carey, Yukari H. Takeo, Qijing Xie, Chuanyun Xu, D.R. Mani, Shuo Han, Alice Y. Ting, Steven A. Carr, Liqun Luo Open Access Shuster and Li et al. introduce iPEEL, a method for cell-type-specific in situ cell-surface proteome profiling in mice. Using iPEEL, they profile the cell-surface proteomes of developing and mature cerebellar Purkinje cells and identify a multifaceted dendritic morphogenesis function for Armh4, a transmembrane protein preferentially expressed in developing Purkinje cells. Reports --------------------------------------------------------------- [Joint coding of visual input and eye/head position in V1 of freely moving mice](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00804-2%3Fdgcid=raven_jbs_etoc_email/1/01000184eda4999b-211d9129-8f5c-4987-9bd1-62f6d0c01468-000000/T2JnIUs2sasjqPyXIGnkZHSf2e8DWIl13-dqAKAsHoE=278) Philip R.L. Parker, Elliott T.T. Abe, Emmalyn S.P. Leonard, Dylan M. Martins, Cristopher M. Niell Parker, Abe, et al. recorded neural activity in freely moving mice together with visual input from the mouse’s perspective. They measured receptive fields during free movement and showed that visual responses in many neurons are multiplicatively modulated by eye and head position. [Independent response modulation of visual cortical neurons by attentional and behavioral states](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00803-0%3Fdgcid=raven_jbs_etoc_email/1/01000184eda4999b-211d9129-8f5c-4987-9bd1-62f6d0c01468-000000/c6glLvnitN6buKJgko3NSd7hSIJ9F8-nem3kwL7hUxc=278) Takahiro Kanamori, Thomas D. Mrsic-Flogel Open Access Cortical responses are influenced by cognitive and behavioral states, but how these states modulate individual neurons is unknown. Kanamori and Mrsic-Flogel show that despite similar effects on neural responses, spatial attention and running act independently to modulate individual neurons in the primary visual cortex, suggesting separable mechanisms for their implementation. Articles --------------------------------------------------------------- [Anatomical barriers against SARS-CoV-2 neuroinvasion at vulnerable interfaces visualized in deceased COVID-19 patients](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)01028-5%3Fdgcid=raven_jbs_etoc_email/1/01000184eda4999b-211d9129-8f5c-4987-9bd1-62f6d0c01468-000000/qJ1rQ5N9PDWhYmMFwDaNGxLOOvarBB_aEDUgbpWrPjc=278) Mona Khan, Marnick Clijsters, Sumin Choi, Wout Backaert, Michiel Claerhout, Floor Couvreur, Laure Van Breda, Florence Bourgeois, Kato Speleman, Sam Klein, Johan Van Laethem, Gill Verstappen, Ayse Sumeyra Dereli, Seung-Jun Yoo, Hai Zhou, Thuc Nguyen Dan Do, Dirk Jochmans, Lies Laenen, Yves Debaveye, Paul De Munter, Jan Gunst, Mark Jorissen, Katrien Lagrou, Philippe Meersseman, Johan Neyts, Dietmar Rudolf Thal, Vedat Topsakal, Christophe Vandenbriele, Joost Wauters, Peter Mombaerts, Laura Van Gerven Open Access Khan et al. visualized infected cells, ongoing viral replication, and extracellular virions in postmortem tissue samples of COVID-19 patients who died during an acute phase of infection. They identified anatomical barriers protecting against SARS-CoV-2 neuroinvasion at vulnerable interfaces along the olfactory projection and in the frontal lobe of the brain. [Myeloid cell interferon secretion restricts Zika flavivirus infection of developing and malignant human neural progenitor cells](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00807-8%3Fdgcid=raven_jbs_etoc_email/1/01000184eda4999b-211d9129-8f5c-4987-9bd1-62f6d0c01468-000000/RHnYm6MS-u_k_qq1prZAZ7xYdTUrwDzY_Z6_igCcIKY=278) Harry Bulstrode, Gemma C. Girdler, Tannia Gracia, Alexander Aivazidis, Ilias Moutsopoulos, Adam M.H. Young, John Hancock, Xiaoling He, Katherine Ridley, Zhaoyang Xu, John H. Stockley, John Finlay, Clement Hallou, Teodoro Fajardo, Daniel M. Fountain, Stijn van Dongen, Alexis Joannides, Robert Morris, Richard Mair, Colin Watts, Thomas Santarius, Stephen J. Price, Peter J.A. Hutchinson, Emma J. Hodson, Steven M. Pollard, Irina Mohorianu, Roger A. Barker, Trevor R. Sweeney, Omer Bayraktar, Fanni Gergely, David H. Rowitch Open Access Zika virus (ZIKV) infects parallel neural progenitor cell populations in the developing brain and in glioblastoma brain tumors. Bulstrode et al. demonstrate that interferon secretion by human brain myeloid cells can render each neural progenitor population refractory to ZIKV infection, with important implications for neuroprotection and viral oncolysis. [In vitro neurons learn and exhibit sentience when embodied in a simulated game-world](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00806-6%3Fdgcid=raven_jbs_etoc_email/1/01000184eda4999b-211d9129-8f5c-4987-9bd1-62f6d0c01468-000000/TXqWervbMPsE1b0WfsRgKR6eGdXzlkGon6yWk84yvAM=278) Brett J. Kagan, Andy C. Kitchen, Nhi T. Tran, Forough Habibollahi, Moein Khajehnejad, Bradyn J. Parker, Anjali Bhat, Ben Rollo, Adeel Razi, Karl J. Friston Open Access The DishBrain system is the first real-time synthetic biological intelligence platform that demonstrates that biological neurons can adjust firing activity in a way that suggests the ability to learn to perform goal-oriented tasks when provided with simple electrophysiological sensory input and feedback while embodied in a game-world. [Long-range functional loops in the mouse olfactory system and their roles in computing odor identity](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00810-8%3Fdgcid=raven_jbs_etoc_email/1/01000184eda4999b-211d9129-8f5c-4987-9bd1-62f6d0c01468-000000/iWteYfajGI7eLkfn9odWt0rzhfpYRUBDlo51zOKSXHg=278) Honggoo Chae, Arkarup Banerjee, Marie Dussauze, Dinu F. Albeanu Chae, Banerjee, et al. identify distinct feedback loops mediated by the mouse olfactory bulb outputs (mitral and tufted cells) and their preferred cortical targets. They suggest that in addition to the mitral-to-piriform cortex pathway, the non-canonical tufted-to-anterior olfactory nucleus pathway is ideally placed for decoding odor identity and intensity. [Cardiovascular baroreflex circuit moonlights in sleep control](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00802-9%3Fdgcid=raven_jbs_etoc_email/1/01000184eda4999b-211d9129-8f5c-4987-9bd1-62f6d0c01468-000000/G8K6nGdxrBGC-04nKZw9akLh71SWiKHCCx3WiA1JkxI=278) Yuanyuan Yao, Zeke Barger, Mohammad Saffari Doost, Chak Foon Tso, Dana Darmohray, Daniel Silverman, Danqian Liu, Chenyan Ma, Ali Cetin, Shenqin Yao, Hongkui Zeng, Yang Dan Open Access Yao et al. show that the activity of neurons at key stages of baroreflex pathways in the mouse brain stem promotes sleep in addition to decreasing the blood pressure and heart rate, indicating that a basic circuit for autonomic cardiovascular control is also integral to sleep-wake brain-state regulation. [REM sleep-active hypothalamic neurons may contribute to hippocampal social-memory consolidation](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00809-1%3Fdgcid=raven_jbs_etoc_email/1/01000184eda4999b-211d9129-8f5c-4987-9bd1-62f6d0c01468-000000/sL7ggZE5CQsjv0gu-lLTPmcVJYAbQSXzfYcqlopeBAc=278) Han Qin, Ling Fu, Tingliang Jian, Wenjun Jin, Mengru Liang, Jin Li, Qianwei Chen, Xinyu Yang, Haoran Du, Xiang Liao, Kuan Zhang, Rui Wang, Shanshan Liang, Jiwei Yao, Bo Hu, Shuancheng Ren, Chunqing Zhang, Yanjiang Wang, Zhian Hu, Hongbo Jia, Arthur Konnerth, Xiaowei Chen Qin et al. identify two groups of REM sleep-active supramammillary neurons, one projecting to the hippocampal CA2 and the other to the dentate gyrus. They find that these two cell groups critically contribute to REM-sleep-associated consolidation of social and spatial memories, respectively. [Neurodevelopmental patterns of early postnatal white matter maturation represent distinct underlying microstructure and histology](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00859-5%3Fdgcid=raven_jbs_etoc_email/1/01000184eda4999b-211d9129-8f5c-4987-9bd1-62f6d0c01468-000000/DuwH1KAokm9uaR1wGLeUU_fYnm7UPbHVH-BNZfvmtyA=278) Arash Nazeri, Željka Krsnik, Ivica Kostović, Sung Min Ha, Janja Kopić, Dimitrios Alexopoulos, Sydney Kaplan, Dominique Meyer, Joan L. Luby, Barbara B. Warner, Cynthia E. Rogers, Deanna M. Barch, Joshua S. Shimony, Robert C. McKinstry, Jeffrey J. Neil, Christopher D. Smyser, Aristeidis Sotiras Using high-resolution T2-/T1-weighted MR images from a large sample, Nazeri et al. identify reproducible patterns of coordinated white matter maturation during the early postnatal period that correspond to distinct developmental trajectories, microstructure, and histology. These results provide important context for understanding the complexities of white matter development in health and disease. Correction --------------------------------------------------------------- [Loss of mouse Stmn2 function causes motor neuropathy](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)01002-9%3Fdgcid=raven_jbs_etoc_email/1/01000184eda4999b-211d9129-8f5c-4987-9bd1-62f6d0c01468-000000/68uU5hZQS0zo70YtOA7Po9GBAnIgKRxQdiJcZrLm82I=278) Irune Guerra San Juan, Leslie A. Nash, Kevin S. Smith, Marcel F. Leyton-Jaimes, Menglu Qian, Joseph R. Klim, Francesco Limone, Alexander B. Dorr, Alexander Couto, Greta Pintacuda, Brian J. Joseph, D. 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